Download or read book Multiparametric Statistics written by Vadim Ivanovich Serdobolskii and published by Elsevier. This book was released on 2007-10-18 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph presents mathematical theory of statistical models described by the essentially large number of unknown parameters, comparable with sample size but can also be much larger. In this meaning, the proposed theory can be called "essentially multiparametric". It is developed on the basis of the Kolmogorov asymptotic approach in which sample size increases along with the number of unknown parameters.This theory opens a way for solution of central problems of multivariate statistics, which up until now have not been solved. Traditional statistical methods based on the idea of an infinite sampling often break down in the solution of real problems, and, dependent on data, can be inefficient, unstable and even not applicable. In this situation, practical statisticians are forced to use various heuristic methods in the hope the will find a satisfactory solution.Mathematical theory developed in this book presents a regular technique for implementing new, more efficient versions of statistical procedures. Near exact solutions are constructed for a number of concrete multi-dimensional problems: estimation of expectation vectors, regression and discriminant analysis, and for the solution to large systems of empiric linear algebraic equations. It is remarkable that these solutions prove to be not only non-degenerating and always stable, but also near exact within a wide class of populations.In the conventional situation of small dimension and large sample size these new solutions far surpass the classical, commonly used consistent ones. It can be expected in the near future, for the most part, traditional multivariate statistical software will be replaced by the always reliable and more efficient versions of statistical procedures implemented by the technology described in this book.This monograph will be of interest to a variety of specialists working with the theory of statistical methods and its applications. Mathematicians would find new classes of urgent problems to be solved in their own regions. Specialists in applied statistics creating statistical packages will be interested in more efficient methods proposed in the book. Advantages of these methods are obvious: the user is liberated from the permanent uncertainty of possible instability and inefficiency and gets algorithms with unimprovable accuracy and guaranteed for a wide class of distributions.A large community of specialists applying statistical methods to real data will find a number of always stable highly accurate versions of algorithms that will help them to better solve their scientific or economic problems. Students and postgraduates will be interested in this book as it will help them get at the foremost frontier of modern statistical science.- Presents original mathematical investigations and open a new branch of mathematical statistics- Illustrates a technique for developing always stable and efficient versions of multivariate statistical analysis for large-dimensional problems - Describes the most popular methods some near exact solutions; including algorithms of non-degenerating large-dimensional discriminant and regression analysis

Download or read book An Introduction to Applied Multivariate Analysis with R written by Brian Everitt and published by Springer Science & Business Media. This book was released on 2011-04-23 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The majority of data sets collected by researchers in all disciplines are multivariate, meaning that several measurements, observations, or recordings are taken on each of the units in the data set. These units might be human subjects, archaeological artifacts, countries, or a vast variety of other things. In a few cases, it may be sensible to isolate each variable and study it separately, but in most instances all the variables need to be examined simultaneously in order to fully grasp the structure and key features of the data. For this purpose, one or another method of multivariate analysis might be helpful, and it is with such methods that this book is largely concerned. Multivariate analysis includes methods both for describing and exploring such data and for making formal inferences about them. The aim of all the techniques is, in general sense, to display or extract the signal in the data in the presence of noise and to find out what the data show us in the midst of their apparent chaos. An Introduction to Applied Multivariate Analysis with R explores the correct application of these methods so as to extract as much information as possible from the data at hand, particularly as some type of graphical representation, via the R software. Throughout the book, the authors give many examples of R code used to apply the multivariate techniques to multivariate data.

Download or read book Living Without Mathematical Statistics written by Herbert Ruefer and published by Springer. This book was released on 2018-09-28 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: The underlying principles invented and developed by Dr. Genichi Taguchi (1924 - 2012), for the design of experiments or simulation calculations in multi-parameter systems, are today known as Taguchi Method. Due to the great success, it was extended to many other areas. The book explains the basics of this method in as much detail as necessary and as simply and graphically as possible. The author shows how broad the current application spectrum is and for which different tasks it can be used. The application examples range from optimizing a fermentation process in biotechnology to minimizing costs in mechanical production and maintaining and improving competitiveness in industrial production. The processes described are ideally suited to finding reliable and precise solutions for a wide variety of problems relatively quickly. A real competitive advantage not only in research but also for companies that want to remain competitive in international business competition. Contents Part 1: Analysis of Variables Part 2: Pattern Recognition and Diagnosis Part 3: Prognosis Target groups Students, scientists, engineers or those responsible for development and products learn to use the Taguchi Method with this book - even without any previous mathematical-statistical knowledge. The author Herbert Ruefer studied physics and obtained his doctorate at the Technical University Karlsruhe, Germany. After a research stay at IBM, San Jose, California, he taught at the San Marcos National University in Lima, Peru. He then took on research, development, and training tasks in the chemical industry in Germany. During this time, the first personal contacts with Dr. Genichi Taguchi and Dr. Yuin Wu took place. After his active professional life, he dedicated himself to special optical methods for astronomical observations. He also lectures at the Universidad Nacional Mayor de San Marcos which awarded him an honorary doctorate in 2017.

Download or read book Advanced Statistics For Health Research written by Richard J Butler and published by World Scientific. This book was released on 2023-04-11 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Statistics for Health Research provides a rigorous geometric understanding of models used in the analysis of health data, including linear and non-linear regression models, and supervised machine learning models. Models drawn from the health literature include: ordinary least squares, two-stage least squares, probits, logits, Cox regressions, duration modeling, quantile regression and random forest regression. Causal inference techniques from the health literature are presented including randomization, matching and propensity score matching, differences-in-differences, instrumental variables, regression discontinuity, and fixed effects analysis. Codes for the respective statistical techniques presented are given for STATA, SAS and R.

Download or read book Simultaneous multiparametric and multidimensional cardiovascular magnetic resonance imaging written by Aleksandra Radjenovic and published by Frontiers Media SA. This book was released on 2023-06-30 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Flexible Imputation of Missing Data Second Edition written by Stef van Buuren and published by CRC Press. This book was released on 2018-07-17 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between these replacements reflects our ignorance of the true (but missing) value. Each of the completed data set is then analyzed by standard methods, and the results are pooled to obtain unbiased estimates with correct confidence intervals. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing-data problem. This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the MICE package as developed by the author. This new edition incorporates the recent developments in this fast-moving field. This class-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by verbal statements that explain the formula in accessible terms. The book sharpens the reader’s intuition on how to think about missing data, and provides all the tools needed to execute a well-grounded quantitative analysis in the presence of missing data.

Download or read book Measurement Techniques Platforms and Sensors written by and published by Academic Press. This book was released on 2009-08-26 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elements of Physical Oceanography is a derivative of the Encyclopedia of Ocean Sciences, Second Edition and serves as an important reference on current physical oceanography knowledge and expertise in one convenient and accessible source. Its selection of articles—all written by experts in their field—focuses on ocean physics, air-sea transfers, waves, mixing, ice, and the processes of transfer of properties such as heat, salinity, momentum and dissolved gases, within and into the ocean. Elements of Physical Oceanography serves as an ideal reference for topical research. References related articles in physical oceanography to facilitate further research Richly illustrated with figures and tables that aid in understanding key concepts Includes an introductory overview and then explores each topic in detail, making it useful to experts and graduate-level researchers Topical arrangement makes it the perfect desk reference

Download or read book Introduction to the Science of Medical Imaging written by R. Nick Bryan and published by Cambridge University Press. This book was released on 2010 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This landmark text from world-leading radiologist describes and illustrates how imaging techniques are created, analyzed and applied to biomedical problems.

Download or read book High Throughput Screening Methods written by Joshua A Bittker and published by Royal Society of Chemistry. This book was released on 2016-12-05 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.

Download or read book Uncertainty aware Integration of Control with Process Operations and Multi parametric Programming Under Global Uncertainty written by Vassilis M. Charitopoulos and published by Springer Nature. This book was released on 2020-02-05 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces models and methodologies that can be employed towards making the Industry 4.0 vision a reality within the process industries, and at the same time investigates the impact of uncertainties in such highly integrated settings. Advances in computing power along with the widespread availability of data have led process industries to consider a new paradigm for automated and more efficient operations. The book presents a theoretically proven optimal solution to multi-parametric linear and mixed-integer linear programs and efficient solutions to problems such as process scheduling and design under global uncertainty. It also proposes a systematic framework for the uncertainty-aware integration of planning, scheduling and control, based on the judicious coupling of reactive and proactive methods. Using these developments, the book demonstrates how the integration of different decision-making layers and their simultaneous optimisation can enhance industrial process operations and their economic resilience in the face of uncertainty.

Download or read book Spectral Techniques In Proteomics written by Daniel S. Sem and published by CRC Press. This book was released on 2007-03-30 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Facilitating the innovation, development, and application of new spectroscopic methods in proteomics, Spectral Techniques in Proteomics provides a broad overview of the spectroscopic toolbox that can be used, either with proteome or sub-proteome mixtures or with individual/purified proteins studied in parallel. It gives a modest overview of

Download or read book Principles of Data Mining and Knowledge Discovery written by Jan Komorowski and published by Springer Science & Business Media. This book was released on 1997-06-13 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the First European Symposium on Principles of Data Mining and Knowledge Discovery, PKDD '97, held in Trondheim, Norway, in June 1997. The volume presents a total of 38 revised full papers together with abstracts of one invited talk and four tutorials. Among the topics covered are data and knowledge representation, statistical and probabilistic methods, logic-based approaches, man-machine interaction aspects, AI contributions, high performance computing support, machine learning, automated scientific discovery, quality assessment, and applications.

Download or read book Innate Immune Cell Therapy of Cancer written by Asha B. Pillai and published by Frontiers Media SA. This book was released on 2023-09-13 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.

Download or read book Data science and digital service delivery in healthcare written by Koichi Fujiwara and published by Frontiers Media SA. This book was released on 2023-02-07 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Medicinal Chemistry III written by and published by Elsevier. This book was released on 2017-06-03 with total page 4609 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Download or read book 11th international meeting on visualizing biological data VIZBI 2021 written by Sean O’Donoghue and published by Frontiers Media SA. This book was released on 2022-12-16 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book 6th International Conference on Nanotechnologies and Biomedical Engineering written by Victor Sontea and published by Springer Nature. This book was released on 2023-10-15 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reports on advances in fundamental and applied research at the interface between nanotechnology and biomedical engineering. Gathering peer-reviewed contributions to the 6th International Conference on Nanotechnologies and Biomedical Engineering, ICNBME held on September 20-23, 2023, in Chisinau, Republic of Moldova, this second volume of the proceedings focuses on clinical engineering and instrumentation, bioinformatics, image and signal processing techniques, and new technologies for medical diagnosis, treatment and personalised medicine. With a good balance of theory and practice, the book offers a timely snapshot of multidisciplinary research at the interface between physics, chemistry, biomedicine, materials science, and engineering.