Download or read book Pharmaceutical Suspensions written by Alok K. Kulshreshtha and published by Springer Science & Business Media. This book was released on 2009-11-05 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.
Download or read book Pharmaceutical Suspensions written by Alok K. Kulshreshtha and published by Springer. This book was released on 2010 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Suspension Concentrates written by Tharwat F. Tadros and published by Walter de Gruyter GmbH & Co KG. This book was released on 2017-02-20 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Suspension Concentrates is a survey into the theory of the formulation and stabilization of suspensions, elaborating on the breaking of aggregates and agglomerates and the role of dispersing agents on flocculation and electrostatic and steric stabilization. Practical analysis by rheology is discussed. Suspension Concentrates is ideal for research scientists and Ph.D. students investigating chemistry, chemical engineering and colloidal science.
Download or read book Dispersion of Powders written by Tharwat F. Tadros and published by John Wiley & Sons. This book was released on 2012-04-24 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Teaching the fundamental knowledge required for successful dispersion of powders in a liquid, this book covers a host of topics -- from recent advances to industrial applications. In 15 chapters it supports formulation chemists in preparing a suspension in a more rational way, by applying the principles of colloid and interface science, while at the same time enabling the research scientist to discover new methods for preparing stable suspensions. Essential reading for those working in the pharmaceutical, cosmetic, food, paint, ceramic and agricultural industries.
Download or read book Pharmaceutical Dosage Forms written by Herbert Lieberman and published by CRC Press. This book was released on 2020-08-26 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stressing the theory involved in formulating suspensions, emulsions, and colloidal drug products, this Second Edition of a well-received reference test highlights typical formulations, the avoidance of formulation pitfalls, and compliance with established regulatory principles.
Download or read book Pharmaceutical Compounding and Dispensing written by John F. Marriott and published by Pharmaceutical Press. This book was released on 2010 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supplementary videos demonstrating various dispensing procedures can be viewed online at www.pharmpress.com/PCDvideos. --Book Jacket.
Download or read book Drug Stability for Pharmaceutical Scientists written by Thorsteinn Loftsson and published by Academic Press. This book was released on 2014-01-25 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in the pharmaceutical and related industries. Illustrates important theoretical concepts with numerous examples, figures, calculations, learning problems and questions for self-study and retention of material Provides answers and explanations to test your knowledge Enables you to better understand key concepts such as rate and order of reaction, reaction equilibrium, complex reaction mechanisms and more Includes an in-depth discussion of both aqueous and solid drug solutions and contains the latest international regulatory requirements on drug stability
Download or read book Transport Processes in Pharmaceutical Systems written by Gordon L. Amidon and published by CRC Press. This book was released on 1999-11-24 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity. Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems. Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems discusses the crucial relationship between the transport process and thermodynamic factors analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces covers prodrug design for improving membrane transport addresses the effects of external stimuli in altering some natural and synthetic polymer matrices examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions and more! Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.
Download or read book Pharmaceutical Emulsions and Suspensions written by Françoise Nielloud and published by CRC Press. This book was released on 2000-02-25 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analyzes construction of experiments, focusing on variables, models, matrices, and reproducibility. This timely reference systematically examines the basic concepts and theoretical issues, methodologies for experiment and measurement, and practical health applications of emulsions and dispersions-describing formulation problems and identifying potential carriers for the delivery or targeting of new drugs. Evaluates anionic, cationic, and nonionic surfactants as dispersing, emulsifying, foaming, penetrating, and wetting agents. Written by more than 20 international researchers, Pharmaceutical Emulsions and Suspensions discusses uses of macroemulsions and (submicron) microemulsions illuminates delivery devices such as microparticles, nanospheres, liposomes, and mixed micelles investigates the application of self-emulsifying drug delivery systems (SEDDS) introduces techniques for increasing drug solubility with nanosuspensions addresses stabilization, flocculation, and coagulation problems in pharmaceutical and cosmetic suspensions surveys drug delivery by way of dermatological, follicular, and ocular routes explains the pharmacodynamics, bioavailability, and pharmacokinetics in the drug formulation development process compares and contrasts monomeric and micellar adsorption at oil-water interfaces and more! Containing over 1800 references, tables, equations, drawings, and micrographs, Pharmaceutical Emulsions and Suspensions is an ideal resource for pharmacists; physical, surface, colloid, cosmetic, food, and agricultural chemists; and upper-level undergraduate and graduate students in these disciplines.
Download or read book Formulation Technology written by Hans Mollet and published by John Wiley & Sons. This book was released on 2008-11-21 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many chemical substances or compounds - organic or inorganic, natural or synthetic - are not used in their pure form. In order for the active ingredient to be most effective or to obtain the ideal delivery form for the market, the actual synthesis and purification steps are followed by formulation to give end products that range from powders, agglomerates, and granules to suspensions, emulsions, microemulsions, microcapsules, instant preparations, liposomes, and tablets. Formulation combines colloid and surface chemistry with chemical process engineering; sometimes it consists of a simple mixing operation, sometimes it requires an entire series of rather complicated engineering procedures such as comminution, dispersion, emulsification, agglomeration or drying. This book covers basic physico-chemical theory as well as its applications in the chemical industry for the production of pharmaceuticals, agrochemicals, pigments and dyes, food, detergents, cosmetics and many other products; it also provides chemists and chemical engineers with the necessary practical tools for the understanding of the structure/ activity relationship.
Download or read book Surfactant Systems written by D. Attwood and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now twelve years since Solubilization by Surface-Active Agents appeared. Since the publication of that monograph the subject has expanded rapidly as the unique potential of surfactants has become known to a wider circle of scientists. In a recent review Menger (Accounts of Chemical Research, 12 (1979) 111) estimated that since 1970 there have been over 2800 publications on micelles and micellization alone. The topic of catalysis in micellar media was in an early stage of development in 1968 but the growth in this subject has given rise to an excellent textbook by Fendler and Fendler. We have felt for some time that a revision of Solubilization by Surface-Active Agents was overdue. The book has been out of print for some time. Owing to pressure of other work, Professor P. H. Elworthy and Dr C. B. Macfarlane were unable to undertake the work of revision but while working together on an undergraduate textbook the present authors decided to set to work, realizing both the impossibility of producing a comprehensive textbook and the need to alter the scope of the book. Micellar solubilization occurs over a relatively small surfactant concentration range; because of this and because the phenomenon is never observed in isolation, we have extended the text to include surface activity, emulsions and suspensions and, as our emphasis is on formulation of medicinal products, to the of the toxicology of surface-active agents.
Download or read book Physicochemical Principles of Pharmacy written by Alexander Taylor Florence and published by . This book was released on 1988 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the physicochemical background to the design and use of pharmaceutical dosage forms. It goes beyond the introductory aspects of the subject to show how basic physicochemical principles are essential to an understanding of every aspect of drug action, from the dosage form to the site of action in the body. This is not a textbook of physical chemistry for pharmacists, but is a book which bridges the gap between basic first-year physical chemistry and the more applied practice of later years. This extensively revised second edition includes much new material, illustrations and references to take into account recent scientific developments and curriculum changes.
Download or read book Handbook of Pharmaceutical Manufacturing Formulations written by Sarfaraz K. Niazi and published by CRC Press. This book was released on 2004-04-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, this book covers liquid drugs, which include formulations of non-sterile drugs administered by any route in the form of solutions (monomeric and multimeric), suspensions (powder and liquid), drops, extracts, elixirs, tinctures, paints, sprays, colloidons, emul
Download or read book Applied Surfactants written by Tharwat F. Tadros and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: While currently available titles either focus on the basics or on very specific subtopics, this text meets the need for a comprehensive survey of surfactants and their properties, with a strong emphasis on applications and their correlation to the fundamentals. The author covers their classification, physical properties, phase behavior, adsorption, effects - such as wetting, spreading and adhesion - as well as industrial applications in personal care and cosmetics, pharmaceuticals, agrochemicals and food products. Professor Tadros is a well-known expert on the topic of surfactants, with much experience in colloid science. Here, he uses his industrial experience to close the gap between fundamentals of surfactants and their relevance and applications in practice.
Download or read book Pharmaceutical Blending and Mixing written by P. J. Cullen and published by John Wiley & Sons. This book was released on 2015-07-20 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. The contributors are a combination of leading academic and industrial experts, who provide an informed and industrially relevant perspective of the topic. This is an essential book for the pharmaceutical manufacturing industry, and related academic researchers in pharmaceutical science and chemical and mechanical engineering.
Download or read book Aulton s Pharmaceutics written by Michael E. Aulton and published by Elsevier Health Sciences. This book was released on 2013 with total page 909 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.
Download or read book FASTtrack Pharmaceutics Dosage Form and Design 2nd edition written by David S. Jones and published by Pharmaceutical Press. This book was released on 2016-06-13 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: FASTtrack Pharmaceutics – Dosage Form and Design focuses on what you really need to know in order to pass your pharmacy exams. It provides concise, bulleted information, key points, tips and an all-important self-assessment section, including MCQs.
