Download or read book Nitrosoureas written by Archie W. Prestayko and published by Elsevier. This book was released on 2013-10-22 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitrosoureas: Current Status and New Developments covers the preclinical and clinical status of nitrosoureas. The book presents preclinical studies on the development of the nitrosoureas; combination chemotherapy with nitrosoureas plus other anticancer drugs against animal tumors; EORTC studies with novel nitrosoureas; and chemical decomposition of chloroethylnitrosoureas. The text also includes preclinical studies on the metabolism of nitrosoureas; DNA crosslinking and the origin of sensitivity to chloroethylnitrosoureas; modification of DNA and RNA bases; and carbamoylating activity of nitrosoureas. Clinical studies on subacute and chronic toxicities associated with nitrosourea therapy; the toxicity of high-dose BCNU with autologous marrow support; and the clinical pharmacology of the nitrosoureas are also considered. The book further tackles clinical studies on nitrosoureas in the therapy of Hodgkin's disease; nitrosourea-containing combinations in small-cell lung cancer; adjuvant therapy of brain tumors with nitrosoureas; and clinical use of nitrosoureas in gastrointestinal cancer. Oncologists, toxicologists, biochemists, pharmacologists, and other scientists working in drug development will find the text invaluable.

Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Download or read book Handbook of Brain Tumor Chemotherapy written by Herbert B. Newton and published by Elsevier. This book was released on 2005-12-19 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including "targeted agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease. Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy. - Provides the most up to date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics, for the treatment of brain tumors - Broadly appeals to anyone interested in the field of Neuro-Oncology and in the treatment of patients with brain tumors - Useful to clinicians interested in a thorough overview of the use of chemotherapy in patients with a broad range of brain tumors as well as serving as a source of background information to basic scientists and pharmaceutical researchers with an interest in the molecular therapeutics of brain tumors

Download or read book The Anticancer Drugs written by William B. Pratt and published by . This book was released on 1994 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer. The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. Drawing on the fields of authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine, this timely book is extensively referenced and provides a historical background for the development of each class of drugs.

Download or read book Cancer Treatment Reports written by and published by . This book was released on 1987 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer Treatment Symposia written by and published by . This book was released on 1983 with total page 918 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1974 with total page 1260 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Antineoplastic and Immunosuppressive Agents written by Alan C. Sartorelli and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 1100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a single volume the entire field of drugs employed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons to publish the material in two parts, although the plan of the work constitutes, at least in the editors' view, a single integrated treatment of this research area. A number of factors have contributed to the continuous expansion of research in the areas of cancer chemotherapy and immunosuppression. Active compounds have been emerging at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories through out the world. At the molecular level, knowledge of the modes of action of established agents has continued to expand, and has permitted rational drug design to play a significantly greater role in a process which, in its early years, depended almost completely upon empirical and fortuitous observations.

Download or read book Secondary Neoplasias Following Chemotherapy Radiotherapy and Immunosuppression written by Ursula Rüther and published by Karger Medical and Scientific Publishers. This book was released on 2000-01-01 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: '... This book, by Ruther and colleagues, is a very comprehensive review of the mechanisms of carcinogenesis, clinical features and therapies for secondary malignancies. '... Its an excellent resource for those interested in the subject, as well as oncologists who are increasingly forced to deal with second cancers. The material is well referenced.'

Download or read book Cancer Management in Man written by Paul V. Woolley and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, the last in this series on cancer growth and Moreover, the current status of plant-derived vinca alka progression, is a companion volume to Volume IX and loids and non-alkaloid natural products is summarized. further explores established and novel approaches for the Advances in hyperthermia and additional approaches for therapy of patients with malignant neoplasms. The stra the therapy of malignancies are also presented. tegies reflected in these volumes are direct extrapolations The volume continues with chapters on bone marrow from the basic science of cancer biology, growth and pro transplantation as well as hematologic and nutritional sup gression described in earlier volumes of this series. Some port for the cancer patient. Blood pressure in the cancer approaches are directed towards the eradication or modifi patient, therapy for nausea and vomiting as well as pain are cation of the properties of heterogeneous malignant tumor discussed. The last chapter is devoted to the problems of the cells at various stages of tumor progression, while other terminally ill, including evaluations of the burden relatives approaches are directed towards modification of the host and friends of the cancer patient have to bear. antitumor defense systems, e. g. , enhancement of host anti It is clear that important advances in the basic science of tumor immune reactivity.

Download or read book New Anticancer Drugs written by S.K. Carter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer Chemotherapy Reports written by and published by . This book was released on 1973 with total page 1154 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Antitumor Drug Radiation Interactions written by Bridget T. Hill and published by CRC Press. This book was released on 2018-01-10 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the experimental data on drug-radiation interactions. Special emphasis is placed on clinically-useful antitumor drugs. Particular reference is made to appropriate timing, concentration and sequencing of drug-radiation combinations. It includes discussions on the relative merits of experimental data derived from animal versus human tumors. This book also presents a section on the potential for new model systems or alternative test procedures for evaluating therapeutic benefits and cytotoxicities. Results of randomized clinical studies are reviewed with emphasis on recent studies involving protocols specifically designed to test the benefits from optimal integration of chemotherapy with radiotherapy. This book is intended for laboratory researchers in the field and clinicians interested in using the combined modality approach. It is also a useful resource for radiologists, oncologists, and all those interested in cancer research.

Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Download or read book Pharmacology for Pharmacy and the Health Sciences written by Michael Boarder and published by Oxford University Press. This book was released on 2017 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book adopts a novel patient-centred approach to introduce drug action at the cellular and molecular level while developing clinical topics in the context of individual patients and their experience of illness. In so doing, it takes the important step of relating the scientific basis of pharmacology to real-life pharmacy practice.

Download or read book Aliphatic Carcinogens written by Joseph C. Arcos and published by Elsevier. This book was released on 2013-10-22 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Induction of Cancer: Structural Bases and Biological Mechanisms Volume IIIA deals with the organic and biochemical principles behind cancer. This volume contains the continuation of Volume IIA, which tackles structure-activity relationships of chemical carcinogens, the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity. Under this is non-conjugated organic compounds. The text is recommended for doctors, organic chemists, and biochemists with an advanced knowledge in biochemistry and organic chemistry and would like to know more the biochemical processes of cancer.

Download or read book Cancer Therapeutics written by Beverly A. Teicher and published by Springer Science & Business Media. This book was released on 1996-12-03 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer drug discovery has been and continues to be a process of ingenuity, serendip ity, and dogged determination. In an effort to develop and discover better therapies against cancer, investigators all over the world have increased our knowledge of cell biology, biochemistry, and molecular biology. The goal has been to define therapeuti cally exploitable differences between normal and malignant cells. The result has been an increased understanding of cellular and whole-organism biology and an increased respect for the flexibility and resiliency ofbiologically systems. Thus, as some new therapeutic targets have been defined and new therapeutic strategies have been attempted, so have some new biological hurdles resulting from tumor evasion of the intended therapeutic attack been discovered. Historically, anticancer drugs have originated from all available chemical sources. Synthetic molecules from the chemical industry, especially dyestuffs and warfare agents, and natural products from plants, microbes, and fungi have all been potential sources of pharmaceuticals, including anticancer agents. There is no shortage of molecules; the challenge has been and continues to be methods of identifying molecules that have the potential to be therapeutically important in human malignant disease. "Screening" remains the most important and most controversial method in cancer drug discovery. In vitro screens have generally focused on cytotoxicity and have identified several highly cytotoxic molecules. Other endpoints available in vitro are inhibition of proliferation, 3 inhibition of [ H]thymidine incorporation into DNA and various viability assays, based most frequently on dye exclusion or metabolism.