Download or read book Psychiatric Pharmacogenomics written by David Mrazek and published by Oxford University Press. This book was released on 2010-06-10 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication. The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients. The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes. The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.

Download or read book Pharmacogenomics in Precision Medicine written by Weimin Cai and published by Springer. This book was released on 2021-06-13 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Download or read book Prescribing Psychotropics From Drug Metabolism to Genetics From Drug Interactions to Genetics written by Chris Aiken and published by . This book was released on 2021-10 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prescribing Psychotropics bridges the gap between the complexities of drug pharmacokinetics and everyday clinical practice, providing clinicians more insight into how psychiatric drugs behave (or misbehave!) once their patients take them. The book also includes a series of unusually practical charts and tables that prescribers will find invaluable as they make medication decisions. What you'll find inside: The basics of drug metabolism What you really need to know about drug interactions Food and drink effects on medications Recreational drug interactions Gender and drug metabolism Drug metabolism and ethnicity More than 70 quick-reference tables, charts, and figures

Download or read book Clinical Handbook of Psychotropic Drugs written by Kalyna Z. Bezchlibnyk-Butler and published by Hogrefe & Huber Publishing. This book was released on 1989 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes bibliography, glossary, and an extensive index which cross-references generic and trade names. New editions are available on a subscription basis.

Download or read book Pharmacogenetics of Psychotropic Drugs written by Bernard Lerer and published by Cambridge University Press. This book was released on 2011-04-28 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenetics and pharmacogenomics are areas of significant importance at the interface of molecular genetics and psychopharmacology, with implications for drug development and clinical practice. This 2002 book provides a conceptual framework for understanding and studying the pharmacogenetics of psychotropic drugs, reviews advances in the field, and describes the established findings. Coverage extends to antipsychotics, antidepressants, mood stabilising, cognitive-enhancing and anxiolytic drugs. Chapters also examine the interface of pharmacogenetics with substance dependence and brain imaging, and consider its impact on the biotechnology and pharmaceutical industries. This book defines the young field of pharmacogenetics as it applies to psychotropic drugs, and is therefore of interest to all clinicians and researchers working in this field.

Download or read book Pharmacogenomics written by Yui-Wing Francis Lam and published by Academic Press. This book was released on 2013-02-12 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. - Multi-contributed book and chapters are written by contributors who are experts in their field - Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be - Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications - Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Download or read book Psychiatric Pharmacogenetics written by David Durham and published by Bookbaby. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatric Pharmacogenetics from concepts to cases is a book written by two authors who are highly distinguished leaders in this cutting edge field. The book gives a synopsis of the history of how the science of pharmacogenetics evolved, how this new science can help address the mounting cost of managing adverse drug events, and explains the physiology of pharmacogenetics - the Cytochrome P450 system. This book is unique in that it is the first of its kind to dedicate a chapter on how adopting pharmacogenetic technology in clinical practice can markedly reduce medico-legal risk, and increase quality of care. It also dedicates chapters on the ethics and social impact of this burgeoning technology. Finally, and certainly not least, this book provides fifteen detailed clinical cases selected from clinic and hospital patients. For the busy psychiatric practitioner, this book promises to advance their knowledge and skills by giving them practical information they can employ immediately.

Download or read book Principles of Pharmacogenetics and Pharmacogenomics written by Russ B. Altman and published by Cambridge University Press. This book was released on 2012-01-23 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences.

Download or read book Genetic Influences on Response to Drug Treatment for Major Psychiatric Disorders written by Janusz K. Rybakowski and published by Springer. This book was released on 2016-02-04 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by global experts, this book provides a modern comprehensive insight into the pharmacogenetics of treatment of major psychoses: schizophrenia, bipolar disorder and depression. The pharmacogenomics of three categories of the most important psychiatric drugs, antipsychotics, antidepressants and mood stabilizers, has been updated and reviewed. Some promising directions and perspectives for future research in pharmacogenetics in major psychoses are indicated. They are, among others, connected with the development of new methods in molecular genetics and with linking pharmacogenetics assessment with biomarkers, including neuroimaging ones. Finally, the attempts to use pharmacogenetics of antipsychotic, antidepressant and mood-stabilizing drugs in practice are presented. New pharmacogenetic tools may greatly contribute to introducing personalized medicine into psychiatric clinical practice.

Download or read book Practical Psychopharmacology written by Joseph F. Goldberg and published by Cambridge University Press. This book was released on 2021-04-29 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide translating clinical trials findings, across major psychiatric disorders, to devise tailored, evidence-based treatments.

Download or read book The Genetics of African Populations in Health and Disease written by Muntaser E. Ibrahim and published by Cambridge University Press. This book was released on 2019-12-19 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.

Download or read book Melatonin Neuroprotective Agents and Antidepressant Therapy written by Francisco López-Muñoz and published by Springer. This book was released on 2016-11-16 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. .

Download or read book Schizophrenia Genesis written by Irving I. Gottesman and published by W. H. Freeman. This book was released on 1990-09-15 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sorting out fact from fiction, one of the world's leading experts presents an absorbing account of what is actually know about the complex subject of schizophrenia.

Download or read book Pharmacogenomics in Psychiatry written by M. Schwab and published by Karger Medical and Scientific Publishers. This book was released on 2010-06-25 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, there have been major developments in the fields of pharmacogenetics and pharmacogenomics, with the potential to make drug treatments in psychiatric medicine more effective. However, improvements in drug efficacy and tolerability, as well as finding the optimal dosage, can only be realized if in vivo mechanisms of drug action and ADME (absorption, distribution, metabolism, excretion) processes (pharmacokinetics) of psychopharmacological agents are better understood. In this volume, current progress and perspectives in pharmacogenetic testing of drug-metabolizing enzymes, drug transporters and other drug targets involved in the response to psychotropic agents are described extensively. This provides a timely overview of what has been achieved in the area of psychiatric pharmacogenomics alongside some promising directions and perspectives for future research.Psychiatrists, general medical doctors as well as pharmacologists and clinical pharmacologists will find new insights into the development and applications of pharmacogenomics in psychiatry.

Download or read book Managing the Side Effects of Psychotropic Medications Second Edition written by Joseph F. Goldberg, M.D., M.S. and published by American Psychiatric Pub. This book was released on 2018-08-10 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book has been divided into three main sections. Part I deals with global issues that bear on the assessment and formulation of possible adverse effects and with pertinent concepts related to basic pharmacology, physiology, and medical monitoring. The chapters in Part II present information organized by individual organ systems or specific medical circumstances rather than by drugs or drug classes. This approach seems to provide a logical and comprehensible format that allow readers to search out information as referenced by a particular side effect (and its varied potential causes) and to locate a discussion of practical management strategies. Part III focuses on summary recommendations covering all the material presented in the book and is followed by helpful appendixes on self-assessment questions and resources for practitioners. The book is meant to serve as a ready reference that simultaneously provides scientific and scholarly discussion of available treatment options and presents their scientific rationales."--page xx.

Download or read book Clinical Handbook of Psychotropic Drugs for Children and Adolescents written by Dean Elbe and published by . This book was released on 2019-01-21 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: New in this edition:¿ Drugs for ADHD thoroughly revised and updated¿ Antipsychotics with many changes and additions, including fully revised lab tests/monitoring¿ Antidepressants fully revised, including new sections on irreversible MAO-B inhibitor and serotonin modulator and stimulator (SMS), revised frequency of adverse effects table and switching strategies recommendations¿ Hypnotics completely revised¿ Mood stabilizers fully revised and a new toxicity comparison table added¿ Drugs of abuse and treatment of substance use disorder comprehensively revised¿ New unapproved treatments with significant updates, including: anti-inflammatories and NMDA agents in anxiety/OCD, cannabis use, and irritability of autism¿ New agents include: brexpiprazole, cariprazine, hypnotic suvorexant, tasimelteon, vortioxetine¿ New formulations and trade names include: Adasuve, Alprazolam Intensol, Aptensio XR, Aristada, Belbuca, Belsomra, Brintellix, Bunavail, Cotempla XR-ODT, Dyanavel XR, Eldepryl, EMSAM, Evekeo, Hemangeol, Hetlioz, Innopran XL, Invega Trinza, Khedezla, Metadol-D, Mydayis, NyQuil, Quillichew ER, Quillivant XR, Rexulti, Som-Pam, Tegretol (liquid), Trintellix, Versacolz, Vraylar, Vyvanse, Zelapar, ZenzediThe Clinical Handbook of Psychotropic Drugs for Children and Adolescents has become a standard reference and working tool for psychiatrists, pediatricians, psychologists, physicians, pharmacists, nurses, and other mental health professionals.¿ Packed with unique, easy-to-read comparison charts and tables (dosages, side effects, pharmacokinetics, interactions¿) for a quick overview of treatment options¿ Succinct, bulleted information on all classes of medication: on- and off-label indications, side effects, interactions, pharmacodynamics, nursing implications, and much more - all you need to know for each class of drug¿ Potential interactions and side effects summarized in comparison charts¿ With instantly recognizable icons and in full color throughout, allowing you to find at a glance all the information you seek¿ Clearly written patient and caregiver information sheets for download as printable PDF filesThis book is a must for all mental health professionals working with children and adolescents who need an up-to-date, easy-to use, comprehensive summary of all the most relevant information about psychotropic drugs.

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.