Download or read book On the Biomechanical Properties of the Cornea with Particular Reference to Refractive Surgery written by Jesper Østergaard Hjortdal and published by . This book was released on 1998 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Corneal Biomechanics written by C.J. Roberts and published by Kugler Publications. This book was released on 2017-05-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: While lecturing in recent months at a number of prominent institutions, I asked some of the residents and fellows whether and how they might benefit from a book on corneal biomechanics. The typical response was the look of a deer caught in the headlights as they tried to intuit the “appropriate” answer, but had little understanding or insight as to why this would be an important and useful knowledge base for them now, or in the future. I then posed the question differently. “Would a book that explained corneal biomechanical principles and testing devices and their application in detecting eyes at risk for developing keratoconus and post-LASIK ectasia, understanding the biomechanical impact of specific types of keratorefractive surgery and riboflavin UV-A corneal collagen cross-linking, and the impact of corneal biomechanics on the fidelity of intraocular pressure measurement and risk for glaucoma progression be of interest?” Framed in this context, the answer I got was a resounding, “Yes!” Therein lies a fundamental disconnect that highlights both the opportunity and need to educate all ophthalmologists about this nascent field. This comprehensive book is strengthened by the breadth of contributions from leading experts around the world and provides an important resource for ophthalmologists at all levels of training and experience. It gives a panoramic snapshot of our understanding of corneal biomechanics today, bridging the gap between theoretical principles, testing devices that are commercially available and in development as well as current and potential future clinical applications. While there has been a long-held appreciation that all types of keratorefractive surgery have an impact and interdependence on corneal biomechanics and wound healing, the initial finite element analyses that were applied to understand radial keratotomy were limited by incorrect assumptions that the cornea was a linear, elastic, homogenous, isotropic material.1 With the advent of excimer laser vision correction, critical observations indicated that Munnerlyn’s theoretic ablation profiles did not account for either lower or higher order (e.g. spherical aberration) refractive outcomes,2 suggesting that there were important components missing from the equation—e.g., corneal biomechanics and wound healing. In a seminal editorial, Roberts3 pointed out that the cornea is not a piece of plastic, but rather a material with viscoelastic qualities. Since that time, much has been learned about spatial and depth- related patterns of collagen orientation and interweaving, as well as the biomechanical response to different keratorefractive surgeries that sever tension-bearing lamellae, as the cornea responds to and redistributes stress induced by IOP, hydration, eye rubbing, blinking and extraocular muscle forces.3-6 The first reports of post-LASIK ectasia7 highlighted the need to identify a biomechanical signature of early keratoconus as well as corneas at high risk of developing ectasia irrespective of their current topography or tomography. The introduction of two instruments into clinical use—the Ocular Response Analyzer (ORA) and the Corneal Visualization Scheimpflug Technology (Corvis ST)—that allow measurement of various biomechanical metrics further catapulted the field. The availability of these instruments in routine clinical settings allowed the systematic study of the effect of age, collagen disorders, collagen cross-linking, corneal rings, flaps of various depths, contour, sidecut angulation, pockets, and flockets, just to name of few. Future application of biomechanics to the sclera may improve our understanding of the development and prevention of myopia, as well as scleral surgeries and treatments under development for presbyopia. It was appreciated by Goldmann and Schmidt that corneal thickness and curvature would influence the measurement of applanation tonometry. The recent ability to measure some corneal biomechanical metrics have led to IOP measurement that may be more immune both to their influence and the impact of central corneal thickness (CCT). Certain chapters in this book explain how a thin cornea could be stiffer than a thick one and that stiffness is also impacted by IOP, thereby precluding simplistic attempts to adjust IOP measurements using nomograms based upon CCT alone. Also highlighted is how corneal hysteresis, the ability of the cornea to absorb and dissipate energy during the bidirectional applanation response to a linear Gaussian air puff, appears to be an independent risk factor for glaucoma progression and rate of progression.9,10 This comprehensive book starts out with a section devoted to outlining basic biomechanical principles and theories, teaching us the language of what Dupps11 has referred to as “mechanospeak”, thus providing a context and common vocabulary to better comprehend the following chapters. By first defining basic concepts such as stress-strain relationships and creep, this theoretical basis is later applied to explain the pathogenesis of corneal diseases, e.g., explaining how a focal abnormality in corneal biomechanical properties precipitates a cycle of decompensation and localized thinning and steepening, clinically expressed as ectasia progression. These early chapters further detail biomechanical differences between in-vivo and ex-vivo testing, between human and animal corneas and sclera, and between methods of testing. The second section provides a thorough description of two FDA-approved devices to measure corneal biomechanics in the clinic (i.e., the ORA and the Corvis ST), as well as an overview of potential future technologies, including OCT with air puff stimulus, ocular pulse elastography, and Brilloiun microscopy. The third and final section of the book is a thorough treatise on how to interpret the metrics derived from the waveform provided by available clinical devices; their adjunct use in ectasia risk screening; the comparative biomechanical impact of various keratorefractive surgeries and corneal procedures such as PRK, LASIK, SMILE, and corneal collagen cross-linking; the impact of corneal biomechanics on IOP measurement; and potential biomechanical markers of enhanced susceptibility to glaucoma progression. This compendium of our current knowledge of corneal biomechanics, its measurement and application, provides a strong foundation to more fully understand advances in keratorefractive and corneal surgery, diseases, and treatments, all of which are interdependent on and influence inherent corneal biomechanical properties and behavior. Both the robust aspects and limitations of our current understanding are presented, including the challenge of creating accurate and predictive finite element models that incorporate the impact of IOP, corneal thickness, geometry, and scleral properties on corneal biomechanics. This book provides a key allowing clinical ophthalmologists and researchers to grasp the basics and nuances of this exciting field and to shape it as it evolves in the future.
Download or read book Corneal Biomechanics and Refractive Surgery written by Fabio A. Guarnieri and published by Springer. This book was released on 2014-11-27 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a unique approach not found in any other text for those looking to improve the clinical results of refractive surgery by gaining a better understanding of corneal biomechanics and the instrumentation related to it. Written by leading experts in the field, this book provides authoritative coverage of the interactions of the cornea and the bioinstrumentation, such as corneal topography, pachymetry, aberrometers, tonometry and optical coherence tomography. Organized in an easy-to-read manner, Corneal Biomechanics and Refractive Surgery is designed for refractive surgeons and general ophthalmologists alike and describes the biomechanical role of the corneal tissue and how each part is affected in refractive surgery. Additionally, showing what the bioinstrumentation can measure, how models can improve understanding of the interaction between biomechanics, bioinstrumentation, and refractive surgery, and how these models and bioinstrumentation together can improve the refractive results, are also discussed.
Download or read book Clinical and Laboratory Investigation of the Biomechanical Properties of the Cornea written by Tariq Alhamad and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the biomechanical properties of the cornea is important in order to develop and improve new reliable standard procedures which can be used effectively to assess corneal behaviour in any disease condition, or before/after any ocular surgery. We believe that the Ocular Response Analyzer (ORA) is the only device that can measures the biomechanical properties of the cornea in vivo. However, it has been used for the first time both in vivo and in vitro. This thesis presents a clinical and laboratory investigation of the biomechanical properties of the cornea before/after LASIK and corneal cross-linking to improve our understanding of the knowledge required in both the laboratory and the clinic. Different machines were used in this project, including an ORA, an Oculus Pentacam, a spectrophotometer and a UV-X Illumination system. Laser in situ keratomileusis (LASIK) is, at present, one of the most well-known operations used to correct refractive errors; however, ocular problems arising from corneal thinning have been reported in some previous studies. Therefore, I looked at the effects of surgery on the central/peripheral thickness and the anterior/posterior curvature, and determined to what extent they affect the biomechanical properties of the cornea. During the past decade, much research has focused on improving and developing a new operation called corneal collagen cross-linking with riboflavin and UVA, which is used to stop the progression of keratectasia in the cornea (which occurs in keratoconus and sometimes follows refractive surgery). In the next phase, a range of experiments were conducted on cross-linking to determine to what extent this operation affects the molecular structure and biomechanical properties of the cornea. This thesis has shown for the first time that it is possible to obtain ORA signals in vitro and this opened up the possibility of examining whole eyes as well as excised corneas. It is also confirmed that the values of CH do not represent only a corneal biomechanical property, but rather depend on the presence of the rest of the eye. These in vitro studies have opened up a number of possibilities the future corneal biomechanical studies.
Download or read book Copeland and Afshari s Principles and Practice of Cornea written by Robert A. Copeland and published by JP Medical Ltd. This book was released on 2013-02-28 with total page 1666 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cornea is the transparent front part of the eye covering the iris and the pupil, allowing light to enter and covering two thirds of the eye’s focusing tasks. This two volume set is a comprehensive guide to the latest research and techniques for the cornea. Beginning with basic science, examination techniques and epidemiology, the following chapters discuss the diagnosis and the medical and surgical treatment of numerous different conditions and diseases that may affect the cornea. Written by an extensive international editor and author team, this manual features more than 1300 full colour clinical and histopathological images, as well as a DVD demonstrating a multitude of surgical techniques described in the book. Key points Comprehensive two volume set describing diagnosis and treatment of numerous corneal disorders Features more than 1300 colour images and illustrations Includes a DVD demonstrating surgical techniques and procedures Extensive international author and editor team
Download or read book Ocular Biomechanics in Health and Pathophysiology written by Matthew A. Reilly and published by Frontiers Media SA. This book was released on 2024-06-13 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanical mechanisms may contribute to a large number of visual processes and pathologies, including glaucoma, keratoconus, refractive surgery, accommodation, presbyopia, myopia, hyperopia, trauma, retinal detachment, ocular development, vitreous substitution, cataract surgery, corneal transplant, and many others. Departures from homeostatic loading may drive a large number of these processes in ways we are only beginning to recognize. This Research Topic will explore how ocular biomechanics contribute to both the homeostasis and pathophysiology of the eye and visual system. It is generally unknown whether changes in load drive changes in biomechanical properties or vice versa. Clarifying driving forces for disease and elucidating the pathophysiologic response will ultimately enable the development of targeted treatments for many ocular and visual diseases for which biomechanics plays a role.
Download or read book Biomechanics of the Eye written by Cynthia J. Roberts and published by Kugler Publications. This book was released on 2018-04-20 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering all major components of the ocular system, this state-of-the-art text is essential for vision scientists, biomedical engineers, and advanced clinicians with an interest in the role of mechanics in ocular function, disease, therapeutics, and surgery. With every chapter, leading experts strengthen the arguments that biomechanics is an indispensable and rapidly evolving tool for understanding and managing ocular disease.
Download or read book Investigation of Corneal Biomechanical and Optical Behaviors by Developing Individualized Finite Element Model written by Mengchen Xu and published by . This book was released on 2019 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The biomechanics of the cornea has a significant impact on its optical behavior. Alterations in corneal biomechanics lead to abnormalities in the surface topography and affect ocular aberrations that degrade retinal image quality. The goal of this thesis work is aimed towards investigating the interaction of corneal biomechanical and optical behaviors through development of an individualized corneal model based on the finite element method that accounts for the large variations in corneal geometry and material properties. The goal of the thesis can be divided into four specific aims. First, we investigated the biomechanical and optical behaviors of a healthy normal cornea at various IOPs through numerical simulations based on a widely accepted anisotropic hyperelastic FE model. We conducted a sensitivity analysis based on a powerful experimental/statistical technique, the DOE method. The biomechanical and optical responses of the cornea to IOP elevation as well as the relative contribution of multiple geometrical and material parameters to corneal biomechanical and optical behaviors were evaluated. We found that the radius of curvature of the cornea was the most important geometric parameter that contributes to both biomechanical and optical behaviors of the cornea. For material parameters, corneal apical displacement was influenced nearly evenly by matrix stiffness, fiber stiffness and nonlinearity. However, the corneal optical aberrations were primarily affected by the matrix stiffness and the distribution of collagen fibril dispersion. These findings have important implications for future theoretical and experimental studies of the cornea, especially for the development of an individualized cornea model. Second, we proposed new methods for material characterization of individual corneas. We aimed to characterize a complete set of material parameters for developing an individualized 3-D anisotropic hyperelastic corneal model, which provides accurate prediction of the interrelation between corneal biomechanics and optics of a specific cornea. We proposed novel methods mainly focusing on the individual quantification of three challenging material parameters, including collagen fiber stiffness, collagen fiber nonlinearity and collagen fibril dispersion using optical information of the cornea to overcome the traditional challenges in corneal material characterization. The new material characterization method could also be beneficial for future development of an in vivo individualized biomechanical model of the cornea and the investigation of the impact of corneal biomechanics on patient's visual performance for clinical applications. Third, we evaluated the clinical significance of corneal biomechanical modeling in one of the important clinical applications, laser refractive surgery. An accurate prediction of the biomechanical response of the cornea to tissue ablation would help to predict postoperative surgical outcomes, which can be taken into account in developing new surgical paradigms for obtaining optimal surgical outcomes. The predictive ability of our biomechanical model was evaluated by simulating myopic corrections in PRK surgery. Our findings suggest that both of the spatial variation in collagen fibril dispersion and the depth-dependent extrafibrillar matrix stiffness play a significant role in the postoperative biomechanical and optical outcomes. Characterization of these two material features helps to predict more accurate trend of the HOAs induced by the surgical process. Lastly, we explored a novel method to induce in vivo IOP elevation for potential future development of an in vivo corneal model. Our new material characterization methods require a measurement of corneal optical behavior at varied IOP levels. Therefore, we investigated the potential of developing an in vivo individualized corneal model for clinical applications by developing an efficient and non-contract method to control IOP elevation in vivo. For the first time, we showed that in vivo IOP can be temporarily elevated and controlled in an innovative, safe, non-contact way using an inversion table. The research presented in this thesis helps to gain understandings of the biomechanical and optical responses of individual corneas to various intraocular pressures and to corneal surgery, such as laser vision correction. Furthermore, the capabilities and techniques described in the thesis may be applied to investigate underlying mechanisms, diagnosis and treatments of other clinically important ophthalmic pathologies such as keratoconus, post-refractive ectasia and glaucoma."--Pages ix-xi.
Download or read book The Biology of the Eye written by Jorge Fischbarg and published by Elsevier. This book was released on 2005-12-09 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I would therefore like to acknowledge and thank the following for their outstanding contributions to editing the work: Dr. Morten Dornonville la Cour (MD, Dr. Med. Sci.) solicited and edited the chapters on retina, RPE, choroid, vitreous, immunology, and sclera. Dr. la Cour is a Lecturer, Eye Department, Copenhagen University Hospital, specializes in vitreoretinal surgery, and frequently lectures in the international scene. A trained mathematician, he has done research in retinal pigment epithelial physiology in the laboratories of Drs. Thomas Zeuthen and Sheldon Miller. Dr. Friedrich P.J. Diecke and Dr. Elliott M. Kanner also provided invaluable editorial assistance. Dr Diecke, who was formerly Professor and Chairman of the Department of Physiology, UMDNJ-New Jersey Medical School, is a Professor Emeritus at that institution. His research has concentrated on membrane transport mechanisms in lens epithelial cells, corneal endothelial cells and peripheral nerve and on the regulation of vascular smooth muscle contraction. Dr. Elliott M. Kanner was born in Canada in 1970. He graduated from Yale University in 1992 with a BS/MS degree in Molecular Biophysics and Biochemistry. He received his PhD degree from the Rockefeller University in 1999 and his MD degree from Weill/Cornell in 2001. He is currently an Ophthalmology resident at Columbia University. Jorge Fischbarg, December 2005 This book explores the many recent novel ideas about the eye in a systematic and synthetic way. It includes both basic sciences and applications towards clinical research. Chapters include both anatomical and functional descriptions of the different ocular tissues and treatments of a few subjects of practical importance for ophthalmologists. This book is intended for students in basic biomedical science interested in the eye, as well as ophthalmologists a comprehensive source on recent developments in ocular research. * Combines basic science and practical opthalmological subjects * Written with the simplicity of a textbook, while maintaining the comprehensive and rigorous approach of science papers * Includes contributions by well-known experts
Download or read book Biomechanics of Eye Globe and Methods of Its Study written by Irina Bubnova and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of biomechanical properties of eye globe is necessary both for correct selection of candidates for refractive surgery and right choice of operative intervention parameters. No less important, it is for corneal ectatic disease diagnostics and monitoring. Also it gives inestimable contribution for interpretation of intraocular pressure (IOP) indices especially in cases with irregular eye shape or after past corneal surgical procedures. Moreover, it allows studying injury mechanism by glaucoma process on optic nerve head fibers. Above it, scleral biomechanical properties research is necessary for the investigation of pathophysiologic factors of myopia manifestation and progression. This chapter is devoted to review of existed to date methods of study of eye fibrous tunic biomechanical properties. It describes mathematical, experimental, and clinical models provided evaluation of unsearchable by direct measurement parameters. It also observes effective technics of impact on both sclera and cornea with the aim of correction of its biomechanical condition.
Download or read book Human Eye Imaging and Modeling written by E. Y. K. Ng and published by CRC Press. This book was released on 2012-06-05 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced image processing and mathematical modeling techniques are increasingly being used for the early diagnosis of eye diseases. A comprehensive review of the field, Human Eye Imaging and Modeling details the latest advances and analytical techniques in ocular imaging and modeling. The first part of the book looks at imaging of the fundus as well as infrared imaging. It begins by exploring developments in the analysis of fundus images, particularly for the diagnosis of diabetic retinopathy and glaucoma. It also reviews anterior segment imaging and reports on developments in ocular thermography, especially the use of thermal imaging as the basis of tear evaporimetry and dry eye diagnosis. The second part of the book delves into mathematical modeling of the human eye. Coverage includes modeling of the eye during retinal laser surgery, a framework for optical simulation, heat distribution using a 3D web-splines solution, and exposure to laser radiation. The text also examines computer simulation of the human eye based on principles of heat transfer, as well as various bioheat equations to predict interior temperatures based on the surface temperature. Featuring contributions by established experts in eye imaging, this is a valuable reference for medical personnel and researchers who want to know more about state-of-the-art computer-based imaging and detection methods. It presents novel imaging and modeling algorithms that can aid in early diagnosis, with the aim of enriching the lives of people suffering from eye abnormalities.
Download or read book Tools for Improved Refractive Surgery written by Ibrahim Seven and published by . This book was released on 2014 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cornea is the outermost layer of the human eye where the tissue meets with the external environment. It provides the majority of the eye's refractive power and is the most important ocular determinant of visual image formation. The refractive power of the cornea derives from its shape, and this shape is a function of the ocular biomechanical properties and loading forces such as the intraocular pressure (IOP). With having the majority of refractive power in the eye, the cornea is the primary tissue of interest for refractive intervention. Globally, the predominant mode of surgical treatment of refractive disorders is photoablation. However, optical power regression over time and under/over correction due to neglected corneal biomechanical properties were still observed following refractive procedures including LASIK, PRK, Astigmatic, Keratotomy etc., especially at high degree corrections. Also, some evolving procedures such as corneal collagen crosslinking (CXL), a collagen stiffening procedure most commonly performed through UVA photoactivation of riboflavin in the corneal stroma, currently lack surgical guidance for optimizing visual outcomes. Thus, there is a need for methods that explore the patient-specific treatment planning strategies for refractive procedures. This work will have a potential impact in translating mechanical principles into corneal surgical planning in order to provide a better guidance and predictive environment to the corneal surgeons.The goals of this thesis are threefold: 1) To develop patient specific models from clinical LASIK cases and to compare the outcomes of these models with clinical outcomes in a patient population. 2) To simulate investigational procedures that utilize CXL. 3) To advance a potential approach to characterize corneal mechanical properties in vivo.
Download or read book Biomechanics written by and published by BoD – Books on Demand. This book was released on 2019-01-30 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have taught a variety of courses in biomechanics, introductory and advanced, at multiple universities in Canada. I have not been able to find or use an appropriate textbook for students whose background is not biomedical engineering. It should be noted that there are many outstanding books on biomechanics; however, they are usually not very introductory or the topics covered are too detailed, which makes it impossible for those audiences to make effective use of the book. The present book is an attempt to fill this gap. No previous familiarity of anatomy, biology, or physiology is expected, and in fact every chapter begins with a review of the relevant necessary background. Each chapter then highlights identification and explanation of the indispensable aspects of the associated biomechanics issues.
Download or read book Life Cycle Tribology written by Duncan Dowson and published by Elsevier. This book was released on 2005-10-13 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 31st Leeds-Lyon Symposium on Tribology was held at Trinity and All Saints College in Leeds under the title "Life Cycle Tribology" from Tuesday 7th September until Friday 10th September 2004. Over the three days of presentations that followed, life cycle tribology was explored across a range of areas including automotive tribology, bearings, bio-degradability and sustainability, bio-tribology, coatings, condition monitoring, contact mechanics, debris effects, elastohydrodynamic lubrication, lubricants, machine systems, nanotribology, rolling contact fatigue, transmissions, tribochemistry and wear and failure. Invited talks in these fields were presented by leading international researchers and practitioners, namely C.J. Hooke, J.A. Williams, R.J.K. Wood, G. Isaac, S.C. Tung, D. Price, I. Sherrington, M. Hadfield, K. Kato, R.I. Taylor, H.P. Evans, R.S. Dwyer-Joyce and H. Rahnejat.
Download or read book Journal of the Royal Society Interface written by and published by . This book was released on 2005 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Corneal Cross Linking written by Farhad Hafezi and published by CRC Press. This book was released on 2024-06-01 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Corneal Cross-Linking, Second Edition represents an innovative approach to treating primary acquired and secondary induced ectatic disorders. In addition, corneal cross-linking (CXL) has promising applications as an alternative in the treatment of corneal infectious and non-infectious melting, as well as conditions such as Fuchs’ endothelial dystrophy. The new and expanded Second Edition of Corneal Cross-Linking by Drs. Farhad Hafezi and J. Bradley Randleman will provide a concise yet comprehensive summary of the CXL process, including the basic science foundations, treatment protocols and outcomes, recognition and management of potential complications, and modification of standard protocol for special circumstances. Given all the changes in this rapidly progressing field, many brief topics from the first edition have now grown into full chapters or sections. These include expanded sections on alternative treatment protocols, corneal imaging and biomechanics, combing cross-linking with other refractive treatments, and a section devoted specifically to the most highly debated controversies in the field today. With each chapter being fully updated plus including over twenty new chapters that covers the latest advances and future directions, Corneal Cross-Linking, Second Edition represents the cutting-edge of CXL research and clinical practice. “Since the publication of the first edition of this book in 2013, our knowledge of corneal cross-linking has again significantly increased, both scientifically and clinically. Today, concise recommendations (guidelines for cross-linking) help the clinician to select the patients, make decisions, and provide optimal treatment” -Eberhard Spoerl, PhD and Theo Seiler, MD, PhD
Download or read book Biomechanics of the Eye in Health and Disease written by Hans Vellara and published by . This book was released on 2018 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purpose The structural properties of the cornea are essential to its function as a resilient, transparent, refractive surface of the eye. It exhibits classic viscoelastic biomechanical properties such as elasticity, creep, stress relaxation, and hysteresis. The advent of in vivo ocular biomechanical assessment using the CorVis ST has attracted significant interest as it enables a new investigative approach to ocular examinations, enabling quantitative structural analysis to be performed in vivo, under more physiological conditions than previously possible. This thesis is focused on the biomechanical properties of the eye in health and disease. Methods Study Participants were assessed with various examination techniques with respect to their ocular status. This includes but was not limited to: slit-lamp biomicroscopy, corneal topography, and the CorVis ST. Results An in vivo collateral globe displacement occurs when a short-acting air-pulse is applied onto the cornea. The separated corneal and orbital components of this overall displacement were isolated through external analysis of the CorVis ST. Isolation and removal of the orbital component should be employed when analysing deformation characteristics in diseases that only affect the cornea. The subsequent studies examined the usage of these separated components with various keratoplasty techniques, keratoconus, corneal collagen cross-linking, glaucoma, thyroid eye disease, and corneal dystrophies. Conclusions In vivo biomechanical assessments provided a link between early in vitro laboratory experiments and clinical practice. It provides a potentially useful adjunct to the standard clinical examination.
