Download or read book Nickel catalyzed Reactions of Organomagnesium and Organozinc Reagents with Sulfur Compounds written by James Myron Hanna and published by . This book was released on 1987 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organozinc Derivatives and Transition Metal Catalysts written by Janine Cossy and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-05-22 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organozinc reagents are less reactive than Grignard reagents but they are much more chemoselective. Since the Negishi cross-coupling reaction developed by Ei-ichi Negishi, who was awarded the Nobel Price in chemistry in 2010, a number of cross-coupling reactions involving organozinc derivatives and transition metal catalysts (Pd, Ni, Fe, Co, Cu, ...) has been tuned up to form C-C bonds. This book on "Organozinc derivatives and transition metal catalysts" has been written by experts in the field and is a complement to the book entitled "Grignard reagents and transition metal catalysts" (a De Gruyter book, edited by J. Cossy). Grignard reagents or organozinc reagents, that is the question? From a given substrate, what is the best organometallic reagent and the best transition metal to form a C-C bond by using a cross-coupling reaction? The solution might be found in these two books.
Download or read book The Organometallic compounds of zinc and magnesium written by Henry Wren and published by . This book was released on 1913 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transition metal Catalyzed Cross coupling Reactions of Functionalized Organometallic Reagents Nickel catalyzed Amination of Aryl Chlorides and Preparation and Reactions of Organozinc Reagents written by Georg Manolikakes and published by . This book was released on 2008 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organomagnesium Methods in Organic Chemistry written by Basil J. Wakefield and published by Academic Press. This book was released on 1995-03-16 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book opens with a general overview of the constitution and reactivity of organomagnesium compounds, followed by information on handling them and on their detection and estimation. Throughout, practical aspects aswell as principles are emphasized. The chapters on the synthesis of organomagnesium compounds cover the preparation of special forms of metallic magnesium and the reaction of magnesium with substrates such as dienes, as well as the traditional preparation of Grignard reagents. Preparations by metallation and metal-halogen exchanges are also included, as are newer methods such as hydromagnesiation of alkenes and alkynes. Systematic coverage is provided on synthetically useful reactions of organomagnesium compounds. Of fundamental importance in organic synthesis are carbon-carbon bond forming reactions; additions to carbon-carbon, carbon-nitrogen, carbon-oxygen, and carbon-sulfur multiple bonds; and nucleophilic substitution at carbon. The formation of carbon-heteroatom bonds in organic compounds is described, where the heteroatom is hydrogen, nitrogen, oxygen, sulfur, or halogen. Finally, the use of organomagnesium compounds in preparing other organometalloid and organometallic compounds is outlined. Representative experimental procedures are included throughout the book, and tables with references to well-described examples are provided. - Presents a general overview of the constitution and reactivity of organomagnesium compounds - Provides coverage on the detection and estimation of organomagnesium compounds - Emphasizes practical aspects as well as principles - Covers the preparation of special forms of metallic magnesium and the reaction of magnesium with substrates such as dienes - Includes preparations by metallation and metal-halogen exchanges - Reviews new preparation methods such as hydromagnesiation of alkenes and alkynes - Outlines information on synthetically useful reactions of organomagnesium compounds - Describes the formation of carbon-heteroatom bonds in organic compounds - Addresses the use of organomagnesium compounds in preparing other organometalloid and organometallic compounds - Includes representative procedures and tables with references to well-described examples
Download or read book Low valent Nickel mediated Reactions of Grignard Reagents with an Oxazoline a Thiazoline Isoxazoles Oxazoles Thiazoles and Arylammonium Salts written by Aili Han and published by . This book was released on 1987 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nickel Catalysis in Organic Synthesis written by Sensuke Ogoshi and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference to nickel chemistry for every scientist working with organometallic catalysts Written by one of the world?s leading reseachers in the field, Nickel Catalysis in Organic Synthesis presents a comprehensive review of the high potential of modern nickel catalysis and its application in synthesis. Structured in a clear and assessible manner, the book offers a collection of various reaction types, such as cross-coupling reactions, reactions for the activation of unreactive bonds, carbon dioxide fixation, and many more. Nickel has been recognized as one of the most interesting transition metals for homogeneous catalysis. This book offers an overview to the recently developed new ligands, new reaction conditions, and new apparatus to control the reactivity of nickel catalysts, allowing scientists to apply nickel catalysts to a variety of bond-forming reactions. A must-read for anyone working with organometallic compounds and their application in organic synthesis, this important guide: -Reviews the numerous applications of nickel catalysis in synthesis -Explores the use of nickel as a relatively cheap and earth-abundant metal -Examines the versatility of nickel catalysis in reactions like cross-coupling reactions and CH activations -Offers a resource for academics and industry professionals Written for catalytic chemists, organic chemists, inorganic chemists, structural chemists, and chemists in industry, Nickel Catalysis in Organic Synthesis provides a much-needed overview of the most recent developments in modern nickel catalysis and its application in synthesis.
Download or read book Nickel Catalyzed Cross Coupling Reactions written by Luke Edward Hanna and published by . This book was released on 2016 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cross-coupling technology has become an indispensable tool for the rapid and efficient synthesis of complex molecules. Over the past few decades a foundational understanding of organometallic chemistry has been laid using palladium and other precious metals. Recent research on first row base metal catalysts such as nickel, cobalt and iron has uncovered new and complementary modes of reactivity compared to their more well-studied precious metal counterparts. While nickel sits one row above palladium on the periodic table, ongoing research has illustrated that nickel possesses a unique reactivity profile. Thus, while nickel is commonly thought of as a cheaper alternative to palladium, research in the field of nickel catalysis has demonstrated far more potential than this. The unique propensity of nickel to undergo single electron chemistry as well as its ability to break strong carbon oxygen bonds make research into nickel reactivity an immensely beneficial endeavor to the fields of inorganic, organometallic and synthetic organic chemistry.Chapter 1 describes the development of a stereospecific Suzuki coupling of benzylic carbamates and pivalates with aryl- and heteroarylboronic esters. The reaction proceeds with selective inversion or retention at the electrophilic carbon, depending on the identity of the ligand used. Tricyclohexylphosphine ligand provides products with retention of configuration at the electrophilic carbon, while an N-heterocyclic carbene ligand SIMes provides products with inversion.Chapter 2 discusses the development of a regio- and stereoselective nickel-catalyzed hydroarylation of alkynes using propargylic carbamates as directing groups. The reaction proceeds under mild reaction conditions using arylboronic acids in the absence of base. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the method is applied to the synthesis of tamoxifen.Chapter 3 details a nickel-catalyzed cross-electrophile coupling reaction of benzylic esters and aryl halides. Both inter- and intramolecular variants proceed under mild reaction conditions. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the first example of a stereospecific cross-electrophile coupling of a secondary benzylic ester is described.Chapter 4 presents secondary benzylzinc reagents generated from 2-pyridylcarbinols using a nickel catalyst and diethylzinc. Substrates are activated in situ using a chlorophosphate reagent. Quenching the organozinc reagents allows for facile deoxygenation of 2-pyridylcarbinols in a one-pot reaction with straightforward incorporation of a deuterium label from deuteromethanol. An intramolecular conjugate addition of a secondary benzylzinc reagent with an alpha,beta-unsaturated ester is also demonstrated.
Download or read book Sulfur Compounds Advances in Research and Application 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sulfur Compounds—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Hydrogen Sulfide. The editors have built Sulfur Compounds—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hydrogen Sulfide in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Sulfur Compounds—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book The Chemistry of Organomagnesium Compounds 2 Volume Set written by Zvi Rappoport and published by John Wiley & Sons. This book was released on 2008-04-14 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnesium remains almost unique among the metals in its ability to react directly with a wide variety of compounds. This organic chemistry field has seen steady progress, and a volume on this topic is long overdue. In the tradition of the Patai Series this title treats all aspects of functional groups, containing chapters on the theoretical and computational foundations; on analytical and spectroscopic aspects with dedicated chapters on Mass Spectrometry, NMR, IR/UV, etc.; on reaction mechanisms; on applications in syntheses. Depending on the functional group there are also chapters on industrial use, on effects in biological and/or environmental systems. Since the area of Organomagnesium Chemistry continues to grow far beyond the classical Grignard Reagents, this is an essential resource to help the reader keep abreast of the latest developments.
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2005 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Chemistry of Organomagnesium Compounds 2 Volume Set written by Zvi Rappoport and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnesium remains almost unique among the metals in its ability to react directly with a wide variety of compounds. This organic chemistry field has seen steady progress, and a volume on this topic is long overdue. In the tradition of the Patai Series this title treats all aspects of functional groups, containing chapters on the theoretical and computational foundations; on analytical and spectroscopic aspects with dedicated chapters on Mass Spectrometry, NMR, IR/UV, etc.; on reaction mechanisms; on applications in syntheses. Depending on the functional group there are also chapters on industrial use, on effects in biological and/or environmental systems. Since the area of Organomagnesium Chemistry continues to grow far beyond the classical Grignard Reagents, this is an essential resource to help the reader keep abreast of the latest developments.
Download or read book Comprehensive Organic Synthesis written by and published by Newnes. This book was released on 2014-02-14 with total page 9815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively
Download or read book Grignard Reagents and Transition Metal Catalysts written by Janine Cossy and published by Walter de Gruyter GmbH & Co KG. This book was released on 2016-04-25 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1912, the Chemistry Nobel Prize was awarded for the discovery of the so-called Grignard reagents. Nowadays, many transition metal variants are developed to modify reactivity and selectivity of the C–C bond formation reaction. The Grignard reaction is one of the fundamental organometallic reactions, often used in alcohol syntheses. With transition metals like iron, cobalt and nickel or with noble metals like copper, silver and palladium, modern Grignard reagents can be designed in reactivity, selectivity and functional group tolerance. This book, written by international experts, presents an overview on timely Grignard chemistry involving transition metals.
Download or read book Synthesis of Diaryl and Heteroaryl Sulfides and Development of Stereospecific Nickel catalyzed Cross coupling Reactions written by Ivelina M. Yonova and published by . This book was released on 2013 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of synthetic methods for the mild and efficient construction of carbon-carbon and carbon-heteroatom bonds is an active field of research in organic and organometalic chemistry. The utility of such transformations is displayed in their applications to the synthesis of structurally interesting and biologically active compounds. Furthermore, development of new methods can expand our knowledge and understanding of fundamental reactivity of organic and organometallic intermediates. Herein, I report results from two projects: (1) use of reactive sulfenyl chlorides for the synthesis of diaryl and heteroaryl thioethers, and (2) a stereospecific nickel-catalyzed Kumada cross-coupling reaction of benzylic ethers. Both projects emphasize on expanding the scope to include heterocyclic moieties. A mild protocol for the synthesis of thioethers is described. In a one-pot procedure, thiols are converted to sulfenyl chlorides and reacted with arylzinc reagents in the absence of a transition metal catalyst. This method allows for the synthesis of a variety of diaryl and heteroaryl sulfides without the use of harsh reaction conditions or expensive metal catalysts. A stereospecific nickel-catalyzed Kumada cross-coupling reaction of benzylic ethers containing sensitive N-heterocyclic moieties has been developed. To gain access into this class of substrates we have incorporated a traceless activating group that facilitates oxidative addition. Lewis acid activation of an ether moiety by magnesium salts accelerates oxidative addition, resulting in an increased rate of cross-coupling pathway as compared to unfavorable side reactions. Investigation of the reactivity of nickel complexes has allowed for the stereospecific construction of tertiary benzylic carbon stereocenters and expansion of the scope of the nickel-catalyzed cross-coupling reaction to include the use of long chain alkylmagnesium reagents containing beta-hydrogens. This methodology is applied to the synthesis of a number of enantioenriched diarylalkanes, a common structural motif in biologically active complexes. Mechanistic investigations are consistent with a racemization pathway involving a nucleophilic displacement of a pi-benzylnickel intermediate by a low-valent nickel species.
Download or read book Preparation and Applications of Benzylic Zinc Chlorides written by Albrecht Metzger and published by . This book was released on 2010 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organozinc Reagents written by Paul Knochel and published by Oxford University Press on Demand. This book was released on 1999 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable and unique text, written by world-renowned researchers, covers the application of these reagents to organic synthesis. The book is written in a clear and concise manner, containing step-by-step experimental procedures, and should be a valuable resource to new postgraduate students and experienced researchers alike.
