Download or read book Models for Prostate Cancer Pcbr written by Daniel Murphy and published by . This book was released on 1980-03 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comparative Analysis of Classification Models for Prostate Cancer written by Khaled Saad Alqahtani and published by . This book was released on 2014 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Animal Models for the Study of Human Disease written by Ann-Christin Gaupel and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt: In humans, the natural history of prostate cancer spans 30–40 years, which makes it a difficult disease to model in rodents. Furthermore, the molecular pathology of prostate cancer responsible for tumor initiation and progression is complex and often redundant. The sequential changes in oncogene and tumor suppressor gene expression during prostate cancer progression have not been fully delineated. Despite these issues, there are model systems, including carefully designed orthotopic xenograft models, that provide robust platforms for drug evaluation and studying the effects of diet and environmental stress on prostate carcinogenesis. Comprehensive transgenic and knockout models have also been developed that recapitulate individual steps in tumor initiation and metastatic progression and highlight the importance of the tumor microenvironment. While very few of the transgenic and knockout systems recapitulate the entire natural history of prostate cancer, individual model systems provide valuable genetic insight into the biological consequences of disrupting prostate homeostasis.

Download or read book Models for prostate cancer written by Adriaan van Bokhoven and published by . This book was released on 2004 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mouse Models for Prostate Cancer Initiation and Progression written by Minjung Kim and published by . This book was released on 2001 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Prostate Cell Culture Models for Studies on Prostate Cancer Progression and Chemoprevention written by Salmaan Taher Abdul Quader and published by . This book was released on 1999 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Histopathological Analysis of Mouse Models of Prostate Cancer written by Thomas R. Vorrius and published by . This book was released on 2007 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mouse Models of Prostate Cancer Bone Metastasis written by David M. Cunningham and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mouse Models of Prostate Cancer Progression and Bone Metastasis written by Srinivas Nandana and published by . This book was released on 2010 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Prostate Cancer Model Systems Molecular and Cellular Mechanisms Early Detection and Therapies written by Tanya I. Stoyanova and published by Frontiers Media SA. This book was released on 2022-08-08 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Experimental Models of Prostate Cancer Bone Metastasis written by Marta Garcia López and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Tumor Suppressor Genes in the Pathogenesis of Prostate Cancer written by Suzana Sturlini Couto and published by . This book was released on 2008 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Animal Models of Prostate Cancer written by Manal Y. Gabril and published by . This book was released on 2003 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Developing Pre Clinical Mouse Models of Prostate Cancer written by Kenneth C. Valkenburg and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Defeating Prostate Cancer written by National Cancer Institute (U.S.). Prostate Cancer Progress Review Group and published by . This book was released on 1998 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Signal Transduction Based Mouse Models of Prostate Cancer written by and published by . This book was released on 2003 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: These studies aimed to create a prostate cancer mouse model consortium. The overall objective of this study is to determine the mechanisms governing prostate cancer genesis and progression thereby leading to a better understanding and treatment for this disease. The studies brought together investigators at distinct institutions (Albert Einstein College of Medicine (AECOM) Memorial Sloan Kettering Cancer Center (MSKCC), Beth Israel Deaconess Medical Center- Harvard/Massachusetts Institute of Technology Health Sciences and Technology, HMS/MIT) and UC Davis to develop and share a) mouse models engineered through sharing distinct models generated by each program member b) software technology that will allow for the simultaneous analysis of histopathology and genetic composition of the emerging murine prostate tumors at the different institutions c) software technology for functional clustering of data derived from microarray analysis of tumor samples.

Download or read book A Mouse Model for Prostate Cancer written by and published by . This book was released on 2001 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse models of carcinogenesis have provided significant insights into the molecular mechanisms of tumor suppressor gene function. Our goal is to develop mouse models that recapitulate early stages of prostate carcinoma. Using such models we have demonstrated that the Nkx3.1 homeobox gene represents a prostate-specific tumor suppressor that undergoes epigenetic inactivation through loss of protein expression. Loss-of-function of Nkx3.1 in mice results in histopathological defects that resembles prostate cancer initiation in humans, and cooperates with loss-of-function of the Pten tumor suppressor gene in cancer progression. Furthermore, our findings suggest that the molecular mechanisms that mediate this cooperativity include the synergistic activation of Akt (protein kinase B), a key modulator of cell growth and survival. We propose that interactions between tissue-specific regulators such as Nkx3.1 and broad-spectrum tumor suppressors such as Pten underlie the distinct phenotypes of different cancers.