Download or read book Pharmaceutical Chemistry of Antihypertensive Agents written by Gyorgy Szasz and published by CRC Press. This book was released on 1990-12-19 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Chemistry of Antihypertensive Agents, provides the only comprehensive treatment of anti-hypertensive properties (e.g., structure-activity relationship, analytics, and metabolism) of pharmaceutical chemicals. The topics discussed include diuretics, renin inhibitors, angiotensin-converting enzyme inhibitors, a-blocking agents, b-adrenergic antagonists, and vasodilators. Data is supported by more than 1400 references and 300 chemical structures. This book is essential reading for physicians and pharmaceutical researchers, as well as pharmaceutical chemistry students.

Download or read book Neurocritical Care Pharmacotherapy written by Eelco F. M. Wijdicks and published by Oxford University Press. This book was released on 2018 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurocritical Care Pharmacotherapy: A Clinican's Guide is a practical, succinct but comprehensive pharmacy handbook provides up-to-date clinical guidance on the effective selection, prescription, and usage of neurocritical care drugs for patients with acute neurologic illnesses. The treatment of the critically ill neurologic patient is often difficult, specialized, and includes drugs infrequently used in other intensive care units such as antiepileptic drugs, osmotic agents or acute immunotherapy such as intravenous immunoglobulin and plasma exchange. This text discusses choosing the right combination of drugs; how to correctly prescribe and administer the drugs; how to monitor drug efficacy and side effects; how neurocritical care drugs interact with other medications; and comprehensive coverage of current treatment options. Key Feature of this Manual Include - A brief discussion of the basic pharmacology of each neurocritical drug, with an emphasis on how to select and use these drugs in multiple clinical contexts. - 150 drugs accompanied by a diagram for quick comprehension and drug administration guides. - Unique blending of expertise of neurointensivist with a critical care pharmacist to provide a vital resource for both specialities - References for further reading that are oriented toward utility in clinical practice.

Download or read book Piperidine Based Drug Discovery written by Ruben Vardanyan and published by Elsevier. This book was released on 2017-06-12 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. - Explores this extremely important heterocycle to a high level of detail - Describes synthesis methods for 70 current drugs based on Piperidine scaffolds - Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine - Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Download or read book Side Effects of Drugs written by L. Meyler and published by . This book was released on 1952 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Download or read book Textbook of Organic Medicinal and Pharmaceutical Chemistry written by Charles Owens Wilson and published by Lippincott Williams & Wilkins. This book was released on 1977 with total page 1150 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Preparation of Phytopharmaceuticals for the Management of Disorders written by Chukwuebuka Egbuna and published by Academic Press. This book was released on 2020-11-03 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preparation of Phytopharmaceuticals for the Management of Disorders: The Development of Nutraceuticals and Traditional Medicine presents comprehensive coverage and recent advances surrounding phytopharmaceuticals, nutraceuticals and traditional and alternative systems of medicines. Sections cover the concepts of phytopharmaceuticals, their history, and current highlights in phytomedicine. Also included are classifications of crude drugs, herbal remedies and toxicity, traditional and alternative systems of medicine, nanotechnology applications, and herbal cosmeticology. Final sections cover applications of microbiology and biotechnology in drug discovery. This book provides key information for everyone interested in drug discovery, including medicinal chemists, nutritionists, biochemists, toxicologists, drug developers and health care professionals. Students, professors and researchers working in the area of pharmaceutical sciences and beyond will also find the book useful. - Includes the history and current highlights in phytomedicine, along with classifications of crude drugs, herbal drug technologies and herbal cosmeticology - Provides detailed information on herbal remedies and toxicity, traditional and alternative systems of medicine, and applications of microbiology and biotechnology in drug discovery - Discusses the nutritional and health benefits of nutraceuticals and how they help in the management and treatment of metabolic diseases

Download or read book Synthesis of Essential Drugs written by Ruben Vardanyan and published by Elsevier. This book was released on 2006-03-10 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO's Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references

Download or read book Synthesis of Best Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

Download or read book Essentials of Botanical Extraction written by Subhash C. Mandal and published by Academic Press. This book was released on 2015-02-02 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Botanical Extraction: Principles and Applications provides a unique, single source of valuable information on the various botanical extraction methods available, from conventional to the use of green and modern extraction technologies including ultrasounds, microwaves, pressurized liquids, and supercritical fluids. Most extracts obtained from botanicals are often poorly characterized with unidentified active or inactive constituents. A wise selection of an extraction strategy is vital to drug discovery from medicinal plants as extraction forms the basic first step in medicinal plant research. This book also explores the mathematical hypotheses and innovations in botanical extractions and analyzes different post extraction operations so that dependency on serendipity is reduced and the same be converted into programmed drug discovery. - Reviews the history and current state of natural product drug discovery and development, highlighting successes and current issues - Explains the application of chemometric tools in extraction process design and method development - Introduces process intensification as applied to the processing of medicinal plant extracts for rapid and cost-effective extraction

Download or read book Prodrugs written by Valentino Stella and published by Springer Science & Business Media. This book was released on 2007-03-12 with total page 1447 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.

Download or read book Integration of Pharmaceutical Discovery and Development written by Ronald T. Borchardt and published by Springer Science & Business Media. This book was released on 2006-01-19 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.

Download or read book Drug Facts and Comparisons 2006 written by and published by Facts & Comparisons. This book was released on 2005 with total page 2654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Facts and Comparisons contains up-to-date, comprehensive information on over 22,000 Rx and almost 6,000 OTC items grouped by therapeutic category for ease of comparison. The annual hardbound edition features the Color Locator, a full-color section of photos of the most frequently prescribed tablets and capsules organized by color for easy visual identification. The book answers questions about: actions, indications and contraindications; warnings and precautions; interactions between drugs; adverse reactions; administration, dosage, and overdosage; patient information. Comparisons are provided: Of drug to drug; of different dosage forms; name brands are compared to name brands and to generics. Facts and Comparisons are also given on Centers for Disease Control biologicals and antiparasitic drugs; IV solutions; therapeutic and diagnostic ophthalmic preparations; diagnostic aids and radiographic contrast media and products; NCI investigational chemotherapeutic drugs; combination cancer chemotherapy regimens.

Download or read book Iodine Chemistry and Applications written by Tatsuo Kaiho and published by John Wiley & Sons. This book was released on 2014-10-09 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers iodine, its chemistry, and its role in functional materials, reagents, and compounds. • Provides an up-to-date, detailed overview of iodine chemistry with discussion on elemental aspects: characteristics, properties, iodides, and halogen bonding • Acts as a useful guide for readers to learn how to synthesize complex compounds using iodine reagents or intermediates • Describes traditional and modern processing techniques, such as starch, cupper, blowing out, and ion exchange resin methods • Includes seven detailed sections devoted to the applications of iodine: Characteristics, Production, Synthesis, Biological Applications, Industrial Applications, Bioorganic Chemistry and Environmental Chemistry, and Radioisotopes • Features hot topics in the field, such as hypervalent iodine-mediated cross coupling reactions, agrochemicals, dye sensitized solar cells, and therapeutic agents

Download or read book Textbook of Medicinal Chemistry Vol I E Book written by V Alagarsamy and published by Elsevier Health Sciences. This book was released on 2013-06-17 with total page 1010 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharm. students, this book will also be useful for M. Pharm. as well as M. Sc. organic chemistry and pharmaceutical chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing enormous information on all the topics in medicinal chemistry of synthetic drugs. Salient Features Contains clear classification, synthetic schemes, mode of action, metabolism, assay, pharmacological uses with the dose and structure–activity relationship (SAR) of the following classes of drugs: Drugs acting on inflammation Drugs acting on respiratory system Drugs acting on digestive system Drugs acting on blood and blood-forming organs Drugs acting on endocrine system Contains a complete section on chemotherapy and the various classes of chemotherapeutic agents. Also includes recent topics like anti-HIV agents Contains brief introduction about the physiological and pathophysiological conditions of diseases and their treatment under each topic Provides well-illustrated synthetic schemes and alternative synthetic routes for majority of drugs that help in quick and enhanced understanding of the subject Covers the syllabi of majority of Indian universities

Download or read book Comprehensive Hypertension E Book written by Gregory Y. H. Lip and published by Elsevier Health Sciences. This book was released on 2007-06-28 with total page 1247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is today's most in-depth reference for any cardiologist, internist, or nephrologist interested in hypertension. Drawing from international experience in cardiology, physiology, and nephrology, Drs. Lip and Hall have assembled a group of section editors and contributors second to none. You'll find the long-term effects of primary and secondary hypertension and a lengthy section on hypertensions for special populations featured prominently. Prevention and treatment of hypertension are covered in detail, from lifestyle and diet issues to drug choice and delivery, and the section on comparison of guidelines is unique to this book. Find comprehensive coverage of hypertension including pathogenesis, prevention, and treatment all in one practical volume. See the complete systemic problems of hypertension at a glance with detailed, full-color illustrations of cellular and clinical manifestations. Simplify navigating the complexities of hypertension using algorithms for clinical exam and diagnosis. Get specific insight into prevention and treatment of hypertension in special populations. Go global with a comprehensive section on worldwide guidelines and the application of clinical material to local standards of practice.

Download or read book Pharmaceutical Chemistry Ii written by A. V. Kasture and published by Pragati Books Pvt. Ltd.. This book was released on 2014-05 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction. Centrak Nervous System Stimulants. Antidepressants and Antinxienty Agent (Anxiolytic). Antipsychotic Agents and Hallucinogens. General Anaestetics. Hypnotics and Sedatives. Skeletal Muscle Relaxants. Tranquilizing Agents. Anticonvulsant Drugs. Analgesics (Narcotcs). Anpyertic Analgesics. Nonsteroidal Anti- Inflammatory Agents. Adrenergic Agents. Adrenergic Blocking Agents. Cardiovascular Agents. Histamines & Antihistaminic Agents. antitussives & Expectorants. Coagulants and Anticoagulants