Download or read book Neurons and the DHA Principle written by Raymond C. Valentine and published by CRC Press. This book was released on 2012-10-26 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies with bacteria and other systems suggest that the omega-3 fatty acid DHA confers great benefits to neurons in maximizing both speed of neural impulses and energy efficiency. Unfortunately, studies also show that DHA’s ease of oxidation damages membrane integrity. Exploring this duality, Neurons and the DHA Principle proposes a new model for the causes of neurodegeneration, in which DHA-enriched membranes of neurons become dysfunctional and energetically wasteful, triggering the premature death of neurons. The challenge of this book is to digest how DHA acts as an essential building block of neurons while also conspiring for their assassination during aging. As the book reviews the extraordinary properties of DHA in life forms from deep-sea bacteria to human neurons, it asks: Is there a trade-off between speed and efficiency of brain function enabled by DHA versus longevity or life span? Has modern medicine advanced significantly in the treatment of the body but not necessarily of the brain? What are the molecular explanations for the decline in brain health during the age of longevity? A full accounting of the roles of DHA in neurons requires balancing the enormous benefits of these molecules against the risks. Introducing the dual chemical personalities of DHA from an evolutionary perspective, Neurons and the DHA Principle explores DHA from the standpoint of benefit–risk analysis, opening new perspectives for understanding how DHA functions in neurons.
Download or read book Omega 3 Fatty Acids and the DHA Principle written by Raymond C. Valentine and published by CRC Press. This book was released on 2009-12-03 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The physical-chemical properties of the omega-3 fatty acid DHA (docosahexaenoic acid) enable it to facilitate rapid biochemical processes in the membrane. This effect has numerous benefits, including those involved in the growth of bacteria, rapid energy generation, human vision, brain impulse, and photosynthesis, to name a few. Yet DHA also carrie
Download or read book Human Longevity written by Raymond C. Valentine and published by CRC Press. This book was released on 2014-09-18 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised vers
Download or read book Principles of Orthomolecularism written by R. A. S. Hemat and published by Urotext. This book was released on 2004 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Omega Fatty Acids in Brain and Neurological Health written by Ronald Ross Watson and published by Academic Press. This book was released on 2019-06-12 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research has clearly established a link between omega fatty acids and general health, particularly cardiovascular health. Omega Fatty Acids in Brain and Neurological Health, Second Edition, illustrates the importance of omega-3 fatty acids in longevity, cognitive impairment and structure and function of the brain's neurons and also the adverse effects of omega-6 fatty acids on neurological function. This book encompasses some of the most recent research on the links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep and neurodegenerative diseases. This completely updated second edition focuses on the counterbalancing dietary and tissue omega-6 fatty acids as well as it studies the effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases. - Provides a comprehensive introduction to omega-3 and omega-6 fatty acids in neurological health and directions for future research - Features novel focus on the adverse effects of omega-6 fatty acids on neurological function and the counterbalancing of dietary and tissue omega-6 - Illustrates the importance of omega-3 fatty acids in longevity and cognitive impairment - Features new chapters on early effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases - Discusses links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements
Download or read book Principles of Nutrigenetics and Nutrigenomics written by Raffaele De Caterina and published by Academic Press. This book was released on 2019-09-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. - Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics - Includes a valuable guide to ethics for genetic testing for nutritional advice - Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts - Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book
Download or read book Principles of Modern Urology written by R.A.S Hemat and published by Urotext. This book was released on 1998-12-31 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Modern Urology is an authorative guide to urology and integrated urology. Principles of Modern Urology is an advanced urological textbook. This book begins by showing you how to implement your pathobiology, anatomy and physiology into practical simple approach to every client you meet. This book was written for medical student, resident and professional in medicine and especially urology. The author had adapted his proven teaching strategies into a unique approach that makes integrated urology accessible, and provides the foundations for understanding urology based upon the principles of structural pathobiology. Principles of Modern Urology presents well-integrated and practical approach to most urological condition. It is a versatile retrievable e-book. Principles of Modern Urology provides the reader with current concepts of the pathobiology and interventions for diseases. Anatomy, physiology, and radiology are also included within specific topical chapters. Principles of Modern Urology is based on the extensive international clinical and teaching experience of the author, both in traditional and integrated systems of medical schools.
Download or read book Rossi s Principles of Transfusion Medicine written by Toby L. Simon and published by John Wiley & Sons. This book was released on 2016-05-23 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available Led by a world class Editor team, including two past-presidents of AABB, a past- President of the American Board of Pathology and members of the FDA Blood Products Advisory Committee , and international contributor team Comprehensive reference resource, considered the gold standard in transfusion Covers current hot topics such as donor care – including the frequency of donation and management of iron deficiency/status), patient blood management, hemovigilance, cstem cell therapies, and global aspects of the organization of transfusion and transplant services New material on molecular immunohematology Companion website includes figures, full text and references
Download or read book Principles of Cellular Molecular and Developmental Neuroscience written by Oswald Steward and published by . This book was released on 1989 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Deciphering the Role of Long chain Acyl CoA Synthetase 6 in Brain Lipid Metabolism and Neuroprotection written by Regina Fernandez Fernandez and published by . This book was released on 2021 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The omega-3 fatty acid, docosahexaenoic acid (DHA), is highly enriched in the central nervous system (CNS) and thought to protect against neurological dysfunction. Due to its neuroprotective nature, DHA is widely considered a medicinal preventative strategy and treatment. However, while dietary DHA supplementation increases DHA levels in peripheral tissues, it often fails to increase brain DHA levels. The indirect relationship between dietary-DHA and brain-DHA enrichment highlights the existence of unique mechanisms that allow DHA to be metabolized in the brain. The mechanisms regulating DHA enrichment in the brain remain unclear. The purpose of this dissertation was to answer fundamental questions about the mechanisms that regulate brain DHA metabolism by testing the hypothesis that a specific fatty acid metabolizing enzyme, long-chain acyl-CoA synthetase isoform 6 (ACSL6), is required for enrichment of DHA into the brain. As reviewed in my first-author literature review published in PLEFA in September 2020, ACSL6 is one of a large family of 26 acyl-CoA synthetase (ACS) enzymes that catalyze the initial step in cellular fatty acid metabolism and serve as potential master regulators of brain phospholipid acyl-chain diversity. Of all the ACSs, ACSL6 is almost exclusively expressed in the CNS and has been shown to have substrate preference for DHA. To test our hypothesis, we genetically targeted ACSL6 to create a novel conditional ACSL6-deficient mouse (Acsl6-/-). We discovered that whole-body Acsl6 deletion results in a significant 35-72% reduction in DHA-containing phospholipids in the CNS. Our initial findings for this animal model were published as my first first-author research article in PNAS in October of 2018, and our findings were of such great interest that the article was mentioned on the cover of the issue and was accompanied by a complementary commentary highlighting the importance of our discovery. We then went on to combine in situ fluorescence hybridization, several genetically targeted mouse models, lipidomics, and MALDI lipid imaging to demonstrated that ACSL6 in neurons regulates the enrichment of DHA in the brain. We also have shown that ACSL6 expressed in astrocytes does alter membrane acyl-chain content, but does not impact DHA, which we mechanistically explain is due to cell-type specific expression of ACSL6 variants that contain altered fatty acid binding domains. After many behavioral assessments, we found that ACSL6 knockout mice were hyporesponsive to auditory and foot-shock sensory stimulation, exhibited hyperlocomotion, and showed altered short-term working spatial memory. Acsl6-/- mice displayed exacerbated astrogliosis in an age-dependent manner and accompanied with increased inflammation and gliosis. This neuroinflammation occurred independent of changes in pro- and anti-inflammatory lipid mediators suggesting there is an alternative mechanism triggering the neuroinflammation. RNA-seq data revealed downregulation of synaptic proteins' gene expression in Acsl6-/- mice as early as 2 months of age. Thus, we hypothesized that ACSL6-mediated DHA deficiency results in gradual synaptic function deregulation that contributes to increased neuroinflammation during aging. These age-dependent findings are currently under revisions for publication. Together, these data identified ACSL6 in neurons as an important regulator of DHA metabolism that plays a neuroprotective role during aging and on memory and motor function. This dissertation work has led to the discovery of an important and fundamental mechanism by which the parenchyma of the central nervous system controls fatty acid metabolism, particularly for the neuroprotective omega-3 fatty acid DHA.
Download or read book Buddha s Brain written by Rick Hanson and published by ReadHowYouWant.com. This book was released on 2011-07-13 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jesus, Moses, Mohammed, Gandhi, and the Buddha all had brains built essentially like anyone else's, yet they were able to harness their thoughts and shape their patterns of thinking in ways that changed history. With new breakthroughs in modern neuroscience and the wisdom of thousands of years of contemplative practice, it is possible for us to shape our own thoughts in a similar way for greater happiness, love, compassion, and wisdom. Buddha's Brain joins the forces of modern neuroscience with ancient contemplative teachings to show readers how they can work toward greater emotional well-being, healthier relationships, more effective actions, and deepened religious and spiritual understanding. This book will explain how the core elements of both psychological well-being and religious or spiritual life-virtue, mindfulness, and wisdom--are based in the core functions of the brain: regulating, learning, and valuing. Readers will also learn practical ways to apply this information, as the book offers many exercises they can do to tap the unused potential of the brain and rewire it over time for greater peace and well-being.
Download or read book Polyunsaturated Fatty Acid Metabolism written by Graham C. Burdge and published by Elsevier. This book was released on 2018-05-04 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This book captures these findings in a manner that marks the state-of-the-art, placing them in the wider context of PUFA metabolism and nutritional science. Users will find a comprehensive discussion on the topic that presents the contributions of leading researchers who combine their knowledge to create a cohesive academic resource for researchers, those involved in production, and health policymakers. - Provides a comprehensive view of polyunsaturated fatty acid metabolism - Describes underlying metabolism on lipids that include polyunsaturated fatty acids - Includes discussions on recent findings on the genetic and epigenetic regulation of polyunsaturated fatty acid metabolism
Download or read book Principles and Practice of Clinical Electrophysiology of Vision second edition written by John R. Heckenlively and published by MIT Press. This book was released on 2006-04-07 with total page 1033 pages. Available in PDF, EPUB and Kindle. Book excerpt: The long-awaited second edition of an authoritative reference on electrophysiologic vision testing, including detailed information on techniques and problems, basic physiology and anatomy, theoretical concepts, and clinical findings; with extensive new material. This authoritative text is the only comprehensive reference available on electrophysiologic vision testing, offering both practical information on techniques and problems as well as basic physiology and anatomy, theoretical concepts, and clinical correlations. The second edition, of the widely used text, offers extensive new material and updated information: 65 of the 84 chapters are completely new, with the changes reflecting recent advances in the field. The book will continue to be an essential resource for practitioners and scholars from a range of disciplines within vision science. The contributions not only cover new information—important material that is likely to become more important in the next decade—but also offer a long-range perspective on the field and its remarkable development in the last century. After discussing the history and background of clinical electrophysiology, the book introduces the anatomy of the retina and principles of cell biology in the visual pathways at the molecular, physiological, and biochemical levels. It relates these new findings to the techniques and interpretations of clinical tests, including the electro-oculogram (EOG), electroretinogram (ERG), and visual evoked potentials (VEP), which are discussed in detail, as are equipment, data acquisition and analysis, principles and protocols for clinical testing, diseases and dysfunction, and animal testing. Notable additions for this edition include chapters on the origin of electroretinogram waveforms, multifocal techniques, testing in standard laboratory animals, recent advances in analysis of abnormalities in disease, and the applications of these techniques to the study of genetic abnormalities.
Download or read book Survival of the Fattest written by Stephen C. Cunnane and published by World Scientific. This book was released on 2005 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: How did humans evolve larger and more sophisticated brains? In general, evolution depends on a special combination of circumstances: part genetics, part time, and part environment. In the case of human brain evolution, the main environmental influence was adaptation to a OCyshore-basedOCO diet, which provided the worldOCOs richest source of nutrition, as well as a sedentary lifestyle that promoted fat deposition. Such a diet included shellfish, fish, marsh plants, frogs, birdOCOs eggs, etc. Humans and, and more importantly, hominid babies started to get fat, a crucial distinction that led to the development of larger brains and to the evolution of modern humans. A larger brain is expensive to maintain and this increasing demand for energy results in, succinctly, survival of the fattest."
Download or read book Principles of Drug Therapy in Neurology written by Michael V. Johnston and published by . This book was released on 2008-05 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Drug Therapy, Second Edition provides comprehensive coverage of current drug therapy in neurology while providing the background information that neurologists and other clinicians need to understand its rationale. The range of new drugs available for treatment of neurological disorders is expanding rapidly along with rapid advances in the neurosciences that are uncovering disease mechanisms. Although there are many sources of drug information, most are limited to basic information about indications, dose and side effects. However the complexity of the nervous system is enormous and the information needed to understand drug effects is accordingly often not readily available in a single source. The book addresses that issue by presenting 18 focused, disease-related chapters by authors who are expert clinical sub-specialists as well as experts on drug therapy. The first chapter on fundamentals of drug therapy in neurology provides a readable synopsis of how the classic pharmacology concepts such as pharmacodynamics and pharmacokinetics are related to therapy in neurology. This section also discusses the pathogenesis of potentially serious side effects such as skin rashes and liver disorders, and the role of pharmacogenetics in both drug effect and side effects. Outstanding chapters on movement disorders, epilepsy, and headaches cover major areas of drug treatment in neurology practice. Additional chapters cover stroke, increased intracranial pressure in the intensive care unit, dementia, multiple sclerosis, spinal cord injury and spasticity, neuromuscular disorders and pain. Sleep, central nervous system infections and HIV, and drug intoxications are also covered. Areas of special interest to child neurologists covered in the book include treatment of genetic metabolic disorders and use of stimulants and other medications for childhood cognitive disorders. An excellent chapter is also provided on drug treatment of psychiatric disorders because of the important of psychiatric drugs in neurology practice. This edition has been completely re-written from the successful edition published in the 90s and enlarged commensurate with the exciting progress in treatment in neurology.
Download or read book The Neurobiology of Olfaction written by Anna Menini and published by CRC Press. This book was released on 2009-11-24 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely
Download or read book The Memory Solution written by Julian M. Whitaker and published by Avery. This book was released on 1999 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Julian Whitaker's 10-step program to optimize your memory and brain function.
