Download or read book Concepts and Models for Drug Permeability Studies written by Bruno Sarmento and published by Woodhead Publishing. This book was released on 2015-09-30 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route. - Updated information regarding the most recent in vitro models to study the permeability of drugs - Short and concise chapters covering all the biological barriers with interest in drug permeability - A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models - Simple and clear scientific content, adaptable for young scientists and experimented researchers

Download or read book Permeability Properties of Plastics and Elastomers 2nd Ed written by Liesl K. Massey and published by Cambridge University Press. This book was released on 2003 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensively revised and updated second edition of the only data handbook available on the properties of commercial polymeric films details the permeability characteristics of over 125 major plastic and elastomer packaging materials. New to this edition are 92 resin chapters containing textual summary information including: category, general description, processing methods, applications, and general permeability considerations for water vapor, oxygen, and other gases including aroma and flavor. The product data is presented in graphical and tabular format, retaining the familiar format of the first edition and allowing easy comparison between materials and test conditions.

Download or read book Crustal Permeability written by Tom Gleeson and published by John Wiley & Sons. This book was released on 2016-11-30 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: Permeability is the primary control on fluid flow in the Earth’s crust and is key to a surprisingly wide range of geological processes, because it controls the advection of heat and solutes and the generation of anomalous pore pressures. The practical importance of permeability – and the potential for large, dynamic changes in permeability – is highlighted by ongoing issues associated with hydraulic fracturing for hydrocarbon production (“fracking”), enhanced geothermal systems, and geologic carbon sequestration. Although there are thousands of research papers on crustal permeability, this is the first book-length treatment. This book bridges the historical dichotomy between the hydrogeologic perspective of permeability as a static material property and the perspective of other Earth scientists who have long recognized permeability as a dynamic parameter that changes in response to tectonism, fluid production, and geochemical reactions.

Download or read book Permeability of Biological Membranes written by Gaspar Banfalvi and published by Springer. This book was released on 2016-02-10 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with biological membranes, focuses on permeabilization and pays particular attention to reversible permeabilization to maintain the viability and physiological conditions of the cells. Selective permeability of biological membranes also known as semipermeability, partial permeability or differential permeability allows molecules to diffuse, pass by passive and active or by other types of transport processes mediated by proteins. The first chapter of the book deals with the composition of biological membranes, characterizes cellular membranes of prokaryotic, eukaryotic cells, membranes of cellular organelles and the function of biological membranes. The second chapter provides an overview of bilayer permeability, selectivity of permeabilization and cellular transport processes. Chapter 3 overviews different cell manipulations that aim to make cells permeable while maintaining not only the structural but also the functional integrity of cells. The last chapter deals with applications, particularly with reversible permeabilization to study macromolecular (DNA, RNA, poly-ADP ribose) biosynthetic processes, replication, gene expression, visualization of replicons, intermediates of chromosome condensation, genotoxic chromatin changes, upon treatment with heavy metals and different types of irradiation. The interdisciplinary aspects of the book contribute to the understanding of the structure of nucleic acids, replicative intermediates, Okazaki fragments, RNA primer mechanism, subphases of replication and repair synthesis, replicons, gene expression, chromosome condensation generated a wealth of information that will attract a wide readership. The natural audience engaged in DNA research, including genetics, cell and molecular biology, chemistry, biochemistry, medicine, pharmacy will find essential material in the book.

Download or read book Concrete Permeability and Durability Performance written by Roberto J. Torrent and published by CRC Press. This book was released on 2021-12-22 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Durability and service life design of concrete constructions have considerable socio-economic and environmental consequences, in which the permeability of concrete to aggressive intruders plays a vital role. Concrete Permeability and Durability Performance provides deep insight into the permeability of concrete, moving from theory to practice, and presents over 20 real cases, such as Tokyo’s Museum of Western Art, Port of Miami Tunnel and Hong Kong-Zhuhai-Macao sea-link, including field tests in the Antarctic and Atacama Desert. It stresses the importance of site testing for a realistic durability assessment and details the "Torrent Method" for non-destructive measurement of air-permeability. It also delivers answers for some vexing questions: Should the coefficient of permeability be expressed in m2 or m/s? How to get a "mean" pore radius of concrete from gas-permeability tests? Why should permeability preferably be measured on site? How can service life of reinforced concrete structures be predicted by site testing of gas-permeability and cover thickness? Practitioners will find stimulating examples on how to predict the coming service life of new structures and the remaining life of existing structures, based on site testing of air-permeability and cover thickness. Researchers will value theoretical principles, testing methods, as well as how test results reflect the influence of concrete mix composition and processing.

Download or read book Polymer Permeability written by J. Comyn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers are permeable, whilst ceramics, glasses and metals are gener ally impermeable. This may seem a disadvantage in that polymeric containers may allow loss or contamination of their contents and aggressive substances such as water will diffuse into polymeric struc tures such as adhesive joints or fibre-reinforced composites and cause weakening. However, in some cases permeability is an advantage, and one particular area where this is so is in the use of polymers in drug delivery systems. Also, without permeable polymers, we would not enjoy the wide range of dyed fabrics used in clothing and furnishing. The fundamental reason for the permeability of polymers is their relatively high level of molecular motion, a factor which also leads to their high levels of creep in comparison with ceramics, glasses and metals. The aim of this volume is to examine some timely applied aspects of polymer permeability. In the first chapter basic issues in the mathema tics of diffusion are introduced, and this is followed by two chapters where the fundamental aspects of diffusion in polymers are presented. The following chapters, then, each examine some area of applied science where permeability is a key issue. Each chapter is reasonably self-contained and intended to be informative without frequent outside reference. This inevitably leads to some repetition, but it is hoped that this is not excessive.

Download or read book Permeability Properties of Plastics and Elastomers written by Laurence W. McKeen and published by William Andrew. This book was released on 2011-09-08 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Permeability properties are essential data for the selection of materials and design of products across a broad range of market sectors from food packaging to Automotive applications to Medical Devices. This unique handbook brings together a wealth of permeability data in a form that enables quick like-for-like comparisons between materials. The data is supported by a full explanation of its interpretation, and an introduction to the engineering aspects of permeability in polymers. The third edition includes expanded explanatory text which makes the book accessible to novices as well as experienced engineers, written by industry insider and author Larry McKeen (DuPont), and 20% new data and major new explanatory text sections to aid in the interpretation and application of the data. - A unique collection of permeability data designed to enable quick like-for-like comparisons between different materials - Third edition includes 20% new data and expanded explanatory text, which makes the book accessible to novices as well as experienced engineers - Essential reference for materials engineers, design engineers and applications engineers across sectors including packaging, automotive and medical devices

Download or read book Multiphase Flow in Permeable Media written by Martin J. Blunt and published by Cambridge University Press. This book was released on 2017-02-16 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a fundamental description of multiphase fluid flow through porous rock, based on understanding movement at the pore, or microscopic, scale.

Download or read book Laboratory Testing and Evaluation of Porous Permeable Rock for Nuclear Waste Disposal written by Jerry B. F. Champlin and published by . This book was released on 1967 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Permeability Properties of Plastics and Elastomers written by Laurence W. McKeen and published by William Andrew. This book was released on 2011-09-28 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rev. ed. of: Permeability properties of plastics and elastomers / Massey, Liesl K. c2003. 2nd ed.

Download or read book Tests of the Absorptive and Permeable Properties of Portland Cement Mortars and Concretes Together with Test of Dampproofing and Waterproofing Compounds and Materials written by Rudolph James Wig and published by . This book was released on 1912 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Permeability Properties of Plastics and Elastomers written by Liesl K. Massey and published by William Andrew. This book was released on 2003-01-01 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensively revised and updated second edition of the only data handbook available on the properties of commercial polymeric films details the permeability characteristics of over 125 major plastic and elastomer packaging materials. New to this edition are 92 resin chapters containing textual summary information including: category, general description, processing methods, applications, and general permeability considerations for water vapor, oxygen, and other gases including aroma and flavor. The product data is presented in graphical and tabular format, retaining the familiar format of the first edition and allowing easy comparison between materials and test conditions.

Download or read book An Introduction to Permeable Concrete Pavement for Professional Engineers written by J. Paul Guyer, P.E., R.A. and published by Guyer Partners. This book was released on 2023-11-18 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introductory technical guidance for civil engineers and other professional engineers and construction managers interested in permeable concrete pavements. Here is what is discussed: 1. BACKGROUND, 2. DESIGN, 3. CONSTRUCTION, 4. MAINTENANCE, 5. PERFORMANCE, 6. REFERENCES.

Download or read book Transactions written by American Foundrymen's Society and published by . This book was released on 1925 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Toward Permeable Boundaries of Organizations written by Leopold Ringel and published by Emerald Group Publishing. This book was released on 2018-10-17 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classical concept of organizations as solitary 'walled-in' actors with clear operational boundaries is increasingly being challenged. This volume examines why, examines the impact of these changes on organizations and offers conceptual and empirical insights.

Download or read book Long Term Performance of Permeable Reactive Barriers written by K.E. Roehl and published by Gulf Professional Publishing. This book was released on 2005-04-27 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: While extensive research has been performed on many technological aspects of permeable reactive barriers and a number of contaminants have so far been successfully treated by PRB systems, long-term performance has not been extensively considered and little is known about the processes influencing long-term behaviour. This gap in our knowledge is all the more disadvantageous as design life has a decisive influence on the economic viability of PRBs. The book describes methods for evaluation and enhancement of the long-term performance of PRB systems, especially of those targeting heavy metals, specifically uranium, and organic contaminants by sorption and/or precipitation mechanisms. Major topics in the book are: - Selection and characterisation of suitable reactive materials - Characterisation of the relevant contaminant attenuation processes - Developing new contaminant-binding chemical compounds ("ligands") - Accelerated testing methods to assess the long-term performance of the attenuation mechanisms in PRBs - Evaluation of the influence of site characteristics on PRB performance - Monitoring of existing and new field installations - Coupling of electrokinetic techniques and PRB systems - Large-scale laboratory and field tests and their results It addresses the long-term performance of PRBs, an important feature of this novel remediation technology, systematically. It deals extensively with heavy metal removal, with special emphasis on uranium. A number of case studies, experiences with large-scale modelling and test site experiments provide insight into the practical application of the results. This volume will contribute to the science underpinning groundwater remediation, and this will result in the improvement of quality of life and health and safety.* A systematic approach to investigating the long-term performance of permeable reactive barriers* Development of new contaminant-binding chemical compounds ("ligands"), accelerated testing methods to assess the long-term performance, and efficiency enhancing electrokinetic techniques* Extensive data and information on a Hungarian uranium mining facility; once a carefully kept secret of the Soviet Union

Download or read book New Materials Permeable to Water Vapor written by Harro Träubel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products like wool, leather or cotton are permeable to water vapor. Their complex fibrous structure makes it difficult to imitate this natural phenomenon by synthesis. This book discusses ways to obtain water vapor permeability by microporosity or through a hydrophilic structure. Various areas of application include the medical sector for implants and dialysis, the industrial sector for filtration or for processes requiring the slow release of substances, and the consumer sector for leather substitutes or performance textiles.