Download or read book Paediatric Research written by M. Adinolfi and published by Cambridge University Press. This book was released on 1982-04-22 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subjects reviewed in this Monograph span a wide and exciting field, reflecting many different specialities. They are, however, also closely interrelated as they reflect the eclectic nature of Professor Paul Polani's intellectual interests. The chapters are written by present and past members of his Unit - a Unit internationally recognized for its astute and stimulating discoveries and innovations. The chapters pay tribute to the fact that Paul Polani's viewpoint is that a multidisciplinary approach to the subject of disease is most effective when motivated by genetic philosophy. On this theme the book provides insight into the latest ideas on the genetics of handicap - including counselling, population cytogenetics, prevention of biochemical genetic disorders, repairing genetic damage, the epidemiology of congenital defects, and the prevention of neural-tube defects. All these and the other chapters provide an essential basis for understanding the fields of prevention and treatment.
Download or read book Guide to Paediatric Drug Development and Clinical Research written by Klaus Rose and published by Karger Medical and Scientific Publishers. This book was released on 2010-01-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Children in the developed world have never enjoyed better medical care: mortality has decreased and many fatal diseases of the past can today be prevented or even cured. However, the current practice of pharmacotherapy in children does not reflect existing scientific knowledge and has come under scrutiny by paediatricians, pharmacists and regulatory authorities. In order to advance the development of medicines tailored to paediatric needs, US and EU legislators have taken action, and the WHO has initiated a global paediatric campaign. This book gives an overview over the worldwide activities that increasingly include children in the development of new medicines. Triggered by both a better understanding of how the child's body develops as well as recent legislation in the USA and in Europe, this comprises dosing, ethics, age-appropriate pharmaceutical forms and clinical trials, to name just a few aspects.A wide spectrum of readers will profit from this book, including paediatricians, pharmacists, general practitioners and health care professionals involved in child care and paediatric research, clinical trial personnel, patient advocacy groups, ethics committees, politicians, parents and interested lay persons.
Download or read book Guide to Paediatric Clinical Research written by Klaus Rose and published by Karger Medical and Scientific Publishers. This book was released on 2007 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: As off-label use of medicines in children is no longer acceptable today, paediatric drug development is currently in transition from an almost exclusive academic specialty towards an integrated part of the global process that drives the development of new pharmaceuticals. US and EU governments have made it mandatory for the pharmaceutical industry to investigate medicines in children, thus exposing a multitude of different institutions to paediatric research. Written by exponents of the academia as well as the pharmaceutical industry, regulators and patient advocacy groups, this book explains the background of the US and EU paediatric legislations, gives an analysis of their probable short-, mid- and long-term impact, addresses key operational challenges in paediatric research, and develops a tentative vision where paediatric drug development needs to go. Helping to understand the role of the different stakeholders, the spectrum of readers to profit from this book ranges from paediatricians, general medical personnel and pharmacologists to those involved in regulatory affairs and clinical trials, pharmaceutical company management, patient advocacy groups, ethical committees, politicians and interested lay persons.
Download or read book Paediatric Bronchoscopy written by K.N. Priftis and published by Karger Medical and Scientific Publishers. This book was released on 2010-05-06 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth 'state-of-the-art' critical review of the technique and the applications of flexible and rigid bronchoscopy to infants and children. Written by an international panel of experts, it reviews the technical aspects of the procedure, its common and highly specialized applications as well as its potential alternatives. The chapters are enhanced by a wealth of original figures. A major innovation of the book is the inclusion of online videos from actual bronchoscopies that further illustrate and elaborate on the information provided in the text. The book is addressed to paediatric pulmonologists and otorhinolaryngologists, both experienced and in training, as well as to other personnel who are involved in the performance of the procedures. In addition, it is recommended to pulmonologists for adults and general paediatricians who need to be able to evaluate the usefulness of bronchoscopy for their patients and be aware of its limitations and potential contra-indications.
Download or read book Clinical Research in Paediatric Psychopharmacology written by Philippe Auby and published by Woodhead Publishing. This book was released on 2019-09-15 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Research in Paediatric Psychopharmacology: An Overview of the Ethical, Scientific and Regulatory Aspects provides a practical guide and overview of the ethical, scientific and regulatory aspects of clinical research in pediatric psychopharmacology, also discussing practical points to consider when developing clinical research in this field. The book is ideal for professionals involved in clinical research in pediatric psychopharmacology, i.e., including, but not limited to pediatricians, health care professionals, researchers, investigators, pharmaceutical company personals and potentially ethics committee members. Topics discussed include the role of patient organization and advocacy groups in research, the role of families and patients: 'should I involve my kid in clinical research, and historical, ethical, regulatory, clinical, scientific, intercultural and practical aspects of clinical research in child and adolescent psychopharmacology. - Covers both theoretical and practical aspects of clinical research in paediatric psychopharmacology - Approaches the topic from different angles from the regulatory framework to the patient perspective - Discusses ethical and safety considerations for research in paediatric psychopharmacology - Offers future perspective for paediatric development
Download or read book Issues in Pediatric and Adolescent Medicine Research and Practice 2012 Edition written by and published by ScholarlyEditions. This book was released on 2013-01-10 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Pediatric and Adolescent Medicine Research and Practice: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pediatric Surgery. The editors have built Issues in Pediatric and Adolescent Medicine Research and Practice: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pediatric Surgery in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pediatric and Adolescent Medicine Research and Practice: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Ethical Conduct of Clinical Research Involving Children written by Institute of Medicine and published by National Academies Press. This book was released on 2004-07-09 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent decades, advances in biomedical research have helped save or lengthen the lives of children around the world. With improved therapies, child and adolescent mortality rates have decreased significantly in the last half century. Despite these advances, pediatricians and others argue that children have not shared equally with adults in biomedical advances. Even though we want children to benefit from the dramatic and accelerating rate of progress in medical care that has been fueled by scientific research, we do not want to place children at risk of being harmed by participating in clinical studies. Ethical Conduct of Clinical Research Involving Children considers the necessities and challenges of this type of research and reviews the ethical and legal standards for conducting it. It also considers problems with the interpretation and application of these standards and conduct, concluding that while children should not be excluded from potentially beneficial clinical studies, some research that is ethically permissible for adults is not acceptable for children, who usually do not have the legal capacity or maturity to make informed decisions about research participation. The book looks at the need for appropriate pediatric expertise at all stages of the design, review, and conduct of a research project to effectively implement policies to protect children. It argues persuasively that a robust system for protecting human research participants in general is a necessary foundation for protecting child research participants in particular.
Download or read book Issues in Pediatric and Adolescent Medicine Research and Practice 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 6537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pediatric and Adolescent Medicine Research and Practice. The editors have built Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pediatric and Adolescent Medicine Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Safe and Effective Medicines for Children written by Institute of Medicine and published by National Academies Press. This book was released on 2012-10-13 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children.
Download or read book Paediatrics at a Glance written by Lawrence Miall and published by John Wiley & Sons. This book was released on 2016-04-29 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paediatrics at a Glance provides an introduction to paediatrics and the problems encountered in child health as they present in primary, community and secondary care, from birth through to adolescence. Thoroughly updated to reflect changes in understanding of childhood illness over the last 5 years, the 4th edition of this best-selling textbook diagrammatically summarises the main differential diagnoses for each presenting symptom, while accompanying text covers important disorders and conditions as well as management information. Paediatrics at a Glance: • Is an accessible, user-friendly guide to the entire paediatric curriculum • Features expanded coverage of psychological issues and ethics in child health • Includes more on advances in genetics, screening and therapy of childhood illness • Contains new videos of procedures and concepts on the companion website • Includes a brand new chapter on Palliative Care - an emerging area in the specialty • Features full colour artwork throughout • Includes a companion website at www.ataglanceseries.com/paediatrics featuring interactive self-assessment case studies, MCQs, videos of the procedures and concepts covered in the book, and links to online resources Paediatrics at a Glance is the ideal companion for anyone about to start a paediatric attachment or module and will appeal to medical students, junior doctors and GP trainees as well as nursing students and other health professionals.
Download or read book Pediatric Drug Development written by Andrew E. Mulberg and published by John Wiley & Sons. This book was released on 2013-05-20 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most medicines have never been adequately tested for safety and efficacy in pediatric populations and preterm, infants and children are particularly vulnerable to adverse drug reactions. Pediatric Drug Development: Concepts and Applications, Second Edition, addresses the unique challenges in conducting effective drug research and development in pediatric populations. This new edition covers the legal and ethical issues of consent and assent, the additional legal and safety protections for children, and the appropriate methods of surveillance and assessment for children of varying ages and maturity, particularly for patient reported outcomes. It includes new developments in biomarkers and surrogate endpoints, developmental pharmacology and other novel aspects of global pediatric drug development. It also encompasses the new regulatory initiatives across EU, US and ROW designed to encourage improved access to safe and effective medicines for children globally. From an international team of expert contributors Pediatric Drug Development: Concepts and Applications is the practical guide to all aspects of the research and development of safe and effective medicines for children.
Download or read book Paediatric Medicines written by Great Britain: Parliament: House of Lords: European Union Committee and published by The Stationery Office. This book was released on 2006-02-02 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 50 per cent of all medicines given to children (and about 90 per cent of those given to the newly-born) have never been tested or authorised for use on them. The Committee's report examines the European Commission's proposal to introduce a Regulation (the Clinical Trials Directive) on medicinal products for paediatric use which aims to stimulate the development of medicines for children and lay down rules for testing and approval. Issues discussed include: the need for better regulation of paediatric medicines; the ethical considerations involved in clinical trials on children, including the issue of consent; mechanisms for implementing the Regulation; access to the database of information on clinical trials; the rewards and incentives proposed to stimulate the research and development of medicines; and the legal basis for the regulation under the EC Treaty. The Committee's report recognises the urgent need for effective action at the European level to authorise medicines for paediatric use and gives broad support to the proposed Directive. However, a number of key issues are highlighted, including: the need for improved labelling of medicines; that the guidelines underpinning the Directive should take account of ethical considerations involved to ensure the rights and capacity of children to give informed consent to trials; and concerns are raised about the adequacy of proposed incentive mechanisms.
Download or read book Clinical Pharmacology Current Topics and Case Studies written by Markus Müller and published by Springer Science & Business Media. This book was released on 2011-02-04 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.
Download or read book Buttress s World Guide to Abbreviations of Organizations written by L. Pitman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: The previous edition of this directory extended its coverage of the Far East, Australasia and Latin America, areas previously under-represented. For this new edition emphasis has been given to increasing the number of entries for organizations from Britain, the United States and Australia, and particular attention has been paid to new political organizations in Central and Eastern Europe and the former Soviet Union. The number of entries included has gone up to over 68,000 of which over 9,000 are new or amended. Cross-references from defunct organizations in the previous edition have been deleted, and references (indicated by ex and now) added for organizations which have changed their name since the previous edition. As before, the range of organizations included is broad and only purely local organizations have been excluded. This directory therefore lists official and unofficial organizations, national and international, on all SUbjects: political, economic and social. Acronyms of parent bodies of subsidiary organizations are given where appropriate and equivalencies are used to link acronyms in different languages for the same organization. Further information about the organizations listed can be found in the sources listed in the bibliography. I would like to thank Henry Heaney and Graeme Mackintosh for their advice, and David Grinyer for his technical support. L. M. Pitman Bibliography Adams, R. (ed.) (1993) Centres & Bureaux: A Directory of UK Concentrations of Effort. Information and Expertise, 2nd edn, CBD Research, Beckenham. Barrett, lK. (1993) Encyclopedia of Women's Associations Worldwide, Gale, London.
Download or read book Abuse of Minors in Clinical Studies written by Klaus Rose and published by Ethics International Press. This book was released on 2023-11-25 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the emergence of effective drugs and observed drug toxicities in babies, two mantras emerged: that children are therapeutic orphans, and that children are not small adults. US and EU laws demand pediatric studies as a condition for the approval of new drugs in adults. This is called “Pediatric Drug Development” (PDD). Although apparently reasonable, there are catches. Children are vulnerable at birth, but they grow and become bodily mature with puberty, well before coming of age. Minors are not another species. The 18th birthday, an administrative/ legal limit, does not correspond to a physiological change. Drugs treat the body, not the legal status. PDD results in pointless studies in bodily mature adolescents, and in exaggerated studies in younger minors. An originally well-intentioned concept results in thousands of questionable studies worldwide. This book draws attention to conflicts of interest and ethical dilemmas of PDD and questions its applicability for adolescents and minors that are no longer babies.
Download or read book Medical Ethics Today written by British Medical Association and published by John Wiley & Sons. This book was released on 2012-01-31 with total page 919 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is your source for authoritative and comprehensive guidance from the British Medical Association (BMA) Medical Ethics Department covering both routine and highly contentious medico-legal issues faced by health care professionals. The new edition updates the information from both the legal and ethical perspectives and reflects developments surrounding The Mental Capacity Act, Human Tissue Act, and revision of the Human Fertilisation and Embryology Act.
Download or read book The Child As Vulnerable Patient written by Lynn Hagger and published by Routledge. This book was released on 2016-03-23 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can medical law and ethics take forward the issue of children's empowerment and protection? What are the key factors in considering the balance between protecting the welfare of the young and allowing them rights to autonomy? The Child as Vulnerable Patient investigates the role that a human rights approach can play in establishing the parameters of autonomy and discusses the opportunities presented in the Human Rights Act, the European Convention on the Rights of the Child and new policy initiatives in the NHS. A valuable addition to existing literature in this area, this volume will be of interest to lawyers, health professionals and students of medical law.
