Download or read book New Assay Methods for Cyclic Nucleotides written by Paul Greengard and published by . This book was released on 1972 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cyclic Nucleotides written by J. A. Nathanson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators. Each of the chapters is the work of internationally known researchers who present a lucid and detailed review of their subject and not merely a single laboratory's viewpoint. The chapters emphasize critical assessments of the field rather than mere listings of experimental findings. By so doing, the contributors present the role of cyclic nucleotides in relationship to other intracellular regulators. Each chapter begins with a detailed summary to allow the reader to obtain a rapid overview of subsequent material. In addition, there are extensive bibliographies and a detailed subject index. Wherever pertinent, the chapters contain sections on drug mechanisms, physiological relevance, and disease processes. The Volume is divided into two sections, each beginning with an overview written by Professors T. W. RALL and P. GREENGARD, respectively. The first section focuses on the detailed pharmacology and chemistry of cyclic nucleotides, including their formation, degradation, measurement, and interaction with various modulatory agents, such as receptors and calcium. The second section is concerned with the biochemistry of protein phosphorylation, a process which appears to be one of the most important mechanisms for the intracellular expression of cyclic nucleotide action in eukaryotic cells.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1972 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Cyclic Nucleotides in the Nervous System written by John Daly and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The elucidation of the cellular and molecular bases underlying the inte grated function of the central nervous system, both in disease and in health, must ultimately come from the combined efforts of scientists from many disciplines, including biology, chemistry, histology, pathology, physiology, pharmacology, and psychology. Communication between scientists from these various disciplines-vital to the advancement of our understanding of the function of the nervous system-has become more and more difficult in recent years. Both increasing specialization and the incredible increases in publications pertinent to brain research in a wide spectrum of journals, in symposium volumes, in monographs, in abstracts, and in reviews contrib ute to the problems of cross-communication and even of communication within a scientific discipline. Research on the significance of cyclic nucleo tides to the function of nervous systems is particularly illustrative of the communication problem. Since the initial publications by Sutherland, Rall, and Butcher in the late fifties and early sixties on high levels of adenylate cyclase, phosphodiesterases, and cyclic AMP in brain, the ensuing litera ture of this field has expanded exponentially. At the present time, from five to ten publications relevant to cyclic nucleotides and the nervous system appear each week. Indeed, these are minimal numbers based mainly on examination of literature titles and key index words. Many articles concerned with some aspect of central function contain, buried within their text, experiments with or related to cyclic nucleotides.
Download or read book Research Awards Index written by and published by . This book was released on 1988 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cyclic AMP written by and published by . This book was released on 1979 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Journal of Cyclic Nucleotide Research written by and published by . This book was released on 1981 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Topics in Experimental Endocrinology written by V. H. T. James and published by Academic Press. This book was released on 2013-10-22 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Experimental Endocrinology, Volume 2 covers major developments in the ever-expanding field of endocrinology. The book discusses the progress in cyclic nucleotide research; the hypothalamic control of the anterior pituitary hormone secretion-characterized hypothalamic hypophysiotropic peptides; and the pituitary-ovarian interrelationships in the rat. The text also describes the melatonin and the endocrine role of the pineal organ; the integration of the secretory control mechanisms for insulin, glucagon, and growth hormone; and the biological activity of somatomedin. The chemistry and physiology of parathyroid hormone, calcitonin, and vitamin d; and the physicochemical properties and activities of luteinizing hormone and human chorionic gonadotropin are also encompassed. Endocrinologists, physiologists, and students taking related courses will find the book invaluable.
Download or read book Methods of Hormone Radioimmunoassay written by Bernard Jaffe and published by Elsevier. This book was released on 2012-12-02 with total page 1071 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods of Hormone Radioimmunoassay, Second Edition is a compilation of radioimmunoassay techniques for the quantification of hormones. Various kinds of hormones are considered, namely: intracellular messengers; hypothalamic and pineal hormones; pituitary hormones; thyroid and parathyroid hormones; renal hormones; hormones of the gastrointestinal tract; pancreatic hormones; steroid hormones; uterine and placental hormones; vasoactive peptide hormones; and growth factors. The corresponding method of radioimmunoassay for each hormone is described. This book is comprised of 49 chapters and begins with a discussion on the radioimmunoassay of cyclic adenosine-3',5-monophosphate (cAMP) and cyclic guanosine-3,5'-monophosphate (cGMP), together with problems related to measuring both compounds. The reader is then introduced to prostaglandins and prostaglandin metabolites, thyrotropin-releasing hormone, and gonadotropin-releasing hormone. Pituitaty gonadotropins, prolactin, and thyrotropin are also discussed. The remaining chapters deal with hormones of the gastrointestinal tract, pancreatic hormones, steroid hormones, and growth factors. This monograph is intended for both clinicians and investigators interested in methods of hormone radioimmunoassay.
Download or read book Opioid Research written by Zhizhong Z. Pan and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Opioid research is one of the multidisciplinary research areas that involve advanced techniques ranging from molecular genetics to neuropharmacology, and from behavioral neuroscience to clinical medicine. In current opioid research, it has become increasingly important to use multiple approaches at molecular, cellular, and system levels for investigations on a specific opio- related target system. That often requires understanding and applying cro- field techniques and methods for the success of one’s research projects. Through its broad spectrum of coverage, Opioid Research: Methods and Protocols provides a comprehensive collection of major laboratory methods and protocols in current opioid research, covering topics from molecular and genetic techniques to behavioral analyses of animal models, and then to clinical practice. It will serve as a convenient reference book from which those involved in opioid research will learn or perfect the necessary cross-field techniques. The detailed methods and protocols described in Opioid Research: Methods and Protocols have each been successfully applied in current opioid research. Part I provides molecular techniques for the cloning and expression of opioid receptors, and for the quantitative characterization of their signaling pathways. Part II includes primary techniques for mapping the distributions and detecting the expression levels of opioid receptors, opioid peptides, and their messages in brain tissues and in individual cells. Part III deals with methods for creating in vitro receptor models and in vivo animal models to study opioid functions. Part IV describes practical applications of opioids in clinical medicine for the treatment of pain and opioid addiction.
Download or read book Radiochemical Methods in Analysis written by D. Coomber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to give an account of the principal radiochemical methods used in chemical analysis. It is assumed that the reader already has some background knowledge of radioactivity, available from several general textbooks. For this reason some subjects, e. g. the fundamentals of radio activity, the properties of radiation, statistics of counting procedures, the precautions needed in working with radioactive materials, which could have occupied half the text, are not considered in detail. The different aspects of radiochemical analysis have been covered by specialized books and reviews, e. g. on activation analysis, gamma spectrometry, radiometric titrations. A good deal of information is in the form of reports of meetings and symposia and liquid scintillation counting, for instance, has been mainly covered in this way. There are also a large number of journals. It is therefore hoped that this book will help fill the gap between the introductory texts and the specialized sources, many of which are referred to in the chapter references. The ftrst three chapters in the present volume deal with the methods of measurement of radioactive nuclides. Chapter I gives a general account of detection and measurement techniques. The next two chapters are devoted to two specialized techniques: gamma-ray spectrometry and liquid scintilla tion counting.
Download or read book Dopaminergic Ergot Derivatives and Motor Function written by Kjell Fuxe and published by Elsevier. This book was released on 2013-10-22 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dopaminergic Ergot Derivatives and Motor Function is a collection of papers from the proceedings of an international symposium of the same topic, held in Stockholm on July 24-25, 1978. This collection of papers covers laboratory studies on different subjects such as the anatomy, physiology, biochemistry, and pharmacology of dopaminergic pathways of the brain. This book also discusses clinical research dealing on dopaminergic receptors observed in Parkinsonism and in Huntington's disease. One paper reviews the neural circuitry of the basal ganglia as it is the part of the brain that is first and foremost involved in skeletomuscular mechanisms. Another paper deals with the different groups of ergot derivatives and their structure-activity relationships. The book also addresses the therapeutic activity and toxicity made during these observations. The text then discusses the psychiatric reaction to ergot derivatives, including LSD-induced hallucinations. Another paper examines the effects of dopaminergic ergots on the anterior pituitary function that is limited to the control of prolactin secretion during chronic therapy. This book is valuable to microbiologists, microchemists, and laboratory researchers and scientists dealing with neuro-functions and the brain.
Download or read book Endocrine and Neuroendocrine Mechanisms Of Aging written by Richard C. Adelman and published by CRC Press. This book was released on 2017-07-28 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is the purpose of this volume to present a representative sampling of those neural and hormonal studies which have been the focus of the most intense interest in the recent gerontological research. To this end we have been fortunate to enlist the aid of some of the most competent and innovative investigators in the field. More than this, however, an attempt has been made to provide detailed methodological as well as theoretical evaluation for the areas considered. It is our hope that those researchers interested in this area of regulation during aging will be able to utilize the information contained herein as a basis both for critical analysis as well as for the designing and execution of further experiments in this more important area.
Download or read book Cyclic Nucleotides written by P. D. Kebabian and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 907 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic nucleotides are intimately involved in the consequences of either stimulation or blockade of receptors; therefore, an understanding of the biochemistry of cyclic nucleotides ought to be important for pharmacologists. Pharmacology is a science that among other things investigates chemical compounds that affect the physiology of cells, tissues and organs. Frequently pharmacologists account for the effect of low concentrations of a drug upon a tissue by invoking the presence of a receptor upon the surface of the cell. Traditional pharmacologists excelled at identifying and classifying the properties of receptors. A. J. CLARK'S monograph in the earlier series of the Handbook of Experimental Pharmacology (CLARK 1937) summarized the mathematics underlying the traditional pharmacological approach towards receptors. By its nature, however, classic pharmacology provided little useful information about the intracellular events occurring as a consequence of occupying a receptor; for example, ALQUIST (1948) identified the beta-adrenocep tor, but he did not provide any insight into how stimulation of the receptor produces tissue-specific physiological responses. The discovery of cyclic AMP by RALL and SUTHERLAND (see RALL, Vol. I) led to biochemical investigations of many different receptors (including ALQUIST'S beta-adrenoceptor) that share a cyclic nucleotide as a common factor in the biochemical mechanisms that translate the occupancy of receptors into physiological effects. Ten years ago, in the introduction to their monograph on cyclic nucleotides, ROBISON et al. (1971) commented on the rapid growth of interest in cyclic nucleotides over the preceding years.
Download or read book Vasopressin II written by C. A. Pissiotis and published by Ardent Media. This book was released on 1973 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Methods of Biochemical Analysis written by David Glick and published by John Wiley & Sons. This book was released on 2009-09-25 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical analysis is a rapidly expanding field and is a key component of modern drug discovery and research. Methods of Biochemical Analysis provides a periodic and authoritative review of the latest achievements in biochemical analysis. Founded in 1954 by Professor David Glick, Methods of Biochemical Analysis provides a timely review of the latest developments in the field.
