Download or read book Noninvasive Molecular Markers in Gynecologic Cancers written by Debmalya Barh and published by CRC Press. This book was released on 2015-01-22 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early detection is critical for any given cancer. With the advent of the latest omics technologies, molecular markers in combination with conventional diagnostic and screening methods are emerging as next-generation early diagnostic and prognostic strategies that can allow early-stage diagnosis, resulting in more effective treatment and patient car

Download or read book Cancer Biomarkers written by Debmalya Barh and published by CRC Press. This book was released on 2014-01-30 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers. It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information. Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers. Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis Presents noninvasive early molecular markers in urological cancers Describes gynecological and endocrine cancer markers Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers Addresses hematological malignancies Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin’s lymphoma, and multiple myeloma Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

Download or read book Molecular Pathology of Gynecologic Cancer written by Antonio Giordano and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. It approaches research into the pathology and treatment of gynecologic oncology from both clinical and experimental perspectives. New insights made possible by the introduction of advanced technologies into the field are presented. This new volume will be necessary reading for clinicians and experimental researchers alike.

Download or read book Molecular Diagnosis and Targeting for Gynecologic Malignancy written by Seiji Isonishi and published by Springer Nature. This book was released on 2021-03-05 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.

Download or read book Translational Advances in Gynecologic Cancers written by Michael Birrer and published by Academic Press. This book was released on 2017-01-25 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included. Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus. - Provides a comprehensive description of all evolving translational gynecologic cancer research for clinicians - Identifies knowledge gaps to inform the next research direction - Ties together clinical research and patient needs to help both the researcher and clinician - Addresses genomics, new target therapies, novel tools, and more for ovarian, endometrial, and cervical cancer

Download or read book Gynecologic Cancers written by Kunle Odunsi, MD and published by Demos Medical Publishing. This book was released on 2013-10-09 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gynecologic Cancers summarizes issues related to the treatment of gynecologic cancer including descriptions of optimal multidisciplinary care utilizing all available modalities as well as related issues such as screening and prevention, management for special populations, psychological support and emerging directions in future treatment.

Download or read book IDENTIFICATION OF GENETIC EP written by Huijuan Yang and published by Open Dissertation Press. This book was released on 2017-01-27 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Identification of Genetic and Epigenetic Alterations in Gynecologic Cancers and Their Clinical Implications" by Huijuan, Yang, 楊慧娟, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Identification of Genetic and Epigenetic Alterations in Gynecologic Cancers and Their Clinical Implications Submitted by Yang Hui Juan for the degree of Doctor of Philosophy at The University of Hong Kong in Aug, 2004 Cervical, endometrial and ovarian cancers are relatively common causes of morbidity and mortality in women worldwide. A series of genetic and epigenetic changes contribute to the initiation and progression of human cancers. This study attempted to identify somatic mutations of mitochondrial DNA (mtDNA), nuclear microsatellite instability (nMSI), human papillomavirus (HPV) infection, and CpG island hypermethylation, and their clinical implications, in the three cancers. Somatic mutations of the D-loop region of mtDNA were identified by direct sequencing in 48.9% of 45 endometrial cancers and 34.0% of 50 cervical cancers, and in 20.0% of 25 ovarian cancers reported previously. Mitochondrial microsatellite instability (mtMSI) was the commonest alteration with a frequency of 44.4% in endometrial cancer, higher than the other two cancers. The homopolymorphic C tracts located in the hypervariable segments 1 and 2 (HVS 1 & 2) were hotspots for instability. Abstract 1 nMSI for 7 microsatellite markers was investigated in 66 cervical cancers, 43 endometrial cancers and 44 ovarian cancers by PCR amplification. High-level MSI was identified in 20-30% of the three cancers. The occurrence of nMSI was not associated with mtMSI. HPV 16 DNA was identified by real-time quantitative PCR in 32.1% of 56 ovarian cancers and 15.2% of 46 endometrial cancers, significantly lower than in cervical cancers (64.3% of 129). HPV 18 DNA was detected in 20.9% of cervical cancers and one ovarian cancer (1.8%). The levels of HPV 16 DNA in cervical cancer were significantly higher than the other two cancers, and the incidence or levels of HPV DNA were associated with histological type, stage, grade, or response to radiotherapy. Plasma HPV DNA was identified in more than half of cervical cancers. Its level was associated with the viral load in the paired primary tumor, and changed with the treatment and progression of the disease. Using pooled DNA approach and methylation-specific PCR, the methylation status of the CpG islands of 34 genes was determined in the three cancers. Differential DNA methylation profiles were identified. Some gene changes were shared and others were specific. CpG island hypermethylation for 4 selected genes in each cancer type was identified in 50-70% of patients with the three cancers. The occurrence of DAPK hypermethylation was the highest, in 56.7% of cervical cancers, and independent on HPV infection. It was more common in squamous cell carcinoma than in adenocarcinoma and was an independent prognostic factor for shorter disease-free survival. Aberrant methylation for other genes (BRCA1, hMLH1, MGMT, p14, p16, and PTEN) was also associated with histological subtypes, stage, grade or treatment response. Furthermore, hypermethylated sequences were identified in 58.2% of Abstract 2 plasma samples of cervical cancers, significantly higher than in precancerous diseases and controls. In summary, molecular alterations are different in the three cancers. mtMSI at HVS 1 & 2 might be a potential molecular marker in endometrial cancer. Measurement of HPV DNA copy number in primary tumor and plasm

Download or read book Prognostic and Predictive Factors in Gynecologic Cancers written by Charles F. Levenback and published by CRC Press. This book was released on 2007-09-15 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gynecologic oncology takes a fresh look at a critical aspect of cancer treatment planning. An international team of authors reviews the traditional prognostic and predictive factors such as tumor grade, histologic subtype, and grade and then goes a step further to review the growing number of molecular discoveries that have increasing clinical significance. The book is organized into comprehensive sections on ovarian, endometrial and cervical cancer and includes up to date reviews, newly discovered molecular pathways, genetic markers, molecular imaging techniques, and their relevance to clinical medicine. Prognostic and Predictive Factors in Gynecologic Oncology is illustrated with over 100 figures and is essential reading for oncologists, translational and basic scientists, as well as fellows, residents and students with a special interest in gynecologic oncology.

Download or read book Ovarian Cancer Biomarkers written by Khalid El Bairi and published by Springer Nature. This book was released on 2021-10-09 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.

Download or read book Diagnosis and Management of Ovarian Disorders written by Albert Altchek and published by Elsevier. This book was released on 2003-09-04 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders.KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine

Download or read book Ovarian Cancers written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-04-25 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease-several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.

Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.

Download or read book Blaustein s Pathology of the Female Genital Tract written by Ancel Blaustein and published by Springer Science & Business Media. This book was released on 2011-01-10 with total page 1261 pages. Available in PDF, EPUB and Kindle. Book excerpt: New edition includes more than 350 new illustrations and 22 revised chapters Written by internationally recognized experts Each entry is structured the same way, from general to more specific information, which allows the reader to quickly access key information in every chapter Since the publication of the 1/e in 1977, Blaustein's Pathology of the Female Genital Tract has consolidated its position as the leading textbook of gynecological pathology. an essential reference for all pathologists and residents, this thoroughly updated Sixth Edition includes more than 1500 illustrations in color, i

Download or read book Circulating Tumor Cells written by Mark Jesus M. Magbanua and published by Humana Press. This book was released on 2017-09-15 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores various approaches for enrichment, detection, isolation, and molecular profiling of circulating tumor cells (CTCs). Each chapter provides comprehensive descriptions and guidelines on how to perform innovative experiments in CTC research. Included are protocols for capture of CTCs via filtration and density gradient centrifugation; microfluidic and immunomagnetic separation of CTCs; detection of CTCs by immunocytochemistry, fluorescence in situ hybridization, and flow cytometry; assays designed for genomic characterization and functional analyses of CTCs, and many more. Written in the highly successful Methods in Molecular Biology series format, the chapters in this book include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Circula ting Tumor Cells: Methods and Protocols is a valuable resource for laboratory researchers and clinicians who are interested in furthering their studies on CTCs.

Download or read book Gynecologic and Urologic Pathology written by Maria Rosaria Raspollini and published by Cambridge University Press. This book was released on 2019-02-21 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the similarities and differences in the pathology of the genital and urinary tracts in males and females.

Download or read book Diagnostic Gynecologic and Obstetric Pathology E Book written by Christopher P. Crum and published by Elsevier Health Sciences. This book was released on 2017-10-13 with total page 1332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and practice-oriented, the fully updated 3rd Edition of this easy-to-use text covers the full range of obstetric and gynecologic pathology, including information on treatment and patient management. Written largely by the pathology and clinical faculty at Harvard's Brigham and Women's Hospital, it covers the most up-to-date information available in the field, including molecular genetics and diagnostics. Drs. Christopher P. Crum and Marisa R. Nucci are joined by new editors Scott R. Granter, Brooke E. Howitt, Mana M. Parast, and Theonia K. Boyd, to provide complete, beautifully illustrated coverage of both neoplastic and non-neoplastic disorders of the female genital system, ideal for improving pathological diagnosis. - Provides distinct diagnostic/differential diagnostic criteria for any potential obstetric/gynecologic specimen encountered in practice. - Features more than 2,250 full-color images, key points at the end of each chapter, and an appendix with commonly used ICD-10 codes - Covers topics not often found in gynecologic pathology textbooks, such as vulvodynia, and diseases of the anus. - Approaches topics from a practice-oriented point of view, beginning with clinical presentation and progressing through histopathology, differential diagnosis, and treatment for each disorder. - Emphasizes new practice issues and their biologic basis including approaches to vulvar, cervical and endometrial precursors as well as the underpinnings of cervical, endometrial and ovarian cancer. - A comprehensive look at mesenchymal neoplasia, including not only lower genital tract and uterus but also the retroperitoneum. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Download or read book Management of Endometrial Cancer written by Mansoor R. Mirza and published by Springer. This book was released on 2019-08-26 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical reference book provides up-to-date, evidence-based multidisciplinary guidelines on the epidemiology, biology, diagnosis, and treatment of endometrial cancer. Individual chapters focus on topics such as hormonal interactions, cancer prevention, genetic classification and its clinical applications. Recent advances in diagnostic methods are described. The treatment-oriented chapters include coverage of the roles of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in early-stage disease. Treatment options in advanced disease, including hormonal therapy and targeted therapy, are considered separately, as is the management of rare tumor types. The authors are international key opinion leaders. Summaries of the ESMO/ESGO/ESTRO guidelines on management are included. Each clinical chapter ends with a summary of recommendations with the level of evidence.