Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 416 Two Generation Reproduction Toxicity written by OECD and published by OECD Publishing. This book was released on 2001-01-22 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive systems, and on the growth and ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 414 Prenatal Developmental Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 426 Developmental Neurotoxicity Study written by OECD and published by OECD Publishing. This book was released on 2007-10-15 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 422 Combined Repeated Dose Toxicity Study with the Reproduction Developmental Toxicity Screening Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 19 pages. Available in PDF, EPUB and Kindle. Book excerpt: This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. It has been updated with endocrine disruptor endpoints, in particular measure of anogenital distance and male nipple retention in pups and thyroid examination.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 421 Reproduction Developmental Toxicity Screening Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance.

Download or read book Food Safety Assessment Of Pesticide Residues written by Arpad Ambrus and published by World Scientific. This book was released on 2017-01-05 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pesticides are now accepted as an integral part of modern agricultural production. This book provides analysis of the steps taken by national and international bodies working towards a cohesive global strategy for evaluating the safety of residues in food that result from approved pesticide uses. Also described is the role of the UN Food and Agriculture Organization (FAO), World Health Organization (WHO) and Codex Alimentarius in developing standards that protect the health of the consumers and ensure fair practices in the food trade. It goes on to look at the promotion of good agricultural practice in the use of pesticides and the need for control in their practical use. These include sampling, testing the compliance of marketed products against legal limits and verifying the effectiveness of the safety-based regulatory measures. This is a specialist book for those looking to go into the field of international food safety, for students and lecturers studying the topic, for policy makers working on public health and agricultural issues, and personnel responsible for taking samples and performing the analysis of pesticide formulations and residues.

Download or read book Translational Toxicology and Therapeutics written by Michael D. Waters and published by John Wiley & Sons. This book was released on 2018-01-04 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

Download or read book Food Toxicology written by Debasis Bagchi and published by CRC Press. This book was released on 2016-11-25 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food toxicology studies how natural or synthetic poisons and toxicants in diverse food products cause harmful, detrimental, or adverse side effects in living organisms. Food toxicology is an important consideration as food supply chain is becoming more multinational in origin, and any contamination or toxic manifestation may cause serious, wide-spread adverse health effects. Food Toxicology covers various aspects of food safety and toxicology, including the study of the nature, properties, effects, and detection of toxic substances in food and their disease manifestations in humans. It will also include other aspects of consumer product safety. The first two chapters discuss the measurement of toxicants and toxicity and the importance of dose-response in food toxicology. Additional chapters discuss the aspects of food associated carcinogenesis and food-derived chemical carcinogenesis, food allergy, pathogens associated with fruits and vegetables, and the detrimental effects of radionuclides exposure. The chapters also cover the most important heavy metal contaminants, namely mercury, lead and vanadium, and Fluoride toxicity, which is extensively discussed in its own chapter. Toxicologists, scientists, researchers in food toxicology, nutritionists, and public health care professionals will find valuable information in this book on all possible intricate areas of food toxicology.

Download or read book Developmental and Reproductive Toxicology written by Ronald D Hood and published by CRC Press. This book was released on 2016-04-19 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers e

Download or read book Principles and Methods of Toxicology written by A. Wallace Hayes and published by CRC Press. This book was released on 2007-09-25 with total page 2296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanis

Download or read book Reproductive and Developmental Toxicology written by Ramesh C Gupta and published by Academic Press. This book was released on 2022-02-11 with total page 1558 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Toxicology** Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies. - Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development - Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis - Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more

Download or read book A Comprehensive Guide to Toxicology in Nonclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2016-11-03 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. - Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more - Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules - Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Download or read book Handbook of Cosmetic Science and Technology written by Frank Dreher and published by CRC Press. This book was released on 2022-08-11 with total page 997 pages. Available in PDF, EPUB and Kindle. Book excerpt: With chapters from experienced and internationally renowned contributors holding positions in research, industry, and clinical practice, this is the fifth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for the skin. *Offers in-depth analysis of specific topics in cosmetic science and research *Presents the latest in international research and its translation to practice *Gives an indispensable guide to a hotly competitive area for research and practice

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Document on Classification Systems for Reproductive Toxicity in OECD Member Countries written by OECD and published by OECD Publishing. This book was released on 2002-05-10 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed review document examines member country classification systems for reproductive toxicity.

Download or read book Toxicology and Risk Assessment written by Helmut Greim and published by John Wiley & Sons. This book was released on 2018-11-05 with total page 838 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.

Download or read book Evidence Based Practice in Complementary and Alternative Medicine written by Sanjeev Rastogi and published by Springer Science & Business Media. This book was released on 2012-01-28 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates the ways in which the evidence base is influencing complementary and alternative medicine in general and Ayurveda and allied health practices in particular. The latter have traditionally been prevalent in Asia and are now increasingly attracting interest worldwide. The book is divided into four sections, the first of which examines issues related to acquisition and evaluation of the evidence base. Evidence-based approaches to Ayurvedic diagnosis and therapy are then examined, with a special focus on management of cardiovascular and rheumatological diseases, dental care, and rejuvenating treatments. The final section explores further the challenges of applying evidence-based practice in contemporary and alternative medicine and Ayurveda with a focus upon the issues requiring urgent attention in ongoing decade. The same involves encompassing areas such as Ayurvedic pharmaceutics, practice, education and research within an evidence-based perspective.

Download or read book Perfluoroalkyl Substances in the Environment written by David M. Kempisty and published by CRC Press. This book was released on 2018-08-06 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Per- and polyfluorinated alkyl substances (PFAS), often referred to as per- (and poly) fluorinated compounds (PFCs), have been used for years in many everyday3⁄4 and some lifesaving3⁄4 products. However, their use has been linked to adverse health effects in humans, a problem compounded by their persistence in the environment. This book discusses the various challenges of PFAS in our environment today, including their historical use as well as their chemical and toxicological properties. It also presents robust discussion of analytical challenges and special considerations in sampling. The work goes on to give practical recommendations for dealing with these compounds in today's dynamic regulatory landscape and includes several chapters on various remediation techniques. Key Features: Comprehensive overview of per- and polyfluorinated alkyl substances (PFAS) historical use and chemical/physical properties which help us understand their persistence, transport, and transformation pathways in the environment In-depth analysis of PFAS toxicology Detailed descriptions of conventional and state-of-the-art remediation technologies Practical recommendations for dealing with PFAS in a dynamic regulatory landscape Robust discussion of important sampling and analytical considerations Perfluoroalkyl Substances in the Environment: Theory, Practice, and Innovation explores the challenges across the topical areas of regulation and management, toxicology, environmental remediation, and analytical sampling and analysis.Readers will find this text helpful in understanding complexities associated with PFAS and informing management strategies to effectively protect this and future generations.