Download or read book Neurological Care and the COVID 19 Pandemic E Book written by Ahmad Riad Ramadan and published by Elsevier Health Sciences. This book was released on 2021-08-26 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a comprehensive review of the neuropathology of SARS-CoV-2, Neurological Care and the COVID-19 Pandemic provides up-to-date coverage of the wide array of the pathogen’s neurological symptoms and complications. Drs. Ahmad Riad Ramadan and Gamaledin Osman discuss the neuropathology of SARS-CoV-2, its neurological manifestations, and the impact the pandemic has had on the care of patients with pre-existing neurological conditions. The authors also offer an overview of emerging treatments and vaccines, as well as ways healthcare systems have reorganized in order to respond to the pandemic. Offers a thorough discussion of the impact the virus has had on the care of patients with neurological ailments, accompanied by recommendations on how to care for these patients. Covers the impact of COVID-19 on patients with cerebrovascular diseases, seizures, demyelinating diseases, neuromuscular disorders, movement disorders, headache disorders, cognitive disorders, and neuro-oncological disorders. Includes a detailed case study of how one healthcare system hit hard by COVID-19 successfully transformed itself to respond to the challenges imposed by the pandemic. Consolidates today’s available information on this timely topic into a single, convenient resource.

Download or read book Neurological Complications in COVID 19 written by Johnson Olaleye Oladele and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global health security or international health security (IHS) includes any natural or man-made phenomenon that challenged human health and well-being including emerging infectious diseases such as the current global pandemic: COVID-19. Since the sudden outburst of COVID-19 pandemic in 2019, many COVID-19 patients have exhibited neurological symptoms and signs. Till now, there is no known effective established drug against the highly contagious COVID-19 infection despite the frightening associated mortality rate. This chapter aims to present the mechanism of action of coronavirus-2 (SARS-CoV-2), the clinical neurological manifestations displayed by COVID-19 patients, impact on the global health system and present phytochemicals with neuroprotective ability that can offer beneficial effects against COVID-19 mediated neuropathology. Reports from COVID-19 clinical studies, case reports, and other related literature were evaluated. Neurological complications of COVID-19 include anosmia, acute cerebrovascular disease, acute disseminated post-infectious encephalomyelitis, encephalitis, etc. Also, SARS-CoV-2 -Å-æuld be a neurotropic v-ñru-ï due to its i-ï-æl-∞t-ñ-æn from -Å-μr-μbr-æ-ï-Ä-ñn-∞l flu-ñd. Mult-ñ-Äl-μ n-μur-æl-æg-ñ-Å-∞l d-∞m-∞g-μ displayed by COVID-19 patients might be due to hyperinflammation associated with SARS-CoV-2 infections. Kolaviron, resveratrol, vernodalin, vernodalol, and apigenin are natural phytochemicals with proven anti-inflammatory and therapeutic properties that could extenuate the adverse effects of COVID-19. The phytochemicals have been documented to suppress JNK and MAPK pathways which are essential in the pathogenesis of COVID-19. They also showed significant inhibitory activities against SARS-CoV-2 main protease. Taken together, these phytochemicals may offer neuroprotective benefits against COVID-19 mediated neuropathology and suppress the burden of the pandemic on IHS.

Download or read book Features and Management of Acute and Chronic Neuro Covid written by Marco Cascella and published by Springer Nature. This book was released on 2021-11-27 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delineates that COVID-19 is a multisystem inflammatory disease and how its pathophysiology can predispose patients to an increased risk of neurological problems. Available data suggest the potential neuroinvasive capacity of the SARS-CoV-2 through direct viral damage and indirect entering the CNS by different routes including the vascular system, the olfactory and trigeminal nerves, the cerebrospinal fluid, and the lymphatic system. Furthermore, the pro-inflammatory cytokine storm and oxidative stress can induce microglial activation and damaging the blood-brain barrier, culminating in widespread neuroinflammatory processes. This acute neurotoxicity is clinically expressed as anosmia, ageusia, headache, nausea and vomiting. Other neurologic manifestations such as acute cerebrovascular diseases, encephalitis-based impaired consciousness, and meningitis are also described. The PNS can also be affected and clinical manifestations including Guillain-Barré syndrome, polyneuritis, Miller Fisher Syndrome, and other problems are described. A special issue concerns the neurocognitive dysfunction and altered consciousness manifested as delirium, agitation, and confusion. Non-specific symptoms such as dizziness, and seizures can accompany clinical pictures. Regardless of the admitting diagnosis, a high percentage of patients discharged from ICUs develop disabilities affecting physical, cognitive and psychological activities. The symptoms such as asthenia, memory disturbances, depression, sleep disturbances, anxiety, and Post-traumatic Stress Disorder (PTSD), can configure the so-called Post-intensive Care Syndrome (PICS). Multimodal management during the ICU stay and implementation of follow-up programs on patient discharge can reduce the incidence of this syndrome, improving the quality of life of surviving individuals. In this complex scenario, a careful clinical approach through reliable diagnostic tools, and epidemiological studies aimed at evaluating the dimensions of the problem also in economic terms, is urgently needed. This book represents a valuable aid for all healthcare professionals (intensivists, neurologist and psychiatrists, as well as others) involved in the management of these critically ill patients.

Download or read book Neuroimaging of Covid 19 First Insights based on Clinical Cases written by Simonetta Gerevini M.D. and published by Springer Nature. This book was released on 2021-03-17 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the variability of the effects of Covid-19 on the nervous system (NS), with the purpose to update content and images based on improved scientific evidence. Current available data show that involvement of the NS is frequent in patients with SARS-CoV-2 infection. The most common neurologic syndromes include cerebrovascular disorders, encephalopathies, inflammatory Central Nervous System (CNS) syndromes, peripheral neurologic disorders, psychiatric disorders. The pathophysiology of neurological manifestations is far from being understood. They can be coincidental, common complications of severe viral infection, or direct consequence of the viral infection either via indirect para-infective mechanisms or direct viral penetration of NS. Experimental animal models had previously demonstrated the neuroinvasive potential of SARS-CoV and the detection of viral particles in special structures such as the thalamus, nucleus ambiguous and nucleus of the solitary tract, suggesting that CNS invasion can contribute significantly to the severe outcome not only through direct damage to neurological structures, but also through a potential detrimental effect on cardiorespiratory responses. Up to now, the detection of SARS-CoV-2 RNA in the cerebrospinal fluid of COVID-19 patients has been reported occasionally and conclusive pathological demonstration of the virus in the CNS is lacking. In this scenario, the role of neuroimaging is fundamental. These considerations highlight the urgent need to better clarify the neurotropic potential of the SARS-CoV-2 virus, and to verify on human autoptic tissue the mechanisms demonstrated in the experimental animal model in order to develop potential strategies to prevent CNS invasion and to adapt treatment protocols based on neurological involvement. CT scan is useful to detect large hemorrhage and ischemic lesions, that have been reported in Covid-19 patients, but lacks identifying other possible neurological complications, such as microhemorrhage or encephalitis. MRI could overcome these limitations; in particular the use of specific sequences may reveal microvascular lesions that can occur during the disease course, according to the described pathogenesis. This book will be an invaluable tool for neuroradiologists, radiologists, neurologists, and all physicians involved in the pandemic.

Download or read book Neurology of COVID 19 written by Adnan Qureshi and published by Cambridge Scholars Publishing. This book was released on 2024-05-10 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several neurological manifestations of the severe acute respiratory syndrome coronavirus-2 viral infection (SARS-CoV-2) or Coronavirus Disease 2019 (COVID-19) have previously been identified. This is the first comprehensive book to provide a detailed account of the neurological manifestations of COVID-19. The book provides up-to-date data and guidance for healthcare providers involved in the management of neurological aspects of SARS-CoV-2 infection in order to meet the new challenges related to COVID-19. The book makes reference to previously published stroke guidelines, World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) recommendations, relevant non-neurological-related professional guidelines, personal files, and expert opinions. The book summarizes existing evidence, indicates gaps in our current knowledge, and, when appropriate, formulates practical implications.

Download or read book Consequences of the COVID 19 Pandemic on Care for Neurological Conditions written by Cheng-Yang Hsieh and published by Frontiers Media SA. This book was released on 2022-01-07 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Corona and Related Viruses written by Gary A. Levy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Corona- and related viruses are important human and animal pathogens that also serve as models for other viral-mediated diseases. Interest in these pathogens has grown tremendously since the First International Symposium was held at the Institute of Virology and Immunobiology of the University of Wiirzburg, Germany. The Sixth International Symposium was held in Quebec City from August 27 to September I, 1994, and provided further understanding of the molecular biology, immunology, and pathogenesis of corona-, toro-, and arterivirus infections. Lectures were given on the molecular biology, pathogenesis, immune responses, and development of vaccines. Studies on the pathogenesis of coronavirus infections have been focused mainly on murine coronavirus, and mouse hepatitis virus. Neurotropic strains ofMHV (e.g., JHM, A59) cause a demyelinating disease that has served as an animal model for human multiple sclerosis. Dr. Samuel Dales, of the University of Western Ontario, London, Canada, gave a state-of-the-art lecture on our current under standing of the pathogenesis of JHM-induced disease.

Download or read book Neurological and Neuroscientific Evidence in Aged COVID 19 Patients written by Thomas Wisniewski and published by Frontiers Media SA. This book was released on 2021-12-21 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book COVID 19 in CNS and PNS Basic and Clinical Focus on the Mechanisms of Infection and New Tools for the Therapeutic Approach written by Jorge Matias-Guiu and published by Frontiers Media SA. This book was released on 2022-01-25 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book An Update on Neurological Disorders Post COVID 19 Infection written by Beatrice Paradiso and published by Frontiers Media SA. This book was released on 2023-08-02 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronavirus disease 2019 (COVID-19), produces the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with atypical pneumonia. This infection is a global health challenge producing post-acute sequelae of SARS-CoV-2 infection (PASC), including neuro-PASC in which direct or indirect invasion of the virus into the brain causes immune dysregulation, hormonal disorders, elevated cytokine levels due to immune reaction and chronic inflammation, direct tissue injury, and persistent low-grade infection. The COVID-19 induced-neuroinflammation promotes blood-brain barrier (BBB) disruption, access of antigens and inflammatory factors into the brain, as well as infection or immune-mediated response in the neuromuscular system. It is therefore necessary to explore whether there is a close correlation with the adenosine pathway, the activation of the ACE receptor by the virus, the concentration of IL6 and the neuro-invasive effect of COVID-19. Other points of interest are the analysis of the autonomic dysfunction induced by cytokines; the effect of vaccine mRNA delivery in Central and Peripheral Nervous System, the long-term effects of Covid 19 infection and/or therapeutic approach in different pandemic countries. In this Research Topic we aim to including submissions and research from different countries, which will allow comparisons of loco-regional clinical experiences, diagnostic flow-charts, and different therapeutic approaches.

Download or read book Neurological Involvement in COVID 19 written by Valentina Opancina and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The respiratory system is the most common target of COVID-19, however, various experimental studies and case reports have shown its affinity for neural tissues. In this chapter, we described pathogenesis and propagation of SARS-CoV-2 virus in the nervous system, potential routes of the SARS-CoV-2 invasion in the brain, as well as indirect effects of COVID-19 on multiorgan disorders. We have also presented all of the reported neurological manifestations in COVID-19 with an explanation of possible underlying pathways. Among patients who tested positive on SARS-CoV-2, various neurological irregularities have been described, affecting both the central and peripheral nervous systems. In general, neurological complications in COVID-19 patients occur within 1 and 14 days, in most cases on average on the 5th day of the incubation period. We have demonstrated all of the reported neurological findings, whereas the most commonly reported were headache, dizziness, myalgia, hypogeusia, hyposmia, and impaired consciousness. More serious neurological conditions in COVID-19 included meningitis, encephalitis, and ischemic or hemorrhagic stroke.

Download or read book Neurological Care and the COVID 19 Pandemic written by Gamaleldin Osman, MD and published by Elsevier. This book was released on 2021-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a comprehensive review of the neuropathology of SARS-CoV-2, Neurological Care and the COVID-19 Pandemic provides up-to-date coverage of the wide array of the pathogen's neurological symptoms and complications. Drs. Ahmad Riad Ramadan and Gamaledin Osman discuss the neuropathology of SARS-CoV-2, its neurological manifestations, and the impact the pandemic has had on the care of patients with pre-existing neurological conditions. The authors also offer an overview of emerging treatments and vaccines, as well as ways healthcare systems have reorganized in order to respond to the pandemic. Offers a thorough discussion of the impact the virus has had on the care of patients with neurological ailments, accompanied by recommendations on how to care for these patients. Covers the impact of COVID-19 on patients with cerebrovascular diseases, seizures, demyelinating diseases, neuromuscular disorders, movement disorders, headache disorders, cognitive disorders, and neuro-oncological disorders. Includes a detailed case study of how one healthcare system hit hard by COVID-19 successfully transformed itself to respond to the challenges imposed by the pandemic. Consolidates today's available information on this timely topic into a single, convenient resource.

Download or read book COVID 19 Neuroimmunology and Neural Function written by Thomas Heinbockel and published by BoD – Books on Demand. This book was released on 2022-09-07 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent and ongoing COVID-19 pandemic has changed societies and research around the world. As such, this new book examines the latest developments in the field of neuroscience related to these changes. It includes six chapters in two sections: “COVID-19 Effects: Neurology, Neuroimmunology, Neurogenesis” and “Molecular and Cellular Neurochemistry.” The first section includes chapters that address such topics as COVID’s effect on adult neurogenesis, neurological manifestations of COVID-19, and COVID-19 and seizures. Chapters in the second section discuss peripheral biomarkers in multiple sclerosis, amino acids as neurotransmitters, advancements in RNA sequencing technologies, and more.

Download or read book Neurology of COVID 19 written by Adnan Qureshi and published by . This book was released on 2024-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several neurological manifestations of the severe acute respiratory syndrome coronavirus-2 viral infection (SARS-CoV-2) or Coronavirus Disease 2019 (COVID-19) have previously been identified. This is the first comprehensive book to provide a detailed account of the neurological manifestations of COVID-19. The book provides up-to-date data and guidance for healthcare providers involved in the management of neurological aspects of SARS-CoV-2 infection in order to meet the new challenges related to COVID-19. The book makes reference to previously published stroke guidelines, World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) recommendations, relevant non-neurological-related professional guidelines, personal files, and expert opinions. The book summarizes existing evidence, indicates gaps in our current knowledge, and, when appropriate, formulates practical implications.

Download or read book The Circadian Clock written by Urs Albrecht and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.

Download or read book COVID 19 The neurorehabilitation perspective written by Thomas Platz and published by Frontiers Media SA. This book was released on 2023-06-02 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neuroimmunology and Neurological Manifestations of COVID 19 written by Robert Weissert and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrusion by SARS-CoV-2 of the central nervous system (CNS) and peripheral nervous system (PNS) and direct infection of local cells. In addition, neurological deterioration mediated by molecular mimicry to virus antigens or bystander activation in the context of immunological anti-virus defense can lead to tissue damage in the CNS and PNS. In addition, cytokine storm caused by SARS-CoV-2 infection in COVID-19 can lead to nervous system related symptoms. Endotheliitis of CNS vessels can lead to vessel occlusion and stroke. COVID-19 can also result in cerebral hemorrhage and sinus thrombosis possibly related to changes in clotting behavior. Vaccination is most important to prevent COVID-19 in the nervous system. There are symptomatic or/and curative therapeutic approaches to combat COVID-19 related nervous system damage that are partly still under study.