Download or read book Molecular Genetics of Mycobacteria written by Graham F. Hatfull and published by John Wiley & Sons. This book was released on 2020-08-06 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive collection of perspectives by experts in mycobacterial molecular biology Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today. Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge. Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition, Discusses key areas of current research in mycobacterial genetics Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis Presents genetic approaches for manipulating M. tuberculosis This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.

Download or read book Molecular Genetics of Bacteria written by Jeremy W. Dale and published by John Wiley & Sons. This book was released on 2013-04-22 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fifth edition of this highly successful book provides students with an essential introduction to the molecular genetics of bacteria covering the basic concepts and the latest developments. It is comprehensive, easy to use and well structured with clear two-colour diagrams throughout. Specific changes to the new edition include: More detail on sigma factors, anti-sigma factors and anti-anti sigma factors, and the difference in the frequency of sigma factors in bacteria Expand material on integrons as these are becoming increasingly important in antibiotic resistance Enhanced treatment of molecular phylogeny Complete revision and updating of the final chapter on ‘Gene Mapping and Genomics’ Two-colour illustrations throughout. The focus of the book remains firmly on bacteria and will be invaluable to students studying microbiology, biotechnology, molecular biology, biochemistry, genetics and related biomedical sciences.

Download or read book Molecular Genetics of Bacteria written by Larry Snyder and published by Wiley-Blackwell. This book was released on 2003 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: This advanced level textbook offers an in-depth look at molecular biology and biochemistry. The breadth and diversity of bacterial genetics are explored in discussions of microbial systems beyond the much-studied E Coli.

Download or read book Mycobacteria written by C. Ratledge and published by John Wiley & Sons. This book was released on 2009-04-01 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberculosis continues to kills more people than any other single infective agent. The resurgence of the disease in many countries has produced a heightened awareness of the threat posed by mycobacterial infections. At the same time, there has been an explosion of knowledge of the fundamental properties of mycobacteria, most notably the determination of the complete genome sequence of Mycobacterium tuberculosis. This book provides an up-to-date account of these developments in the molecular biology and immunology of mycobacteria, coupled with allied advances of a more applied nature, such as the use of molecular techniques for diagnosis and epidemiological investigations. With chapters contributed from an international team of experts, it will not only be an essential reference text for the expanding mycobacterial research community, but also will find a prominent place on the shelves of clinicians, infectious disease and public health specialists, diagnostic laboratories, postgraduate students and indeed anyone concerned with the management and investigation of outbreaks of tuberculosis. Comprehensively covers recent advances in the molecular biology of the mycobacteria. First book to be published on this subject since the publishing of the complete genome for the tubercle bacillus (M. tuberculosis). Coincides with a worldwide resurgence of tuberculosis.

Download or read book Molecular Genetics of Bacteria written by J. W. Dale and published by . This book was released on 1996 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Biology of the Mycobacteria written by Johnjoe McFadden and published by Academic Press. This book was released on 1990 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a meeting held at the University of Surrey in September 1989, this book details progress in search since the first reports of cloning of mycobacterial genes were published some five years ago. Mycobacteriologists, bacterial geneticists, and those with an interest in microbial pathogenesis will find this volume to be invaluable.

Download or read book Molecular Genetics of Bacteria written by Jeremy Dale and published by . This book was released on 1998-05-05 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Genetics of Bacteria Third Edition Jeremy W. Dale School of Biological Sciences, University of Surrey, UK This third edition of Jeremy Dale's successful book provides a thoroughly updated and revised introduction to the molecular biology and genetics of bacteria. Molecular Genetics of Bacteria presents both the basic concepts and the most exciting recent developments in a form which is suitable for the needs of students studying microbiology, biotechnology, molecular biology, biochemistry, genetics and related biomedical sciences. The structure of the third edition has undergone a major reorganization and incorporates: * New material on the concept of adaptive mutation, bacterial differentiation, intercellular signalling, conjugative transposons and integrons. * Enhanced coverage of supercoiling, reporter genes, sporulation, PCR and genome sequencing projects. Reviews of the Second Edition: "I recommend this book strongly for the purpose for which it was designed, namely as an introductory text with broad coverage of the subject." Simon Baumberg, University of Leeds, Society for General Microbiology Quarterly ". a text that is readable and attractive to people who may be daunted by more-detailed works." Trends in Microbiology

Download or read book Molecular Genetics of Cell Wall Biosynthesis and Regulation in Mycobacteria written by Faith Prodigalidad Dizon and published by . This book was released on 1999 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Mycobacteriology written by Robert A. Ollar and published by CRC Press. This book was released on 1999-01-04 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents an overview of the clinical pathology of mycobacterial and nonpathogens, data on genetically based methodologies for clinical testing, straightforward protocols for molecular manipulations, and theoretical explanations of the molecular mechanisms involved. It explains the safest and most efficient methods for detecting mycobacterium avium complex, providing the means to combat this common secondary opportunistic infection in AIDS patients.

Download or read book Molecular Genetics of Bacteria written by Larry Snyder and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mycobacterium Tuberculosis Protocols written by Tanya Parish and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide detailed protocols for studying the molecular biology of the pathogen Mycobacterium tuberculosis, and its int- actions with host cells. As established mycobacterial laboratories move - wards exploiting the genome, and laboratories with expertise in other fields apply them to mycobacteria, both traditional and novel methodologies need to be reviewed. Thus the chapters in Mycobacterium tuberculosis Protocols range from perspectives on storage of strains and safety issues to the application of the latest functional genomics technologies. The last few years have been remarkable ones for research into M. tuber- losis. The most important landmark by far has been the completion of the genome sequence of the widely studied H37Rv strain (1). We can now predict every protein and RNA molecule made by the pathogen. This information is or will soon be enriched by the addition of genome sequences of other strains from the M. tuberculosis complex: a second strain of M. tuberculosis, My- bacterium bovis, and the vaccine strain, M. bovis BCG. Valuable comparative data will also be provided by the genome sequences of Mycobacterium leprae, Mycobacterium avium, and Streptomyces coelicolor. Another recent milestone for M. tuberculosis has been the development of efficient mutagenesis me- odologies, the lack of which has been a major handicap in functional studies.

Download or read book Molecular Genetics and Immunobiology of Mycobacteria written by and published by . This book was released on 2002 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Molecular Genetics of Homologous and Illegitimate Recombination in Mycobacteria written by Jason Hinds and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Genetics of Bacteria and Their Viruses written by William Hayes and published by . This book was released on 1964 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mycobacteria Host Interactions Genetics Immunity Pathology written by Alexander S. Apt and published by Frontiers Media SA. This book was released on 2020-12-30 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Molecular Genetic Analysis of Mycobacterium Avium Subsp Paratuberculosis and Mycobacterium Smegmatis written by Govardhan Rathnaiah and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne's disease in ruminants. Moreover, the potential linkage with Crohn's disease makes MAP a concern as a zoonotic pathogen. The generation of comprehensive random transposon mutant libraries is a fundamental genetic technology to determine the role of genes in physiology and pathogenesis. To identify the genomic regions associated with virulence a comprehensive MAP Tn5367 transposon mutant bank was constructed. Assuming random transposition of Tn5367 it was calculated that collection of approximately 14,000 mutants will generate a comprehensive MAP mutant library sufficient to analyze essentiality of all the genes. However, further studies showed that transposition of Tn 5367 is not random due to transposition biases leading to miscalculation of number of mutants required to generate a comprehensive library. To identify the sources of transposition biases and the ideal transposon for generation of comprehensive library, a whole MAP genome analysis comparing the transposon recognition sites for Tn5367 and MycoMarT7 transposons was performed. Results indicate that only MycoMarT7 provides a random representation of insertions in 99% of all MAP genes. Our novel finding is that both transposons have loci-dependent biases with Tn5367 having more bias. These loci-dependent transposition biases lead to an underestimation of the number of independent mutants required to generate a comprehensive mutant library. MycoMarT7 was used to construct a comprehensive transposon mutant library. Analysis of the library indicated that 93.1% of the MAP genes have at least one transposon insertion. Applying a 4-state hidden Markov model, we preliminarily identified 328 essential; 1,103 growth-defect; 2,603 non-essential and 258 growth-advantage genes. This study also analyzed glutamate racemase (MurI) as potential drug target. MurI catalyzes D-glutamate biosynthesis in most eubacteria and some microorganisms also synthesize D-glutamate using D-amino-acid transaminase (Dat). However, in mycobacteria the presence of Dat has not been investigated. In this study, genetic and biochemical evidence is presented for the presence of both pathways in Mycobacterium smegmatis. Thus, the presence of a redundant Dat/MurI pathway negates that specific MurI inhibitors would be effective in the treatment of mycobacterial infections, suggesting that mixed inhibitors or combination of single inhibitors may be necessary.

Download or read book Mycobacteria Protocols written by Tanya Parish and published by Springer Science & Business Media. This book was released on 1998 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laboratory experts present cutting-edge molecular biology techniques for studying the mycobacteria, a medically significant group of organisms responsible for both human and animal disease, including tuberculosis and leprosy. The methods range from basic culture techniques, cell fractionation, and nucleic acid purification to more advanced protocols for the introduction of cloned DNA into mycobacteria, the use of reporter genes, and the expression of foreign genes. There are also important techniques for mycobacteriophages, genome analysis, chemical and transposon mutagenesis, gene replacement, and analysis of gene expression, as well as such clinically useful techniques as antibiotic susceptibility testing, speciation, and RFLP analysis.