Download or read book Mucoadhesive Materials and Drug Delivery Systems written by Vitaliy V. Khutoryanskiy and published by John Wiley & Sons. This book was released on 2014-06-12 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mucoadhesion defined as attachment of synthetic or natural materials to mucosal tissues has been widely exploited in pharmaceutical forms. This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems. The introductory section describes the structure and physiology of various mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). This is followed by chapters on the various methods used to study mucoadhesion and to characterise mucoadhesive properties of various dosage forms. The final section will summarise information on traditional and novel types of mucoadhesive materials, such as chitosan, thiomers, and liposome-based formulations. This book is unique as there is currently no modern book considering mucoadhesion - all other existing books on the topic are either narrowly focused or more than 10 years old. Furthermore, each contributor offers specialist perspectives from a variety of global locations in both industrial and academic research centres.
Download or read book Bioadhesive Drug Delivery Systems written by Edith Mathiowitz and published by CRC Press. This book was released on 1999-07-13 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs. Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport! Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles describes vaginal, nasal, buccal, ocular, and transdermal drug delivery reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts explores issues of product development, clinical testing, and production and more! Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.
Download or read book Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery written by Vitaliy V. Khutoryanskiy and published by MDPI. This book was released on 2020-04-22 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mucoadhesive polymers are widely used in the design of dosage forms for transmucosal drug delivery to the eye, respiratory, gastrointestinal and reproductive tracts. These routes of drug administration offer a number of advantages including improved drug bioavailability, reduced frequency of administration, and the avoidance for the use of injections. This book represents a collection of reviews and original research articles in the area of mucoadhesive polymers and dosage forms. It covers the design of mucoadhesive forms from commercially-available water-soluble polymers, their mixture and complexes as well as some materials, whose mucoadhesive properties were enhanced through chemical modification. With contributions from leading experts in mucoadhesive polymers and formulations, this book will be a very useful source of information for researchers in polymer, pharmaceutical and formulation sciences.
Download or read book Oral Mucosal Drug Delivery and Therapy written by Michael J. Rathbone and published by Springer. This book was released on 2015-03-13 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods. In 11 authoritative chapters, the book affords an in-depth evaluation of the major issues associated with this route of administration, namely the retention of the drug/product at the site of administration and increasing drug permeability through the oral mucosa. The book provides insights into the in vitro and in vivo methods available to assess drug permeability and retention, offers solutions on how to improve the permeation of the drugs through the oral mucosa, and explores approaches to prolong drug/product retention at the site of administration. It also indicates future directions in research and product development. Oral Mucosal Drug Delivery and Therapy is a key resource for those wishing to extend their knowledge of this field.
Download or read book Bioadhesives in Drug Delivery written by K. L. Mittal and published by John Wiley & Sons. This book was released on 2020-05-26 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important and unique book comprises 12 chapters divided into three parts examining the fundamental aspects, bioadhesive formulations, and drug delivery applications. Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; bioadhesive hydrogels and applications; ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.
Download or read book Mucoadhesive Drug Delivery Systems written by Pranshu Tangri and published by LAP Lambert Academic Publishing. This book was released on 2012-08 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on defining the principles of bioadhesive delivery systems based on hydrogels to biological surfaces that are covered by mucus. An overview of the last decade's discoveries on mucoadhesion and applications of mucoadhesive hydrogels as drug carriers is given. Techniques that are frequently used to study the adhesion forces and physicochemical linteractions between hydrogel, mucus, and the underlying mucosa are reviewed. Typical examples of applications of mucoadhesive hydrogels to mucosal routes of delivery are given. Finally, the perspectives of the application of these polymers in drug delivery are discussed.
Download or read book Mucoadhesive Materials for Drug Delivery written by Graham Hunt and published by . This book was released on 1988 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mussel inspired Mucoadhesive Hydrogels for Drug Delivery written by Jinke Xu and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "A controlled drug delivery system can deliver a drug with the right dose, control its release rate and time, and target the site of action in the body. Chitosan (CS) and its derivatives have been extensively used in drug delivery. Additionally, CS is mildly mucoadhesive, i.e. it can stick to mucus. Many drug delivery routes such as oral, buccal, and rectal delivery exploit the presence of a mucosa to deliver the drug. Drug delivery systems made from mucoadhesive materials can stick to the mucosa, thus prolonging the retention of drugs on site and allowing a sustained release of the loaded drugs. CS-based mucoadhesive drug delivery systems have shown improved therapeutic effects in many applications.Recently, the strong adhesion of marine mussels under the sea inspired the development of several water-resistant adhesives. The catechol groups present in large amount in the mussel adhesive proteins contribute to the outstanding adhesion of mussels on many different surfaces. Catechols also interact with biological surfaces, including mucus. These findings inspired us to use catechol-CS mucoadhesive systems to facilitate drug delivery. This was the first time that catechol groups were used to improve the mucoadhesion and thus the efficacy of a drug delivery system.In this work, we developed three types of catechol-containing CS hydrogels as mucoadhesive drug delivery systems for oral, buccal and rectal drug delivery. We introduced catechols into CS hydrogels by simple physical mixing or covalent conjugation. We assessed the efficacy of catechol-containing hydrogels as drug delivery systems and their mucoadhesion both in vitro and in vivo.Our first study showed that simple physical mixing of hydrocaffeic acid in CS-based hydrogels enhanced the mucoadhesion of the gels. The electrostatic interaction between hydrocaffeic acid and CS caused a slow release of this molecule from the CS hydrogel, and enhanced the adhesion of CS on mucus. The mucoadhesion of this hydrogel can be further increased in the presence of oxidizing agents during the contact with mucin. However, if the gel is oxidized before contacting mucin, there is no mucoadhesion enhancement. In our second study we developed a chemically conjugated catechol-CS (Cat-CS) hydrogel crosslinked by genipin. In this case, the immobilized catechols were not released from the gel. This system showed good mechanical properties and great mucoadhesion both in vitro and in vivo. Using this mucoadhesive hydrogel, we succeeded in delivering lidocaine to rabbits through the buccal mucosa. Differently from gels made with unmodified CS, this system established an intimate contact with the rabbit buccal mucosa, achieved a sustained release of the drug, and maintained the drug concentration in the blood at a relatively high level during the 2 h experiment.In our third study we developed an injectable sulfasalazine (SSZ) loaded Cat-CS hydrogel formulation for rectal treatment of ulcerative colitis (UC). In UC mice, rectal SSZ/Cat-CS formulation showed better therapeutic effects with only 50% of the normal oral dose. Most importantly, this formulation reduced the plasma levels of the SSZ metabolite sulfapyridine, which is associated with many side effects of SSZ and toxicity. Thus, these results proved the great potential of mucoadhesive SSZ/Cat-CS rectal formulation in UC treatment. Overall, we developed mussel-inspired catechol-containing CS hydrogels that improved the mucoadhesion and thus the drug efficacy and therapeutic effects in drug delivery." --
Download or read book Mucoadhesive Drug Delivery System written by Avinash Hosmani and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the recent days, the technology of Mucoadhesive drug delivery system has gained so much attention from the researchers in the field of formulation development. The drug delivery system enables the formulator to bring the drug in the close proximity to the mucus membrane with enhanced contact time and contact area. Thus the technology has been successful to bring out benefits like bio-availability enhancement along with the extended release. The book gives the idea about the basic fundamentals of Mucoadhesive systems. From the presented work, one may get information about the properties of mucoadhesive polymers. One may study the formulation of different mucoadhesive drug delivery systems like tablet, suspension and microsphere.
Download or read book Mucoadhesive Drug Delivery Systems Using Optimized Polymer Blends written by Bhupinder Singh and published by LAP Lambert Academic Publishing. This book was released on 2010-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work embodies development and systematic optimization of oral controlled release (CR) mucoadhesive hydrophilic matrices of atenolol using "Design of Experiments". A central composite design was used to optimize drug release profile and bioadhesive strength. Two polymers, namely, Carbopol 934P and sodium CMC, were taken as synergistic factors. The 3-D response surfaces and 2-D contour plots indicated significant effect of both the polymers on ex vivo bioadhesive strength of tablet against porcine gastric mucosa, diffusional release exponent and drug release extension. The optimized drug delivery formulation was selected by feasibility and grid searches based on maximization of the response variables. Validation of drug delivery optimization study using experimental runs indicated high prognostic ability of the chosen experimental design. Besides unraveling the effect of the two factors on various response variables, the study helped in finding the "optimized" formulation with excellent bioadhesive strength and extended release for 24 h, holding immense promise for once-a-day gastroretentive CR formulation and minimizing fluctuations in plasma drug levels.
Download or read book Drug Delivery written by Eric P. Holowka and published by Springer. This book was released on 2014-11-22 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on “Engineering Concepts” reviews the relevant fundamental principles that guide rational design. The following section on “Materials Design” discusses how the design process applies engineering concepts for use in physiological systems. A third section on “Implementation” discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on “Clinical Applications” which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. · Provides a comprehensive description of drug delivery systems from a materials perspective · Includes a wide-ranging discussion of clinical applications of drug delivery systems · Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. · Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type
Download or read book Chemical Aspects of Drug Delivery Systems written by D R Karsa and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite advances in the development of new drugs, a drug may never reach the target organ, or it may be difficult to achieve the necessary level of drug in the body. Large doses can result in serious side effects and can harm normal, as well as diseased, cells and organs, and for this reason it is vital that controlled release and the targeting of delivery systems must evolve in parallel to drug research. Chemical Aspects of Drug Delivery Systems reflects the modern challenge to devise effective drug delivery and targeting systems, giving particular emphasis to recent innovations in the field. Delivery systems described include carbohydrate derivatives, novel nonionic surfactant vesicles and various polymers, including polyacrylates and aqueous shellac solutions, as well as hydrogels. In addition, many of the key issues, such as the understanding of biosystems and targets and the development of materials to provide the deserved carrier and excipient properties for controlled, targeted drug delivery, are considered in depth. This book will be of equal interest to undergraduate, graduate, researcher and those in the pharmaceutical industries, and it complements two previous RSC Special Publications, Encapsulation and Controlled Release and Excipients and Delivery Systems for Pharmaceutical Formulations.
Download or read book Mucoadhesive Nanoparticulate Drug Delivery Systems written by Akhlesh Kumar Singhai and published by LAP Lambert Academic Publishing. This book was released on 2011-10 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant efforts have been devoted to use the potentials of nanotechnology in drug delivery since it offers a suitable means of site-specific and/or time controlled delivery of small or large molecular weight drugs and other bioactive agents.Pharmaceutical nanotechnology focuses on formulating therapeutically active agents in biocompatible nano forms, These systems offer many advantages in drug delivery, mainly focusing on improved safety and efficacy of the drugs, e.g. providing targeted delivery of drugs, improving bioavailability, extending drug or gene effect in target tissue, and improving the stability of therapeutic agents against chemical or enzymatic degradation. Mucoadhesive nanoparticulate Drug Delivery System prolongs the residence time of dosage form at the site of application or absorption. They facilitate an intimate contact of the dosage form with the underlying absorption surface and thus improve the therapeutic performance of the drug. This book is an effort to provide information on such mucoadhesive drug delivery systems that are developed for oral, buccal, nasal, rectal and vaginal routes for both systemic and local effect.
Download or read book Sustained Release Mucoadhesive Microparticles Drug Delivery System written by Suryakanta Swain and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mucoadhesive drug delivery system has received great deal of attention over the past few decades. The major advantages of this system are to prolong the drug residence at a specific site of delivery and solve bioavailability problems. The major focus of this book is to explain the current research tools for designing of mucoadhesive microparticles of rabeprazole sodium and tolterodine tartrate by non-aqueous solvent evaporation technique using ethylcellulose and selected mucoadhesive polymers. The prepared microparticles of the above drugs were characterized for particle size, drug content, swelling index, mucoadhesive strength etc. In-vitro drug release study for both drugs suggested that formulation containing tolterodine tartrate with ethylcellulose based chitosan and rabeprazole sodium with ethylcellulose based HPMC K100M showed consistent drug release up to 24h. Accelerated stability study of optimized formulations such as F4 and F6c up to 6 and 3 months respectively.
Download or read book Nanopharmaceutical Advanced Delivery Systems written by Vivek Dave and published by John Wiley & Sons. This book was released on 2020-12-29 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.
Download or read book Fundamentals of Drug Delivery written by Michael S. Roberts and published by John Wiley & Sons. This book was released on 2021-09-30 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.
Download or read book Novel Drug Delivery Systems and Regulatory Affairs written by Sudhakar Yajaman & Jayaveera K.N. and published by S. Chand Publishing. This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Drug Delivery Systems | Transdermal Drug Delivery Systems | Mucoadhesive Drug Delivery Systems | Targeted Drugdelivery Systems | Regulatory Agencies | Quality Assurance | Good Manufacturing Practices | Validation
