Download or read book Neuronal Co transmission written by John Apergis-Schoute and published by Frontiers Media SA. This book was released on 2019-11-04 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Co Existence and Co Release of Classical Neurotransmitters written by Rafael Gutierrez and published by Springer Science & Business Media. This book was released on 2008-12-16 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dale's Principle postulated that a neuron functions as a metabolic unit, whereby a process occurring in the cell can influence all of the compartments of that given neuron. This was unfortunately transformed in the literature to a principle stating that “a single cell releases only one neurotransmitter”. Until recently, this has influenced many neuroscientists to consider with skepticism the idea that classical neurotransmitters could be co-released from neurons. It is now clear that the “one neuron, one neurotransmitter” postulate is the exception rather than the rule. The aim of this book is to gather the available evidence, provided by the authors that have discovered and studied the co-existence or co-release of several pairs of neurotransmitters, in several neural networks. It will provide a timely overview of a mechanism of neural communication that is likely to attract increasing attention of the neuroscientific community.
Download or read book Pharmacology of Neurotransmitter Release written by Thomas C. Südhof and published by Springer Science & Business Media. This book was released on 2007-12-07 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.
Download or read book Extrasynaptic neurotransmission as a way of modulating multiple neuronal functions written by Francisco F. De-Miguel and published by Frontiers E-books. This book was released on with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extrasynaptic transmission is a unifying term for a wide variety of cellular processes, in which outside of synaptic terminals transmitter substances activate extrasynaptic receptors. Whereas “synaptic transmission” immediately refers to a process occurring at nerve terminals in which the arrival of a presynaptic impulse evokes exocytosis followed by a postsynaptic response within a millisecond time scale, extrasynaptic transmission has a wide diversity of ultrastructural and therefore mechanistic associated phenomena. In comparison to synaptic, extrasynaptic exocytosis may last for seconds or even minutes, thus expanding the timing of neuronal signaling. Extrasynaptic transmission has now been demonstrated in central and peripheral neurons of vertebrates and invertebrates, and involves many different types of transmitter substances than include low molecular weight transmitters (acetilcholine, GABA, glutamate, ATP, and biogenic amines) and peptides (substance P, vasopressin and others). It may occur when transmitters leak out from the synaptic cleft and activate extrasynaptic receptors in neighboring neurons or glial cells, or when axonal varicosities, dendrites or the somata release transmitters in the absence of postsynaptic counterparts. The release mechanisms also vary from one neuron type to another and from one neuronal compartment to another. In some cases, clear vesicles are apposed to the resting plasma membrane, as in presynaptic terminals. In other cases, transmitters are packed onto dense core vesicles that rest at a distance from the release sites. In between, there are multiple morphological combinations that point to complementary mechanisms in different compartments of the same neuron and some times, even in the same compartment. For example, serotonergic varicosities may combine clear and dense core vesicles in stereotyped arrays. This diversity adds complexity to the nervous system and raises many questions that are waiting for answers. Extrasynaptic transmission may be the main source of transmitter molecules causing volume transmission, however this still lacks direct demonstration. From the physiological point of view, one may ask how does the neuronal firing pattern evokes synaptic or extrasynaptic transmitter release or what are the physiological effects of these modes of transmission. From the behavioral point of view it becomes interesting to explore how circuits and therefore behaviors are modulated. Some neurological disfunctions may also be related to deficiencies in extrasynaptic transmission, however, again, direct studies are still lacking. Developmental and evolutionary biologists may also find the topic inspiring. Extrasynaptic transmission not only expands our view about how the nervous system works, but also requires a change in the way we plan our research. New technological and computational tools are now being applied to analyze intracellular and extracellular transmitter mobilizations or long term changes of neuronal circuits. New definitions and mechanisms may become visible. In the meanwhile, this seems to be a good moment for a first common effort to analyze and discuss extrasynaptic transmission in different systems and from different perspectives.
Download or read book Volume Transmission in the Brain written by Kjell Fuxe and published by . This book was released on 1991 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Histamine in the brain written by Jian-Sheng Lin and published by Frontiers Media SA. This book was released on 2015-03-18 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.
Download or read book Human Genes and Genomes written by Leon E. Rosenberg and published by Academic Press. This book was released on 2012-05-21 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences. The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor’s office, in the courtroom and even in social relationships. In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the importance of genes and genomics studies in all aspects of life. With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and its relevance across disciplines. Bridges the gap between basic human genetic understanding and one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease Includes the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more Explores ethical, legal, regulatory and economic aspects of genomics in medicine Integrates historical (classical) genetics approach with the latest discoveries in structural and functional genomics
Download or read book NeuroPsychopharmacotherapy written by Peter Riederer and published by Springer Nature. This book was released on 2022-11-04 with total page 4652 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.
Download or read book Basic Neurochemistry written by R. Wayne Albers and published by Academic Press. This book was released on 2011-11-02 with total page 1121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475
Download or read book Synaptic Transmission written by Stephen D. Meriney and published by Academic Press. This book was released on 2019-06-12 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders. Provides a comprehensive reference on synaptic structure, physiology, function and neurotransmission Discusses many landmark experiments in the field of synaptic transmission to emphasize core principles Includes references to primary scientific literature, relevant review articles and books, many of which could be assigned as discussion material for courses focused on this topic
Download or read book Synaptic Transmission and Neuronal Interaction written by Michael Vander Laan Bennett and published by . This book was released on 1974 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Network Neuroscience written by Flavio Fröhlich and published by Academic Press. This book was released on 2016-09-20 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studying brain networks has become a truly interdisciplinary endeavor, attracting students and seasoned researchers alike from a wide variety of academic backgrounds. What has been lacking is an introductory textbook that brings together the different fields and provides a gentle introduction to the major concepts and findings in the emerging field of network neuroscience. Network Neuroscience is a one-stop-shop that is of equal use to the neurobiologist, who is interested in understanding the quantitative methods employed in network neuroscience, and to the physicist or engineer, who is interested in neuroscience applications of mathematical and engineering tools. The book spans 27 chapters that cover everything from individual cells all the way to complex network disorders such as depression and autism spectrum disorders. An additional 12 toolboxes provide the necessary background for making network neuroscience accessible independent of the reader’s background. Dr. Flavio Frohlich wrote this book based on his experience of mentoring dozens of trainees in the Frohlich Lab, from undergraduate students to senior researchers. The Frohlich lab pursues a unique and integrated vision that combines computer simulations, animal model studies, human studies, and clinical trials with the goal of developing novel brain stimulation treatments for psychiatric disorders. The book is based on a course he teaches at UNC that has attracted trainees from many different departments, including neuroscience, biomedical engineering, psychology, cell biology, physiology, neurology, and psychiatry. Dr. Frohlich has consistently received rave reviews for his teaching. With this book he hopes to make his integrated view of neuroscience available to trainees and researchers on a global scale. His goal is to make the book the training manual for the next generation of (network) neuroscientists, who will be fusing biology, engineering, and medicine to unravel the big questions about the brain and to revolutionize psychiatry and neurology. Easy-to-read, comprehensive introduction to the emerging field of network neuroscience Includes 27 chapters packed with information on topics from single neurons to complex network disorders such as depression and autism Features 12 toolboxes serve as primers to provide essential background knowledge in the fields of biology, mathematics, engineering, and physics
Download or read book Ascaris written by Celia Holland and published by Newnes. This book was released on 2013-05-09 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book tackles a number of different perspectives concerning the parasitic helminth Ascaris, both in animals and in humans and the disease known as ascariasis. It seeks to identify interesting, exciting and novel aspects, which will interest readers from a broad range of disciplines.Over a quarter of the world's population are infected with the human roundworm, and the equivalent in pigs is equally ubiquitous. Both contribute to insidious and chronic nutritional morbidity, and this has been quantified, in humans, as disability adjusted life years approximating 10.5 million. Ascaris larvae develop in host parenteral tissues, and the resultant pathology has been condemnation. Ascariasis, despite its staggering global prevalence and the sheer numbers of people it infects, remains a classic neglected disease. However, renewed interest in the consequences of early infection with worms from the perspective of immune modulation, co-infections and the development of allergy further enhances the relevance of these parasites. Brings together a wide range of topics and approaches and recent, comprehensive and progressive research concerning the neglected parasite Ascaris Provides a blueprint of how a single parasite entity can stimulate interest in basic biology, clinical science, veterinary science, public health and epidemiology Presents a wealth of new insights given that a book on this parasite has not been published for over 20 years 16 chapters from a range of top authors from around the world
Download or read book New Technologies for Glutamate Interaction written by Maria Kukley and published by Humana. This book was released on 2024-04-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the latest technologies used to study the co-existence of neuronal and neuron-glia synapses in the brain. The chapters in this volume are organized into three parts. Part One covers recent advancements in the technical approaches for studying glutamatergic signalling between neurons. Part Two highlights approaches to study the functional role of astrocytes at neuronal synapses. Part Three focuses on fast signalling at neuron-glia synapses, and highlights relevant methods for investigating these unusual synapses, including slice electrophysiology and in vivo gene delivery techniques. In the Neuromethods series style, all chapters contain key advices from experts in the field that are valuable for performing successful experiments on the topic in your laboratory. Cutting-edge and thorough, New Technologies for Glutamate Interactions: Neurons and Glia is a valuable resource for both neuronal and glial physiologists who are interested in learning about and developing new methods to further understand neuronal and neuron-glia synaptic transmission.
Download or read book Non synaptic Interactions Between Neurons written by E. S. Vizi and published by John Wiley & Sons. This book was released on 1984 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Autonomic Neurology written by Eduardo E. Benarroch and published by Oxford University Press. This book was released on 2014-04-03 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to present a focused approach to the pathophysiology, diagnosis, and management of the most common autonomic disorders that may present to the clinical neurologist. Autonomic Neurology is divided into 3 sections. The first section includes 5 chapters reviewing the anatomical and biochemical mechanisms of central and peripheral nervous system control of autonomic function, principles of autonomic pharmacology, and a clinical and laboratory approach to the diagnosis of autonomic disorders. The second section focuses on the pathophysiology and management of orthostatic hypotension, postural tachycardia, baroreflex failure; syncope, disorders of sweating, neurogenic bladder and sexual dysfunction, gastrointestinal dysmotility, and autonomic hyperactivity. The final section is devoted to specific autonomic disorders, including central neurodegenerative disorders; common peripheral neuropathies with prominent autonomic failure; painful small fiber neuropathies; autoimmune autonomic ganglionopathies and neuropathies; focal brain disorders; focal spinal cord disorders; and chronic pain disorders with autonomic manifestations. This book is the product of the extensive experience of its contributors in the evaluation and management of the many patients with autonomic symptoms who are referred for neurologic consultation at Mayo Clinic in Rochester, Minnesota. Autonomic Neurology focuses on clinical scenarios and presentation of clinical cases and includes several figures showing the results of normal and abnormal autonomic testing in typical conditions. Its abundance of tables summarizing the differential diagnosis, testing, and management of autonomic disorders also help set this book apart from other books focused on the autonomic nervous system.
