Download or read book Negative and Positive Transcriptional Regulation by Thyroid Hormone Receptor Isoforms written by Anne Rentoumis and published by . This book was released on 1990 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Thyroid Hormone Regulation of Gene Expression written by G.R. Williams and published by Springer. This book was released on 1994 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the historical perspective and physiological background of the role of thyroid hormones. In both specific target tissues and during development, it provides clinical perspectives and physiological and developmental implications of the interactions between retinoid and vitamin D3 signalling pathways.
Download or read book Analysis of the Molecular Mechanisms of Isoform specific Transcriptional Regulation by Thyroid Hormone Receptors written by Zhihong Yang and published by . This book was released on 2001 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Isoform specific Transcriptional Regulation in the Molecular Mechanisms of Resistance to Thyroid Hormone Syndrome RTH written by Wei Wan and published by . This book was released on 2005 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Thyroid Hormone Receptors written by Aria Baniahmad and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: A panel of outstanding investigators surveys and explains the major cutting-edge methods used in thryroid receptor (TR) research and explains their practical experimental details. Described in step-by-step detail to ensure robust experimental results, the techniques presented cover a wide variety of key areas, including TR in development and knockout (mouse and Xenopus), transcriptional regulation by TRs in both cell-free systems and in living cells, and TR mutant analysis of patients. Additional methods provide powerful tools for the isolation of TR-regulated protein complexes, for studying the oncogene v-Erba in blood cell differentiation, and for target gene analysis in the brain. Microarray chip methods are also presented for analyzing the organs of transgenic mice to identify target genes in the liver.
Download or read book Analysis of the Molecular Basis of Transcriptional Regulation by Thyroid Hormone and Estrogen Receptors written by Jeffrey Morse Holloway and published by . This book was released on 1992 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Thyroid Hormone Metabolism written by Georg Hennemann and published by Marcel Dekker. This book was released on 1986 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification and Characterization of Thyroid Hormone Regulated Genes in Human Fibroblasts by MRNA Differential Display Analysis and Quantitative Competitive Polymerase Chain Reaction written by Betsaida Torres and published by . This book was released on 1995 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Ability of Thyroid Hormone Receptors TRs to Sense T4 3 5 3 5 tetraiodo thyronine as an Agonist Depends on Receptor Isoform and on Cellular Cofactors written by Amy Catherine Schroeder and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Thyroid Hormones (THs) are critical signaling molecules involved in the regulation of vertebrate homeostasis, development, reproduction, and metabolism. THs bind thyroid hormone receptors (TRs), hormone-regulated members of the nuclear receptor transcription factor superfamily. TRs bind DNA in the presence of TH to increase target gene expression involved in a diverse array of biological processes. Of the two major THs, T4 (3,5,3', 5' tetra-iodo-L-thyronine) is classically viewed as a pro-hormone that must be converted to the T3 (3,5,3' tri-iodo-L-thyronine) form for biological activity. Previous TR affinity characterizations for T4 and T3 in solution suggest T3 is the single active TH as T3 binds TRs with greater affinity than T4. However, total plasma concentrations of T4 are much greater than T3 suggesting substantial amounts of T4 are available to bind TRs for potential transcriptional regulation. In this dissertation, I investigated the possibility of T4 acting as an active thyroid hormone for specific TR isoforms in distinct cellular contexts. I found the ability of two major TR isoforms to respond to T4 versus T3 differed, with TR[alpha]1; generally more responsive than TR[beta]1 in in vitro affinity determinations. The response to T4 versus T3 also differed dramatically in different cell types in a manner that could not be attributed to differences in deiodinase activity or in hormone affinity, leading us to examine the role of TR coregulators in this phenomenon. In solution, we note evidence of TR[alpha]1 binding known TR coactivators almost equally in the presence of T3 or T4. However, we find T4 inefficiently releases corepressors from both TR[alpha]1 and TR[beta]1, requiring considerably higher concentrations of T4 than coactivator recruitment. In addition to the TR isoform prevalent in a cell type, the repertoire and abundance of different corepressors and coactivators may regulate a cell's ability to respond to T4. These results suggest T4 may be an active, functional thyroid hormone in specific cell types and may provide explanation as to why certain cell types are less responsive to T4 while also opening up a previously uncharacterized arm of thyroid endocrinology.
Download or read book Transcriptional Regulation by Thyroid Hormone Receptor written by Elizabeth Bozena Helmer and published by . This book was released on 1994 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Hormone Receptors written by Malcolm G. Parker and published by . This book was released on 1991 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.
Download or read book Identification of Isoform specific Coregulators of Thyroid Hormone Receptors written by Johnnie Burm Hahm and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Thyroid hormone receptors (TRs) belong to the nuclear receptor superfamily (NR). TRs are ligand-regulated transcription factors that also participate in non-genomic signaling pathways. TRs are expressed as three major isoforms (TR[alpha]1, TR[beta]1, TR[beta]2) which mediate the majority of thyroid hormone effects in mammals. The TR isoforms are found expressed in a tissue-specific manner with overlapping yet distinct biological roles. The TR[alpha]1 and TR[beta]2 isoforms also have unique transcriptional properties that differ from those of TR[beta]1. To more fully understand the isoform-specific biological and molecular properties of TRs, we have identified a series of previously unrecognized proteins that selectively interact with TR[alpha]1 or TR[beta]2 versus TR[beta]1. Several of these proteins also preferentially enhance the transcriptional activity of TR[beta]2, and are likely to represent novel, isoform-specific coactivators. Additional proteins were also identified in our screen to bind equally to all three TR isoforms; these novel binding partners may function as isoform-independent auxiliary proteins for these and/or other NRs. We propose that a combination of isoform-specific recruitment and tissue-specific expression of these newly identified coregulator candidates serve to customize TR function for different biological purposes in different cell types.
Download or read book Cellular Endocrinology in Health and Disease written by Alfredo Ulloa-Aguirre and published by Academic Press. This book was released on 2021-02-19 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field
Download or read book Handbook of Neuroendocrinology written by George Fink and published by Academic Press. This book was released on 2012 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
Download or read book The Molecular Epidemiology Of Trypanosomes And Leishmania written by Geoff (NA) Hide and published by . This book was released on 2001-01-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Management of Thyroid Disease E Book written by Fredric E. Wondisford and published by Elsevier Health Sciences. This book was released on 2009-06-26 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Management of Thyroid Disease is an exciting new book edited by Fredric Wondisford, MD—developer of the revolutionary new drug, Thyrotropin—and Sally Radovick, MD, with contributions from experts in the field. It fulfills the niche of a succinct, clinical resource to help you translate research into practice. This full-color volume offers valuable information on thyroid cancer and non-cancerous lesions, the effect of drugs on thyroid function, genetic disorders, and more in an accessible, easy-to-read consistent format. Presents the expertise of authors and editorial staff comprised of leaders in the field of thyroid research and clinical management for the best-qualified guidance on diagnosis and treatment. Provides a full-color, comprehensive approach that makes valuable information easy to locate and quick to read. Covers relevant topics applicable to all levels of training and expertise to serve as a detailed clinical reference on everything from the basic to the sophisticated. Captures research advances on hot topics such as thyroid cancer and non-cancerous lesions, the effect of drugs on thyroid function, and genetic disorders so that you can incorporate them into the way you treat patients.
Download or read book Principles of Endocrinology and Hormone Action written by Antonino Belfiore and published by Springer. This book was released on 2018-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.
