Download or read book Neuronal Guidance written by Marc Tessier-Lavigne and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the development of the brain growing nerves send out neuronal processes (axons and dendrites) that connect them to other nerve cells, sensory organs, and muscle tissue. Correct targeting of these is the basis for wiring of the entire nervous system and depends on attractive and repulsive molecular cues that guide the developing neurons to the appropriate destination. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the mechanisms underlying neuronal guidance and branching and their roles in the development and function of the nervous system. The contributors examine the major guidance cues and their receptors, the intracellular signaling pathways they activate, and their function in the context of important phenomena such as laminar organization and dendrite spacing. Other chapters consider the roles of guidance cues in development of neuronal circuits dedicated to the processing of particular sensory stimuli, such as the visual and olfactory systems. In addition, they cover the roles played by guidance cues and their receptors in neuronal regeneration and human genetic disorders, revealing important clinical implications of work in this field. The book also contains chapters discussing the function of guidance molecules in other processes, such as neuronal cell body migration, axon pruning, and regulation of neuronal cell death. In addition, it explores their roles outside the nervous system for example, in development of the vasculature. This volume is thus of general interest to cell and developmental biologists, as well as all neurobiologists interested in how the nervous system develops and functions.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular Migration and Formation of Axons and Dendrites written by Bin Chen and published by Academic Press. This book was released on 2020-06-13 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Migration and Formation of Neuronal Connections, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. This book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the formation of axons and dendrites and cellular migration. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Includes coverage of mechanisms which regulate the formation of axons and dendrites and cellular migration Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity
Download or read book Axon Growth and Guidance written by Dominique Bagnard and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.
Download or read book Cellular Migration and Formation of Neuronal Connections written by and published by Academic Press. This book was released on 2013-05-06 with total page 1081 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
Download or read book Guidance Cues in the Developing Brain written by Ivica Kostovic and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many complex molecular interactions are involved in the development of the mammalian brain. Molecules serving as guidance cues for migratory cells, growing axons and for recognition of postsynaptic targets are a major topic for research because they are directly involved in the formation of neuronal circuits, thus creating the foundation for subsequent functional refinement through interactions with the environment. In addition, most guidance cue molecules are also involved in plasticity, damage repair and regeneration in the adult brain. This volume reviews current knowledge on major classes of molecules involved in: guidance of growing axons; tau proteins involved in the establishment of axonal polarity, outgrowth and contact recognition; gangliosides and lectins involved in neuronal migration, neurite outgrowth and contact recognition; and myelin molecules that inhibit nerve regeneration.
Download or read book Neural Network Perception for Mobile Robot Guidance written by Dean A. Pomerleau and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dean Pomerleau's trainable road tracker, ALVINN, is arguably the world's most famous neural net application. It currently holds the world's record for distance traveled by an autonomous robot without interruption: 21.2 miles along a highway, in traffic, at speedsofup to 55 miles per hour. Pomerleau's work has received worldwide attention, including articles in Business Week (March 2, 1992), Discover (July, 1992), and German and Japanese science magazines. It has been featured in two PBS series, "The Machine That Changed the World" and "By the Year 2000," and appeared in news segments on CNN, the Canadian news and entertainment program "Live It Up", and the Danish science program "Chaos". What makes ALVINN especially appealing is that it does not merely drive - it learns to drive, by watching a human driver for roughly five minutes. The training inputstothe neural networkare a video imageoftheroad ahead and thecurrentposition of the steering wheel. ALVINN has learned to drive on single lane, multi-lane, and unpaved roads. It rapidly adapts to other sensors: it learned to drive at night using laser reflectance imaging, and by using a laser rangefinder it learned to swerve to avoid obstacles and maintain a fixed distance from a row of parked cars. It has even learned to drive backwards.
Download or read book Building Brains written by David J. Price and published by John Wiley & Sons. This book was released on 2011-04-04 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of a brain from its simple beginnings in the embryo to the extraordinarily complex fully-functional adult structure is a truly remarkable process. Understanding how it occurs remains a formidable challenge despite enormous advances over the last century and current intense world-wide scientific research. A greater knowledge of how nervous systems construct themselves will bring huge benefits for human health and future technologies. Unravelling the mechanisms that lead to the development of healthy brains should help scientists tackle currently incurable diseases of the nervous system such as autism, epilepsy and schizophrenia (to name but a few), discover more about the processes that cause the uncontrolled growth associated with cancer and develop possible treatments. Building Brains provides a highly visual and readily accessible introduction to the main events that occur during neural development and the mechanisms by which they occur. Aimed at undergraduate students and postgraduates new to the field, who may not have a background in neuroscience and/or molecular genetics, it explains how cells in the early embryo first become neural, how their proliferation is controlled, what regulates the types of neural cells they become, how neurons connect to each other, how these connections are later refined under the influence of neural activity including that arising from experience, and why some neurons normally die. Key Features: A concise illustrated guide focusing on the core elements of current understanding of neural development, emphasising common principles underlying developmental mechanisms and supplemented by suggestions for further reading. Text boxes throughout provide further detail on selected major advances, issues of particular uncertainty or controversy and examples of human diseases that result from abnormal development. A balanced mammalian/non-mammalian perspective, drawing on examples from model organisms including the fruit fly, nematode worm, frog, zebrafish, chick, mouse, ferret, cat, monkey and human, and emphasising mechanisms that are conserved across species. Introduces the methods for studying neural development including genetics, transgenic technologies, advanced microscopy and computational modeling, allowing the reader to understand the main evidence underlying research advances. Student-friendly, full colour artwork reinforces important concepts; an extensive glossary and definitions in page margins help readers from different backgrounds; chapter summaries stress important points and aid revision. Associated Website includes a complete set of figures from the textbook.
Download or read book Guide to Convolutional Neural Networks written by Hamed Habibi Aghdam and published by Springer. This book was released on 2017-05-17 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This must-read text/reference introduces the fundamental concepts of convolutional neural networks (ConvNets), offering practical guidance on using libraries to implement ConvNets in applications of traffic sign detection and classification. The work presents techniques for optimizing the computational efficiency of ConvNets, as well as visualization techniques to better understand the underlying processes. The proposed models are also thoroughly evaluated from different perspectives, using exploratory and quantitative analysis. Topics and features: explains the fundamental concepts behind training linear classifiers and feature learning; discusses the wide range of loss functions for training binary and multi-class classifiers; illustrates how to derive ConvNets from fully connected neural networks, and reviews different techniques for evaluating neural networks; presents a practical library for implementing ConvNets, explaining how to use a Python interface for the library to create and assess neural networks; describes two real-world examples of the detection and classification of traffic signs using deep learning methods; examines a range of varied techniques for visualizing neural networks, using a Python interface; provides self-study exercises at the end of each chapter, in addition to a helpful glossary, with relevant Python scripts supplied at an associated website. This self-contained guide will benefit those who seek to both understand the theory behind deep learning, and to gain hands-on experience in implementing ConvNets in practice. As no prior background knowledge in the field is required to follow the material, the book is ideal for all students of computer vision and machine learning, and will also be of great interest to practitioners working on autonomous cars and advanced driver assistance systems.
Download or read book Cortical Development written by Ryoichiro Kageyama and published by Springer Science & Business Media. This book was released on 2013-09-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent progress in cortical development research, focusing on the mechanisms of neural stem cell regulation, neuronal diversity and connectivity formation, and neocortical organization. Development of the cerebral cortex, the center for higher brain functions such as cognition, memory, and decision making, is one of the major targets of current research. The cerebral cortex is divided into many areas, including motor, sensory, and visual cortices, each of which consists of six layers containing a variety of neurons with different activities and connections. As this book explains, such diversity in neuronal types and connections is generated at various levels. First, neural stem cells change their competency over time, giving sequential rise to distinct types of neurons and glial cells: initially deep layer neurons, then superficial layer neurons, and lastly astrocytes. The activities and connections of neurons are further modulated via interactions with other brain regions, such as the thalamocortical circuit, and via input from the environment. This book on cortical development is essential reading for students, postdocs, and neurobiologists.
Download or read book Comprehensive Developmental Neuroscience Cellular Migration and Formation of Neuronal Connections written by F. Beaubien and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neurocognitive Development Normative Development written by and published by Elsevier. This book was released on 2019-09-22 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is one of a two-volume work on neurocognitive development, focusing separately on normative and non-normative development. The normative volume focuses on neurology, biology, genetics, and psychology of normative cognitive development. It covers the development of intellectual abilities, visual perception, motor function, language, memory, attention, executive function, social cognition, learning abilities, and affect and behavior. The book identifies when and how these functions develop, the genetics and neurophysiology of their operation, and their evaluation and assessment in clinical practice. This book will serve as a comprehensive reference to researchers in cognitive development in neuroscience, psychology, and medicine, as well as to clinicians and allied health professionals focused on developmental disabilities (child neurologists, pediatric neuropsychologists, child psychiatrists, speech and language therapists, and occupational therapists.) Summarizes research on normative neurocognitive development Includes intellectual abilities, language, memory, attention, motor function, and more Discusses genetics and environmental influences on development Provides interdisciplinary information of use to both researchers and clinicians
Download or read book Comprehensive Developmental Neuroscience Cellular Migration and Formation of Neuronal Connections written by L. Izzi and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of the Nervous System written by Dan H. Sanes and published by Elsevier. This book was released on 2005-11-02 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of the Nervous System, Second Edition has been thoroughly revised and updated since the publication of the First Edition. It presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. The original, artist-rendered drawings from the First Edition have all been redone and colorized to so that the entire text is in full color. This new edition is an excellent textbook for undergraduate and graduate level students in courses such as Neuroscience, Medicine, Psychology, Biochemistry, Pharmacology, and Developmental Biology. - Updates information including all the new developments made in the field since the first edition - Now in full color throughout, with the original, artist-rendered drawings from the first edition completely redone, revised, colorized, and updated
Download or read book Axon Guidance Signaling in C Elegans Motor Neurons and Its Application to Understanding Neurological Disorders written by Shih-Yu Chen and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The hallmark of the nervous system is its ability to process information. This unique feature relies on proper establishment of the entire network of neuronal connections. Axon guidance is one of the early developmental processes that are essential for establishing functional neuronal connections throughout the nervous system. The goal of my work is to understand the molecular mechanisms of axon guidance and its implications in human disorders. During axon guidance the growing axon has to constantly regulate its receptors in order to properly sense concentration differences across a gradient set by a guidance cue. My results showed that the axon guidance signaling molecule MAX-1 is SUMOylated by its interacting partner GEI-17 and regulates UNC-5 receptor through APB-3 containing AP-3 complex in Caenorhabditis elegans motor neurons. The data collected from my studies lead to a model that MAX-1 and APB-3 signaling pathway modulate the dynamic trafficking of axon guidance receptor UNC-5 when axon is guided across a concentration gradient. Defects in neuronal connectivity of the brain are well documented among schizophrenia patients. Although the schizophrenia susceptibility gene Disrupted-in-Schizophrenia 1 (DISC1) has been implicated in various neurodevelopmental processes, its role in regulating axonal connections remains elusive. Using a relatively simple and well-characterized Caenorhabditis elegans motor neurons system, I established a heterologous DISC1 transgenic model to investigate whether DISC1 regulates axon guidance during development. My results revealed a previously unknown function of DISC1 to shape axonal connectivity in the developing nervous system by exploiting the TRIO-RAC-PAK signaling pathway.
Download or read book The Enteric Nervous System written by John Barton Furness and published by . This book was released on 1987 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Developmental Neuroscience Cellular Migration and Formation of Neuronal Connections written by J. Falk and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
