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Book Neurobiology of Addiction

Download or read book Neurobiology of Addiction written by George F. Koob and published by Academic Press. This book was released on 2025-01-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. - Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction - Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work - Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching

Book Drugs  Addiction  and the Brain

Download or read book Drugs Addiction and the Brain written by George F. Koob and published by Academic Press. This book was released on 2014-07-12 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. - Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle - Actual data figures from original sources illustrating key concepts and findings - Introduction to basic neuropharmacology terms and concepts - Introduction to numerous animal models used to study diverse aspects of drug use. - Thorough review of extant work on the neurobiology of addiction

Book Addiction Mechanisms  Phenomenology and Treatment

Download or read book Addiction Mechanisms Phenomenology and Treatment written by W.W. Fleischhacker and published by Springer Science & Business Media. This book was released on 2003-09-04 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Substance-related disorders pose an increasing challenge not only to the field of psychiatry but also to public health. The rapid development of our society has also changed the face of substance use and abuse, both quantitatively and qualitatively. In this volume international experts present reviews of the latest research covering many areas ranging from neurobiology to psychological management, as well as different drugs, from alcohol to ecstasy.

Book Dispelling the Myths About Addiction

Download or read book Dispelling the Myths About Addiction written by Institute of Medicine and published by National Academies Press. This book was released on 1997-11-10 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year about half a million men, women, and children in the United States die from the effects of using nicotine, alcohol, and illegal drugs: one of every four American deaths. Yet research to solve this terrible problem is often perceived as less important than other types of biomedical investigation. Focusing on four major classes of drugs with the greatest social and economic impactâ€"nicotine, alcohol, opioids, and stimulantsâ€"Dispelling the Myths About Addiction examines what is known about addiction and what is needed to develop a talented cadre of investigators and to educate the public about addiction research. The committee explores these areas: Economic costs of addiction. What has been learned about addiction from research into basic neurobiology and the brain, psychosocial and behavioral factors, and epidemiology. Education and training of researchers and the research infrastructure. Public perceptions and their impact on public policy in this field. This volume outlines the challenges and opportunities in addiction research today and makes recommendations to educators, treatment professionals, public and private institutions, and others for how to build support for addiction research and treatment.

Book Medications for Opioid Use Disorder Save Lives

Download or read book Medications for Opioid Use Disorder Save Lives written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-06-16 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.

Book Addiction Neuroethics

    Book Details:
  • Author : Adrian Carter
  • Publisher : Academic Press
  • Release : 2011-10-04
  • ISBN : 0123859743
  • Pages : 347 pages

Download or read book Addiction Neuroethics written by Adrian Carter and published by Academic Press. This book was released on 2011-10-04 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research increasingly suggests that addiction has a genetic and neurobiological basis, but efforts to translate research into effective clinical treatments and social policy needs to be informed by careful ethical analyses of the personal and social implications. Scientists and policy makers alike must consider possible unintended negative consequences of neuroscience research so that the promise of reducing the burden and incidence of addiction can be fully realized and new advances translated into clinically meaningful and effective treatments. This volume brings together leading addiction researchers and practitioners with neuroethicists and social scientists to specifically discuss the ethical, philosophical, legal and social implications of neuroscience research of addiction, as well as its translation into effective, economical and appropriate policy and treatments. Chapters explore the history of ideas about addiction, the neuroscience of drug use and addiction, prevention and treatment of addiction, the moral implications of addiction neuroscience, legal issues and human rights, research ethics, and public policy. - Features outstanding and truly international scholarship, with chapters written by leading experts in neuroscience, addiction medicine, psychology and more - Informs psychologists of related research in neuroscience and vice versa, giving researchers easy one-stop access to knowledge outside their area of specialty

Book Pain Management and the Opioid Epidemic

Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Book Cancer Pain Relief

    Book Details:
  • Author : World Health Organization
  • Publisher : World Health Organization
  • Release : 1996
  • ISBN : 9789241544825
  • Pages : 74 pages

Download or read book Cancer Pain Relief written by World Health Organization and published by World Health Organization. This book was released on 1996 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of a guide, which introduced a simple, yet highly effective method for the relief of cancer pain. Thoroughly revised and updated, the new edition further refines the WHO method, which advocates the use of a small number of relatively inexpensive drugs, including morphine. Revisions draw on experiences with millions of patients around the world as well as new knowledge about the specific pain syndromes unique to cancer. Completely new are chapters describing the international system by which morphine and other opioids are made available for medical purposes. The book has two parts. Part one provides a practical guide to the relief of cancer pain, concentrating on drug treatment as the mainstay of pain management. The most extensive section sets out detailed guidelines for the selection and prescribing of non-opioid analgesics, opioid analgesics, drugs for neuropathic pain, and adjuvant drugs for the treatment of adverse effects, the enhancement of pain relief and the management of concomitant psychological disturbances. Information ranges from explanations of how specific drugs work, through the precautions to take in the presence of certain disorders, to a list of factors that influence the effectiveness of opioids. Concerning the use of opioids, readers are reminded that psychological dependence does not occur in cancer patients and that the only correct dose of morphine is the one that relieves the pain. Part two provides a guide to opioid availability. A discussion of the reasons why opioids continue to be underprescribed or difficult to obtain is followed by an explanation of the Single Convention on Narcotic Drugs.

Book Pathways of Addiction

    Book Details:
  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release : 1996-11-01
  • ISBN : 0309055334
  • Pages : 330 pages

Download or read book Pathways of Addiction written by Institute of Medicine and published by National Academies Press. This book was released on 1996-11-01 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.

Book Methods of Behavior Analysis in Neuroscience

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Book Facing Addiction in America

    Book Details:
  • Author : Office of the Surgeon General
  • Publisher : Createspace Independent Publishing Platform
  • Release : 2017-08-15
  • ISBN : 9781974580620
  • Pages : 420 pages

Download or read book Facing Addiction in America written by Office of the Surgeon General and published by Createspace Independent Publishing Platform. This book was released on 2017-08-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: All across the United States, individuals, families, communities, and health care systems are struggling to cope with substance use, misuse, and substance use disorders. Substance misuse and substance use disorders have devastating effects, disrupt the future plans of too many young people, and all too often, end lives prematurely and tragically. Substance misuse is a major public health challenge and a priority for our nation to address. The effects of substance use are cumulative and costly for our society, placing burdens on workplaces, the health care system, families, states, and communities. The Report discusses opportunities to bring substance use disorder treatment and mainstream health care systems into alignment so that they can address a person's overall health, rather than a substance misuse or a physical health condition alone or in isolation. It also provides suggestions and recommendations for action that everyone-individuals, families, community leaders, law enforcement, health care professionals, policymakers, and researchers-can take to prevent substance misuse and reduce its consequences.

Book Never Enough

    Book Details:
  • Author : Judith Grisel
  • Publisher : Vintage
  • Release : 2019-02-19
  • ISBN : 0385542852
  • Pages : 223 pages

Download or read book Never Enough written by Judith Grisel and published by Vintage. This book was released on 2019-02-19 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW YORK TIMES BESTSELLER • From a renowned behavioral neuroscientist and recovering addict, a rare page-turning work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction. Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey. In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Yet they have their appeal, and Grisel draws on anecdotes both comic and tragic from her own days of using as she limns the science behind the love of various drugs, from marijuana to alcohol, opiates to psychedelics, speed to spice. With more than one in five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide, and Grisel delves with compassion into the science of this scourge. She points to what is different about the brains of addicts even before they first pick up a drink or drug, highlights the changes that take place in the brain and behavior as a result of chronic using, and shares the surprising hidden gifts of personality that addiction can expose. She describes what drove her to addiction, what helped her recover, and her belief that a “cure” for addiction will not be found in our individual brains but in the way we interact with our communities. Set apart by its color, candor, and bell-clear writing, Never Enough is a revelatory look at the roles drugs play in all of our lives and offers crucial new insight into how we can solve the epidemic of abuse.

Book Neurobiology and Treatment of Traumatic Dissociation

Download or read book Neurobiology and Treatment of Traumatic Dissociation written by Ulrich F. Lanius, PhD and published by Springer Publishing Company. This book was released on 2014-05-13 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Print+CourseSmart

Book Alcohol and Opiates

    Book Details:
  • Author : Kenneth Blum
  • Publisher : Elsevier
  • Release : 2012-12-02
  • ISBN : 0323150802
  • Pages : 430 pages

Download or read book Alcohol and Opiates written by Kenneth Blum and published by Elsevier. This book was released on 2012-12-02 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol and Opiates: Neurochemical and Behavioral Mechanisms contains the proceedings of the 1976 conference, ""The Neurochemical and Behavioral Mechanisms of Alcohol and Opiate Dependence"", held in New York. The papers focus on the commonalities and distinctions of alcohol and opiates in terms of neurochemical and behavioral mechanisms. It also highlights key research findings on alcohol and drug dependence as well as advances in the understanding of opiate neurochemistry and the nature of alcoholism. Organized into two sections comprised of 22 chapters, this compilation begins with an overview of the various techniques used to produce and to measure alcohol dependence using animal models. It then discusses the neurochemical components of ethanol dependence, the pharmacogenetics of alcoholism, and the effects of alcohol on behavioral performance. The remaining chapters examine the pharmacology of isoquinoline alkaloids and ethanol interactions, the neurochemical aspects of opiate dependence, the pharmocological heterogeneity of narcotic receptors, and the pharmacology of endogenous opiate-like peptides. The book also introduces the reinforcement of behavior by morphine injections and the metabolic stereospecificity of opiate agonist and antagonist drugs. It concludes with an assessment of future research directions concerning opioid peptides (endorphins). This book is a valuable source of information for those seeking to build clinical programs designed to alleviate the sociological and medical ills associated with alcohol and opiate abuse and drug dependency.

Book The Oxford Handbook of the Neurobiology of Pain

Download or read book The Oxford Handbook of the Neurobiology of Pain written by John N. Wood and published by Oxford University Press, USA. This book was released on 2020 with total page 939 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is currently in development, with individual articles publishing online in advance of print publication. At this time, we cannot add information about unpublished articles in this handbook, however the table of contents will continue to grow as additional articles pass through the review process and are added to the site. Please note that the online publication date for this handbook is the date that the first article in the title was published online.

Book Drugs  the Brain  and Behavior

Download or read book Drugs the Brain and Behavior written by John Brick and published by Routledge. This book was released on 2013-06-26 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore the brain and discover the clinical and pharmacological issues surrounding drug abuse and dependence. The authors, research scientists with years of experience in alcohol and drug studies, provide definitions, historic discoveries about the nervous system, and original, eye-catching illustrations to discuss the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs. You will learn about: • how psychoactive drugs affect cognition, behavior, and emotion • the brain/behavior relationship • the specific effects of major addictive and psychoactive drug groups • new definitions and thinking about abuse and dependence • the medical and forensic consequences of drugs use Drugs, the Brain, and Behavior uses a balance of instruction, illustrations, and tables and formulas that will give you a broad, lasting introduction to this intriguing subject. Whether you're a nurse, chemical dependency counselor, psychologist, or clinician, this book will be a quick reference guide long after the first reading.

Book Dopamine Nation

    Book Details:
  • Author : Dr. Anna Lembke
  • Publisher : Penguin
  • Release : 2023-01-03
  • ISBN : 1524746746
  • Pages : 305 pages

Download or read book Dopamine Nation written by Dr. Anna Lembke and published by Penguin. This book was released on 2023-01-03 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: INSTANT NEW YORK TIMES and LOS ANGELES TIMES BESTSELLER “Brilliant . . . riveting, scary, cogent, and cleverly argued.”—Beth Macy, author of Dopesick, as heard on Fresh Air This book is about pleasure. It’s also about pain. Most important, it’s about how to find the delicate balance between the two, and why now more than ever finding balance is essential. We’re living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting . . . The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we’ve all become vulnerable to compulsive overconsumption. In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain . . . and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery.