Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 435 In Vitro Membrane Barrier Test Method for Skin Corrosion written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to animal skin in situ.

Download or read book Test No 435 In Vitro Membrane Barrier Test Method for Skin Corrosion written by OECD and published by OECD Publishing. This book was released on 2006-08-17 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline is for an in vitro membrane barrier test method that can be used to identify corrosive substances. The test method utilizes an artificial membrane designed to respond to corrosive substances in a manner similar to animal skin in ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 430 In Vitro Skin Corrosion Transcutaneous Electrical Resistance Test Method TER written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal stratum corneum integrity and barrier function.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 431 In vitro skin corrosion reconstructed human epidermis RHE test method written by OECD and published by OECD Publishing. This book was released on 2019-06-18 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 404 Acute Dermal Irritation Corrosion written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 439 In Vitro Skin Irritation Reconstructed Human Epidermis Test Method written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 428 Skin Absorption In Vitro Method written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...

Download or read book Test No 430 In Vitro Skin Corrosion Transcutaneous Electrical Resistance Test TER written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Globally Harmonised System for the Classification and Labelling of Chemicals defines skin corrosion as the production of irreversible tissue damage in the skin following the application of a test material. The test material (150 μL for liquids ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 427 Skin Absorption In Vivo Method written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 403 Acute Inhalation Toxicity written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Health Effects Test No 436 Acute Inhalation Toxicity Acute Toxic Class Method written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 491 Short Time Exposure In Vitro Test Method for Identifying i Chemicals Inducing Serious Eye Damage and ii Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes a cytotoxicity-based in vitro assay that is performed on a confluent monolayer of Statens Seruminstitut Rabbit Cornea (SIRC) cells, cultured on a 96-well polycarbonate microplate.

Download or read book Test No 404 Acute Dermal Irritation Corrosion written by OECD and published by OECD Publishing. This book was released on 2002-04-24 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. This Test Guideline recommends sequential testing strategies, which include the performance of validated and ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 498 In vitro Phototoxicity Reconstructed Human Epidermis Phototoxicity test method written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin phototoxicity (photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after the exposure of the skin to environmental light. The in vitro reconstructed human epidermis phototoxicity test (RhE PT) is used to identify the phototoxic potential of a test chemical after topical application in reconstructed human epidermis (RhE) tissues in the presence and absence of simulated sunlight.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 406 Skin Sensitisation written by OECD and published by OECD Publishing. This book was released on 1992-07-17 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application. In this Test Guideline, the methods preferred over other are: the Guinea Pig Maximisation ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 405 Acute Eye Irritation Corrosion written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 442D In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.