Download or read book Molecular analysis of a human immune response gene written by and published by . This book was released on 1987 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular analysis of a human immune response gene HLA DRw6 written by Marnix L. Bosch and published by . This book was released on 1987 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular analysis of human immune response gene HLA DRw6 written by Marnix Leo Bosch and published by . This book was released on 1987 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Analyses of a Human Immune Response Gene written by and published by . This book was released on 1987 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HLA and MHC written by Michael J. Browning and published by Taylor & Francis. This book was released on 1996 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
Download or read book Computational Analysis of HLA Types and Expression in Human Cancer written by Sahil Sethi and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune System is a biological mechanism that helps on body in fighting against invading foreign agents (also known as pathogens), which may or may not be capable of causing a particular disease. The Immune System can be classified into two subcategories: firstly, the type of immune system with which an individual is born, which is known as Innate Immune System. This type of Immune System is regarded as the first line of defense against the invasion of foreign agents. Secondly, the type of immune system, which evolves over time and is capable of clearing the pathogens completely from body, is known as Adaptive Immune System. This type of Immune System works by creating an immunological memory, just after the first encounter with a new pathogen. It has been shown that the Adaptive Immune System starts working after 12 hours the pathogen being present. The Adaptive Immune System also plays a critical role in the response against cancers and is the target of immunotherapy, which attempts to boost the immune system against specific cancer mutations. The immune system recognizes foreign agents (including cancer-mutated proteins) thanks to a specific group of genes responsible for coding the proteins that are found on the surface of most cells and are known as the Major Histocompatibility Complex(MHC). In human, these genes are known as the Human Leukocyte Antigen (HLA) genes. These genes code for polymorphic (i.e., highly variable between people) proteins that assist in presenting antigens, to start an Adaptive Immune reponse against peptides. This arrangement of genes is found on chromosome 6. The expression of HLA class I molecules is required for an effective immune response. In the adaptive immune response against cancers, HLA molecules are required in the presentation of neoantigens (mutated proteins) on tumor cells to cytotoxic T-lymphocytes. Their reduced expression from the cell surface may lead to escape of these tumors from immunosurveillance. Human leukcocyte antigen (HLA class I molecule downregulation can occur in numerous cancers, and this phenomenon may negatively influence the clinical course of tumors and reduce the effectiveness of T-cell-based immunotherapy. The work presented in this thesis focuses on the analysis of HLA expression in human cancers, showing that while HLA is generally expressed in human cancers, its expression tends to be reduced in more advanced stages of cancer or in tumors that are more aggressive.
Download or read book Immunobiology of HLA written by Bo Dupont and published by Springer. This book was released on 2013-12-20 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: This set reports the results of the 10th International Histocompatibility Workshop, in which 362 laboratories collaborated over a three year period in research projects on the classification of HLA genes and their products. Volume 1 describes the experimental design of the workshop studies and their results. Volume 2 is a collection of papers on the latest developments in the molecular biology of HLA systems. Immunobiology of HLA is a valuable reference for tissue typing laboratories, blood banks, and general research programs on HLA and related diseases because it identifies common sources of HLA genes and gene products to be used as reference reagents, and because it is the only complete compilation of the latest research and results in the field.
Download or read book Molecular Biology of HLA Class II Antigens written by Jack Silver and published by CRC Press. This book was released on 1990-02-28 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication covers the recent veritable explosion in knowledge regarding the genetic organization, structure, and function of the HLA class II region. It deals with the nature of diversity of HLA class II alleles, the molecular basis of this diversity, and the mechanisms by which HLA class II expression is regulated. Also addressed is the relationship of class II polymorphism to susceptibility to autoimmune diseases such as rheumatoid arthritis, insulin dependent diabetes mellitus, and pemphigus vulgaris. The book presents information on allele specific oligonucleotide (ASO) probes and their use in identifying susceptible individuals. It includes chapters which describe how cells transfected with HLA class II genes can be used for functional analysis. An appendix representing a compilation of all the known DR?? DQ?, DQ? sequences is included. This serves as an excellent source of comparison of newly derived sequences. This publication provides information on the enormous progress in the HLA field. It is intended for both the established investigator and the beginner.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1796 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Journal of Immunology written by and published by . This book was released on 1990-02 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Histocompatibility Testing 1984 written by E.D. Albert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Immune Gene Expression written by Marc Feldmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book encompasses the proceedings of a conference held at Trinity College, Oxford on September 21-25, 1985 organized by a committee comprised of Drs. M. Crumpton, M. Feldmann, A. McMichael, and E. Simpson, and advised by many friends and colleagues. The immune response gene workshops that took place were based on the need to understand why certain experimental animal strains were high responders and others were low responders. It was assumed that identification of the immune response (Ir) genes and definition of their products would explain high and low responder status. Research in the ensuing years has identified the Ir gene products involved in antibody responses as the la antigens, or MHC Class II antigens. These proteins are now well defined as members of the immunoglobulin gene superfamily, and their domain structure is known. Epitopes have been defined by multiple mono clonal antibodies and regions of hypervariability identified. Their genes have been identified and cloned. The basic observation of high and low responsive ness to antigen is still not understood in mechanistic terms, however, at either the cellular or molecular level. This is because the rate of progress in immune regulation has been far slower than in the molecular biology of the MHC Class II antigens. This is not surprising, since immune regulation is a very complex field at the crossroads of many disciplines.
Download or read book Mononuclear Phagocytes written by R. van Furth and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mononuclear phagocytes, which include macrophages, monocytes and their precursor cells, are the most important cells in the host defence against micro-organisms and tumor cells. During the last twenty-five years research on the biology of mononuclear phagocytes has increased tremendously. This motivated Professor R. van Furth to organize five international conferences on this subject in Leiden, the Netherlands. The edited proceedings of these meethings were published: in 1970 Mononuclear Phagocytes; in 1975 Mononuclear Phagocytes in Immunity, Infections and Pathology; in 1980 Mononuclear Phagocytes -- Functional Aspects; and in 1985 Mononuclear Phagocytes -- Characteristics, Physiology and Function. Reviews of these volumes, published in international journals, praised them as the most up-to-date state of the art publications. The publication of 1991 includes 88 chapters written by more than 200 authors.
Download or read book Special Listing written by and published by . This book was released on 1981 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Mucosal Immunology written by and published by Academic Press. This book was released on 2012-12-02 with total page 791 pages. Available in PDF, EPUB and Kindle. Book excerpt: Researchers have recently made tremendous progress in the area of mucosal immunology, greatly increasing our understanding of the common mucosal immune system, mucosal infections, and oral immunization. However, thisresearch has not previously been made available in a single work. In its large 81/2"x 11"format, Handbook of Mucosal Immunology covers the entire spectrum of mucosal immunity and is organized in two main sections to present the basic biology of the common mucosal immune system and the immune responses of the mucosae.The first section provides an introduction and historical perspective of the mucosal immune system and includes comprehensive discussion of the development and physiology of mucosal defense. It discusses such topics as the structure and function of themucosal epithelium, characteristics of mucosal-associated lymphoid tissue (MALT), Peyers patches, and concepts of mucosal vaccines. The second section focuses on the secretory immune system with special reference to mucosal diseases in the digestive (GALT), respiratory (BALT), and genitourinary tracts. This information is especially important in light of the current interest in the mechanisms, transmission, and prevention of infectious diseases such as AIDS, hepatitis, and tuberculosis.Virtually all chapters have been authored by the original investigators responsible for key observations on which current concepts are based. This handbook will be an invaluable resource for a diverse group of both researchers and practicing clinicians.Molecular biologists, immunologists, veterinarians, public health workers, physicians in specialties from pediatrics to pulmonology, and graduate students of mucosal immunology will all find this handbook the most complete work on the subject.
Download or read book The Role of HLA Gene Products in the Immune Response to Environmental Antigens written by Pamela Jean Reitnauer and published by . This book was released on 1984 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Genetic Basis of Common Diseases written by Richard Allen King and published by Oxford University Press, USA. This book was released on 1992 with total page 998 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a unique and comprehensive resource for human geneticists and physicians concerned with the genetic causes of diseases routinely seen in research, clinical practice, and genetic counseling. Each of the chapters covers a particular disease, describes the genetic factors involved, and define the relevant biochemical, immunological, and physiological markers. The expert, widely known contributors also detail clinical applications, with advice on how the genetic data can be used to evaluate individuals and families, interpret diagnostic texts, and manage the disease.
