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Download or read book Antibiotic Discovery and Development written by Thomas J. Dougherty and published by Springer Science & Business Media. This book was released on 2011-12-18 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
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Download or read book Organized Crime in Pennsylvania written by Darrell J. Steffensmeier and published by . This book was released on 1991 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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Download or read book Differential Diagnosis of Cardiopulmonary Disease written by Charles V. Pollack Jr. and published by Springer. This book was released on 2019-06-07 with total page 1114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This clinical handbook is designed to aid with the fast and accurate diagnosis of cardiopulmonary disease. Chapters are structured to support the clinical decision-making process and cover key points such as differential diagnosis, typical and atypical presentation, co-morbidities, and critical steps that should not be missed. The text also outlines time-dependent interventions, overall principles of treatment, and disease course. Abundant images and links to external audio and video resources reinforce understanding. Although the chapters are organized to provide ready access to essential information, the scope of the book is comprehensive and addresses topics including acute coronary syndrome, heart failure, pulmonary embolism, primary and secondary lung diseases, and relevant upper gastrointestinal and neuromuscular diseases. Both adult and pediatric considerations are presented. The book is intended for diagnosticians in emergency medicine, critical care, inte rnal medicine, primary care, and related fields. Medical students, residents, and other medical professionals will appreciate the concise and clear approach.
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Download or read book Natural Toxins 2 written by Bal Ram Singh and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: From beach encounters, aquaculture perils, and processed-food poisoning to snake bites and biological warfare, natural toxins seem never to be far from the public's sight. A better understanding of toxins in terms of their origin, structure, structure-function relation ships, mechanism of action, and detection and diagnosis is of utmost importance to human and animal food safety, nutrition, and health. In addition, it is now clear that many of the toxins can be used as scientific tools to explore the molecular mechanism of several biological processes, be it a mechanism involved in the function of membrane channels, exocytosis, or cytotoxicity. Several of the natural toxins have also been approved as therapeutic drugs, which has made them of interest to several pharmaceutical companies. For example, botulinum neurotoxins, which have been used in studies in the field of neurobiology, have also been used directly as therapeutic drugs against several neuromus cular diseases, such as strabismus and blepherospasm. Toxins in combination with modem biotechnological approaches are also being investigated for their potential use against certain deadly medical problems. For example, a combination of plant toxin ricin and antibodies is being developed for the treatment of tumors. The great potential of natural toxins has attracted scientists of varying backgrounds-pure chemists to cancer biologists-to the study of fundamental aspects of the actions of these toxins.
Download or read book Task Force Report Organized Crime written by United States. Task Force on Organized Crime and published by . This book was released on 1967 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents five documents from the President's Commission on Law Enforcement and Administration of Justice: the chapter containing the findings and recommendations relating to the organized crime problems facing the United States and four background papers submitted by outside consultants. The analyses in the Commission report chapter focused on the types and locations of organized crime, the corruption of law enforcement and political systems, the membership and organization of criminal cartels, efforts to control organized crime, and a proposed national strategy against organized crime. Recommendations related to methods of proving criminal violations, investigation and prosecution units, citizens crime commissions, and noncriminal controls such as regulations and media coverage. The four consultants' reports examined the functions and structure of criminal syndicates, corruption of public officials in one jurisdiction, evidence collection in organized crime, and the economic analysis of organized crime.
Download or read book Evolutionary Epistemology Language and Culture written by Nathalie Gontier and published by Springer Science & Business Media. This book was released on 2006-07-25 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time in history, scholars working on language and culture from within an evolutionary epistemological framework, and thereby emphasizing complementary or deviating theories of the Modern Synthesis, were brought together. Of course there have been excellent conferences on Evolutionary Epistemology in the past, as well as numerous conferences on the topics of Language and Culture. However, until now these disciplines had not been brought together into one all-encompassing conference. Moreover, previously there never had been such stress on alternative and complementary theories of the Modern Synthesis. Today we know that natural selection and evolution are far from synonymous and that they do not explain isomorphic phenomena in the world. ‘Taking Darwin seriously’ is the way to go, but today the time has come to take alternative and complementary theories that developed after the Modern Synthesis, equally seriously, and, furthermore, to examine how language and culture can merit from these diverse disciplines. As this volume will make clear, a specific inter- and transdisciplinary approach is one of the next crucial steps that needs to be taken, if we ever want to unravel the secrets of phenomena such as language and culture.
- Author : Nellie Maude Starkey 1893- Knox
- Publisher : Hassell Street Press
- Release : 2021-09-09
- ISBN : 9781013906435
- Pages : 162 pages
Genealogy of the John Pleasant Burton Family Comp by Nellie M Starkey Knox and Wilson Burton Starkey
Download or read book Genealogy of the John Pleasant Burton Family Comp by Nellie M Starkey Knox and Wilson Burton Starkey written by Nellie Maude Starkey 1893- Knox and published by Hassell Street Press. This book was released on 2021-09-09 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.