Download or read book The Melanocortin System written by Roger D. Cone and published by . This book was released on 2003 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the decade before the publication of this study, melanocortin biology matured. Three additional receptors were discovered, and animal models were established addressing the function of each receptor. Researchers now know that the diverse physiologic responses to melanocortins - including their role in development, weight and endocrine regulation, cortisol production, secretion from exocrine glands, and pigmentation - can be defined in terms of individual receptors. In this text, contributors from the field of evolutionary biology, peptide chemistry, pigmentation biology, neuroscience, endocrinology and genetics provide the reader with a comprehensive review of melanocortin biology. Six areas of active research are addressed: peptide and small molecule chemistry; receptor structure and function; energy homeostasis; pigmentation; adrenocorticol function; and behaviour. There are 56 papers and 20 posters altogether, taken from the Fifth Melanocortin Meeting, held in 2002.

Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Download or read book Human Biochemistry written by Gerald Litwack and published by Academic Press. This book was released on 2021-11-28 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers. Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers Provides a fully updated resource on current research in human and medical biochemistry Includes clinical case studies, applications, chapter summaries and review-based questions Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers

Download or read book Surviving Mold written by Ritchie C. Shoemaker and published by Otter Bay Books. This book was released on 2010 with total page 763 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbes, especially molds and bacteria, growing in water-damaged buildings make people sick. The book follows Mold Warriors (published in 2005) as the definitive source of information on "mold" illness, its basis in inflammation, its physiology and its links to politics, lawsuits and science. It has true stories, regarding this increasingly common problem in the US and around the world. if you already know that you could be sickened by mold-damaged buildings, this book will guide you through diagnosis and treatment, through remediation and return to health.

Download or read book Melanocyte Stimulating Hormone written by F. J. H. Tilders and published by . This book was released on 1977 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The MSH Peptides written by A. J. Thody and published by . This book was released on 1980 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Obesity and Binge Eating Disorder written by Simone Munsch and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overweight and obesity have quite recently become a major problem affecting many countries worldwide. This publication gives a comprehensive overview on the current knowledge of the pathophysiological mechanisms in the regulation of hunger and satiety. An

Download or read book Neuropeptides and Immunoregulation written by Berta Scharrer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an updated overview of a rapidly develo- ping and exciting area of investigation dealing with the ro- le of neuropeptides in immunoregulatory processes. Existing texts focus on the bidirectional exchange of signals among the nervous, endocrine and immune systems in mammals, car- ried out primarily by the enkephalin and proopiomelanocortin families of neuropeptides and lymphokines. This collection of material is the first one to include pertinent informa- tion obtained in invertebrates, which has considerably ad- vanced our knowledge of the role of opioid neuropeptides, especiallyin another activity of the immune system, that of autoregulation. The study and interpretation of the remark- able parallelisms between these phenomena observed in inver- tebrates and vertebrates bring new insight into the me- chanisms of neuroimmunobiological integration with both general biological and clinical implications.

Download or read book Hormones written by Anthony W. Norman and published by Academic Press. This book was released on 2014-06-28 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones provides a comprehensive treatment of human hormones viewed in the light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology. The book begins with discussions of the first principles of hormone action and the seven classes of steroid hormones and their chemistry, biosynthesis, and metabolism. These are followed by separate chapters that address either a classical endocrine system, e.g., hypothalamic hormones, posterior pituitary hormones, anterior pituitary hormones, ,thyroid hormones, pancreatic hormones, gastrointestinal hormones, calcium regulating hormones, adrenal corticoids, hormones of the adrenal medulla, androgens, estrogens and progestins, and pregnancy and lactation hormones; or newer domains of hormone action which are essential to a comprehensive understanding of hormone action, including prostaglandins, thymus hormones, and pineal hormones. The book concludes with a presentation of hormones of the future, i.e., cell growth factors. This book is intended for use by first-year medical students, graduate students, and advanced undergraduates in the biological sciences. It is also hoped that this book will fill the void that exists for resource materials for teaching cellular and molecular endocrinology and that it will be employed as an equal partner with most standard biochemistry textbooks to provide a comprehensive and balanced coverage of this realm of biology.

Download or read book Microbial Endocrinology written by Mark Lyte and published by Springer Science & Business Media. This book was released on 2010-04-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.

Download or read book The Melanotropic Peptides written by M.E. Hadley and published by CRC Press. This book was released on 2018-01-18 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three volumes on "The Melanotropic Peptides" are the outcome of a conference of the same name that was held in Tucson, Arizona, from October 11-12, 1986. The format of the three volumes provides a complete coverage of what is known about the Melanotropic Peptides. Volume I provides information on the source, synthesis, chemistry, mechanism of secretion, control of secretion, and the circulation and metabolism of the melanotropic peptides.

Download or read book Basic Physiology for Anaesthetists written by David Chambers and published by Cambridge University Press. This book was released on 2019-07-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.

Download or read book Handbook of Biologically Active Peptides written by Abba Kastin and published by Elsevier. This book was released on 2011-04-28 with total page 1682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. *Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.

Download or read book Fish Endocrinology 2 Vols written by Manfred Reinecke and published by CRC Press. This book was released on 2020-03-05 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past two decades, fish endocrinology has witnessed exciting developments due to our increased knowledge at all levels of biological organizations, including molecular biology, cell biology, physiology and behavior. New insights into development, neurobiology, immunology and molecular genetics closely correlated with classical aspects of endocrinology and represent important contributions to our knowledge on regulatory processes of vertebrates, including fish. The purpose of this book is to overview major advances in numerous research areas of fish endocrinology. Most of the chapters not only review and discuss the state-of-the-art in the respective field, but also show perspectives of future research. The book will be of interest to scientists involved in basic fish research, comparative endocrinology, fisheries and aquaculture as well as for students of fish biology.

Download or read book ACTH Action in the Adrenal Cortex From Molecular Biology to Pathophysiology written by Nicole Gallo-Payet and published by Frontiers Media SA. This book was released on 2017-07-27 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function, the various intracellular signaling cascades, which involve not only protein kinase A, the key mediator of ACTH action, but also phosphatases, phosphodiesterases, ion channels and the cytoskeleton. The importance of the proteins involved in the cell detoxification is also considered, in particular the effect that ACTH has on protection against reactive oxygen species generated during steroidogenesis. The impact of the cellular microenvironment, including local production of ACTH is discussed, both as an important factor in the maintenance of homeostasis, but also in pathological situations, such as severe inflammation. Finally, the Research Topic reviews the role that the pituitary-adrenal axis may have in the development of metabolic disorders. In addition to mutations or alterations of expression of genes encoding components of the steroidogenesis and signaling pathways, chronic stress and sleep disturbance are both associated with hyperactivity of the adrenal gland. A resulting effect is increased glucocorticoid secretion inducing food intake and weight gain, which, in turn, leads to insulin and leptin resistance. These aspects are described in detail in this Research Topic by key investigators in the field. Many of the aspects addressed in this Research Topic still represent a stimulus for future studies, their outcome aimed at providing evidence of the central position occupied by the adrenal cortex in many metabolic functions when its homeostasis is disrupted. An in-depth investigation of the mechanisms underlying these pathways will be invaluable in developing new therapeutic tools and strategies.

Download or read book Neurobiology of Cerebrospinal Fluid 1 written by James H. Wood and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiologic compartmentalization effectively isolates the central nervous system from the rest of the body. This isolation not only provides protection of its delicate function from aberrant peripheral influences but also impedes its diagnostic evaluation. Cerebro spinal fluid (CSF) bathes the brain and spinal cord, is in dynamic equilibrium with its extracellular fluid, and tends to reflect the state of health and activity of the central nervous system. CSF examination is the most direct and popular method of assessing the central chemical and cellular environment in the living patient or mammal. The purpose of this multidisciplined reference text is to provide the sophisticated knowledge of CSF physiology and pathology necessary for the meaningful interpretation of data obtained by various types of CSF analysis. The methodology for reliable CSF collection, storage, preparation, and analysis is discussed with respect to individual, somatotropic, chronologic, endorcinologic, pharmacologic, and possible artifactual var iations in CSF composition. These essential aspects, which ensure the validity of CSF data, are presented to aid the investigator in clinical and experimental protocol formu lation and in elimination of possible sources of error.

Download or read book Sensing the Environment Regulation of Local and Global Homeostasis by the Skin s Neuroendocrine System written by Andrzej T. Slominski and published by Springer Science & Business Media. This book was released on 2012-06-02 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.