Download or read book Oxidative Stress and Metallothionein Gene Regulation written by Mousheng Xu and published by . This book was released on 1996 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Analysis of Metallothionein Gene Expression in Oxidative Stress Related Disorders written by Boitumelo Semete and published by . This book was released on 2004 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzyme-linked immonusorbent assay (ELISA) -- Metallothioneins (MTs) -- Mitochondria -- Reactive oxygen species (ROS) -- Real-time PCR -- Type 2 diabetes mellitus (T2D) -- Ensiem-gekoppelde immonusorbent assay (ELISA) -- Metallothioniene (MTs) -- Reaktiewe suurstofspesies (ROS) -- Kwantitatiewe PKR -- Tipe 2 diabetes mellitus (T2D).
Download or read book Transcriptional Regulation and Function of Yeast Metallothionein During Oxidative Stress written by Katherine Takako Tamai and published by . This book was released on 1993 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metallothionein IV written by C. Klaasen and published by Birkhäuser. This book was released on 2012-12-06 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.
Download or read book Metallothioneins in Biochemistry and Pathology written by Paolo Zatta and published by World Scientific. This book was released on 2008 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.
Download or read book The Effect of Metallothionein Overexpression on the Transcription of Selected Genes Involved in One carbon Metabolism and Oxidative Stress in NDUFS4 deficient Mouse Tissues written by and published by . This book was released on 2020 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex I deficiency -- NDUFS4 defect -- Leigh syndrome -- Metallothionein overexpression -- Oxidative phosphorylation (OXPHOS) -- One-carbon metabolism -- Mitochondrial disease -- Oxidative stress -- mRNA -- Reverse transcription real-time PCR (RT-qPCR) -- Gene expression regulation -- Mouse brain tissue -- Mouse quadriceps tissue -- Antioxidant therapy -- Kompleks I -defek -- NDUFS4-defek -- Leigh se sindroom -- Metallotioneïen 1- ooruitdrukking -- Oksidatiewe fosforilering (OKSFOS) -- Regstreekse kwantitatiewe omgekeerde transkriptase polimerase kettingreaksie (RTq-PCR) -- Een-koolstof -metabolisme -- Mitochondriale siekte -- Oksidatiewe stres -- Regulering van geenuitdrukking -- Muis-breinweefsel -- Muis-kwadrisepsweefsel.
Download or read book Zinc Biochemistry Physiology and Homeostasis written by W. Maret and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapters in this book review the remarkable advances in the field of zinc biology over the last decade. Zinc is essential for life, in particular for growth and development, through its role in hundreds of zinc enzymes and thousands of zinc proteins. Its catalytic, structural, and regulatory functions in these proteins impact metabolism, gene expression, and signal transduction, including neurotransmission. Among the micronutrients, zinc may rank with iron as to its importance for public health. The topics covered range from single molecules to cells and to whole organisms: the chemistry, design, and application of fluorophores for the determination of cellular zinc; the role of zinc in proliferation, differentiation, and apoptosis of cells; proteins that transport, sense, and distribute zinc and together form a cellular homeostatic system; the coordination chemistry of zinc in metalloproteins; the role of zinc in the brain as a neuromodulator/transmitter; the dependence of the immune system on zinc; zinc homeostasis in the whole human body.
Download or read book Metallothionein in Biology and Medicine written by Curtis D. Klaassen and published by CRC Press. This book was released on 1991-08-27 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together work from leading researchers to present the most recent advances in research on metallothionein. This protein interests toxicologists because it is thought that metallothionein protects against metal toxicity and possibly against oxidative stress. It is of interest to pharmacologists because modification of metallothionein levels might have a role in cancer chemotherapy. Nutritionists have an interest in this protein because it appears to be a major storage protein for zinc. Biochemists and molecular biologists will be interested in the mechanisms of regulation of this protein because it is extremely inducible.
Download or read book Oxidative Stress and Signal Transduction written by H.J. Forman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.
Download or read book Oxidative Stress and Redox Regulation written by Ursula Jakob and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.
Download or read book Metallothioneins and Related Chelators written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2015-07-24 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: These sulfur-rich chelators, being important in metal ion homeostasis, find increasing attention. MILS-5, written by 30 internationally recognized experts, focuses on this hot topic. The reader is supported by about 20 tables, more than 80 illustrations and nearly 2000 references. This book is an essential resource for scientists working in a wide range of disciplines from environmental toxicology and inorganic biochemistry all the way through to physiology and medicine.
Download or read book Metal Ions in Gene Regulation written by Simon Silver and published by Springer. This book was released on 1998 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing the subject areas of bacterial systems, animal metal metabolism, and lower eukaryotes and higher plants, 17 papers cover such topics as the role of Fur repressors, the range of gene regulators of cation metabolism in Gram-positive bacteria, metal- regulating examples of bacterial two-component regulatory systems, metal ion regulated gene expression in animals, iron regulation of animal genes, metallothionein regulation of the prokaryotic cyanobacteria, and the regulation of metal cation stress in yeast. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Metallothionein III written by Kazuo T. Suzuki and published by Birkhauser. This book was released on 1993 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metallothioneins in Normal and Cancer Cells written by Piotr Dziegiel and published by Springer. This book was released on 2016-02-04 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system.
Download or read book The Eye written by John V. Forrester and published by Elsevier Health Sciences. This book was released on 2015-06-01 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today's ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science. For the first time, this (print) edition also now comes with bonus access to the complete, fully searchable electronic text - including carefully selected additional information and new video content to further explain and expand on key concepts - making The Eye a more flexible, comprehensive and engaging learning package than ever before. The only all-embracing textbook of basic science suitable for trainee ophthalmologists, optometrists and vision scientists - other books concentrate on the individual areas such as anatomy. Attractive page design with clear, colour diagrams and text boxes make this a much more accessible book to learn from than many postgraduate textbooks. Presents in a readable form an account of all the basic sciences necessary for an understanding of the eye - anatomy, embryology, genetics, biochemistry, physiology, pharmacology, immunology, microbiology and infection and pathology. More on molecular pathology. Thorough updating of the sections on pathology, immunology, pharmacology and immunology. Revision of all other chapters. More colour illustrations Comes with complete electronic version
Download or read book Aging at the Molecular Level written by Thomas von Zglinicki and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.
Download or read book Mechanisms of Glutamate cysteine Ligase GCLM Subunit and Metallothionein 1 MT1 by Oxidative Stress written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The first part of this dissertation focuses on the cellular antioxidant glutathione (GSH). In GSH de novo GSH synthesis, the first and rate-limiting step is catalyzed by glutamate-cysteine ligase (GCL). In this step, glutamate is ligated to cysteine to form Y-glutamylcysteine. GCL is a heterodimer composed of a 73-kDa subunit with catalytic properties (GCLC), and a 31-kDa modifer subunit (GCLM) that improves the efficiency of the holoenzyme. Specifically, this thesis focuses on the mechanisms of transcriptional regulation of mouse Gclm by oxidative stress. Treatment of mouse hepatoma (Hepa-1) cells with tert-butylhydroquinone (tBHQ) produced a robust (8-fold) increase in GCLM mRNA accumulation and this response was at the transcriptional level. Gclm has two main transcription initiation clusters, high GC content, and no canonical TATA box in its proximal promoter. Promoter deletion analysis (4.7 to 0.5 kb) showed high basal and 2-fold inducibility by tBHQ. An electrophile response element (EpRE) is located near the distal transcription start site and is hypothesized to act as a cis-element for Gclm induction. EPRE site-directed mutagenesis and transfection with NRF2 (a transcription factor that transactivates through the EPRE) plasmids demonstrated that this EPRE is only partially required for fBHQ-induction. It is concluded that the Gclm gene has a TATA-less promoter with complex regulation, and may include enhancers located further upstream form the studied constructs. The second part of this dissertation addresses the role of the metal response element binding transcription factor 1 (MTF1) on metallothionein 1 (Mt1) and Gclm gene expression by metals and oxidative stress. For this purpose, Mtf1 was retrovirally-transduced into dko7 or Mtf1( -/- ) cells showing a functional protein. The transduced (MTF1dko7) cells showed a restoration of MT1 mRNA expression by Zn 2+ or Cd 2+ treatment. In contrast, MT1 protein levels were induced only with Zn 2+ but not Cd 2+ . Consequently, MTF1dko7 showed resistance to Zn 2+, but not Cd 2+ -induced toxicity. In parallel experiments Zn 2+ and Cd 2+ induced GCLM mRNA accumulation in MTF1dko7 and dko7 cells. This suggests that Gclm regulation is MTF1-independent. These cells lines can be used to identify novel MTF1 downstream targets.
