Download or read book Mr Clardy from the Committee on Claims Submitted the Following Report To Accompany H R 6545 written by and published by . This book was released on 1898 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Congressional Record written by United States. Congress and published by . This book was released on 1898 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Congressional Record is the official record of the proceedings and debates of the United States Congress. It is published daily when Congress is in session. The Congressional Record began publication in 1873. Debates for sessions prior to 1873 are recorded in The Debates and Proceedings in the Congress of the United States (1789-1824), the Register of Debates in Congress (1824-1837), and the Congressional Globe (1833-1873)
Download or read book Pharmaceutical Biotechnology written by Carlos A. Guzmán and published by Springer. This book was released on 2012-03-14 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Biotechnology is a unique compilation of reviews addressing frontiers in biologicals as a rich source for innovative medicines. This book fulfills the needs of a broad community of scientists interested in biologicals from diverse perspectives—basic research, biotechnology, protein engineering, protein delivery, medicines, pharmaceuticals and vaccinology. The diverse topics range from advanced biotechnologies aimed to introduce novel, potent engineered vaccines of unprecedented efficacy and safety for a wide scope of human diseases to natural products, small peptides and polypeptides engineered for discrete prophylaxis and therapeutic purposes. Modern biologicals promise to dramatically expand the scope of preventive medicine beyond the infectious disease arena into broad applications in immune and cancer treatment, as exemplified by anti-EGFR receptors antibodies for the treatment of breast cancer. The exponential growth in biologicals such as engineered proteins and vaccines has been boosted by unprecedented scientific breakthroughs made in the past decades culminating in an in-depth fundamental understanding of the scientific underpinnings of immune mechanisms together with knowledge of protein and peptide scaffolds that can be deliberately manipulated. This has in turn led to new strategies and processes. Deciphering the human, mammalian and numerous pathogens’ genomes provides opportunities that never before have been available—identification of discrete antigens (genomes and antigenomes) that lend themselves to considerably improved antigens and monoclonal antibodies, which with more sophisticated engineered adjuvants and agonists of pattern recognition receptors present in immune cells, deliver unprecedented safety and efficacy. Technological development such a nanobiotechnologies (dendrimers, nanobodies and fullerenes), biological particles (viral-like particles and bacterial ghosts) and innovative vectors (replication-competent attenuated, replication-incompetent recombinant and defective helper-dependent vectors) fulfill a broad range of cutting-edge research, drug discovery and delivery applications. Most recent examples of breakthrough biologicals include the human papilloma virus vaccine (HPV, prevention of women genital cancer) and the multivalent Pneumoccocal vaccines, which has virtually eradicated in some populations a most prevalent bacterial ear infection (i.e., otitis media). It is expected that in the years to come similar success will be obtained in the development of vaccines for diseases which still represent major threats for human health, such as AIDS, as well as for the generation of improved vaccines against diseases like pandemic flu for which vaccines are currently available. Furthermore, advances in comparative immunology and innate immunity revealed opportunities for innovative strategies for ever smaller biologicals and vaccines derived from species such as llama and sharks, which carry tremendous potential for innovative biologicals already in development stages in many pharmaceutical companies. Such recent discoveries and knowledge exploitations hold the promise for breakthrough biologicals, with the coming decade. Finally, this book caters to individuals not directly engaged in the pharmaceutical drug discovery process via a chapter outlining discovery, preclinical development, clinical development and translational medicine issues that are critical the drug development process. The authors and editors hope that this compilation of reviews will help readers rapidly and completely update knowledge and understanding of the frontiers in pharmaceutical biotechnologies.
Download or read book Surveying Antimicrobial Resistance The New Complexity of the Problem written by Gilberto Igrejas and published by Frontiers Media SA. This book was released on 2020-07-10 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: In January of 2015, under the 1st International Caparica Conference in Antibiotic Resistance, a Research Topic entitled: “Surveying Antimicrobial Resistance: Approaches, Issues, and Challenges to overcome”, was published (http://journal.frontiersin.org/researchtopic/3763/surveying-antimicrobial-resistanceapproaches- issues-and-challenges-to-overcome). The problem of antimicrobial resistance (AMR), caused by excessive and inappropriate use of antibiotics, is a public health issue that concerns us all. The introduction of penicillin in the 1940s, the start of the antibiotics era, has been recognized as one of the greatest advances in therapeutic medicine. However, according to the World Health Organization (WHO), AMR infections are now an increasing worldwide public health threat and a post-antibiotic era is imminent, where common infections and minor injuries could be fatal. AMR is a typical ‘One Health’ problem, in which livestock animals and the environment constitute AMR reservoirs and transmission routes to and from the human population. Without effective antimicrobials to counter and prevent infections, other major achievements in modern medicine, such as organ transplantation, cancer chemotherapy and major surgery, risk being compromised. AMR infections in animals have negative outcomes on animal health, welfare, biosecurity and production. In 2006, the ban of growth promoting antibiotics highlighted antibiotic use in animal production as a risk factor in the development of antibiotic resistant bacteria. Bacteria can be transferred to humans via several routes; consumption of animal products, exposure through contact with animals, and the contamination of ground and surface waters by animal waste products. Therefore, it is of utmost importance that antimicrobial use in animals is reduced to a minimum, without compromising animal health and welfare. Mechanisms of bacterial antibiotic resistance are classified according to the types of antibiotic molecules or their targets in the cell. Environmental antibiotic-resistance genes are spread then acquired by clinically relevant microorganisms. Many resistance genes are conveyed into pathogen genomes via mobile genetic elements such as plasmids, transposons or integrons, increasing the propagation of potential resistant pathogens. Substantial progress has already been made in elucidating the basic regulatory networks that endow bacteria with their extraordinary capacity to adapt to a diversity of lifestyles and external stress factors. So how will we face bacteria in the future?
Download or read book Targets in Heterocyclic Systems written by and published by . This book was released on 1997 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Revolutionary War Records written by Gaius Marcus Brumbaugh and published by . This book was released on 2000-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given in memory of Charles Hudson Edge, Laura James Edge, by Eugene Edge III.
Download or read book Cropland Conversion Program written by and published by . This book was released on 1963 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Annenbergs written by John E. Cooney and published by Simon & Schuster. This book was released on 1982 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is the colorful and dramatic biography of two of America's most controversial entrepreneurs: Moses Louis Annenberg, 'the racing wire king, ' who built his fortune in racketeering, invested it in publishing, and lost much of it in the biggest tax evasion case in United States history; and his son, Walter, launcher of TV Guide and Seventeen magazines and former ambassador to Great Britain."--Jacket.
Download or read book Targets in Heterocyclic Systems written by Orazio A. Attanasi and published by . This book was released on 2009-07-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 11 keeps the international standard of the THS series, covering the synthesis, reactivity, activity (including medicinal) and mass spectrometry of different systems.
Download or read book Virginia Soldiers of 1776 written by Louis Alexander Burgess and published by . This book was released on 1927 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rural Environmental Assistance Program written by and published by . This book was released on 1971 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book This Is Really War written by Emilie Le Beau Lucchesi and published by Chicago Review Press. This book was released on 2019-05-07 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: In January 1940, navy nurse Dorothy Still eagerly anticipated her new assignment at a military hospital in the Philippines. Her first year abroad was an adventure. She dated sailors, attended dances and watched the sparkling evening lights from her balcony. But as 1941 progressed, signs of war became imminent. Military wives and children were shipped home to the states, and the sailors increased their daily drills. When Pearl Harbor was attacked, Dorothy and the other nurses braced for a direct assault. When the all-clear sounded, they raced across the yard to the hospital and prepared for the wounded to arrive. In that frantic dash, Dorothy transformed from a navy nurse to a war nurse. Along with the other women on the nursing staff, she provided compassionate, tireless, critical care. When the Philippines fell to Japan in early January 1942, Dorothy was held captive in a hospital and then transferred to a university along with thousands of civilian prisoners. Cramped conditions, disease and poor nutrition meant the navy nurses and their army counterparts were overwhelmed caring for the camp. They endured disease, starvation, severe overcrowding, and abuse from guards, but also experienced friendship, hope, and some, including Dorothy, even found love.
Download or read book Hidden Illness in the White House written by Kenneth R. Crispell and published by Duke University Press. This book was released on 1988-09-30 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The serious illness of three presidents—Woodrow Wilson, Franklin Delano Roosevelt, and John F. Kennedy—as well as the injury Ronald Reagan received in the assassination attempt upon him have revealed our woefully inadequate system for handling presidential incapacity. The authors believe that this flawed system poses a major threat to the nation, and they provide sobering reports on how the government functioned (or failed to function) during times of presidential impairment. The public was kept in the dark regarding the gravity of the presidential condition, often unaware that critical decisions were being made while the president was suffering from a severe illness. Hidden Illness in the White House contains startling new information on the severity of Roosevelt’s illness during the crucial Yalta negotiations and the fact that Kennedy suffered from Addison’s disease, a life-threatening illness, long before he was elected to the presidency. In each case the authors demonstrate that a largely successful effort was made to conceal the president’s true medical condition from the public.
Download or read book Flood control projects written by United States. Congress. House. Committee on Public Works. Subcommittee on Rivers and Harbors and published by . This book was released on 1954 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Injured Athlete written by Daniel N. Kulund and published by Lippincott Williams & Wilkins. This book was released on 1982 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book ADVANCED MANAGEMENT ACCOUNTING written by Ravi M. Kishore and published by . This book was released on 2007 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and authentic Text Book on ADVANCED MANAGEMENT ACCOUNTING (Cost Management) * An authentic, simple and crisp presentation of the subject matter. * Theoretical questions are given at the end of respective chapters in chronological order. * Fully solved problems are given at the end of respective chapters. This will help students in self-preparation. * The Book takes accounts of recent developments on the subject with special emphasis on Responsibility Accounting, Transfer Pricing, Total Quality Management, Activity Based Costing, Life Cycle Costing, Capacity Management, Just in Time, Target Costing etc. * Point-wise presentation of Text portion with bullets to understand and memorise the subject matter. * Examination orientation makes the book more student friendly. * Concepts are explained with number of illustrations and also number of diagrams are given for clear understanding of subject matter. * The language of the Book is simple and treatment of the subject lucid. Both theory and practice are given equal importance. * All topics, illustrations, problems, tables and diagrams are distinctively numbered for easy location. * The Book will also be of interest to Practising Professionals, Business and Government officials for efficient discharge of their functions.
Download or read book Human Drug Metabolism written by Elizabeth H. Jeffery and published by CRC Press. This book was released on 1993 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Drug Metabolism fills a long-standing gap in the scientific literature on research into drug metabolism in humans. While many books exist on clinical studies, this is the first to wed basic biochemical and molecular biological experiments using human tissue with clinical experiments. Numerous examples of drug metabolism in human tissue (often more meaningful to medical and general health sciences students than animal studies) are presented. Modern techniques used by bench scientists are described for the experimental diagnosis of cancer, toxicity, and genetic susceptibility. A number of different drug metabolizing systems, many focusing on intra-individual variation, are examined. The book also discusses clinically dramatic effects of infection and the host response system on the metabolism of drugs and subsequent toxicity. Human Drug Metabolism is an important reference for pharmacologists, toxicologists, molecular biologists, and biochemists. It will also be useful to medical students and students in general health sciences.
