Download or read book Organocatalytic Cycloadditions for Synthesis of Carbo and Heterocycles written by Prof. Min Shi and published by John Wiley & Sons. This book was released on 2018-03-27 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive resource to the development and recent progress of zwitterion-oriented cycloadditions promoted by organoamines, organophosphines, N-heterocyclic carbenes Organocatalytic Cycloadditions for Synthesis of Carbo- and Heterocycles offers a clear explanationto thedevelopment of and the information on the latest research pertaining to zwitterion-oriented cycloadditions promoted by organoamines, organophosphines, N-heterocyclic carbenes. The authors—noted experts in the field—include a comprehensive review to the investigations of the reaction mechanisms and explore the synthesis of different products from the same starting materials. Filled with illustrative examples and designed to be accessible, the text shows how to control the chemo-, regio- and stereoselectivity and explains the further design of novel cycloaddition reactions catalyzed by organoamines and organophosphines based on zwitterion-oriented synthetic strategy. This important text: Explains why the formation of carbo- and heterocycles is a key transformation in organic synthesis. Offers a clear description to the development of zwitterion-oriented cycloadditions promoted by organoamines, organophosphines, N-heterocyclic carbenes, and explores the latest research Contains the most current examples involving synthetic transformations of organocatalytic cycloadducts Includes contributions from noted experts in the field of organic synthesis Written for organic chemists, pharmaceutical chemists, chemists in industry, graduates, and librarians, Organocatalytic Cycloadditions for Synthesis of Carbo- and Heterocyclesis is the essential guide to the topic.
Download or read book Heterocycles from Carbohydrate Precursors written by El Sayed H. El Ashry and published by Springer Science & Business Media. This book was released on 2007-06-27 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a volume in the series Topics in Heterocyclic Chemistry.Itc- ers the key methods used for designing synthetic approaches to heterocycles from carbohydrates and the value and scope of these methods. Carbohydrates are widely distributed in nature and constitute the largest part of renewable biomasses. Moreover, many carbohydrates and their derivatives are comm- cially available at relatively cheap prices. Consequently their utilization is highly encouraged and economically they are of great signi?cance. Moreover, carbohydrates are highly functionalized compounds that can be readily deri- tized and/or cyclized to provide heterocyclic compounds. This book provides a modern account and an up-to-date description of the advancement in the synthesis of diverse heterocycles from carbohydrates. Carbohydrates can be considered as a source of chiral centers in addition to the variable modi?cation thereof. Herein the elaboration of the carbohydrate molecules for providing different heterocycles is the main objective and team efforts from leaders of the topics has been gathered in this volume. This book is designed to be suitable for students and researchers. It is highly recommended as a reference book and for teaching the fascinating topics related to carbohydrates, heterocycles and organic synthesis. In addition to its importance in academia, it is also an excellent source for information about the variety of methods used in the synthesis of heterocycles important to industry.
Download or read book Synthesis of Heterocycles via Cycloadditions I written by Alfred Hassner and published by Springer. This book was released on 2008-04-10 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature. This series covers hot topics of frontier research summarized by reputed scientists in the field.
Download or read book Synthesis of Heterocycles Via Cycloadditions II written by Alfred Hassner and published by Springer Science & Business Media. This book was released on 2008-07-21 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: See Table of Contents (PMP)
Download or read book Cycloaddition Reactions in Organic Synthesis written by W. Carruthers and published by Elsevier. This book was released on 2013-10-22 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demonstrates the wide scope of cycloaddition reactions, including the Diels-Alder reaction, the ene reaction, 1,3-dipolar cycloadditions and [2+2] cycloadditions in organic synthesis. The author, a leading exponent of the subject, illustrates the ways in which they can be employed in the synthesis of a wide range of carbocyclic and heterocyclic compounds, including a variety of natural products of various types. Special attention is given to intramolecular reactions, which often provide a rapid and efficient route to polycyclic compounds, and to the stereochemistry of the reactions, including recent and developing work on enantioselective synthesis.
Download or read book Synthetic Applications of 1 3 Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products Volume 59 written by Albert Padwa and published by John Wiley & Sons. This book was released on 2003-04-14 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dipolar cycloaddition reactions have found many useful applications in chemistry, particularly with respect to the synthesis of compounds with new chiral centers. Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products updates the popular 1984 edition, featuring the advances made over the past twenty years and focusing on synthetic applications.
Download or read book Advances in Heterocyclic Chemistry written by Eric F.V. Scriven and published by Academic Press. This book was released on 2022-02-15 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Heterocyclic Chemistry, Volume 136 is the latest release in this definitive series in the field of heterocyclic chemistry, one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature is used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds
Download or read book Cycloaddition Reactions in Organic Synthesis written by Shu Kobayashi and published by John Wiley & Sons. This book was released on 2002 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the miners' strike in the 1980s, a worker is killed in the striking coalfields of Wales. Some months later, a government minister thought to be connected with the death is also shot. Lewis Redfern—once a radical but now a political analyst and journalist—pursues the sniper, a lonely hunt that leads him through an imbroglio of civil service leaks to a secret organization: a source of insurrection far more powerful than anyone could have suspected known as the Volunteers. In this fast-paced narrative of espionage and intrigue, Redfern, through his obsessive pursuit of justice, finally encounters the truth about himself as the novel discusses the conflict between moral choice and political loyalty.
Download or read book Synthetic and Computational Investigations Into the Cycloaddition Fluorination Strategy for the Synthesis of Monofluorinated Carbo and Heterocycles written by Colin Yu-hong Lam and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Diels Alder Reaction written by Francesco Fringuelli and published by John Wiley & Sons. This book was released on 2002-01-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: 70 Jahre Forschung an der Diels-Alder-Reaktion: Dieses Buch fasst die wichtigsten und beeindruckendsten Ergebnisse in einzigartiger Weise zusammen! Zunächst werden die Grundprinzipien der Reaktion klar und verständlich anhand übersichtlicher Graphiken erläutert. Spezielle Vorschriften und gegebenenfalls ihre industrielle Umsetzung werden anschließend erklärt. Einen Schwerpunkt bilden auch physikalische und katalytische Verfahren zur Steigerung der Selektivität der Reaktion. Cycloadditionen in konventionellen und unkonventionellen Medien werden vorgestellt. Mit über 1.000 Literaturverweisen!
Download or read book A Tactical 1 3 dipolar Cycloaddition Approach for the Synthesis of Carbohydrate Derived Polycyclic Spiro Heterocycles written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dienamine Catalysis for Organic Synthesis written by Kengadarane Anebouselvy and published by Royal Society of Chemistry. This book was released on 2018-03-02 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade a new era in asymmetric catalysis has been realised by the discovery of L-proline induced chiral enamines from carbonyls. Inspired by this, researchers have developed many other primary catalytic species in situ, more recently secondary catalytic species such as aminals have been identified for use in asymmetric synthesis. High-yielding asymmetric synthesis of bioactive and natural products through mild catalysis is an efficient approach in reaction engineering. In the early days, synthetic chemists mainly focused on the synthesis of complex molecules, with less attention on the reaction efficiency and eco-friendly conditions. Recent investigations have been directed towards the development of atom economy, eco-friendly and enantioselective synthesis for more targeted and efficient synthesis. Building on the momentum of this rapidly expanding research area, Dienamine catalysis for organic synthesis will provide a comprehensive introduction, from the preformed species, in situ generation and onto their applications in the synthesis of bioactive molecules and natural products.
Download or read book N Heterocyclic Carbenes in Organocatalysis written by Akkattu T. Biju and published by John Wiley & Sons. This book was released on 2019-01-07 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizing the emerging field of N-heterocyclic carbenes used in organocatalysis, this is an excellent overview of the synthesis and applications of NHCs focusing on carbon-carbon and carbon-heteroatom bond formation. Alongside comprehensive coverage of the synthesis, characteristics and applications, this handbook and ready reference also includes chapters on NHCs for polymerization reactions and natural product synthesis.
Download or read book Palladium catalyzed Asymmetric Trimethylenemethane Cycloaddition written by Steven Mark Silverman and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of new methods for chemical synthesis is motivated by the desire to add efficient chemo-, regio-, diastereo-, and enantioselective reactions to the repository of transformations available to researchers. In addition to reaction development, a primary goal of methodology research is to fundamentally understand chemical reactivity. This understanding provides the impetus for further discovery, inevitably allowing for the rapid synthesis of complex molecules as well as the development of industrially feasible processes. The research described herein discusses method development and seeks to place it within this context. Cycloaddition reactions have been widely used in organic synthesis since initial accounts of the Diels-Alder reaction were reported over 80 years ago. These reactions can proceed by either stepwise or concerted processes, can be thermally or photochemically initiated, metal catalyzed or non-metal catalyzed, but one unifying feature of this reaction class is the ability to quickly assemble a complex molecular architecture. A method for the synthesis of cyclopentane rings was disclosed by the Trost group in 1979 through the controlled generation of trimethylenemethane (TMM), a three-carbon dipole capable of participating in a palladium-catalyzed stepwise cycloaddition. Over the ensuing 20 years, this procedure was expanded to other five-membered rings, including pyrrolidines and tetrahydrofurans. It was generalized to include [4+3] and [6+3] cycloadditions in addition to the initial [3+2] reaction. However, only minimal advances were made in the establishment of a catalytic, asymmetric variant of the reaction, which would have enormous value in that chiral variants of the above molecules could be prepared. A protocol for the enantioselective TMM reaction was developed and is described herein. The synthesis of novel phosphoramidite ligands was critical in this effort, and the preparation and reactivity of these ligands is detailed. The evolution of the ligand design, commencing with acyclic amine-derived phosphoramidites and leading to cyclic azetidine and pyrrolidine structures is discussed. The initial conditions used to effect an asymmetric TMM reaction using 2-trimethylsilylmethyl allyl acetate were shown to be tolerant of a wide variety of alkene acceptors, providing the desired cyclopentanes with high levels of enantioselectivity. The donor scope was also explored and various substituted systems were tolerated, including one bearing a nitrile moiety and a one bearing a propiolate function. These were reactive with unsaturated acylpyrroles, giving the product cyclopentane rings bearing three stereocenters in high enantioselectivity and complete diastereoselectivity. The nitrile donor was reactive with methyleneoxindoles, providing products containing up to three adjacent stereocenters, two being all-carbon quaternary. Furthermore, ligand controlled diastereoselection was seen. The methodology was further applied to the synthesis of heterocycles. The parent donor successfully reacted with N-aryl and N-Boc imines. A nitrile donor was found to react with a series of N-Tosyl imines, giving the pyrrolidines in high yield. Multiple regioisomers were formed and reaction conditions were developed to favor each product. In the case of N-Tosyl ketimines, the desired cycloadducts containing tetrasubstituted centers were prepared with nearly complete enantio- and diastereoselectivity. The protecting group could be removed to afford a synthetically versatile compound with several handles for further elaboration. Conditions were also developed to perform an enantioselective TMM reaction with aldehydes, giving the desired tetrahydrofurans in moderate to good enantioselectivity. Finally, an asymmetric [4+3] cycloaddition utilizing ortho-quinone methides was successfully performed in an effort to prepare oxepanes. Taken collectively, these results demonstrate that the palladium-phosphoramidite catalyst system represents a versatile method for the rapid assembly of complex molecular architectures from simple starting materials via cycloaddition.
Download or read book Modern Applications of Cycloaddition Chemistry written by Paolo Quadrelli and published by Elsevier. This book was released on 2019-03-20 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Applications of Cycloaddition Chemistry examines this area of organic chemistry, with special attention paid to cycloadditions in synthetic and mechanistic applications in modern organic chemistry. While many books dedicated to cycloaddition reactions deal with the synthesis of heterocycles, general applications, specific applications in natural product synthesis, and the use of a class of organic compounds, this work sheds new light on pericyclic reactions by demonstrating how these valuable tools elegantly solve synthetic and mechanistic problems. The work examines how pericyclic reactions have been extensively applied to different chemistry areas, such as chemical biology, biological processes, catalyzed cycloaddition reactions, and more. This work will be useful for organic chemists who deal with organic chemistry, medicinal chemistry, agrochemistry and material chemistry. Provides details on the synthesis of antiviral and anticancer compounds, marking the key role of unconventional catalyzed cycloaddition reactions for preparing new derivatives in a unique reaction pathway that is scalable in industrial processes Contains the most up-to-date review of the use of pericyclic reactions in drug delivery Includes the enzyme-catalyzed processes involving cycloaddition reactions for different targets, demonstrating that cycloaddition is more common in nature than expected Features new applications for cycloadditions in material chemistry and provides a general view of the most recent results in the area
Download or read book Spirooxindole written by Gautam Patel and published by Elsevier. This book was released on 2024-06-28 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern advances in organic synthesis require compouds having attractive properties with high percentage of yield. Spirooxindole examines the current state of the art, recent progress and new challenges associated with the development of spirooxindole derivatives for various medicinal applications. Owing to their exceptional properties, these compounds can be used in vaious fields, including chemical and pharma industries, and in clinical research. This book has chapters written by experts in several different areas. It serves as a useful reference book for scientists, industrial practitioners, graduate students, and other professionals in the field of hetrocyclic chemistry, medicinal chemistry, organic synthesis clinical research and chemical sciences.The growing interest among the academics and industrial researchers in the field of organic chemistry and medicinal chemistry is the driving force for the presentation of this edited book. Consolidates information on each aspect of this novel compound and its applications in various fields, covering the entire spectrum of up-to-date literature citations, current market, and patents Provides a comprehensive, in-depth description of spirooxindole derivatives as well as multipurpose scaffolds Highlights green synthesis and nanocatalysis Describes in-depth various medicinal applications Covers both synthesis and applications
Download or read book Green Approaches in Medicinal Chemistry for Sustainable Drug Design written by Bimal K. Banik and published by Elsevier. This book was released on 2020-04-09 with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis
