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Book Non Vitamin K Antagonist Oral Anticoagulants  Clinical Use  Real World Data  and Reversal of Anticoagulant Effect

Download or read book Non Vitamin K Antagonist Oral Anticoagulants Clinical Use Real World Data and Reversal of Anticoagulant Effect written by Özcan Başaran and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice and is associated with a higher risk of thromboembolic events. CHA2DS2VASc score enables identification of those patients with AF who will most benefit from anticoagulation therapy and low-risk patients with AF who do not need any antithrombotic therapy. Antithrombotic drugs especially oral anticoagulants (OACs) are the mainstay of therapy to prevent stroke in patients with AF. Although vitamin K antagonists (VKAs) were the only available drugs for decades, numerous non-vitamin K antagonist oral anticoagulants (NOACs) have been developed and marketed for stroke prevention in recent years. The risk of stroke was reported to decline up to 68 % with OAC therapy, associated with good anticoagulation control with VKAs, assessed by time in therapeutic range (TTR). In low TTR values, VKAs were found to be associated with severe complications, and a minimum TTR of 58 % should be achieved to expect a net benefit from being on OAC therapy. Narrow therapeutic index, drug-drug interactions, and the need for close monitoring are the main disadvantages of VKAs, and management of patients have dramatically improved after the introduction of NOACs. NOACs have a more predictable anticoagulant affect which allows a fixed-dose regimen. The efficacy and safety of NOACs have been shown not only in large randomized controlled clinical trials but also in observational studies. The main advantages of NOACS such as "fixed-dose regimen" and "no need for regular anticoagulant therapy monitoring" may also be the Achilles heel of the use of these agents. Fixed-dose regimen may not be appropriate for elderly, for patients with chronic kidney disease, and for patients using interacting drugs. Adherence to NOAC therapy is another concern as it may be as low as 50 % in the chronic use of cardiovascular drugs, especially if the drug has no apparent affect to the patient. Thus, appropriate use of OACs among non-valvular AF (NVAF) patients is essential for stroke prophylaxis. We intended to review the use of OAC therapy among (NVAF) patients.

Book Anticoagulation Therapy

    Book Details:
  • Author : Ozcan Basaran
  • Publisher : BoD – Books on Demand
  • Release : 2016-09-08
  • ISBN : 9535126660
  • Pages : 152 pages

Download or read book Anticoagulation Therapy written by Ozcan Basaran and published by BoD – Books on Demand. This book was released on 2016-09-08 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The available parenteral and oral anticoagulants have a large clinical use. Understanding biochemistry of anticoagulants may help to improve therapeutic strategies. Resistance to vitamin K antagonist drugs might be a problem for rodent populations. Patients who have thrombogenic risk factors should be anticoagulated. The need for cardiac implantable electronic devices is increasing, and there is a substantial number of patients who are on oral anticoagulant therapy. Prothrombin complex concentrate and other plasma concentrates are useful to deal with over-coagulated situations. The efficacy and safety of non-vitamin K antagonist oral anticoagulants have been proven in large phase III trials. The real-world data suggest even better outcomes with these agents compared to vitamin K antagonists.

Book Non Vitamin K Antagonist Oral Anticoagulants

Download or read book Non Vitamin K Antagonist Oral Anticoagulants written by Eduard Shantsila and published by Springer. This book was released on 2015-12-21 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an essential guide to the medical treatment of thrombosis and presents core principles of anticoagulant therapeutics as well as drug recommendations. Written by recognized experts in the field, this concise, accessible handbook provides a unique and valuable resource in the cardiovascular field, both for those currently in training, and for those already in clinical or research practice.

Book Treatment of Non vitamin K Antagonist Oral Anticoagulants

Download or read book Treatment of Non vitamin K Antagonist Oral Anticoagulants written by Masaaki Uno and published by Springer. This book was released on 2016-10-31 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes new concepts and strategies for the clinical application of non-vitamin K antagonist oral anticoagulants (NOACs) for stroke. Although vitamin K antagonists have traditionally been used for the prevention of stroke, there are some problems associated with their use, such as the risk of intracranial hemorrhage, the need for dietary restrictions, and individual variability. Recently, NOACs have been introduced as alternatives to traditional anticoagulants and are becoming an option for treating stroke patients around the globe. However, their use is not without risk. Each chapter describes the successful use of NOACs for stroke patients and discusses their future impact from various points of view. The book is primarily written for neurosurgeons and neurologists but is also of interest to cardiologists involved in stroke treatment.

Book Oral Anticoagulants

    Book Details:
  • Author : L. Poller
  • Publisher : CRC Press
  • Release : 1996-08-02
  • ISBN : 9780340552667
  • Pages : 288 pages

Download or read book Oral Anticoagulants written by L. Poller and published by CRC Press. This book was released on 1996-08-02 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Warfarin and related drugs have been used for over half a century in prevention and treatment of thrombotic disorders. Only recently however has their clinical role been firmly established by randomised studies and their benefit/risk ratio improved by lower dose therapy with improvements in laboratory monitoring. 'Oral Anticoagulants' is the first comprehensive, practical survey of the subject available. An international team of recognised experts provide detailed coverage on the mode of action; clinical pharmodynamics; magnitude and sources of variability in individuals response to oral anticoagulant; methods of individualising dosing regimens; laboratory monitoring; and comparison between the different currently prescribed oral anticoagulants.

Book Anticoagulation Therapy

Download or read book Anticoagulation Therapy written by and published by . This book was released on 19?? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Direct Oral Anticoagulants

Download or read book Direct Oral Anticoagulants written by Riccardo Proietti and published by Springer Nature. This book was released on 2021-06-28 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concisely covers the latest developments in the application of direct oral anticoagulants (DOACs) within cardiovascular medicine. It details the pharmacodynamics and pharmacokinetic mechanisms of DOACs and their application in treating patients with conditions ranging from coronary heart disease through kidney disease and cancer, including their perioperative management. Direct Oral Anticoagulants: From Pharmacology to Clinical Practice systematically describes the underlying mechanisms associated with DOACs and their use to treat a range of conditions and is an indispensable resource for all trainee and practicing physicians in a range of disciplines seeking a concise up-to-date resource on the topic.

Book Anticoagulation Therapy

Download or read book Anticoagulation Therapy written by Joe F. Lau and published by Springer. This book was released on 2018-04-16 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants.

Book Diez Werner

    Book Details:
  • Author :
  • Publisher :
  • Release : 1983
  • ISBN :
  • Pages : pages

Download or read book Diez Werner written by and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Oral Anticoagulation Therapy

Download or read book Oral Anticoagulation Therapy written by Kathryn Kiser and published by Springer. This book was released on 2017-05-31 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the amount and complexity of information surrounding the the target specific oral anticoagulants a lengthy didactic educational format has the potential to be overwhelming to the reader and difficult to translate and apply to direct patient care. The proposed book will educate clinicians utilizing a series of clinical cases to simultaneously develop the readers’ knowledge base, problem-solving skills, and practically apply their new knowledge to a variety of clinical situations. These will be short focused case presentations that provide critical information and pose questions to the reader at key points in the decision making process. The cases will be relevant to what clinicians will encounter not only on a daily basis, but also reflective of scenarios that clinicians will not encounter regularly, but that they will have to act upon (e.g. a bleeding patient, patient scheduled for elective or emergent procedure, patient with changing renal function, patient on drugs that have a plausible yet unstudied drug interaction with a target specific oral anticoagulant etc). Included in the case studies will be evidence-based discussions (with appropriate references) that provide immediate feedback on the different treatment alternatives that were offered. The case studies will be designed to instruct the reader how to select and effectively utilize the most appropriate agent for a given clinical scenario. They will focus on key features of the target specific oral anticoagulants, what they have in common, how they are unique from each other, as well as illustrating the clinical decision process one should take when selecting an agent or managing a patient already receiving one of the target specific oral agents. ​

Book Management of Acute Pulmonary Embolism

Download or read book Management of Acute Pulmonary Embolism written by Stavros V. Konstantinides and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical volume highlights traditional, novel, and evolving aspects of the diagnosis and treatment of pulmonary embolism (PE). The contributors comprise an international team of experts. Important aspects of diagnosis, risk stratification, and differential treatment of patients with PE are presented in a concise, yet comprehensive manner. Emphasis is placed on specific issues related to PE, including pregnancy, cancer, thrombophilia, and air travel.

Book Clinical Handbook of Cardiac Electrophysiology

Download or read book Clinical Handbook of Cardiac Electrophysiology written by Benedict M. Glover and published by Springer Nature. This book was released on 2021-06-22 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensively revised second edition provides a practically applicable guide for the management of cardiac arrhythmia. This subject has continued to expand rapidly, and it is therefore critical to understand the basic principles of arrhythmia mechanisms in order to assist with diagnosis and the selection of an appropriate treatment strategy. Comprehensively revised chapters cover a variety of aspects of cardiac electrophysiology in an easy-to-digest case-based format. For each case of arrhythmia, relevant illustrations, fluoroscopy images, ECGs and endocavity electrograms are used to describe the etiology, classification, clinical presentation, mechanisms, electrophysiology set up and relevant trouble-shooting procedures. New topics covered include the application of new antiarrhythmic drugs in tandem with ablation, techniques for the ablation of atrial fibrillation and electrophysiological assessments available for identifying instances of atrial tachycardia. Clinical Handbook of Cardiac Electrophysiology presents a comprehensive overview of cardiac electrophysiology, making it a valuable reference for practicing and trainee cardiac electrophysiologists, cardiologists, family practitioners, allied professionals and nurses.

Book Antithrombotic Therapy

Download or read book Antithrombotic Therapy written by Richard C. Becker and published by Professional Communications. This book was released on 2010-12-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical application of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute MI, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease, (venous thromboembolic disease and pulmonary embolism). Results of major clinical trials and their implications for clinical practice.

Book The ESC Textbook of Cardiovascular Medicine

Download or read book The ESC Textbook of Cardiovascular Medicine written by A. John Camm and published by . This book was released on 2019 with total page 3198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Cerebral Small Vessel Disease

Download or read book Cerebral Small Vessel Disease written by Leonardo Pantoni and published by Cambridge University Press. This book was released on 2014-05 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.

Book Stroke Prevention in Atrial Fibrillation

Download or read book Stroke Prevention in Atrial Fibrillation written by Greg Flaker and published by Elsevier Health Sciences. This book was released on 2018-05-24 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of stroke risks among patients with treated and untreated atrial fibrillation, in addition to best practices for management and treatment of patients with atrial fibrillation to minimize stroke risks. This concise, clinically-focused resource by Dr. Greg Flaker consolidates today’s available information on this timely topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee cardiologists as well as general practitioners treating and monitoring these patients. Covers a broad spectrum of management and treatment options for atrial fibrillation including anticoagulants, surgical and implanted devices. Presents information on recent drug trials to keep you up to date with the latest developments. Includes guidance on anticoagulation in special situations, such as cardioversion and ablation, in addition to atrial fibrillation treatment in patients with other medical conditions including cancer, major bleeding disorders, and renal or liver disease. Chapter on Risk Stratification assists in identifying patients with a high risk of stroke and predicting treatment outcomes. Chapter on The New Anticoagulation Clinic overviews best practices for patient education, compliance, follow-up monitoring, and quality assurance to aid in better patient outcomes.

Book Perioperative Hemostasis

    Book Details:
  • Author : Carlo Enrique Marcucci
  • Publisher : Springer
  • Release : 2014-09-17
  • ISBN : 3642550045
  • Pages : 456 pages

Download or read book Perioperative Hemostasis written by Carlo Enrique Marcucci and published by Springer. This book was released on 2014-09-17 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: All anesthesiologists are confronted with patients who show bleeding disorders, whether congenital, acquired, or pharmacologically induced. Although many studies, meta-analyses, guidelines, and textbooks have been published on the subject, they mostly cover specific aspects or require a thorough knowledge of hemostasis. The goal of this book is to provide the anesthesiologist with an overview of hemostasis and the mechanisms underlying bleeding and coagulation in general and to assist in the understanding of specific coagulation disorders as they may occur in the various anesthesia subspecialties. It is hoped that, through the provision of practical information and tools, the book will help residents and trained anesthesiologists to manage one of the most frustrating challenges that they face: the bleeding patient. A full understanding of coagulation requires a lifelong career, and this book is not intended to replace the consulting hematologist, whose expert opinion should always be sought. The available procoagulant blood products and drugs all have potentially dangerous side-effects; furthermore, in bleeding disorders pitfalls are frequent and a misdiagnosis can have potentially catastrophic consequences. The aim of the editors is thus instead to enhance the collaboration between the disciplines of Anesthesiology and Hematology.