Download or read book Molecular Basis of Resilience written by Patrick L. Iversen and published by Springer. This book was released on 2018-09-29 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process. Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in “nonlinear anomalies.” An example includes medical countermeasures for Ebola and Marburg viruses under the “Animal Rule.” Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis illustrate how chemicals disrupt genomes. Historic research ignored RNA damage from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed. Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience. Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question “what informs molecular mechanisms of resilience?” that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience.

Download or read book Stress Resilience written by Alon Chen and published by Academic Press. This book was released on 2019-11 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress Resilience: Molecular and Behavioral Aspects presents the first reference available on the full-breadth of cutting-edge research being carried out in this field. It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. World-renowned experts provide chapters that cover everything from the neural circuits of resilience, the effects of early-life adversity, and the transgenerational inheritance of resilience. This unique and timely book will be a go-to resource for neuroscientists and biological psychiatrists who want to improve their understanding of the consequences of stress and on how some people are able to avoid it. Approaches resilience as a process rather than as a static trait Provides basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance Presents thorough coverage of both the genetic and environmental factors that contribute to resilience

Download or read book Stress Resilience written by Alon Chen and published by Academic Press. This book was released on 2019-10-31 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress Resilience: Molecular and Behavioral Aspects presents the first reference available on the full-breadth of cutting-edge research being carried out in this field. It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. World-renowned experts provide chapters that cover everything from the neural circuits of resilience, the effects of early-life adversity, and the transgenerational inheritance of resilience. This unique and timely book will be a go-to resource for neuroscientists and biological psychiatrists who want to improve their understanding of the consequences of stress and on how some people are able to avoid it. Approaches resilience as a process rather than as a static trait Provides basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance Presents thorough coverage of both the genetic and environmental factors that contribute to resilience

Download or read book A New Biology for the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2009-11-20 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now more than ever, biology has the potential to contribute practical solutions to many of the major challenges confronting the United States and the world. A New Biology for the 21st Century recommends that a "New Biology" approach-one that depends on greater integration within biology, and closer collaboration with physical, computational, and earth scientists, mathematicians and engineers-be used to find solutions to four key societal needs: sustainable food production, ecosystem restoration, optimized biofuel production, and improvement in human health. The approach calls for a coordinated effort to leverage resources across the federal, private, and academic sectors to help meet challenges and improve the return on life science research in general.

Download or read book Resilience written by Steven M. Southwick and published by Cambridge University Press. This book was released on 2023-09-07 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life presents us all with challenges. Most of us at some point will be struck by major traumas such as the sudden death of a loved one, a debilitating disease, or a natural disaster. What differentiates us is how we respond. In this important book, three experts in trauma and resilience answer key questions such as What helps people adapt to life's most challenging situations?, How can you build up your own resilience?, and What do we know about the science of resilience? Combining cutting-edge scientific research with the personal experiences of individuals who have survived some of the most traumatic events imaginable, including the COVID-19 pandemic, this book provides a practical resource that can be used time and time again. The experts describe ten key resilience factors, including facing fear, optimism, and relying on role models, through the experiences and personal reflections of highly resilient survivors. Each resilience factor will help you to adapt and grow from stressful life events and will bring hope and inspiration for overcoming adversity.

Download or read book The Molecular Basis of Drug Addiction written by Shafiqur Rahman and published by Academic Press. This book was released on 2016-01-28 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addiction. - Contains contributions from leading authorities - Informs and updates on all the latest developments in the field

Download or read book Advancements in Developing Abiotic Stress Resilient Plants written by M. Iqbal R. Khan and published by CRC Press. This book was released on 2022-06-21 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants often encounter abiotic stresses including drought, salinity, flooding, high/low temperatures, and metal toxicity, among others. The majority of these stresses occur simultaneously and thus limit crop production. Therefore, the need of the hour is to improve the abiotic stresses tolerance of crop plants by integrating physiology, omics, and modern breeding approaches. This book covers various aspects including (1) abiotic stress responses in plants and progress made so far in the allied areas for trait improvements, (2) integrates knowledge gained from basic physiology to advanced omics tools to assist new breeding technologies, and (3) discusses key genes, proteins, and metabolites or pathways for developing new crop varieties with improved tolerance traits.

Download or read book Moral Resilience written by Cynda Hylton Rushton and published by Oxford University Press. This book was released on 2018-10-02 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Suffering is an unavoidable reality in health care. Not only are patients and families suffering but also the clinicians who care for them. Commonly the suffering experienced by clinicians is moral in nature, in part a reflection of the increasing complexity of health care, their roles within it, and the expanding range of available interventions. Moral suffering is the anguish that occurs when the burdens of treatment appear to outweigh the benefits; scarce human and material resources must be allocated; informed consent is incomplete or inadequate; or there are disagreements about goals of treatment among patients, families or clinicians. Each is a source of moral adversity that challenges clinicians' integrity: the inner harmony that arises when their essential values and commitments are aligned with their choices and actions. If moral suffering is unrelieved it can lead to disengagement, burnout, and undermine the quality of clinical care. The most studied response to moral adversity is moral distress. The sources and sequelae of moral distress, one type of moral suffering, have been documented among clinicians across specialties. It is vital to shift the focus to solutions and to expanded individual and system strategies that mitigate the detrimental effects of moral suffering. Moral resilience, the capacity of an individual to restore or sustain integrity in response to moral adversity, offers a path forward. It encompasses capacities aimed at developing self-regulation and self-awareness, buoyancy, moral efficacy, self-stewardship and ultimately personal and relational integrity. Clinicians and healthcare organizations must work together to transform moral suffering by cultivating the individual capacities for moral resilience and designing a new architecture to support ethical practice. Used worldwide for scalable and sustainable change, the Conscious Full Spectrum approach, offers a method to solve problems to support integrity, shift patterns that undermine moral resilience and ethical practice, and source the inner potential of clinicians and leaders to produce meaningful and sustainable results that benefit all.

Download or read book Coral Bleaching written by Madeleine J. H. van Oppen and published by Springer. This book was released on 2018-07-05 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most serious consequences of global climate change for coral reefs is the increased frequency and severity of mass coral bleaching events and, since the first edition of this volume was published in 2009, there have been additional mass coral bleaching events. This book provides comprehensive information on the causes and consequences of coral bleaching for coral reef ecosystems, from the genes and microbes involved in the bleaching response, to individual coral colonies and whole reef systems. It presents detailed analyses of how coral bleaching can be detected and quantified and reviews future scenarios based on modeling efforts and the potential mechanisms of acclimatisation and adaptation. It also briefly discusses emerging research areas that focus on the development of innovative interventions aiming to increase coral climate resilience and restore reefs.

Download or read book Resilience and Mental Health written by Steven M. Southwick and published by Cambridge University Press. This book was released on 2011-08-18 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans are remarkably resilient in the face of crises, traumas, disabilities, attachment losses and ongoing adversities. To date, most research in the field of traumatic stress has focused on neurobiological, psychological and social factors associated with trauma-related psychopathology and deficits in psychosocial functioning. Far less is known about resilience to stress and healthy adaptation to stress and trauma. This book brings together experts from a broad array of scientific fields whose research has focused on adaptive responses to stress. Each of the five sections in the book examines the relevant concepts, spanning from factors that contribute to and promote resilience, to populations and societal systems in which resilience is employed, to specific applications and contexts of resilience and interventions designed to better enhance resilience. This will be suitable for clinicians and researchers who are interested in resilience across the lifespan and in response to a wide variety of stressors.

Download or read book Resilience in Aging written by Barbara Resnick and published by Springer Science & Business Media. This book was released on 2010-10-14 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The many significant technological and medical advances of the 21st century cannot overcome the escalating risk posed to older adults by such stressors as pain, weakness, fatigue, depression, anxiety, memory and other cognitive deficits, hearing loss, visual impairment, isolation, marginalization, and physical and mental illness. In order to overcome these and other challenges, and to maintain as high a quality of life as possible, older adults and the professionals who treat them need to promote and develop the capacity for resilience, which is innate in all of us to some degree. The purpose of this book is to provide the current scientific theory, clinical guidelines, and real-world interventions with regard to resilience as a clinical tool. To that end, the book addresses such issues as concepts and operationalization of resilience; relevance of resilience to successful aging; impact of personality and genetics on resilience; relationship between resilience and motivation; relationship between resilience and survival; promoting resilience in long-term care; and the lifespan approach to resilience. By addressing ways in which the hypothetical and theoretical concepts of resilience can be applied in geriatric practice, Resilience in Aging provides inroads to the current knowledge and practice of resilience from the perspectives of physiology, psychology, culture, creativity, and economics. In addition, the book considers the impact of resilience on critical aspects of life for older adults such as policy issues (e.g., nursing home policies, Medicare guidelines), health and wellness, motivation, spirituality, and survival. Following these discussions, the book focuses on interventions that increase resilience. The intervention chapters include case studies and are intended to be useful at the clinical level. The book concludes with a discussion of future directions in optimizing resilience in the elderly and the importance of a lifespan approach to aging.

Download or read book From Molecules to Minds written by Institute of Medicine and published by National Academies Press. This book was released on 2008-12-07 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience has made phenomenal advances over the past 50 years and the pace of discovery continues to accelerate. On June 25, 2008, the Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders hosted more than 70 of the leading neuroscientists in the world, for a workshop titled "From Molecules to Minds: Challenges for the 21st Century." The objective of the workshop was to explore a set of common goals or "Grand Challenges" posed by participants that could inspire and rally both the scientific community and the public to consider the possibilities for neuroscience in the 21st century. The progress of the past in combination with new tools and techniques, such as neuroimaging and molecular biology, has positioned neuroscience on the cusp of even greater transformational progress in our understanding of the brain and how its inner workings result in mental activity. This workshop summary highlights the important issues and challenges facing the field of neuroscience as presented to those in attendance at the workshop, as well as the subsequent discussion that resulted. As a result, three overarching Grand Challenges emerged: How does the brain work and produce mental activity? How does physical activity in the brain give rise to thought, emotion, and behavior? How does the interplay of biology and experience shape our brains and make us who we are today? How do we keep our brains healthy? How do we protect, restore, or enhance the functioning of our brains as we age?

Download or read book The Mirror Neuron System written by Christian Keysers and published by Psychology Press. This book was released on 2016-06 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Mirror neurons are premotor neurons, originally discovered in the macaque brain , that discharge both during execution of goal-directed actions and during the observation of similar actions executed by another individual. They therefore ¿mirror¿ others¿ actions on the observer's motor repertoire. In the last decade an impressive amount of work has been devoted to the study of their properties and to investigate if they are present also in our species. Neuroimaging and electrophysiological techniques have shown that a mirror-neuron system does exist in the human brain as well. Among ¿mirror¿ human areas, Broca¿s area (the frontal area for speech production) is almost constantly activated by action observation. This suggests a possible evolutionary link between action understanding and verbal communication. In the most recent years, mirror-like phenomena have been demonstrated also for domains others than the pure motor one. Examples of that are the somatosensory and the emotional systems, possibly providing a neurophysiological basis to phenomena such as embodiment and empathy. This special issue collects some of the most representative works on the mirror-neuron system to give a panoramic view on current research and to stimulate new experiments in this exciting field.

Download or read book Resilience and Vulnerability written by Suniya S. Luthar and published by Cambridge University Press. This book was released on 2003-05-05 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Table of contents

Download or read book Genomics and Breeding for Climate Resilient Crops written by Chittaranjan Kole and published by Springer Science & Business Media. This book was released on 2013-06-18 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Climate change is expected to have a drastic impact on agronomic conditions including temperature, precipitation, soil nutrients, and the incidence of disease pests, to name a few. To face this looming threat, significant progress in developing new breeding strategies has been made over the last few decades. The first volume of Genomics and Breeding for Climate-Resilient Crops presents the basic concepts and strategies for developing climate-resilient crop varieties. Topics covered include: conservation, evaluation and utilization of biodiversity; identification of traits, genes and crops of the future; genomic and molecular tools; genetic engineering; participatory and evolutionary breeding; bioinformatics tools to support breeding; funding and networking support; and intellectual property, regulatory issues, social and political dimensions. ​

Download or read book Healthy Resilient and Sustainable Communities After Disasters written by Institute of Medicine and published by National Academies Press. This book was released on 2015-09-10 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the devastation that follows a major disaster, there is a need for multiple sectors to unite and devote new resources to support the rebuilding of infrastructure, the provision of health and social services, the restoration of care delivery systems, and other critical recovery needs. In some cases, billions of dollars from public, private and charitable sources are invested to help communities recover. National rhetoric often characterizes these efforts as a "return to normal." But for many American communities, pre-disaster conditions are far from optimal. Large segments of the U.S. population suffer from preventable health problems, experience inequitable access to services, and rely on overburdened health systems. A return to pre-event conditions in such cases may be short-sighted given the high costs - both economic and social - of poor health. Instead, it is important to understand that the disaster recovery process offers a series of unique and valuable opportunities to improve on the status quo. Capitalizing on these opportunities can advance the long-term health, resilience, and sustainability of communities - thereby better preparing them for future challenges. Healthy, Resilient, and Sustainable Communities After Disasters identifies and recommends recovery practices and novel programs most likely to impact overall community public health and contribute to resiliency for future incidents. This book makes the case that disaster recovery should be guided by a healthy community vision, where health considerations are integrated into all aspects of recovery planning before and after a disaster, and funding streams are leveraged in a coordinated manner and applied to health improvement priorities in order to meet human recovery needs and create healthy built and natural environments. The conceptual framework presented in Healthy, Resilient, and Sustainable Communities After Disasters lays the groundwork to achieve this goal and provides operational guidance for multiple sectors involved in community planning and disaster recovery. Healthy, Resilient, and Sustainable Communities After Disasters calls for actions at multiple levels to facilitate recovery strategies that optimize community health. With a shared healthy community vision, strategic planning that prioritizes health, and coordinated implementation, disaster recovery can result in a communities that are healthier, more livable places for current and future generations to grow and thrive - communities that are better prepared for future adversities.

Download or read book Beneficial Microbes in Agro Ecology written by N. Amaresan and published by Academic Press. This book was released on 2020-05-14 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beneficial Microbes in Agro-Ecology: Bacteria and Fungi is a complete resource on the agriculturally important beneficial microflora used in agricultural production technologies. Included are 30 different bacterial genera relevant in the sustainability, mechanisms, and beneficial natural processes that enhance soil fertility and plant growth. The second part of the book discusses 23 fungal genera used in agriculture for the management of plant diseases and plant growth promotion. Covering a wide range of bacteria and fungi on biocontrol and plant growth promoting properties, the book will help researchers, academics and advanced students in agro-ecology, plant microbiology, pathology, entomology, and nematology. - Presents a comprehensive collection of agriculturally important bacteria and fungi - Provides foundational knowledge of each core organism utilized in agro-ecology - Identifies the genera of agriculturally important microorganisms