Download or read book Novel Molecular Targets and Treatments for Gastroesophageal Cancer 2nd edition written by Bin Li and published by Frontiers Media SA. This book was released on 2024-01-10 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastroesophageal cancer is among the most common malignant diseases worldwide and is associated with high mortality rates, leading to a substantial burden on public health and healthcare systems around the world. Chemotherapeutic drugs have achieved great success in the treatment of esophageal cancer; however, they also bring cytotoxicity to other organs and often have serious side effects. With the development of molecular diagnostics and biomarker discovery, the application of precision medicine has emerged to improve clinical outcomes. New antineoplastic therapy development is a timely topic in light of the recent development of precision medicine. New biotherapies aim to inhibit or regulate different targets, which are thought to be functionally selective or overexpressed in some types of tumors. In particular, progress has been made to understand the molecular biology of gastrointestinal cancer, resulting in the discovery of various molecular targets, such as KRAS, PD-1, PD-L1, EGFR, HER2 and VEGF. Moreover, anticancer agents, such as pembrolizumab, olaparib, trastuzumab, bevacizumab, either as single agents or in combination with conventional chemotherapy, have become part of the standard of care for treatment of advanced gastroesophageal cancer. This Research Topic provides a platform for recent studies on novel molecular targets and treatments for gastroesophageal cancer. Both Original Research articles and Reviews are welcome. Subjects may include but are not limited to: 1) Oncogenes and tumor suppressors; 2) Drug sensitivity/resistance; 3) Tumor metastasis and tumor microenvironment; 4) Biomarker discovery and epigenetic regulation.

Download or read book Geography written by and published by . This book was released on 1975 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes section "Reviews" and other bibliographical material.

Download or read book Integrated Waste Biorefineries Achieving Sustainable Development Goals 2nd edition written by Mohammad Rehan and published by Frontiers Media SA. This book was released on 2024-01-11 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United Nations' Sustainable Development Goals (SDGs) are designed to revolutionize societies to prepare for the future challenges. However, the practical implementation of such goals in many domains is are yet to be achieved despite of unique essence. Sustainable energy production (aligned with SDG 7), clean water and sanitation (aligned with SDG 6), sustainable waste services (aligned with SDG 11), and mitigating climate change impacts (aligned with SDG 13) have been the prime focus of SDGs. Moreover, much attention is being paid to research and development activities on waste prevention, reduction, recycling, and reuse to achieve responsible consumption and production (aligned with SDG 12). Waste biorefineries have emerged as a sustainable environmental management solution to achieve not only the aforementioned SDGs, but also to accomplish no poverty (aligned with SDG 1) and zero hunger (aligned with SDG 2) and to maintain well-being and good health aligned with (SDG 3) and decent work and economic growth (aligned with SDG 8) worldwide. This is true because integrated waste biorefineries can efficiently and sustainably produce fuels, heat, energy, power, and multiple value-added products and chemicals. It can further facilitate the transition from linear to circular economies and mitigate the major challenges faced, including environmental pollution, climate change, and adverse effects on public health. This Research Topic will focus on different types of waste biorefineries, current status, practical implications, optimization of waste-to-energy technologies, detailed life assessment studies, and future opportunities with a vision to achieve SDGs in the areas of sustainable energy generation, waste management, circular economies, and climate change mitigation. The editorial team of this special issue, consisting of world-renowned scientists including Highly Cited Researchers, welcomes submissions of original research articles, review articles, short communications, industrial and/or country/region case studies that covers the following enlisted topics: • Waste biorefineries (e.g., organic waste biorefinery, agricultural and forestry waste biorefinery, etc.) • Integration of different types of biorefineries • Sustainable development goals • Waste to energy technologies • Energy and resource recovery from biomass and other waste • Renewable and sustainable energy systems • Biomass and waste supply chain • Sustainable waste management systems • Mitigation of environmental pollution and climate change • Life cycle assessment • Sustainable circular and bio-based economies.

Download or read book International Arms Control written by Coit D. Blacker and published by Stanford University Press. This book was released on 1984 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, this is an exhaustive analysis of national and international arms control: its history, philosophy, achievements and future prospects as well as its political, military and economic ramifications. Includes the complete text of the SALT II treaty and texts of major arms control agreements. ISBN 0-8047-1211-5 : $45.00; ISBN 0-8047-1212-0 (pbk.) : $16.95.

Download or read book Unity written by and published by . This book was released on 1919 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Precipice written by Toby Ord and published by Hachette Books. This book was released on 2020-03-24 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This urgent and eye-opening book makes the case that protecting humanity's future is the central challenge of our time. If all goes well, human history is just beginning. Our species could survive for billions of years - enough time to end disease, poverty, and injustice, and to flourish in ways unimaginable today. But this vast future is at risk. With the advent of nuclear weapons, humanity entered a new age, where we face existential catastrophes - those from which we could never come back. Since then, these dangers have only multiplied, from climate change to engineered pathogens and artificial intelligence. If we do not act fast to reach a place of safety, it will soon be too late. Drawing on over a decade of research, The Precipice explores the cutting-edge science behind the risks we face. It puts them in the context of the greater story of humanity: showing how ending these risks is among the most pressing moral issues of our time. And it points the way forward, to the actions and strategies that can safeguard humanity. An Oxford philosopher committed to putting ideas into action, Toby Ord has advised the US National Intelligence Council, the UK Prime Minister's Office, and the World Bank on the biggest questions facing humanity. In The Precipice, he offers a startling reassessment of human history, the future we are failing to protect, and the steps we must take to ensure that our generation is not the last. "A book that seems made for the present moment." —New Yorker

Download or read book I Can See Clearly Now 3rd Edition written by Bob Maddison and published by Lulu.com. This book was released on 2013-10-20 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the ultimate story of the origin of the univers, a subsequent 'god' and humanity, and every one's search for reality. Seriously.

Download or read book The Future of Nature written by Libby Robin and published by Yale University Press. This book was released on 2013-10-22 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This anthology provides an historical overview of the scientific ideas behind environmental prediction and how, as predictions about environmental change have been taken more seriously and widely, they have affected politics, policy, and public perception. Through an array of texts and commentaries that examine the themes of progress, population, environment, biodiversity and sustainability from a global perspective, it explores the meaning of the future in the twenty-first century. Providing access and reference points to the origins and development of key disciplines and methods, it will encourage policy makers, professionals, and students to reflect on the roots of their own theories and practices.

Download or read book Science and Technology of Terrorism and Counterterrorism Second Edition written by Mark A. Prelas and published by CRC Press. This book was released on 2010-08-10 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, resources on terrorism and counterterrorism tend to focus on the social, behavioral, and legal aspects of the subject, with minimal emphasis on the scientific and technological aspects. Taking into account these practical considerations, the second edition of Science and Technology of Terrorism and Counterterrorism discusses the nature of terrorism and the materials used by terrorists. It describes how intelligence professionals and law enforcement personnel can detect and destroy these materials, and how they can deal with terrorist groups. This volume begins by introducing the shift in analysis of terrorist attacks after September 11, 2001 and summarizes selected case studies. It discusses the origin and nature of terrorism and the factors involved in diplomacy. Covering a broad range of topics, the book examines: Aerosol dispersion of toxic materials Bioterrorism and the manufacture, detection, and delivery of biological agents Agricultural terrorism Nuclear terrorism and nuclear weapons systems, threats, and safeguards Chemical terrorism, including manufacture, detection, delivery, and decontamination Cyber-terrorism Personal protective equipment The role of government at federal, state, and local levels The role of international agencies and their resources, capabilities, and responsibilities The National Infrastructure Protection Plan As terrorist activities increase globally, it is critical that those charged with protecting the public understand the myriad of ways in which terrorists operate. While we cannot predict where, when, and how terrorists will strike, our vigilance in staying abreast of the terrorist threat is the only way to have a fighting chance against those who seek to destroy our world.

Download or read book Surveyor and Municipal and County Engineer written by and published by . This book was released on 1928 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bookseller and Stationer written by and published by . This book was released on 1923 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Business Intelligence and Performance Management written by Peter Rausch and published by Springer Science & Business Media. This book was released on 2013-02-15 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the 21st century business environments have become more complex and dynamic than ever before. Companies operate in a world of change influenced by globalisation, volatile markets, legal changes and technical progress. As a result, they have to handle growing volumes of data and therefore require fast storage, reliable data access, intelligent retrieval of information and automated decision-making mechanisms, all provided at the highest level of service quality. Successful enterprises are aware of these challenges and efficiently respond to the dynamic environment in which their business operates. Business Intelligence (BI) and Performance Management (PM) offer solutions to these challenges and provide techniques to enable effective business change. The important aspects of both topics are discussed within this state-of-the-art volume. It covers the strategic support, business applications, methodologies and technologies from the field, and explores the benefits, issues and challenges of each. Issues are analysed from many different perspectives, ranging from strategic management to data technologies, and the different subjects are complimented and illustrated by numerous examples of industrial applications. Contributions are authored by leading academics and practitioners representing various universities, research centres and companies worldwide. Their experience covers multiple disciplines and industries, including finance, construction, logistics, and public services, amongst others. Business Intelligence and Performance Management is a valuable source of reference for graduates approaching MSc or PhD programs and for professionals in industry researching in the fields of BI and PM for industrial application.

Download or read book An Atlas of Operative Laparoscopy and Hysteroscopy Second Edition written by Jacques Donnez and published by CRC Press. This book was released on 2001-05-15 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its introduction in the 1980s, the use of endoscopic surgery in gynecology has grown tremendously, its equipment improved, and methods refined. Today it is clear that the future of gynecologic surgery lies in the realm of minimally invasive techniques. An Atlas of Operative Laparoscopy and Hysteroscopy, Second Edition is not just a how-to-do-the-surgery book, but also a guide to the pathogenesis, pathophysiology, and epidemiology of the urogynecological area. Thoroughly updated to reflect advances in methods and technology, the book covers established techniques such as laparoscopic tubal anastomosis, endometrial ablation, and ovarian surgery, to cite just a few. It pays special attention to emerging procedures and technologies, including the use of robotics and the treatment of carcinoma. Of particular importance is the section on complications, which shows you how to recognize and avoid potential pitfalls. With more than 850 illustrations, most in full color, An Atlas of Operative Laparoscopy and Hysteroscopy, Second Edition is informative and thorough. As a reference, as a text, and as a surgical manual, it provides the grounding in current and emerging surgical techniques you need to stay at the top of your field.

Download or read book The Electrical Engineering Handbook Second Edition written by Richard C. Dorf and published by CRC Press. This book was released on 1997-09-26 with total page 2758 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1993, the first edition of The Electrical Engineering Handbook set a new standard for breadth and depth of coverage in an engineering reference work. Now, this classic has been substantially revised and updated to include the latest information on all the important topics in electrical engineering today. Every electrical engineer should have an opportunity to expand his expertise with this definitive guide. In a single volume, this handbook provides a complete reference to answer the questions encountered by practicing engineers in industry, government, or academia. This well-organized book is divided into 12 major sections that encompass the entire field of electrical engineering, including circuits, signal processing, electronics, electromagnetics, electrical effects and devices, and energy, and the emerging trends in the fields of communications, digital devices, computer engineering, systems, and biomedical engineering. A compendium of physical, chemical, material, and mathematical data completes this comprehensive resource. Every major topic is thoroughly covered and every important concept is defined, described, and illustrated. Conceptually challenging but carefully explained articles are equally valuable to the practicing engineer, researchers, and students. A distinguished advisory board and contributors including many of the leading authors, professors, and researchers in the field today assist noted author and professor Richard Dorf in offering complete coverage of this rapidly expanding field. No other single volume available today offers this combination of broad coverage and depth of exploration of the topics. The Electrical Engineering Handbook will be an invaluable resource for electrical engineers for years to come.

Download or read book Evangelical Millennialism in the Trans Atlantic World 1500 2000 written by C. Gribben and published by Springer. This book was released on 2015-12-04 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers the first complete overview of the intellectual history of one of the most significant contemporary cultural trends – the apocalyptic expectations of European and American evangelicals – in an account that guides readers into the origins, its evolution, and its revolutionary potential in the modern world.

Download or read book Annual Editions written by Thomas J. Badey and published by Dushkin/McGraw-Hill. This book was released on 2004-08 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides access to a range of selected articles from some of the respected magazines, newspapers, and journals published. This volume contains well-illustrated articles by sociologists, political scientists, researchers, and writers providing a useful perspective on important topics in the study of violence and terrorism.

Download or read book Hugo Grotius written by Henk J.M. Nellen and published by BRILL. This book was released on 2014-11-10 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hugo Grotius (1583-1645) is the most famous humanist scholar of the Dutch Golden Age. He wrote influential works on the laws of war and peace, Dutch history and the unification of the churches. His plea for a freedom of the seas in Mare liberum offered the Dutch East India Company a ready justification for the establishment of a trading empire in the East Indies. As far as his daily duties left him any spare time, he penned confidential, learned and beautifully-written letters. This voluminous correspondence offers a trove of information on Grotius’ life and works, and forms the basis of his newest biography which sketches a life caught in a fierce struggle for peace in Church and State.