Download or read book The Therapeutic Use of N Acetylcysteine NAC in Medicine written by Richard Eugene Frye and published by Springer. This book was released on 2018-09-20 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.

Download or read book Glutamate and Neuropsychiatric Disorders written by Zoran M. Pavlovic and published by Springer Nature. This book was released on 2022-04-10 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.

Download or read book Translational Medicine in the Diagnosis and Treatment of Cancer based on Oncogenetics From Bench to Bedside written by Changjing Cai and published by Frontiers Media SA. This book was released on 2023-12-07 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational medicine was first mentioned in 1992 by Choi D. W and has since become a rapidly expanding area within biomedical research. It is based on the ‘bench to bedside’ approach, which describes it’s relationship between basic science and clinical practice. In 2008, Drs Conway and Dougherty provided a 3 step process to translational medicine and how it should be implemented to transform healthcare systems. The first step is the translation of basic science into clinical research (T1). The second step (T2) focuses on making healthcare more patient specific, basing itself on providing ‘the right treatment for the right patient in the right way at the right time’. T2 also looks for this science to be translated into practice guidelines for clinicians, policy makers and the patients themselves. The final step (T3) addresses the ‘how’ of implementing these ideas, so that high quality healthcare can be delivered reliably to all patients in all settings of care. T3 activities would include policy changes that could serve to bring about meaningful change towards this goal. Cancer is a major public health problem worldwide. Clarifying the etiology and pathogenesis of cancer is of great significance to the prevention, diagnosis, and treatment of the disease. The bench to bedside pattern can be a useful method for cancer-related studies. This Research Topic aims to highlight the emerging role of oncogenetics in cancer, and discuss potential challenges of diagnosis and treatment, from the bench to the bedside.

Download or read book Handbook of Substance Misuse and Addictions written by Vinood B. Patel and published by Springer Nature. This book was released on 2022-10-17 with total page 3261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Substance misuse and addictions are a public health issue. They affect the well-being of each community and nation as a whole. It is, therefore, necessary to identify, educate, and treat individuals who are addicted to substances. Policies and procedures go hand-in-hand with public health education and safety. The science behind the public health issues of one drug may be applicable to other drugs as well. However, marshalling all of the aforementioned information into a single source is somewhat difficult due to the wide array of material. The Editors address this by compiling the research in this single reference work that serves as a "one-stop-shopping" approach to everything readers need to know about the scientific basis of public health and addictions and agents of misuse. Apart from active agents that have a plant or chemical basis, there is a need to consider that there are other forms of addiction which may have common modes of causality or prevention. These include food addiction, gaming, gambling, and other non-drug addictions. These types of addiction may be related to the addiction of drugs. The Handbook of Substance Misuse and Addictions: From Biology to Public Health offers a holistic understanding of the relationship between public health and substance misuse. The text provides a common platform upon which other forms of addiction or substance misuse can be understood and treated. Addiction processes involve understanding the biological processes as well as behavior, psychology, sociology, and public health, all of which are interlinked. This Handbook is a useful reference for lecturers, students, researchers, practitioners, and other professionals in public health, addiction science, epidemiology, health education, health promotion, and health sciences.

Download or read book Recent Advancements in Product Design and Manufacturing Systems written by B. B. V. L. Deepak and published by Springer Nature. This book was released on with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neuroimaging Approaches to the Study of Tinnitus and Hyperacusis written by Zhenchang Wang and published by Frontiers Media SA. This book was released on 2021-08-05 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Neurobiology and Treatment of OCD Accelerating Progress written by Naomi A. Fineberg and published by Springer Nature. This book was released on 2021-07-20 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book highlights important new research approaches of clinical relevance, written by prominent researchers in the field of OCD and related disorders. A broad range of topics is covered, beginning with a description of the phenotypic features of the OCD followed by chapters on developmental aspects, animal models, genetic and biological models including neuro-inflammation, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered including clinical and pharmacogenetic treatment models. In this way the volume brings together the key disciplines involved in the neurobiological understanding of OCD to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators and clinicians interested in the present state of OCD research.

Download or read book Neurocircuitry of Addiction written by Nicholas W. Gilpin and published by Academic Press. This book was released on 2022-11-29 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: People use drugs for many different reasons, including the pursuit of "high," social factors and self-medication of other conditions. Many millions of people are addicted to at least one substance, and the cost of addiction is immense, at both the individual and societal levels. Neurocircuitry of Addiction is the first book of its kind, with a focus on addiction neuroscience from a neural circuit perspective. This book begins with a primer on circuit-based neuroscience that equips the reader with an understanding of the applications described throughout the book. Each subsequent chapter positions a different brain region at the "center" of addiction neurocircuitry and goes on to describe the anatomical connectivity of that brain region, how those circuits are affected by drug exposure, and the role of those circuits in controlling addiction-related behaviors. All chapters of this book are written by content experts for a target audience that has some basic neuroscience background, but no prior in-depth knowledge regarding the neurocircuitry of addiction. - Reviews the circuit-based tools that are used by scientists to investigate neural circuit function - Describes how acute and chronic alcohol and drug exposure affect neural circuit function - Describes the state of the science regarding the role of specific neural circuis in drug addiction - Chapters include data from both human neuroscience and animal models

Download or read book Molecular mechanisms of substance abuse and its neurotoxicity written by Jie Yan and published by Frontiers Media SA. This book was released on 2023-01-13 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genome Editing Technologies for Crop Improvement written by Kaijun Zhao and published by Springer Nature. This book was released on 2022-08-01 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the relevant information related to genome editing tools and their roles in crop improvement. The book contains a brief introduction about various genome editing tools and their application in major crops. It discusses the genome editing approaches and the strategies used for genome editing in different crops. Some of the chapters cover the detailed methodology of sgRNA design, vector construction and transformation in different crops followed by data analysis. A few chapters focus on the applications of genome editing tools towards crop improvement. This book will be of particular interest to plant biologists working in the field of genome editing and crop breeders. It will provide valuable information and useful material for our readers’ experimental work.

Download or read book Peer Review of the Automatic Exchange of Financial Account Information 2023 Update written by OECD and published by OECD Publishing. This book was released on 2023-11-29 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report presents the latest conclusions of the peer reviews of the legal frameworks put in place by jurisdictions to implement the AEOI standard and two new initial effectiveness reviews. It supplements and builds upon the assessments of the legal frameworks and the initial reviews of the effectiveness of their implementation in practice published in 2022, for around 100 jurisdictions that were the first to commit to commence AEOI.

Download or read book Saving Species on Private Lands written by Lowell E. Baier and published by Rowman & Littlefield. This book was released on 2020-03-09 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner, Independent Press Award - Conservation/Green, 2021 The only hope for successful conservation of America’s threatened, endangered, and at-risk wildlife is through voluntary, cooperative partnerships that focus on private land, where over 75% of at-risk species can be found. Private landowners form the bedrock of these partnerships, and they have a long history of rising to meet the challenge of conservation. But they can’t do it alone. This book is a guide for private landowners who want to conserve wildlife. Whether engaged in farming, ranching, forestry, mining, energy development, or another business, private working lands all have value as wildlife habitat, with the proper management and financial support. This book provides landowners and their partners with a roadmap to achieve conservation compatible with their financial and personal goals. This book introduces the art and language of land management planning as well as regulatory compliance with laws such as the Endangered Species Act of 1973. It categorizes and explains the tools used by wildlife professionals to implement conservation on private lands. Moreover it documents the multitude of federal, state, local, and private opportunities for landowners to find financial and technical assistance in managing wildlife, from working with a local NGO to accessing the $6 billion per year available through the federal Farm Bill.

Download or read book Care Justice written by Nancy R. Hooyman and published by Taylor & Francis. This book was released on 2024-08-27 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book develops a care justice framework to critique and disrupt current policies and reframe a policy blueprint for elevating a just organization of care for unpaid family caregivers and underpaid home care workers assisting older adults. In doing so, Hooyman invites readers to envision a society that fully values the essential work of care. The book is distinctive in its analysis of the interrelationships among both types of care laborers, who often face structural constraints on their decision to care and whose work is devalued and marginalized. Their care work affects every member of society, but it is generally invisible to others, and its economic value is rarely recognized by policymakers. How care work is organized and unrewarded typically has the most financial, physical, and emotional costs for women, people of color, and immigrants across the life course. Inequities for care workers by race, immigrant status, class, and sexual orientation are rooted in systemic racism, sexism, classism, xenophobia, and homophobia. In this book, policy priorities and change strategies are reframed to attain the six core components of a care justice framework, which include fundamental structural changes to elevate care work, ensure meaningful choice to care, and reduce systemic inequities faced by care workers. This framework is informed by feminism, Black feminism, intersectionality, and care theory. By conceptualizing care justice, the author aims to stimulate new discourse and action related to the care of older adults – the most important work in society – and make the seemingly unattainable attainable. This timely book will be salient to anyone committed to diversity, equity, and inclusion and with an interest in policy, gerontology, disability studies, ethnic studies, feminist studies, social justice, social work, and social welfare.

Download or read book Reimagining Singapore written by Chee-Hoo Lum and published by Springer Nature. This book was released on 2023-08-01 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book approaches the subject of contemporary art by exploring the social embeddedness and identities of Singaporean artists. Linking artistic processes and production to both personal worlds and wider issues, the book examines how artists negotiate their relationships between self and society and between artistic freedom and social responsibility. It is based on original research into the discourses and artistic practices of local artists, with a special focus on emerging artists and artists whose work and perspectives engage with questions of identity. Reimagining contemporary Singapore and their place within it, artists are asserting their multiple and heterogeneous self-identities and contesting hegemonic norms and notions, as they negotiate and adapt to the world around them. This book is relevant to students and researchers in the fields of cultural studies, media studies, art, sociology of art, arts education, and race and ethnicity studies.

Download or read book The Oxford Handbook of Nonsuicidal Self Injury written by Elizabeth Lloyd-Richardson and published by Oxford University Press. This book was released on 2024-05-06 with total page 1297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Handbook of Nonsuicidal Self-Injury is a compendium of up-to-date research and knowledge of topics germane to the field of nonsuicidal self-injury (NSSI). Edited by renowned scholars Elizabeth E. Lloyd-Richardson, Imke Baetens, and Janis L. Whitlock, the handbook brings together cutting-edge research from a group of internationally distinguished scholars. It covers a wide array of topics including epidemiology, function, neurophysiological processes, lived experience, and intervention and prevention approaches. This comprehensive text will serve as a go-to guide for scholars, clinicians, and anyone with interest in understanding, treating, and preventing self-injury.

Download or read book Oxidative Stress Antioxidants Transcription Factors and Assimilation of Signal Transduction Pathways in Obesity Related Disorders written by Terry D. Hinds, Jr and published by Frontiers Media SA. This book was released on 2021-10-21 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editors Terry Hinds and David Stec have submitted patents related to bilirubin and obesity related disorders. The other Topic Editor declare no potential conflicts of interest with regards to the Research Topic subject.

Download or read book Neuroscience Research and Textbook 2 written by Aliasghar Tabatabaei Mohammadi and published by Nobel TM. This book was released on 2022-11-10 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research and textbook about new advances in neuroscience.