Download or read book Oncolytic Viruses Genetically Engineering the Future of Cancer Therapy written by Benjamin Gesundheit and published by Frontiers Media SA. This book was released on 2016-11-22 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to genetically engineer oncolytic viruses in order to minimize side effects and improve the selective targeting of tumor cells has opened up novel opportunities for treating cancer. Understanding the mechanisms involved and the complex interaction between the viruses and the immune system will undoubtedly help guide the development of new strategies. Theranostic biomarkers to monitor these therapies in clinical trials serve an important need in this innovative field and demand further research.

Download or read book Gene Therapy for Cancer written by Kelly K. Hunt and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Download or read book Cancer Gene Therapy by Viral and Non viral Vectors written by Malcolm Brenner and published by John Wiley & Sons. This book was released on 2014-02-25 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. Presented in three parts, Cancer Gene Therapy by Viral and Non-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy of Cancer • Cancer Therapy with RNAi delivered by Non-viral Membrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in Gene Therapy • Remaining Obstacles to the Success of Cancer Gene Therapy Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.

Download or read book Progress in Cancer Immunotherapy written by Shuren Zhang and published by Springer. This book was released on 2016-05-30 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors.

Download or read book Oncolytic Virus written by Fouad Sabry and published by One Billion Knowledgeable. This book was released on 2022-10-05 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is Oncolytic Virus A virus is said to be oncolytic if it targets cancer cells for infection and then proceeds to destroy those cells. As a result of the oncolysis, infected cancer cells are being eliminated, which results in the production of additional infectious virus particles called virions, which further contribute to the elimination of the residual tumor. It is believed that oncolytic viruses not only induce the direct killing of tumor cells, but also activate the host's anti-tumor immune system responses. [Citation needed] [Citation needed] In addition to this, oncolytic viruses are able to influence the microenvironment of the tumor in a variety of different ways. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Oncolytic virus Chapter 2: Virotherapy Chapter 3: Virus latency Chapter 4: Herpes simplex virus Chapter 5: Tony Minson Chapter 6: Genetically modified virus Chapter 7: Pelareorep Chapter 8: Pexastimogene devacirepvec Chapter 9: Herpes simplex research Chapter 10: Jennerex Chapter 11: Talimogene laherparepvec Chapter 12: Oncolytic herpes virus Chapter 13: Oncolytic adenovirus Chapter 14: GL-ONC1 Chapter 15: Genelux Corporation Chapter 16: ONCOS-102 Chapter 17: Akseli Hemminki Chapter 18: Infected cell protein 34.5 Chapter 19: Oncolytic AAV Chapter 20: HSV epigenetics Chapter 21: Transgene (company) (II) Answering the public top questions about oncolytic virus. (III) Real world examples for the usage of oncolytic virus in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of oncolytic virus' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of oncolytic virus.

Download or read book Cancer Gene Therapy written by David T. Curiel and published by Springer Science & Business Media. This book was released on 2007-11-03 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Download or read book Viral Therapy of Human Cancers written by Joseph G. Sinkovics and published by CRC Press. This book was released on 2004-12-28 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring contributions from nearly 30 leading authorities, this pioneering work gauges the potential for viruses to act as oncolytic and anti-tumor agents for the treatment of cancers in humans-detailing the cancer-combative properties exhibited by viruses in nature, genetically engineered viruses, and viral oncolysates as evidenced in basic and experimental studies.

Download or read book Engineering Tumor specific Oncolytic Adenoviruses with Small Molecule controlled Expanded Tropisms written by Shigeki Joseph Miyake-Stoner and published by . This book was released on 2017 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: A promising new strategy for cancer therapy is the use of engineered oncolytic viruses, adapted from their natural properties of seeking out and destroying cells to effectively find and specifically eliminate cancer cells. The overarching goal of the work presented here is to engineer powerful new adenoviruses that can preferentially infect tumor cells via disparate receptors, and replicate exclusively in cells that have lost tumor suppressor pathways. Since the creation of adenoviruses with novel tropism is limited by the ability to build and test new genetic designs, we desired targetable oncolytic adenoviruses with a modular platform that would enable rapid identification of new and controllable targeting moieties. We employed the property of rapamycin-induced FRB/FKBP heterodimerization to construct adenoviruses with chemically-controlled tropism by inserting FRB into the adenovirus and genetically encoding a functionalized FKBP fusion protein. We validated the targeting of this new class of viruses in culture using a panel of NCI breast cancer cell lines, targeting the frequently-upregulated cancer marker EGFR. We demonstrate that our targeting components are compatible with other virus modifications and that new adenoviruses with these mutations are able to infect and destroy a model of intractable triple negative breast cancer. Based on our findings, rapid discovery of effective targeting moieties for oncolytic adenoviruses should be possible, and we should avoid limiting the potency of future vectors by disrupting the highly evolved adenovirus capsid structure. While oncolytic adenoviruses have already shown to be safe in clinical trials, we have improved the replication specificity of an oncolytic virus based on the function of adenovirus genes that overlap with frequent tumor mutations. It has been shown that mutation in adenovirus E1A can prevent its inactivation of cell cycle-regulator retinoblastoma protein (Rb), and this mutation is the basis of selectivity for an oncolytic adenovirus in clinical trials. However, adenovirus also encodes E4orf6/7, which acts downstream of Rb by activating the cellular transcription factor E2F1 that also drives the cell cycle. We have combined mutations in E1A and E4orf6/7 and discovered highly selective oncolytic adenoviruses that have the promise to be the basis for safe and potent oncolytic cancer therapies.

Download or read book Immunotherapy Cancer Battle Innovative Approaches for Success written by Azhar ul Haque Sario and published by Azhar ul Haque Sario. This book was released on 2024-08-29 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlock the future of cancer treatment with "Immunotherapy Cancer Battle: Innovative Approaches for Success." This comprehensive guide dives deep into the revolutionary world of cancer immunotherapy, exploring the cutting-edge strategies and breakthroughs that are reshaping how we combat this relentless disease. From the foundational discoveries of immune checkpoint inhibitors to the advanced engineering of CAR T-cells, this book provides an in-depth journey through the evolution of immunotherapy. Chapter by chapter, you’ll uncover the remarkable stories behind these treatments—how they were developed, the science that drives them, and the incredible impact they've had on patients' lives. You'll learn about the groundbreaking clinical trials that have led to life-changing approvals for various cancers, offering hope where there once was none. But this book isn't just about the successes—it's also about the ongoing challenges and innovations in the field. You’ll explore how scientists and clinicians are continually pushing the boundaries, combining immunotherapies with traditional treatments like chemotherapy and radiation to maximize efficacy. You’ll delve into the world of tumor-infiltrating lymphocytes (TILs) and their potential for personalized treatment, as well as the promise of cancer vaccines that could one day prevent or treat cancers with unparalleled precision. Ever wondered how viruses might be used to fight cancer? You'll find out in the chapter on oncolytic virus therapy, where viruses are re-engineered to selectively infect and destroy cancer cells. Plus, you’ll read about the exciting developments in adoptive cell transfer (ACT) therapies, including T-cells, natural killer (NK) cells, and cytokine-induced killer (CIK) cells, all working together to diversify and strengthen our immune responses. The book also covers innovative strategies like bispecific antibodies, which simultaneously engage two different targets, and next-generation immune checkpoints that go beyond PD-1 and CTLA-4 to offer new hope for patients. You'll gain insight into the complexities of the tumor microenvironment and how modulating it can enhance the effectiveness of immunotherapies, creating a more hostile environment for cancer to thrive. And that's not all. "Immunotherapy Cancer Battle" takes you through the futuristic applications of nanotechnology and epigenetic modulation in cancer treatment, showcasing how these cutting-edge fields are being harnessed to boost immune responses and deliver therapies more precisely than ever before. You’ll discover the potential of precision immunotherapy, which tailors treatments based on individual genetic and molecular profiles, and the role of artificial intelligence in optimizing these personalized strategies. The book also doesn’t shy away from the real-world challenges of immunotherapy, including the management of immune-related adverse events (irAEs) and the unique considerations required for pediatric patients. It explores the mechanisms behind resistance to immunotherapy and the strategies being developed to overcome these barriers, ensuring more patients can benefit from these innovative treatments. In its final chapters, "Immunotherapy Cancer Battle" expands its focus to a global perspective, addressing the disparities in access to these life-saving treatments. It looks at the efforts being made to bridge the gap, ensuring that advancements in cancer care reach every corner of the world. Whether you are a medical professional, researcher, or someone affected by cancer, this book is an invaluable resource that not only informs but inspires. With its comprehensive coverage and forward-looking insights, "Immunotherapy Cancer Battle: Innovative Approaches for Success" is more than just a book—it's a blueprint for the future of cancer treatment. Join us in exploring these pioneering frontiers and envision a world where cancer is no longer a death sentence but a disease we can outsmart, treat, and one day, perhaps, completely eradicate.

Download or read book Immunotherapy Cancer Battle written by Azhar ul Haque Sario and published by Azhar Sario Authorship and Publishing. This book was released on 2024-08-29 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlock the future of cancer treatment with "Immunotherapy Cancer Battle: Innovative Approaches for Success." This comprehensive guide dives deep into the revolutionary world of cancer immunotherapy, exploring the cutting-edge strategies and breakthroughs that are reshaping how we combat this relentless disease. From the foundational discoveries of immune checkpoint inhibitors to the advanced engineering of CAR T-cells, this book provides an in-depth journey through the evolution of immunotherapy. Chapter by chapter, you’ll uncover the remarkable stories behind these treatments—how they were developed, the science that drives them, and the incredible impact they've had on patients' lives. You'll learn about the groundbreaking clinical trials that have led to life-changing approvals for various cancers, offering hope where there once was none. But this book isn't just about the successes—it's also about the ongoing challenges and innovations in the field. You’ll explore how scientists and clinicians are continually pushing the boundaries, combining immunotherapies with traditional treatments like chemotherapy and radiation to maximize efficacy. You’ll delve into the world of tumor-infiltrating lymphocytes (TILs) and their potential for personalized treatment, as well as the promise of cancer vaccines that could one day prevent or treat cancers with unparalleled precision. Ever wondered how viruses might be used to fight cancer? You'll find out in the chapter on oncolytic virus therapy, where viruses are re-engineered to selectively infect and destroy cancer cells. Plus, you’ll read about the exciting developments in adoptive cell transfer (ACT) therapies, including T-cells, natural killer (NK) cells, and cytokine-induced killer (CIK) cells, all working together to diversify and strengthen our immune responses. The book also covers innovative strategies like bispecific antibodies, which simultaneously engage two different targets, and next-generation immune checkpoints that go beyond PD-1 and CTLA-4 to offer new hope for patients. You'll gain insight into the complexities of the tumor microenvironment and how modulating it can enhance the effectiveness of immunotherapies, creating a more hostile environment for cancer to thrive. And that's not all. "Immunotherapy Cancer Battle" takes you through the futuristic applications of nanotechnology and epigenetic modulation in cancer treatment, showcasing how these cutting-edge fields are being harnessed to boos

Download or read book Recent Advances in Cancer Research and Therapy written by Xin-Yuan Liu and published by Elsevier. This book was released on 2012-05-18 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy. There is also a discussion of current cancer research in China including traditional Chinese medicine. Written by leading scientists in the field, this book provides an essential insight into the current state of cancer therapy and treatment. Includes a wide range of research areas including a focus on biotherapy and the development of novel cancer therapeutic strategies. Formatted for a broad audience including all working in researching cancer treatments and therapies. Discusses special traits and results of Chinese cancer research.

Download or read book Viral Nanoparticles written by Nicole F. Steinmetz and published by CRC Press. This book was released on 2019-08-21 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book overviews the applications of viral nanoparticles (VNPs) in areas ranging from materials science to biomedicine. It summarizes the many different VNP building blocks and describes chemistries that allow one to attach, entrap, or display functionalities on VNPs. The book outlines the strategies for the construction of 1-, 2-, and 3-D arrays, highlights the achievements in utilizing VNPs as tools for novel biosensors and nanoelectronic devices, and describes efforts in designing VNPs for biomedical applications, including their use as gene delivery vectors, novel vaccines, imaging modalities, and applications in targeted therapeutics.

Download or read book Isolation of Potential Oncolytic Mutants of Tanapoxvirus with Targeted Deletions and Insertions written by Mohamed Abdusalam Elswad and published by . This book was released on 2013 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer remains a major health problem despite the advances in conventional cancer therapy. Remarkable advances in molecular biology and genetic engineering have improved the possibility of a novel cancer treatment using animal viruses, called oncolytic viruses. Patients receiving this kind of therapy may develop immunity against the viral therapy, thereby limiting the extended use of the same oncolytic virus multiple times. As such, a large pool of oncolytic viruses must be available for the success of such a therapy. Here, we describe several Tanapoxvirus (TPV) mutant viruses designed for this purpose. TPVK02LmCherry is a genetically modified TPV, which lacks the 2L protein that has been shown to bind and inhibit the biological activities of multiple human cytokines. TPVK02L/66R is a double knockout TPV, where 2L and 66R (viral thymidine kinase) genes are both deleted. These mutants may potentially enhance the viral tropism toward the cancer cells rather than normal cells. Further engineering of the TPV for the aim of activating the anti-tumor innate immunity was achieved by inserting the bacterial flagellin (FLiC) gene into the viral genome (TPVK066R/2L-FliC). This multi-mechanistic approach may enhance the oncolytic properties of TPV as an oncolytic virus.

Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Download or read book Nanopharmaceuticals Principles and Applications Vol 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Download or read book Gene Therapy of Cancer written by Peter Walden and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.

Download or read book CRISPR Cas Enzymes written by and published by Academic Press. This book was released on 2019-01-25 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: CRISPR-Cas Enzymes, Volume 616, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered in this release include CRISPR bioinformatics, A method for one-step assembly of Class 2 CRISPR arrays, Biochemical reconstitution and structural analysis of ribonucleoprotein complexes in Type I-E CRISPR-Cas systems, Mechanistic dissection of the CRISPR interference pathway in Type I-E CRISPR-Cas system, Site-specific fluorescent labeling of individual proteins within CRISPR complexes, Fluorescence-based methods for measuring target interference by CRISPR-Cas systems, Native State Structural Characterization of CRISRP Associated Complexes using Mass Spectrometry, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Updated release includes the latest information on the CRISPR-Cas Enzymes