Download or read book Particulate Interactions in Dry Powder Formulation for Inhalation written by Xian Ming Zeng and published by CRC Press. This book was released on 2000-10-26 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles established in surface and colloidal chemistry with pharmaceutical powder technology. It discusses some of the factors affecting particulate interactions, and particle-fluid interaction in the respiratory tract. It review some of the studies carried out in dry powder formulation development, and proposes possible strategies in improving DPI efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).
Download or read book Particulate Interactions in Dry Powder Formulations for Inhalation written by Xian Ming Zeng and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Delivery to the Lung written by Hans Bisgaard and published by CRC Press. This book was released on 2001-10-02 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Examines the behavior of inspired spherical particles in the respiratory tract!Featuring over 1300 references, drawings, tables, and photographs.
Download or read book Polymers Coatings written by Inamuddin and published by John Wiley & Sons. This book was released on 2020-05-27 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: The explores the cutting-edge technology of polymer coatings. It discusses fundamentals, fabrication strategies, characterization techniques, and allied applications in fields such as corrosion, food, pharmaceutical, biomedical systems and electronics. It also discusses a few new innovative self-healing, antimicrobial and superhydrophobic polymer coatings. Current industrial applications and possible potential activities are also discussed.
Download or read book Particle Interactions in Complex Dry Powder Inhaled Formulations and Single Particle Aerosol Mass Spectrometry written by Martin Jetzer and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Delivery to the Respiratory Tract written by David Ganderton and published by . This book was released on 1987 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: In treating diseases of the respiratory tract, the direct administration of drugs has great advantages in terms of clinical efficiency. This book reviews the most important recent developments in drug delivery systems to the respiratory tract. Starting with a detailed description of lung strucure and function, successive chapters investigate the usefulness of the pulmonary presention of beta-agonists, steroids and chromoglycate, and explain metabolic function and susceptibility to chemical damage from the environment, showing that the lung is far from being a passive organ. Further contributions demonstrate the importance of mucus in humidification, particle capture and particle removal before attention is given to the practical problems of drug delivery and the commercially viable devices available to the pharmaceutical technologist: the metered dose inhaler, the powder inhaler, and the jet nebuliser. The final chapter examines the future role of intranasal delivery systems, based upon the principles described.
Download or read book Advances in Pulmonary Drug Delivery written by Philip Chi Lip Kwok and published by CRC Press. This book was released on 2016-12-19 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.
Download or read book Particulate Interactions in Dry Powder Formulation for Inhalation written by Xian Ming Zeng and published by CRC Press. This book was released on 2000-10-26 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles established in surface and colloidal chemistry with pharmaceutical powder technology. It discusses some of the factors affecting particulate interactions, and particle-fluid interaction in the respiratory tract. It review some of the studies carried out in dry powder formulation development, and proposes possible strategies in improving DPI efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).
Download or read book Fundamentals of Drug Delivery written by Heather A. E. Benson and published by John Wiley & Sons. This book was released on 2021-10-12 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.
Download or read book Physical Characterization of Pharmaceutical Solids written by Harry G. Brittain and published by CRC Press. This book was released on 1995-07-19 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference provides the first systematic coverage available in a single-source volume on the application of materials science techniques to the pharmaceutical field-offering a comprehensive program for the physical characterization of raw materials, drug substances, and formulated products.
Download or read book Controlled Pulmonary Drug Delivery written by Hugh D.C. Smyth and published by Springer Science & Business Media. This book was released on 2011-06-24 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.
Download or read book Formulation and Analytical Development for Low Dose Oral Drug Products written by Jack Zheng and published by John Wiley & Sons. This book was released on 2009-02-09 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are unique challenges in the formulation, manufacture, analytical chemistry, and regulatory requirements of low-dose drugs. This book provides an overview of this specialized field and combines formulation, analytical, and regulatory aspects of low-dose development into a single reference book. It describes analytical methodologies like dissolution testing, solid state NMR, Raman microscopy, and LC-MS and presents manufacturing techniques such as granulation, compaction, and compression. Complete with case studies and a discussion of regulatory requirements, this is a core reference for pharmaceutical scientists, regulators, and graduate students.
Download or read book Excipient Development for Pharmaceutical Biotechnology and Drug Delivery Systems written by Ashok Katdare and published by CRC Press. This book was released on 2006-07-28 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: To facilitate the development of novel drug delivery systems and biotechnology-oriented drugs, the need for new, yet to be developed, and approved excipients continues to increase. Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems serves as a comprehensive source to improve understanding of excipients and forge potential new avenues for regulatory approval. This book presents detailed, up-to-date information on various aspects of excipient development, testing, and technological considerations for their use. It addresses specific details such as historical perspective, preclinical testing, safety, and toxicology evaluation, as well as regulatory, quality, and utility aspects. The text also describes best practices for use of various functional excipients and extensive literature references for all topics.
Download or read book Dry Powder Inhalers written by Teerapol Srichana and published by . This book was released on 2017 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Author Biography: Dr. Teerapol Srichana graduated from Prince of Songkla University in 1989 (Bachelor of Pharmacy), hold a Master of Pharmaceutical Science from the Gent University, Belgium, and a Ph.D. from the King's College London, United Kingdom in 1998. Currently he is an Associate Professor in the Department of Pharmaceutical Technology, Prince of Songkla University (PSU), Thailand and also serves as the Dean of the Graduate School at the PSU. He is currently the Director of Drug Delivery System Excellence Center and NANOTEC-PSU Center of Excellence on Drug Delivery. In his scientific career, he has served on numerous academic boards and committees, and published more than 150 research articles, reviews and book chapters, which are highly cited. Book Description: This book is a compilation of most works published during 2000-2016 in the area of dry powder inhalers, especially related to the issues with formulation and device design. The dry powder inhalers aim to deliver the medication to the respiratory airways. It is suitable for postgraduate students and researchers who work in the areas of dry powder inhalers. It provides some background knowledge in size characterization, flow properties, forces, and interaction of air and particles. It also ends with in vitro quality control of dry powder inhalers. This book was finished in Hawaii where the author spent his time during April 2016. Thank you to Prince of Songkla University for the financial support. The author had to work very hard for one month without a holiday. Thank you to Prof. Aran Pattanothai for overseeing this work to make sure that the researchers were on schedule all the time. Thanks to the author's staff at the Graduate School, Prince of Songkla University who had to work hard and be patient when the author was not in the office. Thanks to the author's wife and son who had to wait for him at home in Thailand. Thanks to Dr. Tan Suwandecha and Dr. Janwit Dechraksa for their great efforts in copy editing and compiling all the references. The author also thanks Dr. Somchai Sawatdee and Dr. Dhamodharan Bakkiyaraj for their comments, and Dr. Padmavathi Alwar Ramanujam for her proofreading. The greatest help was from Professor Alan Coombes, Professor Pornanong Aramwit, and Dr. Brian Hodgeson for their criticisms and comments to make this book readable. Target Audience: Undergraduate students, postgraduate students in the areas of aerosol science, medical and pharmaceutical sciences. It is useful for post doctorate and researcher in pulmonary drug delivery.
Download or read book Metered Dose Inhaler Technology written by Tol S. Purewal and published by CRC Press. This book was released on 1997-12-31 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metered Dose Inhaler Technology explores the technologies of pressurized metered dose inhalation (MDI) delivery systems and provides practical, easy-to-use guidance to effective product formulation. With contributions from an international panel of authors, the book addresses the global phase-out of chloroflurocarbon chemicals (CFCs), the generation of propellant systems to replace them, and their associated new medications and therapies. Topics include the manufacture of metered dose inhalers, particle size analysis in inhalation therapy, development and testing, pharmcokinetics and metabolism of propellants, toxicology, and more.
Download or read book An Approach to Understanding Particle particle Interactions in Dry Powder Inhalers written by Seth Patrick !Nowaseb and published by . This book was released on 1994 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inhaled Medicines written by Stavros Kassinos and published by Academic Press. This book was released on 2021-02-05 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues
