Download or read book P type ATPases in Health and Disease written by Sigrid A. Langhans and published by Frontiers Media SA. This book was released on 2019-01-11 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Metal Transporters written by Jose M. Arguello and published by Academic Press. This book was released on 2012-10-25 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise

Download or read book Environmental Health Perspectives written by and published by . This book was released on 2000 with total page 1724 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book International Review of Cytology written by Kwang W. Jeon and published by Elsevier. This book was released on 2006-10-06 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address cell biology of membrane trafficking in human disease; the biology of the gaucher cell; intracellular signals and events activated by cytokines of the TNF superfamily; cellular and molecular biology of orphan G-protein coupled receptors; organization and function of the actin; cytoskeleton in developing root cells.

Download or read book Regulation of Ca2 ATPases V ATPases and F ATPases written by Sajal Chakraborti and published by Springer. This book was released on 2015-12-10 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biological membranes of cellular organization enfold an important group of membrane proteins called the ATPases, which are not only versatile in maintaining chemical gradient and electrical potential across the membrane but also bring metabolites necessary for cell metabolism and drive out toxins, waste products and solutes that otherwise can curb cell functions. ATPases are distributed virtually in all live forms starting from unicellular to multicellular and also in viruses. There are different types of ATPases, which differ in function and structure and in the type of ions they transport. The three main types of the ion pump ATPase family are: (i) P-type ATPases that transport different ions across membranes and Ca2+ATPases belongs to this catagory (ii) F-type ATPase in mitochondria, chloroplasts and bacterial plasma membranes produce ATP using the proton gradient; and (iii) V-type ATPase catalyzes ATP hydrolysis to transport solutes and maintains acidic pH in organelles like lysosomes. Genetic defects in either of the ATPases cause several diseases and a number of researches have demonstrated the involvement of the members of ATPases in the cell pathology and diseases, thereby penetrating exciting new areas of our understanding. In this book, the authors summarize recent knowledge about the molecular mechanisms associated with Ca2+-ATPase, V-ATPase and F-ATPase in intracellular and extracellular Ca2+ transport, mitochondrial ATP synthase, vesicular H+ transport, and lysosomal pH regulation. This book thereby bridges the gap between fundamental research and biomedical and pharmaceutical applications. The book provides an informative resource to improve ATPase research and modern therapeutic approaches toward different life threatening diseases that are associated with dysregulation of the ATPases.

Download or read book Regulation of Membrane Na K ATPase written by Sajal Chakraborti and published by Springer. This book was released on 2015-12-16 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Na+-K+ ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra ne domain adjacent to the isoform(s) of α-β subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled “Regulation of Membrane Na+-K+ ATPase” for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.

Download or read book The Alkali Metal Ions Their Role for Life written by Astrid Sigel and published by Springer. This book was released on 2016-02-09 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.

Download or read book The Na K ATPase written by Jean-Daniel Horisberger and published by R. G. Landes. This book was released on 1994 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text addresses the question, How does the sodium pump pump'. A variety of primary structure information is available, and progress has been made in the functional characterization of the Na, K-pump, making the answer to this question possible, within reach of currently used techniques

Download or read book Essentials of Medical Geology written by Olle Selinus and published by Academic Press. This book was released on 2005-01-25 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative reference volume emphasizes the importance and interrelationships of geological processes to the health and diseases of humans and animals. Its accessible format fosters better communication between the health and geoscience communities by elucidating the geologic origins and flow of toxic elements in the environment that lead to human exposure through the consumption of food and water. For example, problems of excess intake from drinking water have been encountered for several inorganic compounds, including fluoride in Africa and India; arsenic in certain areas of Argentina, Chile, and Taiwan; selenium in seleniferous areas in the U.S., Venezuela, and China; and nitrate in agricultural areas with heavy use of fertilizers. Environmental influences on vector borne diseases and stormflow water quality influences are also featured. Numerous examples of the environmental influences on human health from across the globe are also presented and discussed in this volume. * Covers recent advances and future research topics at the intersection of environmental science and public health * Developed by 60 experts from 20 countries and edited by professionals from the International Working Group on Medical Geology * Includes 200+ color photographs and illustrations * Organizes information in a highly structured format for easy reference * Written for a broad audience, ranging from students, researchers, and medical professionals to policymakers and the general public

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Tietz Textbook of Clinical Chemistry and Molecular Diagnostics E Book written by Nader Rifai and published by Elsevier Health Sciences. This book was released on 2017-01-16 with total page 4785 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition provides the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests. This classic clinical chemistry reference offers encyclopedic coverage detailing everything you need to know, including: analytical criteria for the medical usefulness of laboratory tests, variables that affect tests and results, laboratory medicine, applications of statistical methods, and most importantly clinical utility and interpretation of laboratory tests. It is THE definitive reference in clinical chemistry and molecular diagnostics, now fully searchable and with quarterly content updates, podcasts, clinical cases, animations, and extended content online through Expert Consult. - Analytical criteria focus on the medical usefulness of laboratory procedures. - Reference ranges show new approaches for establishing these ranges — and provide the latest information on this topic. - Lab management and costs gives students and chemists the practical information they need to assess costs, allowing them to do their job more efficiently and effectively. - Statistical methods coverage provides you with information critical to the practice of clinical chemistry. - Internationally recognized chapter authors are considered among the best in their field. - Two-color design highlights important features, illustrations, and content to help you find information easier and faster. - NEW! Internationally recognized chapter authors are considered among the best in their field. - NEW! Expert Consult features fully searchable text, quarterly content updates, clinical case studies, animations, podcasts, atlases, biochemical calculations, multiple-choice questions, links to Medline, an image collection, and audio interviews. You will now enjoy an online version making utility of this book even greater. - UPDATED! Expanded Molecular Diagnostics section with 12 chapters that focus on emerging issues and techniques in the rapidly evolving and important field of molecular diagnostics and genetics ensures this text is on the cutting edge and of the most value. - NEW! Comprehensive list of Reference Intervals for children and adults with graphic displays developed using contemporary instrumentation. - NEW! Standard and international units of measure make this text appropriate for any user — anywhere in the world. - NEW! 22 new chapters that focus on applications of mass spectrometry, hematology, transfusion medicine, microbiology, biobanking, biomarker utility in the pharmaceutical industry and more! - NEW! Expert senior editors, Nader Rifai, Carl Wittwer and Rita Horvath, bring fresh perspectives and help ensure the most current information is presented. - UPDATED! Thoroughly revised and peer-reviewed chapters provide you with the most current information possible.

Download or read book Advances in Membrane Proteins written by Yu Cao and published by Springer. This book was released on 2018-06-28 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarizes advances in biochemical and biophysical property of membrane proteins as well as their applications in biomedicine. It is organised into 2 themed parts. This part focuses on mass processing and transportation and provides deep and comprehensive information on specific groups of membrane proteins including channels and transporters, nuclear and cytoplasmic membrane proteins, and membrane embedded enzymes. Their structures, functions, related diseases as well as their roles in drug discovery are fully discussed. Interesting topics cover fundamental concepts, latest progress and critical puzzles yet to be solved. This work will appeal to a wide readership within the membrane structural and functional biology field. Junior scientists could use it to fast track into the field. Advanced scientists will find it helpful to gain a broader view of the field beyond their area of specialization.

Download or read book Manganese in Health and Disease written by Lucio G Costa and published by Royal Society of Chemistry. This book was released on 2014-11-27 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Manganese in the diet is nutritionally essential for normal physiologic functioning. However, excessive exposure to manganese has been associated with developmental, neurodegenerative and other disorders. The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases. A large section devoted to health effects presents the latest research that associates manganese exposure to potential human diseases. Any scientists, health professional or regulator involved with metal exposure and toxicology should find this volume essential reading. Students and researchers in neurotoxicology will also find this book a useful reference.

Download or read book Nutrition and Biochemistry of Phospholipids written by Bernard F. Szuchaj and published by The American Oil Chemists Society. This book was released on 2003-05-30 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phospholipids are involved in many intrinsic applications within the cell and are part of all major tissue and concentrated in vital organs that require neuronal interactions. This book contains the program presented at the 8th International Congress of ILPS and includes sessions covering phospholipids metabolism in brain function, choline and galactosphingolipids in health and disease, phospholipids in cardiovascular, liver, and muscle health, and finally, phospholipids in infant nutrition. This book, which contains these current research activities and updates, should stimulate the scientific community to continue working on phospholipids in biochemistry and nutrition.

Download or read book Membrane Proteins Production for Structural Analysis written by Isabelle Mus-Veteau and published by Springer. This book was released on 2014-06-20 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book updates the latest development in production, stabilization and structural analysis techniques of membrane proteins. This field has made significant advances since the elucidation of the first 3-D structure of a recombinant G Protein Coupled Receptor (GPCR), rhodopsin, with the structure of several more GPCRs having been solved in the past five years. In fact, the 2012 Nobel Prize in Chemistry was awarded for groundbreaking discoveries on the inner workings of GPCRs. This book is essential reading for all researchers, biochemists and crystallographers working with membrane proteins, who are interested by the structural characterization of their favorite protein and who wish to follow the expression, migration, modifications and recycling of a membrane protein.

Download or read book Issues in Biochemistry and Biophysics Research 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 1907 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Biochemistry and Biophysics Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biochemistry and Biophysics Research. The editors have built Issues in Biochemistry and Biophysics Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biochemistry and Biophysics Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biochemistry and Biophysics Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Cardiac Electrophysiology From Cell to Bedside E Book written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2013-10-11 with total page 1397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald’s Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips.