Download or read book Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family written by Aron B. Fisher and published by MDPI. This book was released on 2019-05-13 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The peroxiredoxin family was discovered approximately 30 years ago and is now recognized as one of the most important families of enzymes related to antioxidant defense and cellular signaling. Peroxiredoxin 6 shares the basic enzymatic functions that characterize this family, but also exhibits several unique and crucial activities. These include the ability to reduce phospholipid hydroperoxides, phospholipase A2 activity, and an acyl transferase activity that is important in phospholipid remodeling. This book describes the available models for investigating the unique functions of PRDX6 and its role in normal physiological function, as well its roles in the pathophysiology of diseases including cancer, diseases of the eye, and male fertility.
Download or read book Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family written by Aron B. Fisher and published by . This book was released on 2019 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The peroxiredoxin family was discovered approximately 30 years ago and is now recognized as one of the most important families of enzymes related to antioxidant defense and cellular signaling. Peroxiredoxin 6 shares the basic enzymatic functions that characterize this family, but also exhibits several unique and crucial activities. These include the ability to reduce phospholipid hydroperoxides, phospholipase A2 activity, and an acyl transferase activity that is important in phospholipid remodeling. This book describes the available models for investigating the unique functions of PRDX6 and its role in normal physiological function, as well its roles in the pathophysiology of diseases including cancer, diseases of the eye, and male fertility.
Download or read book Peroxiredoxin Systems written by Leopold Flohé and published by Springer Science & Business Media. This book was released on 2007-09-04 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a broad survey on the peroxiredoxins. It involves almost all groups that contributed significant insights into the emerging field. Coverage discusses the diverse biological roles of the new protein family in the context of other antioxidant systems like those based on heme or selenium catalysis. In addition, the book highlights related future perspectives.
Download or read book Redox Chemistry and Biology of Thiols written by Beatriz Alvarez and published by Academic Press. This book was released on 2022-05-25 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Redox Chemistry and Biology of Thiols offers an applied, comprehensive overview of redox chemistry and biology of thiol-dependent processes. Running from basic biology and chemistry of redox phenomena to research methods and highlighting recently identified roles of thiols across cellular and bodily systems, this book draws upon a range of disciplines to illuminate new research directions, new applications of thiol studies, and clinical translation. Sections cover thiol oxidizing species, thiol reactivity and modifications, thioredoxin, glutaredoxin, glutathione, peroxidases, thiol repair enzymes, thiol oxidative signaling, disulfide bond formation, thiol-based redox biosensors, cysteine and hydrogen sulfide metabolism, iron-sulfur cluster biogenesis, thiols in chloroplasts, blood thiols, sugar and polyamine thiols in pathogenic organisms, redox medicine (therapeutic applications of thiols and drug development), as well as methods and bioinformatics tools. Runs from basic thiol biology and chemistry to applications and clinical translation Provides methods and protocols that will power new research across biomedicine, cell biology, plant biology, drug development, and protein folding and modulation Includes chapter contributions from international leaders in the field
Download or read book Biology of Brain Disorders written by Daniela Tropea and published by Frontiers Media SA. This book was released on 2018-01-31 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain disorders, including neurological and neuropsychiatric conditions, represent a challenge for public health systems and society at large. The limited knowledge of their biology hampers the development of diagnostic tools and effective therapeutics. A clear understanding of the mechanisms that underlie the onset and progression of brain disorders is required in order to identify new avenues for therapeutic intervention. Overlapping genetic risk factors across different brain disorders suggest common linkages and pathophysiological mechanisms that underlie brain disorders. Methodological and technological advances are leading to new insights that go beyond traditional hypotheses. Taking account of underlying molecular, cellular and systems biology underlying brain function will play an important role in the classification of brain disorders in future. In this Research Topic, the latest advances in our understanding of biological mechanisms across different brain disorders are presented. The areas covered include developments in neurogenetics, epigenetics, plasticity, glial cell biology, neuroimmune interactions and new technologies associated with the study of brain function. Examples of how understanding of biological mechanisms are translating into research strategies that aim to advance diagnoses and treatment of brain disorders are discussed.
Download or read book Peroxiredoxin Systems written by Leopold Flohé and published by Springer Science & Business Media. This book was released on 2007-09-05 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a broad survey on the peroxiredoxins. It involves almost all groups that contributed significant insights into the emerging field. Coverage discusses the diverse biological roles of the new protein family in the context of other antioxidant systems like those based on heme or selenium catalysis. In addition, the book highlights related future perspectives.
Download or read book Dietary Interventions in Liver Disease written by Ronald Ross Watson and published by Academic Press. This book was released on 2019-01-10 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dietary Interventions in Liver Disease: Foods, Nutrients, and Dietary Supplements provides valuable insights into the agents that affect metabolism and other health-related conditions in the liver. It provides nutritional treatment options for those suffering from liver disease. Information is presented on a variety of foods, including herbs, fruits, soy and olive oil, thus illustrating that variations in intake can change antioxidant and disease preventing non-nutrients that affect liver health and/or disease promotion. This book is a valuable resource for biomedical researchers who focus on identifying the causes of liver diseases and food scientists targeting health-related product development. Provides information on agents that affect metabolism and other health-related conditions in the liver Explores the impact of composition, including differences based on country of origin and processing techniques Addresses the most positive results from dietary interventions using bioactive foods to impact liver disease, including reduction of inflammation and improved function
Download or read book Antioxidants and Antioxidant Enzymes in Higher Plants written by Dharmendra K. Gupta and published by Springer. This book was released on 2018-03-10 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of antioxidants and antioxidant enzymes and their role in the mechanisms of signaling and cellular tolerance under stress in plant systems. Major reactive oxygen species (ROS)-scavenging/modulating enzymes include the superoxide dismutase (SOD) that dismutates O2 into H2O2, which is followed by the coordinated action of a set of enzymes including catalase (CAT), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and peroxiredoxins (Prx) that remove H2O2. In addition to the ROS scavenging enzymes, a number of other enzymes are found in various subcellular compartments, which are involved in maintaining such redox homeostasis either by directly scavenging particular ROS and ROS-byproducts or by replenishing antioxidants. In that respect, these enzymes can be also considered antioxidants. Such enzymes include monodehydroascorbate reductase (MDAR), dehydroascorbate reductase (DHAR), glutathione reductase (GR), alternative oxidases (AOXs), peroxidases (PODs) and glutathione S-transferases (GSTs). Some non-enzymatic antioxidants, such as ascorbic acid (vitamin C), carotenes (provitamin A), tocopherols (vitamin E), and glutathione (GSH), work in concert with antioxidant enzymes to sustain an intracellular steady-state level of ROS that promotes plant growth, development, cell cycles and hormone signaling, and reinforces the responses to abiotic and biotic environmental stressors. Offering a unique compilation of information on antioxidants and antioxidant enzymes, this is a valuable resource for advanced students and researchers working on plant biochemistry, physiology, biotechnology, and signaling in cell organelles, and those specializing in plant enzyme technology.
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Download or read book Thrombolytics Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thrombolytics: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Thrombolytics in a compact format. The editors have built Thrombolytics: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Thrombolytics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Thrombolytics: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Genomic and Biochemical Characterisation of the B PR61 Regulatory Subunit Family of Protein Phosphatase 2A written by Ellen Martens and published by Leuven University Press. This book was released on 2004 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is a Ph.D. dissertation. Reversible protein phosphorylation has become widely recognized as the most important reaction for the regulation of protein functioning in eukaryotic cells, being involved in switching cellular activities from one state to another and, in this way, regulating different cellular functions. It is the major mechanism by which cells respond to extracellular signals, such as hormones and growth factors, and control all events at various stages of the cell cycle, as well as the response of the cell to environmental and nutritional stresses. As much as one-third of cellular proteins have been estimated to undergo reversible protein phosphorylation, underlining the importance, and widespread occurrence of this modification. Contents include: General Introduction, Protein Phosphates, Multimetric Structure of PP2A, PP2A as a Kinase Phosphate, Aims of the Work, Materials and Methods, Results, B'/PR61-Interacting Proteins, Discussion."
Download or read book Advances in Cyanobacterial Biology written by Prashant Kumar Singh and published by Academic Press. This book was released on 2020-02-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cyanobacterial Biology presents the novel, practical, and theoretical aspects of cyanobacteria, providing a better understanding of basic and advanced biotechnological application in the field of sustainable agriculture. Chapters have been designed to deal with the different aspects of cyanobacteria including their role in the evolution of life, cyanobacterial diversity and classification, isolation, and characterization of cyanobacteria through biochemical and molecular approaches, phylogeny and biogeography of cyanobacteria, symbiosis, Cyanobacterial photosynthesis, morphological and physiological adaptation to abiotic stresses, stress-tolerant cyanobacterium, biological nitrogen fixation. Other topics include circadian rhythms, genetics and molecular biology of abiotic stress responses, application of cyanobacteria and cyanobacterial mats in wastewater treatments, use as a source of novel stress-responsive genes for development of stress tolerance and as a source of biofuels, industrial application, as biofertilizer, cyanobacterial blooms, use in Nano-technology and nanomedicines as well as potential applications. This book will be important for academics and researchers working in cyanobacteria, cyanobacterial environmental biology, cyanobacterial agriculture and cyanobacterial molecular biologists. Summarizes the various aspects of cyanobacterial research, from primary nitrogen fixation, to advanced nano-technology applications Addresses both practical and theoretical aspects of the cyanobacterial application Includes coverage of biochemical and molecular approaches for the identification, use and management of cyanobacteria
Download or read book NADPH Oxidases Revisited From Function to Structure written by Edgar Pick and published by Springer Nature. This book was released on 2023-06-22 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field. The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.
Download or read book Redox Signaling and Regulation in Biology and Medicine written by Claus Jacob and published by John Wiley & Sons. This book was released on 2009-05-06 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.
Download or read book Hydrogen Peroxide and Cell Signaling Part A written by and published by Academic Press. This book was released on 2013-06-19 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as photooxidation of amplex red to resorufin, boronate-based fluorescent probes, and visualization of intracellular hydrogen peroxide with HyPer. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers hydrogen peroxide and cell signaling Contains chapters on such topics as photooxidation of amplex red to resorufin, boronate-based fluorescent probes, and visualization of intracellular hydrogen peroxide with HyPer
Download or read book Antioxidants and Reactive Oxygen Species in Plants written by Nicholas Smirnoff and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive oxygen species (ROS) are produced during the interaction of metabolism with oxygen. As ROS have the potential to cause oxidative damage by reacting with biomolecules, research on ROS has concentrated on the oxidative damage that results from exposure to environmental stresses and on the role of ROS in defence against pathogens. However, more recently, it has become apparent that ROS also have important roles as signalling molecules. A complex network of enzymatic and small molecule antioxidants controls the concentration of ROS and repairs oxidative damage, and research is revealing the complex and subtle interplay between ROS and antioxidants in controlling plant growth, development and response to the environment. This book covers these new developments, generally focussing on molecular and biochemical details and providing a point of entry to the detailed literature. It is directed at researchers and professionals in plant molecular biology, biochemistry and cell biology, in both the academic and industrial sectors.
Download or read book Spermatogenesis written by C. Yan Cheng and published by CRC Press. This book was released on 2018-09-03 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: Senior investigators internationally have here collaborated to produce an international reference work. Each contributor provides critical and thought provoking concepts and ideas based on the latest developments in their field. The result is a must read and timely reference work for investigators who are interested in how spermatogenesis is currently understood and which are the most promising avenues for future research; an Introduction sets the context for the chapter and points out the relevance of the research for basic research scientists and clinicians.
