Download or read book Nerve Growth Factor and Pain written by Paola Sarchielli and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nerve growth factor (NGF) has a key role not only in the development of sensory and autonomic neurons, but also in the processes of nociception. Several central and peripheral mechanisms have been postulated as the basis of effects of NGF in nociceptive pathways. It has been implicated both in inflammatory and neuropathic pain mechanisms and strategies against NGF, its receptors, and down-stream intracellular signalling activated by this neurotrophin (NT) have been proposed for the treatment of these pathological conditions. This book examines recent evidence of the involvement of NGF in painful diseases and suggests the potential usefulness of anti-NGF strategies as novel analgesics for these disabling pathological conditions.
Download or read book A Role for Nerve Growth Factor in Arthritic Pain written by Geraldine Longo and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Although chronic pain is the most common symptom of arthritis, relatively little is known about the mechanisms driving it. Upregulation of nerve growth factor (NGF) in inflammatory states has been associated with increased nociception. NGF promotes the growth and survival of sympathetic and primary sensory neurons by exerting its biological activity through its cognate receptor TrkA. Previous research has shown that, in the CNS, NGF is released from cells as a precursor (proNGF) together with the enzymes required for its conversion into the mature form (mNGF) and for its degradation. Interestingly, in a rat model of poly-arthritis, our lab demonstrated that sympathetic fibers invaded the upper dermis of the skin over the inflamed joints, a region from where they are normally absent. These ectopic fibers wrapped around peptidergic nociceptive fibers.
Download or read book Translational Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2009-11-24 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical
Download or read book Neural Regeneration written by Kwok-Fai So and published by Academic Press. This book was released on 2015-02-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including: Neural regeneration in lower vertebrates Neural regeneration in the peripheral nervous system Neural regeneration in the central nervous system Transplantation-mediated neural regeneration Clinical and translational research on neural regeneration The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China. Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries. This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research.
Download or read book Basic Neurochemistry written by George J. Siegel and published by Lippincott Raven. This book was released on 1999 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Download or read book A Study of the Role of Nerve Growth Factor in Inflammatory and Neuropathic Pain Disorders written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Acute Pain written by Lesley Bromley and published by Oxford University Press. This book was released on 2010-06-03 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers the fundamentals of pain, the pharmacology of drugs used, and summarises the current evidence base for the management of acute pain. It provides practical direct clinical applications and strategies for the management of specific medical conditions in patient groups such as the elderly
Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Download or read book A Study of the Role of Nerve Growth Factor in Inflammatory and Neuropathic Pain Disorders written by Joanne Garrah and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Essence of Analgesia and Analgesics written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2010-10-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Download or read book Encyclopedia of Pain written by G.F. Gebhart and published by Springer. This book was released on 2013-11-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Pain includes more than 3,000 entries and provides clear, detailed and up-to-date coverage of the current state of research, and treatment of pain. In addition, detailed essays provide in-depth information on all aspects of nociception and pain, including substrates, causes, pathophysiology, symptoms and signs, diagnoses and treatment. A thousand color figures enhance understanding of this too-little-understood topic. The book is available in print, in online only form, or in a print-online bundle.
Download or read book Saga Of The Nerve Growth Factor The Preliminary Studies Discovery Further Development written by Rita Levi-montalcini and published by World Scientific. This book was released on 1997-04-01 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of articles written by Nobel Laureate Rita Levi-Montalcini and published from 1942 to 1995. Studies described in the first part set the stage for the discovery of a protein molecule which became known as the Nerve Growth Factor (NGF), described in detail in the second part. The NGF synthesized in minute amounts in all vertebrate tissues, plays an essential role in the differentiation and survival of several nerve cell populations in the peripheral and central nervous system. The discovery of the NGF was defined by the Nobel Foundation as a milestone in developmental neurobiology, and the author was awarded in 1986 with this prestigious award. Studies pursued in subsequent years and still in progress, have unveiled other fundamental properties of the NGF, described in the third part of this volume.
Download or read book Peripheral Nerve Regeneration written by Giovanna Gambarotta and published by Frontiers Media SA. This book was released on 2019-12-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cytokines and Pain written by L.R. Watkins and published by Springer. This book was released on 2013-03-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.
Download or read book Growth Factors as Drugs for Neurological and Sensory Disorders written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Degeneration of sensory receptors or of the nerves innervating them leads to a sensory deficit. Various strategies have been tried for promoting regrowth of sensory receptors, particularly in the eye and ear. The latest data from experimental studies in animals are presented in the book including applications of BDNF and CNTF in the eye and epidermal growth factor in the ear.
Download or read book Synaptic Plasticity in Pain written by Marzia Malcangio and published by Springer. This book was released on 2009-07-10 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primary sensory neurons respond to peripheral stimulation and project to the spinal cord. Specifically, the population of neurons which respond to damaging stimuli terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second order neurons. It has recently become clear that the strength of this first pain synapse is plastic and modifiable by several modulators, including neuronal and non-neuronal regulators, and studies on the fundamental processes regulating the plasticity of the first pain synapse have resulted in the identification of new targets for the treatment of chronic pain. This book will be of interest to a wide readership in the pain field.
Download or read book Bacterial NanoCellulose written by Miguel Gama and published by CRC Press. This book was released on 2016-04-19 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book dedicated to the potential applications and unique properties of bacterial cellulose (BC), this seminal work covers the basic science, technology, and economic impact of this bulk chemical as well as the companies and patents that are driving the field. It reviews the biosynthesis and properties of BC, including genetics and characterization; discusses the advancing technology as it relates to product development, bioreactors, and production; and analyzes the economic impact of BC on a diverse range of industry applications, including materials and biomaterials, biological and polymer sciences, and electromechanical engineering.
