Download or read book Modern Methods in Stereoselective Aldol Reactions written by Rainer Mahrwald and published by John Wiley & Sons. This book was released on 2013-02-22 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: The selective formation of bondings between molecules is one of the major challenges in organic chemistry, and the so-called aldol reaction is one of the most important for this purpose. These reactions are a highly useful tool for developing such novel substances as natural products and pharmaceuticals. Likes its highly successful and much appreciated predecessor, "Modern Aldol Reactions", this ready reference provides a systematic overview of methodologies for installing a required configuration during an aldol addition step, but shifts the focus so as to cover the latest developments. As such, it presents a set of brand new tools, including vinylogous Mukaiyama-aldol reactions and substrate-controlled aldol reactions, as well as asymmetric induction in aldol additions. Furthermore, new developments in existing stereoselective aldol additions are described, such as the deployment of supersilyl groups or organocatalyzed aldol additions. All of these methodologies are presented in the context of their deployment in the total synthesis of natural products.
Download or read book Stereoselective Synthesis written by M. Nógrádi and published by Wiley-VCH. This book was released on 1987 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modern Aldol Reactions 2 Volume Set written by Rainer Mahrwald and published by John Wiley & Sons. This book was released on 2004-08-06 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: At long last, the complete spectrum of the aldol reaction is presented here in this two-volume handbook. Top authors guarantee contributions of the highest quality, beginning with fundamentals and then moving on to enolates and catalytic aldol reactions, including the Mukaiyama Reaction. Further sections are devoted to enzymatic aldol reactions in synthesis as well as such related reactions as the Henry, Ene and Aldol-Tishchenko reactions. The wealth of information contained here allows a comprehensive overview of this important topic in organic chemistry, removing the need for the hitherto time-consuming research among the widely dispersed literature. With a foreword by Professor D. A. Evans.
Download or read book Stereoselective Synthesis in Organic Chemistry written by Atta-ur-Rahman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Classics in Stereoselective Synthesis written by Erick M. Carreira and published by John Wiley & Sons. This book was released on 2009-02-09 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Die wichtigsten und nützlichsten Methoden der modernen stereoselektiven Synthese sind in diesem Band zusammengefasst. Viele anschauliche Beispiele für die Darstellung von Wirkstoffen und Naturstoffen regen zur gezielten Abwandlung und Integration in eigene Synthesewege an. Dabei geht es den Autoren weniger darum, das Gebiet in seiner Gesamtheit darzustellen; vielmehr versuchen sie, die wirklich grundlegenden Ansätze auszuwählen, die jeder organische Synthesechemiker kennen und anwenden sollte.
Download or read book Stereoselective Synthesis of Drugs and Natural Products written by Vasyl Andrushko and published by John Wiley & Sons. This book was released on 2013-08-16 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.
Download or read book Modern Methods of Organic Synthesis written by W. Carruthers and published by Cambridge University Press. This book was released on 1978-06-22 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of this well-known textbook discusses some modern methods used in organic synthesis, and aims to show the value and scope of these methods and how they are used in the synthesis of complex molecules. The general plan of the book follows that of the second edition, but the opportunity has been taken to bring the book up to date and to take account of advances in knowledge and of new reactions which have come into use since publication of the earlier editions. Particular emphasis is placed on highly stereoselective organic chemistry, including stereoselective alkylations, aldol reactions, oxidations, epoxidations and reductions. New methods for the stereoselective formation of carbon-carbon double bonds, and modern application reactions are also fully considered. The book will be of use to students of chemistry and biochemistry at graduate and senior undergraduate level. It will also interest practising scientists in industry and research establishments who wish to familiarise themselves with modern synthetic methods.
Download or read book Stereoselective Aldol Condensation Methodology with Applications to Total Synthesis written by John William Crossley Lampe and published by . This book was released on 1983 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stereochemistry and Stereoselective Synthesis written by Mihály Nógrádi and published by John Wiley & Sons. This book was released on 2016-06-22 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a well-respected and experienced author, this textbook fills the gap for a concise introduction to the key concepts of organic stereochemistry and the most important classical and modern methods in stereoselective synthesis. The concepts are extensively illustrated in color, with practical examples and question-answer sets to help consolidate the reader's knowledge. In addition, animations are available from the Wiley website. A must-have for students in chemistry, biochemistry, and life sciences, as well as researchers in pharmaceutical and agrochemical companies in need of a quick introduction to the field.
Download or read book Modern Methods of Organic Synthesis written by W. Carruthers and published by Cambridge University Press. This book was released on 2004-10-14 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook on modern methods of organic synthesis.
Download or read book Science of Synthesis Stereoselective Synthesis Vol 2 written by Gary A. Molander and published by Thieme. This book was released on 2014-05-14 with total page 1062 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbonyl and imino groups are two of the most integral functional groups employed in organic synthesis. Specific topics discussed: reduction, alkylation, alkenylation, and arylation of these groups, as well as asymmetric aldol, Mannich, and Morita-Bayliss-Hillman reactions. This volume is part of a 3-volume set: Science of Synthesis Stereoselective Synthesis Workbench Edition Further information about Stereoselective Synthesis (including sample pages and the table of contents)
Download or read book Aldol Reactions written by Rainer Mahrwald and published by Springer Science & Business Media. This book was released on 2009-05-15 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aldol Reactions provides a comprehensive up-to-date overview of aldol reactions including application of different metal enolates; catalytic aldol additions catalyzed by different Lewis acids and Lewis bases; enantioselective direct aldol additions; antibodies and enzyme catalyzed aldol additions and the recent aggressive development of organocatalyzed aldol additions. The power of each method is demonstrated by several applications in total synthesis of natural products. The pros and cons of these methodologies with regard to stereoselectivity, regioselectivity and application in total synthesis of natural products are discussed. Great importance is set to the diverse possibilities of the manual of aldol reaction to install required configurations in complicated natural product synthesis.
Download or read book Regio and Stereoselective Aldol Reaction written by David Scott Garvey and published by . This book was released on 1982 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organocatalysis written by Maurizio Benaglia and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-07-19 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organocatalysis is considered today one of the three pillars in asymmetric catalysis, along with biocatalysis and organometallic catalysis. The possibility to combine organocatalysis with radical chemistry, photocatalysis and enabling technologies opened new avenues in organic synthesis.
Download or read book Principles of Asymmetric Synthesis written by R.E. Gawley and published by Elsevier. This book was released on 1996-11-21 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.
Download or read book Some Modern Methods of Organic Synthesis written by W. Carruthers and published by Cambridge University Press. This book was released on 1986 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The general plan of the book follows that of the second edition, but the opportunity has been taken to bring the book up to date and to take account of advances in knowledge and of new reactions which have come into use since publication of the earlier editions.
Download or read book Principles of Asymmetric Synthesis written by Robert E. Gawley and published by Elsevier. This book was released on 2012-05-29 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis, this book presents a detailed analysis of the factors that govern stereoselectivity in organic reactions. After an explanation of the basic physical-organic principles governing stereoselective reactions, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Practical Aspects of Asymmetric Synthesis" provides a critical overview of the most common methods for the preparation of enantiomerically pure compounds, techniques for analysis of stereoisomers using chromatographic, spectroscopic, and chiroptical methods. The authors then present an overview of the most important methods in contemporary asymmetric synthesis organized by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions, one chapter on reductions, and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). This organization allows the reader to compare the leading methods for asymmetric synthesis in an appropriate context. A highlight of the book is the presentation and discussion of transition states at the current level of understanding, for important reaction types. In addition, extensive tables of examples are used to give the reader an appreciation for the scope of each reaction. Finally, leading references are provided to natural product synthesis that has been accomplished using a given reaction as a key step. Authoritative glossary to aid understanding of stereochemical terminology Explanations of the key factors influencing stereoselectivity with numerous examples, organized by reaction type A handy reference guide to the literature of asymmetric synthesis for practitioners in the field
