Download or read book Test No 483 Mammalian Spermatogonial Chromosomal Aberration Test written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells
Download or read book Test No 483 Mammalian Spermatogonial Chromosome Aberration Test written by OECD and published by OECD Publishing. This book was released on 1997-07-21 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This test measures chromosome events in spermatogonial germ cells and is, therefore, expected to be predictive of induction of inheritable mutations in germ cells. Male Chinese hamsters and mice are commonly used. Animals are exposed to the test ...
Download or read book OECD Guidelines for the Testing of Chemicals written by and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 473 In Vitro Mammalian Chromosomal Aberration Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 475 Mammalian Bone Marrow Chromosomal Aberration Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
Download or read book Test No 483 Mammalian Spermatogonial Chromosomal Aberration Test written by Organisation de coopération et de développement économiques and published by . This book was released on 2015 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 483 Mammalian Spermatogonial Chromosomal Aberration Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells.
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 478 Rodent Dominant Lethal Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the Dominant lethal (DL) test is to investigate whether chemical agents produce mutations resulting from chromosomal aberrations in germ cells.
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 485 Genetic toxicology Mouse Heritable Translocation Assay written by OECD and published by OECD Publishing. This book was released on 1986-10-23 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 474 Mammalian Erythrocyte Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 482 Genetic Toxicology DNA Damage and Repair Unscheduled DNA Synthesis in Mammalian Cells in vitro written by OECD and published by OECD Publishing. This book was released on 1986-10-23 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 479 Genetic Toxicology In vitro Sister Chromatid Exchange Assay in Mammalian Cells written by OECD and published by OECD Publishing. This book was released on 1986-10-23 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 443 Extended One Generation Reproductive Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 415 One Generation Reproduction Toxicity Study written by OECD and published by OECD Publishing. This book was released on 1983-05-26 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for reproduction testing is designed to provide general information concerning the effects of a test substance (Solid, liquid, gas or vapour) on male and female reproductive performance. The test substance is administered orally ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay written by OECD and published by OECD Publishing. This book was released on 2022-06-30 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 477 Genetic Toxicology Sex Linked Recessive Lethal Test in Drosophila melanogaster written by OECD and published by OECD Publishing. This book was released on 1984-04-04 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
