Download or read book Nuclear Receptors in Drug Metabolism written by Wen Xie and published by John Wiley & Sons. This book was released on 2008-11-03 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.
Download or read book Studies on Nuclear Receptors Involved in Drug Metabolism written by Göran Bertilsson and published by . This book was released on 2001 with total page 47 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Receptors as Drug Targets written by Eckhard Ottow and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.
Download or read book Pharmacogenetics of Nuclear Receptors and Drug Transporters in Inflammatory Bowel Disease and Hepatic Drug Metabolism written by Jessica Mwinyi and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Download or read book Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases written by J.L. Junien and published by IOS Press. This book was released on 2008-07-16 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear receptors are a family of transcription factors consisting of 49 members identified in the human genome. Nuclear receptors regulate transcription by binding to response elements in the regulatory regions of target genes and thereby affect expression of genes involved in differentiation, growth, lipid homeostasis, inflammation and immunity. Over the past two decades significant advances have been made in the understanding of the regulation of gene expression by nuclear receptors. The knowledge on nuclear receptors has delivered novel therapies for lipid control and hormone replacement, and for management of cancer and diabetes. Therefore, nuclear receptors are attractive molecular targets for design of therapy for diabetes, obesity, atherosclerosis, cancer, inflammation and neurodegeneration. The focus of this volume is centered on the mechanistic involvement of nuclear receptors in cardiological, metabolic and neurological disorders, on possible explanation of pathways involved in pathogenesis, on susceptibility to and prevention of metabolic and neurological disorders and on the aspects of drug finding including chemistry and rational drug design. This volume reviews recent progress on nuclear receptors critically and will intrigue those pursuing interest in physiology, pathology and medicine.
Download or read book Nuclear Hormone Receptors written by Malcolm G. Parker and published by . This book was released on 1991 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.
Download or read book Topics on Drug Metabolism written by James Paxton and published by BoD – Books on Demand. This book was released on 2012-02-22 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.
Download or read book Nuclear Receptors written by Mostafa Z. Badr and published by Springer Nature. This book was released on 2021-09-28 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.
Download or read book Development and Analysis of Nuclear Receptor Mouse Models in the Study of Drug Metabolism and Neonatal Jaundice written by Dallin Schow Lindahl and published by . This book was released on 2014 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the relationship between nuclear receptors and drug metabolizing enzymes (DMEs) is important because it is closely associated with the metabolism of endogenous and xenobiotic compounds as well as drug-drug interactions. This study is divided into two parts : 1) the creation of a PXR transgenic mouse model and 2) the regulation of the UDP-glucuronosyltransferase 1A (UGT1A) locus through activation of the liver x receptor [alpha] (LXR[alpha]). The transgenic mouse line that contains the human pregnane X receptor (hPXR) transgene was established and the PXR transgene was determined to be functional by elevated levels of cytochrome p450 3a11 (Cyp3a11) in response to hPXR activator rifampicin. Crossing this transgenic mouse line with the mouse line Tg(UGT1A1*1)Ugt-/-Pxr-/- (hUGT1*1/Pxr-/-) line, previously established in the lab, we created a Tg(UGT1A1*1)Ugt-/-Tg(Pxr)Pxr-/- (hUGT1*1/hPXR) mouse line. For the second aim of this study, humanized UGT1A (hUGT1) mice were administered the LXR agonist, T090137, and the results show a significant induction of UGT1A1 in the liver and intestinal tissues compared with the control mice, suggesting that the LXR[alpha] regulates the UGT1A locus. These results are further supported by a significant reduction of serum bilirubin levels in response to T090137 treatment. Work is ongoing to create Lxr[alpha]-null mice on a hUGT1A background (hUGT1/- Lxr-/ mice). In conclusion, these two mice lines, hUGT1*1/hPXR and hUGT1A/Lxr[alpha]-/-, are potentially useful to study the roles of PXR and LXR in the UGT1A locus regulation that may have significant implications in altering glucuronidation activity of xenobiotics and endogenous compounds, including bilirubin.
Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Download or read book Drug Metabolism in Diseases written by Wen Xie and published by Academic Press. This book was released on 2016-09-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic
Download or read book The Nuclear Receptor Superfamily written by Iain J. McEwan, PhD and published by Humana Press. This book was released on 2008-12-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.
Download or read book Drug Discovery and Development written by Omboon Vallisuta and published by BoD – Books on Demand. This book was released on 2015-06-03 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.
Download or read book Receptor Regulation written by R. J. Lefkowitz and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: ROBERT J. LEFKOWITZ, M. D. Receptor Regulation (Receptors and Recognition, Series B, Volume 13) Edited by R. J. Lefkowitz Published in 1981 by Chapman and Hall, 11 New Fetter Lane, London EC4P 4EE © 1981 Chapman and Hall The study of hormone and drug receptors has become one of the most excit ing and rapidly moving areas of biomedical research. Elucidation of receptor mechanisms and receptor structure has become the common goal of many scientists from diverse backgrounds. The rapid advances achieved have been due, in large part, to the concentrated effort of workers from a variety of disciplines including classical pharmacology, biochemistry, endocrinology, cell biology, genetics' and molecular biology, among others. Hormone and drug receptors appear to be of three major types, which may be classified by their cellular locations. Found in the plasma membranes of cells are the receptors for a wide variety of polypeptide hormones, catecholamines and a variety of neurotransmitters. Included within this group are those receptors coupled to the enzyme adenylate cyclase. The second group of receptors are the soluble cytoplasmic receptors for the steroid hormones. A third type of hormone receptor is the receptor for the thyroid hormones which appears to be confined to the nucleus. Not only may these different types of receptor be distinguished in terms of their cellular locations but also by their mechanisms of action.
Download or read book Nuclear Receptors in Development and Disease written by and published by Academic Press. This book was released on 2017-05-17 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Receptors in Development and Disease, Volume 125, the latest volume in the Current Topics in Developmental Biology series, covers nuclear receptors in development and disease, and includes contributions from an international board of authors. New chapters in this release cover the Evolution of Nuclear Receptors and Ligand Signaling: Towards a Soft Key–Lock Model?, The Function and Evolution of Nuclear Receptors in Insect Embryonic Development, Nuclear Receptors in Skeletal Homeostasis, Estrogen Hormone Biology, and the Mechanisms of Glucocorticoid Action During Development. The book's chapters provide a comprehensive set of reviews that cover such topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural development. Covers the area of nuclear receptors in development and disease Includes contributions from an International board of authors Provides a comprehensive set of reviews on topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural developments
Download or read book Biased Signaling in Physiology Pharmacology and Therapeutics written by Brian J Arey and published by Elsevier. This book was released on 2014-06-05 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling
