Download or read book Neurochemical Systems and Signaling written by Ghulam Md Ashraf and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human brain made up of billions of neurons; communicate with each other through chemical messengers which are referred to as neuroactive substances. These neuroactive substances include neurotransmitters, neuromodulators, neurohormones and neuromodulators. Some neurotransmitters also act as neuromodulators and neurohormones. It would be cynical if there will ever be general covenant about the meanings of these neuroactive substances including neurotransmitters since the term neurotransmitter has traditionally been used very loosely indeed which includes neurotransmitters, neurohormones, neuromodulators and neuromodulators. Any alterations in functioning of these neuroactive substances can cause diseases. The brain is the ultimate center that regulates all neurological and behavioral aspects of body through neuronal communications mediated via various neurochemicals as discussed above. Thus, neurologic and psychiatric disorders in most cases are result of disturbed neurochemical balance. Besides the multifaceted involvement of billions of neuronal cells, CNS is a complex organization with its diverse number of neurotransmitter systems as compared to autonomic nervous system, in which the parasympathetic system works on "rest and digest" phenomenon and sympathetic system on "fight or flight" phenomenon. There are more than 20 neurotransmitter systems and multiple receptors for each neurotransmitter as discussed in above sections. Any alterations in neurochemical balance are expressed in the form of neurological or psychiatric disorders like epilepsy, Parkinson's disease (PD), Alzheimer's disease, psychosis, depression, etc. Acetylcholine, noradrenaline, dopamine and 5-HT are of utmost importance amongst neurotransmitters for their profound role in pathogenesis of various neurologic and psychiatric disorders in humans. Yet, the involvement of various proteins and peptides such as neurotrophic factors, growth factors, and endogenous chemical compounds cannot be ignored. Day by day the suffering of people owing to imbalance of neurotransmitter is increasing. Various factors for example, stress, diet, genetics and disclosure to toxins such as alcohol and nicotine are liable for this imbalance. This imbalance may progress thoughtful mental health complaints. The main purpose of this book is to give the comprehensive overview of the neurological diseases associated with neurochemical imbalances. This book will be very effective for readers to get complete idea about neuronal signaling and linked neurological disorders as well as current status and future opportunities and challenges. It will provide a brief account of neurotransmission, as either a study or high-yield revision aid.

Download or read book Neurochemical Systems and Signaling written by Ghulam Md Ashraf and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Human brain made up of billions of neurons; communicate with each other through chemical messengers which are referred to as neuroactive substances. These neuroactive substances include neurotransmitters, neuromodulators, neurohormones and neuromodulators. Some neurotransmitters also act as neuromodulators and neurohormones. It would be cynical if there will ever be general covenant about the meanings of these neuroactive substances including neurotransmitters since the term neurotransmitter has traditionally been used very loosely indeed which includes neurotransmitters, neurohormones, neuromodulators and neuromodulators. Any alterations in functioning of these neuroactive substances can cause diseases. The brain is the ultimate center that regulates all neurological and behavioral aspects of body through neuronal communications mediated via various neurochemicals as discussed above. Thus, neurologic and psychiatric disorders in most cases are result of disturbed neurochemical balance. Besides the multifaceted involvement of billions of neuronal cells, CNS is a complex organization with its diverse number of neurotransmitter systems as compared to autonomic nervous system, in which the parasympathetic system works on "rest and digest" phenomenon and sympathetic system on "fight or flight" phenomenon. There are more than 20 neurotransmitter systems and multiple receptors for each neurotransmitter as discussed in above sections. Any alterations in neurochemical balance are expressed in the form of neurological or psychiatric disorders like epilepsy, Parkinson's disease (PD), Alzheimer's disease, psychosis, depression, etc. Acetylcholine, noradrenaline, dopamine and 5-HT are of utmost importance amongst neurotransmitters for their profound role in pathogenesis of various neurologic and psychiatric disorders in humans. Yet, the involvement of various proteins and peptides such as neurotrophic factors, growth factors, and endogenous chemical compounds cannot be ignored. Day by day the suffering of people owing to imbalance of neurotransmitter is increasing. Various factors for example, stress, diet, genetics and disclosure to toxins such as alcohol and nicotine are liable for this imbalance. This imbalance may progress thoughtful mental health complaints. The main purpose of this book is to give the comprehensive overview of the neurological diseases associated with neurochemical imbalances. This book will be very effective for readers to get complete idea about neuronal signaling and linked neurological disorders as well as current status and future opportunities and challenges. It will provide a brief account of neurotransmission, as either a study or high-yield revision aid"--

Download or read book Neurochemical Systems and Signaling written by Ghulam Md Ashraf and published by CRC Press. This book was released on 2023-06-30 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human brain is made up of billions of neurons that communicate with each other through chemical messengers, which are referred to as neuroactive substances. These neuroactive substances include neurotransmitters, neuromodulators, and neurohormones. Some neurotransmitters also act as neuromodulators and neurohormones. It is unlikely that there would ever be a consensus about the meanings of these neuroactive substances, including neurotransmitters, since the term ‘neurotransmitter’ has traditionally been used very loosely indeed, to include neurotransmitters, neurohormones, and neuromodulators. Any alterations in the functioning of these neuroactive substances can cause diseases. The brain is the ultimate center that regulates all neurological and behavioral aspects of the body through neuronal communications mediated via various neurochemicals. Thus, neurological and psychiatric disorders are, in most cases, the result of disturbed neurochemical balance. Besides the multifaceted involvement of billions of neuronal cells, the central nervous system is a complex organization with a diverse number of neurotransmitter systems, as compared to the autonomic nervous system, in which the parasympathetic system works on the ‘rest and digest’ phenomenon, and the sympathetic system works on the ‘fight or flight’ phenomenon. There are more than 20 neurotransmitter systems and multiple receptors for each neurotransmitter. Any alterations in neurochemical balance are expressed in the form of neurological or psychiatric disorders such as epilepsy, Parkinson’s disease, Alzheimer’s disease, psychosis, depression, etc. Acetylcholine, noradrenaline, dopamine, and 5-HT are of the utmost importance among neurotransmitters for their profound role in the pathogenesis of various neurological and psychiatric disorders in humans. Yet the involvement of various proteins and peptides, such as neurotrophic factors, growth factors, and endogenous chemical compounds, cannot be ignored. Day by day, the suffering of people due to an imbalance of neurotransmitters is increasing. Various factors, for example stress, diet, genetics, and toxins such as alcohol and nicotine, contribute to this imbalance. This imbalance may lead to mental health complaints. The main purpose of this book is to give a comprehensive overview of the neurological diseases associated with neurochemical imbalances. This book will help readers gain a comprehensive understanding of neuronal signaling and related neurological disorders, as well as status and future opportunities and challenges. It will provide a brief account of neurotransmission, as either a study or high-yield revision aid.

Download or read book Basic Neurochemistry written by Scott Brady and published by Academic Press. This book was released on 2011-11-02 with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

Download or read book Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-08-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Download or read book From Molecules to Networks written by John H. Byrne and published by Academic Press. This book was released on 2014-05-23 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches 80% updated and new content New Chapter on "Biophysics of Voltage-Gated Ion Channels" New Chapter on "Synaptic Plasticity" Includes a chapter on the Neurobiology of Disease Highly referenced, comprehensive and quantitative Full color, professional graphics throughout All graphics are available in electronic version for teaching purposes

Download or read book Tourette Syndrome written by Davide Martino and published by Oxford University Press. This book was released on 2022 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tourette syndrome (TS) has become increasingly recognised within society and has gained scientific interest worldwide. Knowledge of its clinical presentation, mechanisms of disease, and available treatment approaches has increased remarkably over the last two decades. Likewise, the way clinicians, teachers, social care workers, and families face the problems manifested by patients with TS is rapidly evolving. Tourette Syndrome, edited by Davide Martino and James F. Leckman, offers a unique opportunity to capture this knowledge advance through a comprehensive and up-to-date overview. Tourette Syndrome covers all the main aspects related to TS, analyzing its complex clinical presentation, the novel viewpoints of causes and mechanisms, state-of-the-art assessment techniques, and the diversity of treatment options. Multidisciplinarity is the main asset of this volume, which represents a source of consultation for a wide audience of professionals, integrated with video tutorials related to particularly complex areas of patient management. Medical and PhD students, as well as post-doctoral scientists, will be able to use the volume as a valuable learning source.

Download or read book Neurodevelopment and Schizophrenia written by Matcheri S. Keshavan and published by Cambridge University Press. This book was released on 2004-11-18 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was originally published in 2004 and concerns developmental neurobiology. In the decade preceding publication, developmental neurobiology made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. Each contributor to this volume provides a fresh overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.

Download or read book Experimental Neurochemistry written by Abel Lajtha and published by Springer. This book was released on 1982-12-01 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume of the Handbook does not parallel any volume of the first edition; it is one more sign, or reflection, of the expansion of the field. By emphasizing the experimental approach, it illustrates the tools that have re cently become available for investigating the nervous system. Also, perhaps even more than other volumes, it illustrates the multidisciplinary nature of the field, requiring multidisciplinary methodology. It is now recognized that the availability of methodology is often the rate-limiting determinant of studies and that improvements or innovations in instrumentation can open up new avenues. A new improved method, although opening up new possibilities and being crucial to making advances, is only a tool whose use will determine its use fulness. If we do not recognize its possibilities, its use will be limited; if we do not recognize its limitations, it will mislead us. It is the possibilities and limitations and the results obtained that are illustrated here.

Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Download or read book Neurobiology of Body Fluid Homeostasis written by Laurival Antonio De Luca Jr. and published by CRC Press. This book was released on 2013-10-01 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely symposium entitled Body-Fluid Homeostasis: Transduction and Integration was held at Araraquara, São Paulo, Brazil in 2011. This meeting was convened as an official satellite of a joint gathering of the International Society for Autonomic Neuroscience (ISAN) and the American Autonomic Society (AAS) held in Buzios, Rio de Janeiro. Broad international participation at this event generated stimulating discussion among the invited speakers, leading to the publication of Neurobiology of Body Fluid Homeostasis: Transduction and Integration. Drawn from the proceedings and filled with rich examples of integrative neurobiology and regulatory physiology, this volume: Provides updated research using human and animal models for the control of bodily fluids, thirst, and salt appetite Explores neural and endocrine control of body fluid balance, arterial pressure, thermoregulation, and ingestive behavior Discusses recent developments in molecular genetics, cell biology, and behavioral plasticity Reviews key aspects of brain serotonin and steroid and peptide control of fluid consumption and arterial pressure The book highlights research conducted by leading scientists on signal transduction and sensory afferent mechanisms, molecular genetics, perinatal and adult long-term influences on regulation, central neural integrative circuitry, and autonomic/neuroendocrine effector systems. The findings discussed by the learned contributors are relevant for a basic understanding of disorders such as heat injury, hypertension, and excess salt intake. A unique reference on the neurobiology of body fluid homeostasis, this volume is certain to fuel additional research and stimulate further debate on the topic.

Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq

Download or read book Mapping the Brain and Its Functions written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in brain research have been made, but investigators who face the resulting explosion of data need new methods to integrate the pieces of the "brain puzzle." Based on the expertise of more than 100 neuroscientists and computer specialists, this new volume examines how computer technology can meet that need. Featuring outstanding color photography, the book presents an overview of the complexity of brain research, which covers the spectrum from human behavior to genetic mechanisms. Advances in vision, substance abuse, pain, and schizophrenia are highlighted. The committee explores the potential benefits of computer graphics, database systems, and communications networks in neuroscience and reviews the available technology. Recommendations center on a proposed Brain Mapping Initiative, with an agenda for implementation and a look at issues such as privacy and accessibility.

Download or read book Histamine in the brain written by Jian-Sheng Lin and published by Frontiers Media SA. This book was released on 2015-03-18 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.

Download or read book Emotion written by Ross Buck and published by Cambridge University Press. This book was released on 2016-12-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emotions suffuse our lives: a symphony of feeling - usually whispering and murmuring in pianissimo but occasionally screaming and shouting in fortissimo crescendo - filling every waking moment and even invading our dreams. We can always be conscious of how happy, sad, annoyed, or anxious we feel, and also of the feelings we have relative to other persons: pride, envy, guilt, jealousy, trust, respect, or resentment. Developments in brain imaging and in capturing nuances of nonverbal display now enable the objective study of emotion and how biologically-based primary emotions relate to higher-level social, cognitive, and moral emotions. This book presents an integrated developmental-interactionist theory of emotion, viewing subjective feelings as voices of the genes: an affective symphony composed of dissociable albeit interactive neurochemical modules. These primordial voices do not control, but rather cajole our behavior with built-in flexibility, enabling the mindful application of learning, reason, and language.

Download or read book The Diagnosis and Management of Agitation written by Scott L. Zeller and published by Cambridge University Press. This book was released on 2017-02-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to the origins and treatment options for agitation, a common symptom of psychiatric and neurologic disorders.