Download or read book Mutant Unveiled written by Mel Teshco and published by Mel Teshco. This book was released on 2020-10-02 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: A mutant tortured and barely alive. A woman restrained by a society she no longer trusts. When Khalisa first sets eyes on the barely conscious mutant, Zielle, she isn’t prepared for the anguish within at seeing firsthand what the scientists in the Dome’s facility are doing to the ‘monsters’ who live outside the air-cleansed compound. But then she’s always rebelled against the rules. Always questioned and defied everything she’s been told since she and her brother, Dwight, were captured and saved from outside, where the chemical fallout would have turned them mutant too. What she and her brother don’t know is that they are dormant mutants whose powers are yet to be triggered. They are also the last hope of saving a mutant clan, whose leader, Zielle, volunteers to be captured by the evil humans so that he can find and rescue the mutant siblings. But it’s only Khalisa he can free, and on the run from the humans who’d do anything possible to recapture them, he has to convince Khalisa that he’s on her side…and that the sizzling chemistry between them is just an added bonus.
Download or read book The Queen written by Mel Teshco and published by Mel Teshco. This book was released on 2020-10-02 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dragons have searched the universe to find their one true mate… Twelve months has been and gone. The Riddich dragons are finally reunited and have brought with them their Earth mates. All too soon they form a plan with their unlikely, newfound friends. They'll land on the icy planet of Tantonic, their mission: to kill the evil Tantonic Queen and her soldiers, and release any surviving prisoners. But can the heat loving Riddich Dragons survive the cold and outwit the vicious Tantonic Queen who all but wiped out their mighty race? Or will they perish, or worse, be drained of their powers before they've even had a chance to avenge their fallen people?
Download or read book Kinomics written by Heinz-Bernhard Kraatz and published by John Wiley & Sons. This book was released on 2015-08-11 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by the world's leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field. Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown. The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.
Download or read book Rb and Tumorigenesis written by Maurizio Fanciulli and published by Springer Science & Business Media. This book was released on 2007-02-26 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rb and Tumorigenesis examines how recent advances have demonstrated the interaction of Rb with chromatin remodeling enzymes. This new title explores the potential roles of these interactions in Rb functions and provides some evidence that distinct Rb co-repressor may target different genes in different phases of the cell cycle. This book will interest cell biologists, graduate students and researchers.
Download or read book Molecular Biology written by Abraham Marcus and published by Elsevier. This book was released on 1989-01-01 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biochemistry of Plants, Volume 15: Molecular Biology presents information pertinent to gene expression, cytoskeletal proteins, and hydroxyproline-rich glycoprotein. This book discusses the specific gene systems and examines the regulatory regions within the genes. Organized into 17 chapters, this volume starts with an overview of the important mechanism for regulating gene expression, which is significant in the selective turnover of gene products. This book then proceeds with a discussion of the concept of protein degradation and the extracellular carriers of genetic information. Other chapters review the viral and plasmid systems, which are relevant to plants. This text discusses as well the phenotypic changes in plants, including plant genetic tumor and habituated plant tissues that exhibit hormone autotrophic growth. The final chapter examines the importance of genetic manipulation at the cellular level via protoplast fusion, cell selection, and transformation. Biologists, biochemists, enzymologists, biophysicists, and plant scientists will find this book extremely useful.
Download or read book Antiviral Drug Development written by Erik De Clercq and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Epigenetics and Disease written by Susan M. Gasser and published by Springer Science & Business Media. This book was released on 2010-10-17 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.
Download or read book The Developmental Basis of Quantitative Genetic Variation Revealed by the Maize Mutant Polymitotic written by David Paul West and published by . This book was released on 1986 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics of Bacteria written by Sheela Srivastava and published by Springer Science & Business Media. This book was released on 2013-05-21 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Described as the earliest, simplest life forms, with unlimited metabolic versatility, bacteria are ideally suited to answer some very fundamental questions on life and its processes. They have been employed in almost all fields of biological studies, including Genetics. The whole edifice of science of Genetics centers around three processes: the generation, expression, and transmission of biological variation, and bacteria offer immediate advantages in studying all the three aspects of heredity. Being haploid and structurally simple, it becomes easy to isolate mutations of various kinds and relate them to a function. The availability of such mutants and their detailed genetic and biochemical analyses lead to a gamut of information on gene expression and its regulation. While studying the transmission of biological variation, it is clear that unlike their eukaryotic counterpart, a more genetic approach needs to be employed. Transmission of genetic information in most eukaryotic organisms rests on sexual reproduction that allows the generation of genetically variable offspring through the process of gene recombination. Even though bacteria show an apparent preference for asexual reproduction, they too have evolved mechanisms to trade their genetic material. In fact, bacteria not only could acquire many genes from close relatives, but also from entirely distant members through the process of horizontal gene transfer. Their success story of long evolutionary existence will stand testimony to these mechanisms. While teaching a course on Microbial Genetics to the post-graduate students at Delhi University, it was realized that a book devoted to bacterial genetics may be very handy to the students, researchers, and teachers alike. A strong foundation in genetics also helps in comprehending more modern concepts of molecular biology and recombinant DNA technology, always a favorite with the students and researchers. Planning the format of the book, emphasis has been laid on the generation and transmission of biological variability. The omission of expression part is indeed intentional because lots of information is available on this aspect in any modern biology book. The contents are spread over seven chapters and the text is supported with figures/tables wherever possible. The endeavor has been to induce the readers to appreciate the strength of bacterial genetics and realize the contribution of these tiny organisms to the growth of biological sciences as a whole and genetics in particular.
Download or read book Genes Involved in Microbe Plant Interactions written by D.P.S. Verma and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interdependence between species is a law of nature. The degree of this interdependence is vividly evident in the plant-microbial world. Indeed, there is no axenic plant in nature and one finds various forms of interac tions between these two kingdoms ranging from completely innocuous to obligate parasitic. Most of these interactions are poorly understood at the molecular and physiological levels. Only those few cases for which a molecular picture is emerging are discussed in this volume. With the advent of recombinant DNA technology and the realization that some of these interactions are very beneficial to the host plant, a spate of activity to understand and manipulate these processes is occurring. Microbes interact with plants for nutrition. In spite of the large number of plant-microbe interactions, those microbes that cause harm to the plants (i. e. , cause disease) are very few. It is thus obvious that plants have evolved various defense mechanisms to deal with the microbial world. The mecha nisms for protection are highly diverse and poorly understood. Some pathogens have developed very sophisticated mechanisms to parasitize plants, an excellent example for this being crown gall caused by a soil bac terium, Agrobacterium tumefaciens. A remarkable ingenuity is exhibited by this bacterium to manipulate its host to provide nitrogenous compounds which only this bacterium can catabolize. This is carried out by a direct gene transfer mechanism from bacteria to plants.
Download or read book Pediatric Nephrology written by Ellis D. Avner and published by Springer Science & Business Media. This book was released on 2009-08-20 with total page 2059 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.
Download or read book Understanding the Molecular Mechanisms of Plant Responses to Abiotic Stress written by Sang Yeol Lee and published by Frontiers Media SA. This book was released on 2020-02-20 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant responses to environmental stress are governed by complex molecular and biochemical signal transduction processes, which act in coordination to determine tolerance or sensitivity at the whole plant level. Upon exposure to abiotic stress, plants express a sophisticated coordinated response to reprogram interconnected defense networks and metabolic pathways, by alterations in the transcription, translation, and post-translational modification of defense-related genes and proteins. Traditionally, physiological and phenotypic responses were the major ones to be collected in plant stress biology. However, modern studies include the identification of key genes that influence stress tolerance and plant growth under the imposing stress and the verification of gene functions using knock out mutants or overexpression lines. In addition, genomics has become a necessary tool for the understanding of plant stress responses at the whole genome levels. The identification of stress-tolerant plant resources and the investigation of the functional role of the genetic variants is also a valuable tool in this research field. Recently, the advent of CRISPR/Cas genome editing technology, enables these variations to be introduced in crops for improved stress tolerance traits. Through the understanding of the molecular mechanisms involved in plant signaling in response to abiotic stress and crop performance characters under stress conditions, we hope to open new ways for the breeding of superior crops.
Download or read book Calcium A Matter of Life or Death written by and published by Elsevier. This book was released on 2007-09-17 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium is a versatile carrier of signals regulating many aspects of cellular activity such as fertilization to create a new life and programmed cell death to end it. Calcium homeostasis is strictly controlled by channels, pumps and exchangers functioning as gates for calcium entry and release. Given that calcium is such a versatile messenger the field of calcium signaling is continuously and rapidly expanding. This book reviews the most recent developments in calcium signaling by leading experts in the field. It is a state-of-the-art summary of our present knowledge in this quickly growing field and provides insight into the impressive progress made in many areas of calcium signaling, while reminding us of how much remains to be learned.
Download or read book Comprehensive Natural Products II written by and published by Elsevier. This book was released on 2010-03-05 with total page 7944 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas among the established natural products research community—which includes chemists, biochemists, biologists, botanists, and pharmacologists Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats Includes 100% new content, with more than 6,000 figures (1/3 of these in color) and 40,000 references to the primary literature, for a thorough examination of the field Highlights new research and innovations concerning living organisms and their distinctive role in our understanding and improvement of human health, genomics, ecology/environment, and more Adds to the rich body of work that is the first edition, which will be available for the first time in a convenient online format giving researchers complete access to authoritative Natural Products content
Download or read book Research Advances in the Study of Campylobacter Helicobacter Related Organisms written by D Scott Merrell and published by Frontiers E-books. This book was released on with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Campylobacter spp and Helicobacter spp are gastrointestinal pathogens that remain a major cause of acute gastroenteritis and gastric disease, respectively. The 16th International Workshop on Campylobacter, Helicobacter and Related Organisms (CHRO) will be held in Vancouver, British Columbia Canada from August 28-September 1, 2011 and will highlight recent advances in our understanding of the epidemiology, survival mechanisms, host response and pathogenesis of these important species. This Research Topic issue will highlight each of these topics and will attempt to shed insight into our growing understanding of the process of host-pathogen interactions as it relates to Campylobacter and Helicobacter.
Download or read book Therapeutic Targets in Airway Inflammation written by N. Tony Eissa and published by CRC Press. This book was released on 2003-05-13 with total page 998 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction
Download or read book Cell Adhesion and Migration in the Development of Multicellular Organisms written by Takaaki Matsui and published by Frontiers Media SA. This book was released on 2019-01-24 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: During development, cells are generated at specific locations within the embryo and then migrate into their destinations. At their destinations, they assemble together through cell adhesions, eventually leading to the formation of tissues and organs. In some cases, orchestration of cell adhesion and migration produces the global movement of cell groups, called collective cell migration, which is also required for the development of basic tissue structures such as spheres, clusters, and vesicles in the morphogenetic processes of development. Therefore, individual regulation and orchestration of cell adhesion and migration are quite important for appropriate tissue/organ formation during development. However, how cell adhesion and migration are regulated, and orchestrated during development? How cell adhesion and migration affects tissue formation during development? To answer these questions, we assembled several review and research articles in this eBook. By assembling these articles, we could explore the presence of core regulatory mechanisms and deepen the current understanding of cell adhesion and migration during the development of multicellular organisms.
