Download or read book OECD Series on Testing and Assessment Report on Considerations from Case Studies on Integrated Approaches for Testing and Assessment IATA First Review Cycle 2015 Case Studies on Grouping Methods as a Part of IATA written by OECD and published by OECD Publishing. This book was released on 2017-04-13 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: OECD member countries have been making efforts to expand the use of alternative methods in assessing chemicals. The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of ...
Download or read book OECD Series on Testing and Assessment Guidance Document for the Use of Adverse Outcome Pathways in Developing Integrated Approaches to Testing and Assessment IATA written by OECD and published by OECD Publishing. This book was released on 2017-03-10 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). However, there is a need for a systematic framework to characterise the individual biological and toxicological relevance of alternative methods in assessing chemicals in predicting toxicological endpoints.
Download or read book The History of Alternative Test Methods in Toxicology written by and published by Academic Press. This book was released on 2018-10-20 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Download or read book Handbook of Laboratory Animal Science written by Jann Hau and published by CRC Press. This book was released on 2021-05-17 with total page 1890 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where much progress has been made in recent years. Each individual chapter focuses on an important subdiscipline of laboratory animal science, and the chapters can be read and used as stand-alone texts, with only limited necessity to consult other chapters for information. With new contributors at the forefront of their fields, the book reflects the scientific and technological advances of the past decade. It also responds to advances in our understanding of animal behavior, emphasizing the importance of implementing the three Rs: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort. This fourth edition will be useful all over the world as a textbook for laboratory animal science courses for postgraduate and undergraduate students and as a handbook for scientists who work with animals in their research, for university veterinarians, and for other specialists in laboratory animal science.
Download or read book Green Toxicology written by Alexandra Maertens and published by Royal Society of Chemistry. This book was released on 2022-02-01 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.
Download or read book Nanotoxicology written by Alok Dhawan and published by Royal Society of Chemistry. This book was released on 2017-11-13 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fills the significant nanotoxicology and nanosafety knowledge gaps and covers a broad range of topics. It targets postgraduates, academics, and practicing industrialists.
Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-11-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
Download or read book OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment written by OECD and published by OECD Publishing. This book was released on 2017-04-13 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides a set of principles for reporting defined approaches to testing and assessment that can be used as one of ...
Download or read book Nanotechnologies in Food written by Qasim Chaudhry and published by Royal Society of Chemistry. This book was released on 2017-05-17 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnologies in Food provides an overview of the products and applications of nanotechnologies in agri-food and related sectors. Following on from the success of the first edition, this new edition has been revised and updated to bring the reader fully up to date on the emerging technological, societal, and policy and regulatory aspects in relation to nanotechnologies in food. This book contains new chapters discussing some of the aspects that have attracted a lot of debate and research in recent years, such as how the regulatory definition of ‘nanomaterial’ is shaping up in Europe and whether it will result in a number of exciting food additives being regarded as nanomaterials, how the new analytical challenges posed by manufactured nanoparticles in food are being addressed and whether the emerging field of nano delivery systems for food ingredients and supplements, made of food materials or other soft/degradable polymers, can raise any consumer safety concerns. The edition concludes by discussing the future trends of the technological developments in the area of nanotechnologies and potential future ‘fusion’ with other fields, such as biotechnology and synthetic biology. This book provides a source of much needed and up-to-date information on the products and applications of nanotechnology for the food sector - for scientists, regulators, and consumers alike. It also gives an independent, balanced, and impartial view of the potential benefits as well as risks that nanotechnology applications may bring to the food sector. Whilst providing an overview of the state-of-the-art and foreseeable applications to highlight opportunities for innovation, the book also discusses areas of uncertainty in relation to public perception of the new technological developments, and potential implications for consumer safety and current regulatory controls. The book also discusses the likely public perceptions of nanotechnologies in the light of past technological developments in the food sector, and how the new technology will possibly be regulated under the existing regulatory frameworks.
Download or read book Transport and Climate Change written by Tim Ryley and published by Emerald Group Publishing. This book was released on 2012-07-17 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This topical volume covers the intersection between transport and climate change, with papers from the 'Transport & Climate Change' session of the RGS-IBG conference in London, September 2010. It considers the role of transport modes at varying spatial dimensions and a range of perspectives on the relationship between transport and climate change.
Download or read book OECD Environmental Strategy written by Organisation for Economic Co-operation and Development and published by OECD Publishing. This book was released on 2004 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report discusses the progress made by OECD countries towards targets established in 2001, as part of an agreed strategy by OECD Environment Ministers to promote environmentally sustainable policies. The strategy included five key objectives: maintaining the integrity of ecosystems through the efficient management of natural resources; decoupling environmental pressures from economic growth; improving information for decision-making and measuring progress through indicators; links between social and environmental factors and enhancing the quality of life; and global environmental interdependence and improving governance and co-operation. The report highlights the challenges and obstacles that remain if countries are to achieve the objectives by the planned date of 2010.
Download or read book The Politics of International Aviation written by Eugene Sochor and published by Springer. This book was released on 1991-06-18 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: An examination of the politics of international aviation. Topics covered include international conflicts and the safety of air travel, ICAO in the United Nations context, and the problems related to terrorism in the sky, such as setting security standards in airports.
Download or read book Megatrends and Air Transport written by Ruwantissa Abeyratne and published by Springer. This book was released on 2017-08-03 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses megatrends and subsequently applies them to the air transport industry from a legal, ethical and economic perspective. Starting with a detailed discussion on what these megatrends are, the book provides an essential overview of megatrends and air transport, including analytical discussions on how megatrends could affect basic issues such as nationalism and sovereignty, market access in air transport, and commercial space transport. It also delves into the rights of the airline passenger as affected by megatrends. Further, the book analyses a broad range of topics, including: the digital transformation of air transport; technology and air transport; robotic pilots and their legal ramifications; the human-robot interface and the law with focus on the pilot; cognitive computing; and issues of empowerment and connectivity. It discusses in detail United Nations initiatives and initiatives of the International Civil Aviation Organization, considering aspects such as: the new world order; e-trends and air transport; apps that make air travel easier; and apps designed to help the aviation authorities. Further topics include artificial intelligence and air transport and related technical, ethical and economic issues, as well as a legal inquiry into manufacturer’s defects; design defects; and liability for failure to warn of defects. Questions are posed and answers provided on the effects of artificial intelligence and legal issues stemming from its use in air transport. Two major discussions follow on millennials and air transport, and on the Internet of everything as related to air transport. The conclusion ties in megatrends with air transport and offers the industry a way forward for adapting to these trends.
Download or read book Positioning and Power in Academic Publishing Players Agents and Agendas written by F. Loizides and published by IOS Press. This book was released on 2016-05-26 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of electronic publishing has grown exponentially in the last two decades, but we are still in the middle of this digital transformation. With technologies coming and going for all kinds of reasons, the distribution of economic, technological and discursive power continues to be negotiated. This book presents the proceedings of the 20th Conference on Electronic Publishing (Elpub), held in Göttingen, Germany, in June 2016. This year’s conference explores issues of positioning and power in academic publishing, and it brings together world leading stakeholders such as academics, practitioners, policymakers, students and entrepreneurs from a wide variety of fields to exchange information and discuss the advent of innovations in the areas of electronic publishing, as well as reflect on the development in the field over the last 20 years. Topics covered in the papers include how to maintain the quality of electronic publications, modeling processes and the increasingly prevalent issue of open access, as well as new systems, database repositories and datasets. This overview of the field will be of interest to all those who work in or make use of electronic publishing.
Download or read book Department of Defense Dictionary of Military and Associated Terms written by and published by . This book was released on 1984 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Logistics Transportation Systems written by MD Sarder and published by Elsevier. This book was released on 2020-10-17 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Logistics Transportation Systems compiles multiple topics on transportation logistics systems from both qualitative and quantitative perspectives, providing detailed examples of real-world logistics workflows. It explores the key concepts and problem-solving techniques required by researchers and logistics professionals to effectively manage the continued expansion of logistics transportation systems, which is expected to reach an estimated 25 billion tons in the United States alone by 2045. This book provides an ample understanding of logistics transportation systems, including basic concepts, in-depth modeling analysis, and network analysis for researchers and practitioners. In addition, it covers policy issues related to transportation logistics, such as security, rules and regulations, and emerging issues including reshoring. This book is an ideal guide for academic researchers and both undergraduate and graduate students in transportation modeling, supply chains, planning, and systems. It is also useful to transportation practitioners involved in planning, feasibility studies, consultation and policy for transportation systems, logistics, and infrastructure. Provides real-world examples of logistics systems solutions for multiple transportation modes, including seaports, rail, barge, road, pipelines, and airports Covers a wide range of business aspects, including customer service, cost, and decision analysis Features key-term definitions, concept overviews, discussions, and analytical problem-solving
Download or read book Reliability and Statistics in Transportation and Communication written by Igor Kabashkin and published by Springer. This book was released on 2019-03-09 with total page 821 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reports on cutting-edge theories and methods for analyzing complex systems, such as transportation and communication networks and discusses multi-disciplinary approaches to dependability problems encountered when dealing with complex systems in practice. The book presents the most noteworthy methods and results discussed at the International Conference on Reliability and Statistics in Transportation and Communication (RelStat), which took place in Riga, Latvia on October 17 – 20, 2018. It spans a broad spectrum of topics, from mathematical models and design methodologies, to software engineering, data security and financial issues, as well as practical problems in technical systems, such as transportation and telecommunications, and in engineering education.
