Download or read book Preparative Chromatography Techniques written by K. Hostettmann and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few years, increasing attention has been paid to the search for bioactive compounds from natural sources. The success of plant-derived products such as paclitaxel (Taxol) in tumor therapy or artemisinin in the treatment of malaria has provided the impetus for the introduction of numerous research programmes, especially in Industry. A great deal of effort is being expended in the generation of novel lead molecules of vegetable, marine and microbial origin by the use of high throughput screening protocols. When interesting hits are found, it is essen tial to have methods available for the rapid isolation of target compounds. For this reason, both industry and academia need efficient preparative chromatographic separation techniques and experience in their application. Purified natural products are required for complete spectro scopic identification and full characterization of new compo unds, for biological testing and for the supply of pharmaceuti cals, standards, and starting materials for synthetic work. Obtaining pure products from an extract can be a very long, te dious and expensive undertaking, involving many steps. Sometimes only minute amounts of the desired compounds are at hand and these entities may be labile. Thus it is an advantage to have access to as many different methods as possible in order to aid the isolation process. Although a certain amount of trial and error may be involved, nowadays there is the possibility of devising suitable rapid separation schemes by a judicious choice of the different techniques available.
Download or read book High Throughput Analysis in the Pharmaceutical Industry written by Perry G. Wang and published by CRC Press. This book was released on 2008-08-20 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corres
Download or read book New Trends in Early Stage Lung Cancer Presenting as Ground Glass Opacities Clinical Pathological and Molecular Aspects written by Chen Chen and published by Frontiers Media SA. This book was released on 2022-01-17 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Official Gazette of the United States Patent and Trademark Office written by and published by . This book was released on 1996 with total page 964 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book FCC Record written by United States. Federal Communications Commission and published by . This book was released on 2015 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Early stage Lung Cancer written by Xiangpeng Zheng and published by Springer. This book was released on 2018-01-30 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses major issues and advances in the diagnosis and treatment of incidentally detected early-stage lung cancer (ESLC). In Part I, pathology and radiology experts comprehensively review the state-of-the-art advances in individual research fields, and offer an update on the cross-sectional anatomy of the lung and post-processing techniques for CT imaging. Part II focuses on the imaging features, differential diagnosis and radiologic-pathologic correlations of ESLCs in the categories pGGN, mGGN and solid nodules in compliance with the Guidelines on Lung Cancer Screening from the National Comprehensive Cancer Network (NCCN). Part III briefly introduces therapeutic management strategies for ESLCs, including surgical and non-surgical approaches, for instance stereotactic ablative radiation therapy (SABR) and radiofrequency ablation (RFA). Lastly, the authors have meticulously prepared 50 clinical cases of pathologically proven benign and malignant pulmonary nodules with in-depth discussion and experts’ comments to further readers’ understanding of practical imaging and management strategies of ESLCs.
Download or read book Cellular and Molecular Alterations in the Failing Human Heart written by Hansjörg Just and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: The myocardium in heart failure: Cellular and subcellular alterations in the failing human myocardium. H. Just Medizinische Universitatsklinik Freiburg i. Br., Innere Medizin III - Kardiologie, FRG The syndrome of heart failure continues to be a major challenge to clinicians and scientists. Incidence and mortality of the disease are high, the patient is disabled, and is permanently threatened by the high morbidity and mortality. The clinician faces a syndrome of complex pathophysiology. Multiple causes or underlying disorders of the heart have to be differentiated from heart failure itself, which often results in exceedingly difficult diagnoses. Likewise, prognostication meets with difficulties due to problems in separating influences of the underlying disease and the heart failure syndrome itself. In chronic refractory failure annual mortality may exceed 50%. If aortic stenosis or ischemic cardiomyopathy with main stem lesions are present, this percentage may be even higher. The situation becomes particularly threatening to the patient when the reduction in cardiac performance goes along with complex ventricular arrhythmias. Therapy has remained difficult and of limited effectiveness. Major progress was achieved with the introduction of diuretic substances. Of similar importance was the introduction of va so dilating drugs into the treatment of heart failure. The principle of vasodilation has greatly improved our understanding of the disease, and has brought about a major improvement of symptoms, increase of exercise capacity, and reduc tion of mortality. This is especially true for the introduction of the angiotensin converting enzyme inhibitors.
Download or read book The Dynamics of Young Fatherhood written by Bren Neale and published by Policy Press. This book was released on 2024-02-26 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Around 1 in 10 children born in the UK are fathered by men under the age of 25. These men are often from socially disadvantaged areas and frequently overlooked in both research and practice settings. Using findings from a major Economic and Social Research Council study, supplemented with additional data, the authors focus on the transitions of the young men into early parenthood and their unfolding lives thereafter. As negative popular and media discourse around young fathers begins to shift, policy makers, practitioners, researchers and students will find future policy and practice directions designed to nurture the potential of these young men and their children.
Download or read book Legal Services Corporation General Oversight written by United States. Congress. House. Committee on the Judiciary. Subcommittee on Courts, Civil Liberties, and the Administration of Justice and published by . This book was released on 1985 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Copyright Infringement Remedies and Nursing Home videocassette Copyright written by United States. Congress. House. Committee on the Judiciary. Subcommittee on Courts, Intellectual Property, and the Administration of Justice and published by . This book was released on 1990 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Case Reports in Thoracic Oncology 2022 written by Caroline Hayhurst and published by Frontiers Media SA. This book was released on 2024-06-19 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic aims to collect all the Case Reports submitted to the Thoracic Oncology section. All the Case Reports submitted to this collection will be personally assessed by a senior Associate Editor before the beginning of the peer-review process. Please make sure your article adheres to the following guidelines before submitting it. Case Reports highlight unique cases of patients that present with an unexpected diagnosis, treatment outcome, or clinical course. Only Case Reports that are original and significantly advance the field will be considered: 1) RARE case with TYPICAL features. 2) FREQUENT case with ATYPICAL features. 3) Cases with a convincing response to new treatments, i.e. single case of off-label use.
Download or read book International Scientific Conference Energy Management of Municipal Facilities and Sustainable Energy Technologies EMMFT 2018 written by Vera Murgul and published by Springer. This book was released on 2019-05-27 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a collection of the latest studies on and applications for the sustainable development of urban energy systems. Based on the 20th International Scientific Conference on Energy Management of Municipal Facilities and Sustainable Energy Technologies, held in Voronezh and Samara, Russia from 10 to 13 December 2018, it addresses a range of aspects including energy modelling, materials and applications in buildings; heating, ventilation and air conditioning systems; renewable energy technologies (photovoltaic, biomass, and wind energy); electrical energy storage; energy management; and life cycle assessment in urban systems and transportation. The book is intended for a broad readership: from policymakers tasked with evaluating and promoting key enabling technologies, efficiency policies and sustainable energy practices, to researchers and engineers involved in the design and analysis of complex systems.
Download or read book Handbook of Methods and Instrumentation in Separation Science written by and published by Academic Press. This book was released on 2009-11-11 with total page 881 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Methods and Instrumentation in Separation Science, Volume 1 provides concise overviews and summaries of the main methods used for separation. It is based on the Encyclopedia of Separation Science. The handbook focuses on the principles of methods and instrumentation. It provides general concepts concerning the subject matter; it does not present specific procedures. This volume discusses the separation processes including affinity methods, analytical ultracentrifugation, centrifugation, chromatography, and use of decanter centrifuge and dye. Each methodology is defined and compared with other separation processes. It also provides specific techniques, principles, and theories concerning each process. Furthermore, the handbook presents the applications, benefits, and validation of the processes described in this book. This handbook is an excellent reference for biomedical researchers, environmental and production chemists, flavor and fragrance technologists, food and beverage technologists, academic and industrial librarians, and nuclear researchers. Students and novices will also find this handbook useful for practice and learning. - One-stop source for information on separation methods - General overviews for quick orientation - Ease of use for finding results fast - Expert coverage of major separation methods - Coverage of techniques for all sizes of samples, pico-level to kilo-level
Download or read book Fathering and Poverty written by Tarrant, Anna and published by Policy Press. This book was released on 2021-08-05 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anna Tarrant’s revealing research explores the dynamics of men’s caring responsibilities in low-income families’ lives. The book draws on pioneering multigenerational research to examine men’s involvement in care for their families. It interrogates how this is affected by the resources available and the constraints upon them, considering intersections of gender, generation and work, as well as the impact of austerity and welfare support. Illuminating aspects of care within economic hardship that often go unseen, it deepens our understanding of masculinities and family life and the policies and practices that support or undermine men’s participation.
Download or read book Current Aspects of Flavonoids Their Role in Cancer Treatment written by Hardeep Singh Tuli and published by Springer. This book was released on 2019-05-21 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters.
Download or read book Northern Mariana Islands Commonwealth Code written by Northern Mariana Islands and published by . This book was released on 1997 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt:
