Download or read book The Design of Animal Experiments written by Michael Festing and published by SAGE Publications Limited. This book was released on 2016-12-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where there is no alternative to the use of animals in biomedical research, it is important that experiments are well designed and correctly analysed in order to minimise pain and maximize the chance of getting scientifically valid results. Experiments that use too few animals may fail to pick up biologically important effects, while those who use them incorrectly or wastefully may get invalid results while subjecting the animals to unnecessary pain, distress or lasting harm. The Design of Animal Experiments is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when necessary. It covers all randomised controlled experimental designs likely to be needed in laboratory animal research, with worked examples showing how they can be statistically analysed. It suggests the more widespread use of randomised block designs and shows how both males and females can be included in an experiment without the need to increase the total number of animals by using factorial designs. It also includes guidance on the choice of experimental animals. The book covers the learning outcomes of Module 10 and part (ii) of Module 11 of education and training under Directive 2010/63/EU.
Download or read book The Design and Statistical Analysis of Animal Experiments written by Simon T. Bate and published by Cambridge University Press. This book was released on 2014-03-13 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide scientists with a better understanding of statistics, improving their decision-making and reducing animal use.
Download or read book Guidance for the Description of Animal Research in Scientific Publications written by National Research Council and published by National Academies Press. This book was released on 2011-09-16 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.
Download or read book Use of Laboratory Animals in Biomedical and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 1988-02-01 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.
Download or read book The Principles of Humane Experimental Technique written by William Moy Stratton Russell and published by Hyperion Books. This book was released on 1992 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chimpanzees in Research written by Committee on Long-Term Care of Chimpanzees and published by National Academies Press. This book was released on 1997-09-01 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chimpanzees in biomedical and behavioral research constitute a national resource that has been valuable in addressing national health needs. Facilities that house chimpanzees owned and supported by the National Institutes of Health (NIH) have successfully met the research requirements of the scientific community. The captive chimpanzee population in the United States has grown substantially, particularly over the last decade. That growth is due primarily to the success of the NIH-sponsored Chimpanzee Breeding and Research Program, which achieved the birth numbers thought necessary to meet the projected needs of biomedical research. However, the expected level of use of the chimpanzee model in biomedical research did not materialize, and that has created a complex problem that threatens both the availability of chimpanzees for research in the future and the infrastructure required to ensure the well-being of captive chimpanzees used in biomedical research. Because the present system is fragmented, it is impossible to formulate an accurate overview of the size and nature of the chimpanzee population. But, if the chimpanzee is to continue to be used in biomedical research responsibly, effectively, and cost-effectively, we must be able to oversee, track, and coordinate the maintenance and use of chimpanzees and to control the size of the population. To assess the long-range situation and to develop, implement, and monitor the application of policies for the proper use and care of chimpanzees, an authoritative, centralized oversight structure is imperative. Once it is in place, it will be possible to refine and implement this report's recommendations.
Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.
Download or read book Experimental Design and Analysis in Animal Sciences written by Trevor Raymond Morris and published by Cabi. This book was released on 1999 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Design and Analysis in Animals Sciences is the first book to provide detailed instructions on the design and analysis of experiments in animals sciences. Not only does it provide descriptions of the statistics of experiment design, this guide-book contains examples and suggestions that help students in their decisions on which tools are appropriate for each circumstance. The subjects covered include interpretation of dose-response experiments, change-over designs, experiments with animals in pens and paddocks, and balanced and unbalanced designs. This book will be indispensable for any graduate or advanced undergraduate student in the animal sciences.
Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Download or read book Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity written by National Research Council and published by National Academies Press. This book was released on 2001-04-13 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United States Navy has been concerned for some time with protecting its military and civilian personnel from reproductive and developmental hazards in the workplace. As part of its efforts to reduce or eliminate exposure of Naval personnel and their families to reproductive and developmental toxicants, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate chemicals and physical agents for their potential to cause reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology, to prepare this report. In this report, the subcommittee recommends an approach for evaluating agents for potential reproductive and developmental toxicity and demonstrates how that approach can be used by the Navy. This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: James Chen (National Center for Toxicological Research), George Daston (Procter and Gamble Company), Jerry Heindel (National Institute of Environmental Health Sciences), Grace Lemasters (University of Cincinnati), and John Young (National Center for Toxicological Research).
Download or read book Animal Experimentation written by Kathrin Herrmann and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.
Download or read book Principles of Animal Research for Graduate and Undergraduate Students written by Mark A. Suckow and published by Academic Press. This book was released on 2016-12-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Animal Research is the first publication to offer a broad look at animal research science for a student, early researcher, or technician. Offering guidance for all aspects of the research experience, including the research and development of a thesis, model selection, experimental design, IACUC protocol preparation, and animal husbandry and technical procedural needs, the book is a necessary addition to every student, technician, and researcher's education.
Download or read book Design of Experiments for Agriculture and the Natural Sciences written by Reza Hoshmand and published by CRC Press. This book was released on 2018-10-03 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written to meet the needs of both students and applied researchers, Design of Experiments for Agriculture and the Natural Sciences, Second Edition serves as an introductory guide to experimental design and analysis. Like the popular original, this thorough text provides an understanding of the logical underpinnings of design and analysis by selecting and discussing only those carefully chosen designs that offer the greatest utility. However, it improves on the first edition by adhering to a step-by-step process that greatly improves accessibility and understanding. Real problems from different areas of agriculture and science are presented throughout to show how practical issues of design and analysis are best handled. Completely revised to greatly enhance readability, this new edition includes: A new chapter on covariance analysis to help readers reduce errors, while enhancing their ability to examine covariances among selected variables Expanded material on multiple regression and variance analysis Additional examples, problems, and case studies A step-by-step Minitab® guide to help with data analysis Intended for those in the agriculture, environmental, and natural science fields as well as statisticians, this text requires no previous exposure to analysis of variance, although some familiarity with basic statistical fundamentals is assumed. In keeping with the book's practical orientation, numerous workable problems are presented throughout to reinforce the reader's ability to creatively apply the principles and concepts in any given situation.
Download or read book Advances in Animal Experimentation and Modeling written by Ranbir Chander Sobti and published by Academic Press. This book was released on 2021-12-08 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploration in Laboratory Animal Sciences Understanding Life Phenomena updates our knowledge about the newer technologies such as molecular biology, genomics including sequencing, proteomics, transcriptomics, cell culture, stem cell culture, transgenesis and their translation to understand systematics and phylogeny of laboratory animals at molecular level. In seven sections Exploration in Laboratory Animal Sciences Understanding Life Phenomena resolves issues of conservation, applications in environment monitoring, production of drugs and others. Comparative research has enabled use of domestic animal models that translate the advances in basic biosciences to the schemes for human welfare including medicine. Molecular geneticists are unravelling the complexities of mammalian genes and the field of biotechnology is maturing at a fast pace. Additionally, research focused on immunology and animal behavior offer new insight into ways of enhancing animal welfare. The rise in consumption of animal proteins in addition to the challenges of sustaining our natural resources has given animal scientists a vast array of opportunities to engage in integrative systems-based research for meeting the challenges that behold us. Exploration in Laboratory Animal Sciences Understanding Life Phenomena also discusses the manipulation of animals as factories for the production of safe foods, drugs, and sensors and others to meet the contemporary challenges faced by mankind in the new world order created by pandemic of Covid 19. It also includes several chapters on the causation and management of certain diseases and impact of microbes on life. - Provides insight to newer and futuristic technologies to understand disease process and drug design by animal models - Addresses a wide variety of species and covers a wide variety of topics (such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations) to fully prepare for work with all types of animals - Gives a perspective on laboratory animal use that allows to explain the benefits of animal use as required by veterinary technology program accreditation procedure - Includes examples of animal bio-technological techniques (including stem cell and tissue engineering) for their applications to humanity - Offers new insight into ways of enhancing animal welfare by the inclusion of research results focused on immunology and laboratory animal behavior
Download or read book Poultry Science written by and published by . This book was released on 1926 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Agricultural Experimentation written by Thomas Morton Little and published by John Wiley & Sons. This book was released on 1978-04-20 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Logic, research, and experiment; Some basic concepts; The analysis of variance and t tests; The completely randomized design; The randomized complete block design; Mean separation; The latin square design; The split-plot design; The split-split plot; The split-block; Subplots as repeated observations; Transformations; Linear correlation and regression; Curvilinear relations; Shortcur regression methods for equally spaced observations or treatments; Correlalion and regression for more than two variables; Analysis of counts; Heterogeneity; Summary; Improving precision; Selected references; Appendix tables.
Download or read book Bulletin Vermont Agricultural Experiment Station written by Vermont Agricultural Experiment Station and published by . This book was released on 1925 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt:
