Download or read book Modelling and Optimization of Biotechnological Processes written by Lei Zhi Chen and published by Springer. This book was released on 2007-07-04 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mostindustrialbiotechnologicalprocessesareoperatedempirically.Oneofthe major di?culties of applying advanced control theories is the highly nonlinear nature of the processes. This book examines approaches based on arti?cial intelligencemethods,inparticular,geneticalgorithmsandneuralnetworks,for monitoring, modelling and optimization of fed-batch fermentation processes. The main aim of a process control is to maximize the ?nal product with minimum development and production costs. This book is interdisciplinary in nature, combining topics from biotechn- ogy, arti?cial intelligence, system identi?cation, process monitoring, process modelling and optimal control. Both simulation and experimental validation are performed in this study to demonstrate the suitability and feasibility of proposed methodologies. An online biomass sensor is constructed using a - current neural network for predicting the biomass concentration online with only three measurements (dissolved oxygen, volume and feed rate). Results show that the proposed sensor is comparable or even superior to other sensors proposed in the literature that use more than three measurements. Biote- nological processes are modelled by cascading two recurrent neural networks. It is found that neural models are able to describe the processes with high accuracy. Optimization of the ?nal product is achieved using modi?ed genetic algorithms to determine optimal feed rate pro?les. Experimental results of the corresponding production yields demonstrate that genetic algorithms are powerful tools for optimization of highly nonlinear systems. Moreover, a c- bination of recurrentneural networks and genetic algorithms provides a useful and cost-e?ective methodology for optimizing biotechnological processes.

Download or read book Modelling and Control of Biotechnological Processes written by A. Johnson and published by Elsevier. This book was released on 2014-05-17 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modelling and Control of Biotechnological Processes contains the proceedings of the International Federation of Automatic Control's First Symposium on Modeling and Control of Biotechnological Processes held in Noordwijkerhout, The Netherlands, on December 11-13, 1985. The papers explore modeling and control of biotechnological processes such as fermentation and biological wastewater treatment. This book consists of 37 chapters divided into 11 sections and begins with a discussion on the control of fermentation processes; modeling of biotechnical processes; and application of measurement and estimation techniques to biotechnology. The following sections focus on adaptive control theory, applications of adaptive control, and control and modeling of bioreactors. The reader is also introduced to measurement techniques and sensors, with emphasis on pyrolysis mass spectrometry; rapid bioelectrochemical methods; and a self-tuning controller for multiloop controlled fed-batch fermentation. The remaining sections deal with parameter identification and estimation; Kalman filtering techniques; optimization of production processes; modeling of microkinetics; and optimization theory. This monograph will be of interest to researchers and practitioners in the field of biotechnology.

Download or read book Biotechnology for Biofuel Production and Optimization written by Carrie A Eckert and published by Elsevier. This book was released on 2016-01-19 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology for Biofuel Production and Optimization is the compilation of current research findings that cover the entire process of biofuels production from manipulation of genes and pathways to organisms and renewable feedstocks for efficient biofuel production as well as different cultivation techniques and process scale-up considerations. This book captures recent breakthroughs in the interdisciplinary areas of systems and synthetic biology, metabolic engineering, and bioprocess engineering for renewable, cleaner sources of energy. - Describes state-of-the-art engineering of metabolic pathways for the production of a variety of fuel molecules - Discusses recent advances in synthetic biology and metabolic engineering for rational design, construction, evaluation of novel pathways and cell chassis - Covers genome engineering technologies to address complex biofuel-tolerant phenotypes for enhanced biofuel production in engineered chassis - Presents the use of novel microorganisms and expanded substrate utilization strategies for production of targeted fuel molecules - Explores biohybrid methods for harvesting bioenergy - Discusses bioreactor design and optimization of scale-up

Download or read book Proceedings of the 8th International Conference on Foundations of Computer Aided Process Design written by and published by Elsevier. This book was released on 2014-07-14 with total page 835 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume collects together the presentations at the Eighth International Conference on Foundations of Computer-Aided Process Design, FOCAPD-2014, an event that brings together researchers, educators, and practitioners to identify new challenges and opportunities for process and product design. The chemical industry is currently entering a new phase of rapid evolution. The availability of low-cost feedstocks from natural gas is causing renewed investment in basic chemicals in the OECD, while societal pressures for sustainability and energy security continue to be key drivers in technology development and product selection. This dynamic environment creates opportunities to launch new products and processes and to demonstrate new methodologies for innovation, synthesis and design. FOCAPD-2014 fosters constructive interaction among thought leaders from academia, industry, and government and provides a showcase for the latest research in product and process design. - Focuses exclusively on the fundamentals and applications of computer-aided design for the process industries. - Provides a fully archival and indexed record of the FOCAPD14 conference - Aligns the FOCAPD series with the ESCAPE and PSE series

Download or read book Modelling and Control of Biotechnical Processes written by A. Halme and published by Elsevier. This book was released on 2014-05-09 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling and Control of Biotechnical Processes covers the proceedings of the First International Federation of Automatic Control Workshop by the same title, held in Helsinki, Finland on August 17-19, 1982. This book is organized into seven sections encompassing 37 chapters. The opening section deals with the measurement techniques in fermentation processes and the use of automated analyzers to control microbial processes. The next sections consider the concepts of bioreactor modeling and related problems, as well as the modeling and control of biological wastewater treatment processes. Other sections discuss the economic and static optimization, the computer control of production processes, and the application of estimation and identification methods to biotechnological processes. The final sections explore the principles of real-time analysis, use of computer control in specific biotechnical production, process control design, and the modeling of adaptive control. This book is of great value to biotechnologists, biochemists, and control engineers.

Download or read book Process Optimization written by Enrique del Castillo and published by Springer Science & Business Media. This book was released on 2007-09-14 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers several bases at once. It is useful as a textbook for a second course in experimental optimization techniques for industrial production processes. In addition, it is a superb reference volume for use by professors and graduate students in Industrial Engineering and Statistics departments. It will also be of huge interest to applied statisticians, process engineers, and quality engineers working in the electronics and biotech manufacturing industries. In all, it provides an in-depth presentation of the statistical issues that arise in optimization problems, including confidence regions on the optimal settings of a process, stopping rules in experimental optimization, and more.

Download or read book Modelling and Optimization of Biotechnological Processes written by Lei Zhi Chen and published by Springer. This book was released on 2007-07-04 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mostindustrialbiotechnologicalprocessesareoperatedempirically.Oneofthe major di?culties of applying advanced control theories is the highly nonlinear nature of the processes. This book examines approaches based on arti?cial intelligencemethods,inparticular,geneticalgorithmsandneuralnetworks,for monitoring, modelling and optimization of fed-batch fermentation processes. The main aim of a process control is to maximize the ?nal product with minimum development and production costs. This book is interdisciplinary in nature, combining topics from biotechn- ogy, arti?cial intelligence, system identi?cation, process monitoring, process modelling and optimal control. Both simulation and experimental validation are performed in this study to demonstrate the suitability and feasibility of proposed methodologies. An online biomass sensor is constructed using a - current neural network for predicting the biomass concentration online with only three measurements (dissolved oxygen, volume and feed rate). Results show that the proposed sensor is comparable or even superior to other sensors proposed in the literature that use more than three measurements. Biote- nological processes are modelled by cascading two recurrent neural networks. It is found that neural models are able to describe the processes with high accuracy. Optimization of the ?nal product is achieved using modi?ed genetic algorithms to determine optimal feed rate pro?les. Experimental results of the corresponding production yields demonstrate that genetic algorithms are powerful tools for optimization of highly nonlinear systems. Moreover, a c- bination of recurrentneural networks and genetic algorithms provides a useful and cost-e?ective methodology for optimizing biotechnological processes.

Download or read book Computer Applications in Fermentation Technology Modelling and Control of Biotechnological Processes written by N. M. Fish and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Richard Fox Chairman, Scientific Programme Committee Between 25th and 29th September, 1988, 243 people who either apply or research the use of computers in fermentation gathered together at Robinson College, Cambridge, UK. They came from 30 countries. The conference brought together two traditions. Firstly, it continued the series on Computer Applications in Fermentation Technology (ICCAFT) inaugurated by Henri Blanchere in Dijon in 1973 and carried forward in Philadelphia and Manchester. Secondly, it brought the expertise of the many members of the International Federation of Automatic Control (IFAC), who focused their attention on biotechnology at Noordwijkerhout in the Netherlands in December, 1985. I am happy to say that the tradition carries on and a successor meeting will hopefully take place in the USA in 1991. If you find these proceedings useful or stimulating, then we hope to see you there. We set out to make ICCAFT4 a close-knit friendly conference. We housed all who cared to in Robinson College itself and organised no parallel sessions. Because we, the organisers, experience difficulty with the jargon of our colleagues from other disciplines, we asked Bruce Beck to present a breakfast tutorial on modern control and modelling techniques, and we set up informal panel discussions after dinner on two evenings. Neville Fish chaired a forum on the microbiological principles behind models, while Professors Derek Linkens and Ron Leigh led a discussion on expert systems in control.

Download or read book Computational Intelligence Techniques for Bioprocess Modelling Supervision and Control written by Maria Carmo Nicoletti and published by Springer Science & Business Media. This book was released on 2009-06-29 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Intelligence (CI) and Bioprocess are well-established research areas which have much to offer each other. Under the perspective of the CI area, Biop- cess can be considered a vast application area with a growing number of complex and challenging tasks to be dealt with, whose solutions can contribute to boosting the development of new intelligent techniques as well as to help the refinement and s- cialization of many of the already existing techniques. Under the perspective of the Bioprocess area, CI can be considered a useful repertoire of theories, methods and techniques that can contribute and offer interesting alternative approaches for solving many of its problems, particularly those hard to solve using conventional techniques. Although throughout the past years CI and Bioprocess areas have accumulated substantial specific knowledge and progress has been quick and with a high degree of success, we believe there is still a long way to go in order to use the potentialities of the available CI techniques and knowledge at their full extent, as tools for supporting problem solving in bioprocesses. One of the reasons is the fact that both areas have progressed steadily and have been continuously accumulating and refining specific knowledge; another reason is the high level of technical expertise demanded by each of them. The acquisition of technical skills, experience and good insights in either of the two areas is very demanding and a hard task to be accomplished by any professional.

Download or read book Citric Acid Biotechnology written by Bjorn Kristiansen and published by CRC Press. This book was released on 2002-04-12 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers citric acid fermentation methods including recent advances and approaches. The book looks at all aspects of the fermentation process and should be of interest to those working in biotechnology, microbiology and biochemistry.

Download or read book Biotechnology Genetic Engineering Reviews written by Stephen Harding and published by Nottingham University Press. This book was released on 2009-04-01 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Containing more than a dozen original, major review articles from authors published in leading journals and covering important developments in industrial, agricultural, and medical applications of biotechnology, this newest edition from the well-established hardcover review series focuses primarily on the genetic manipulation of organisms. Covering issues ranging from gene expression and genetic regulations to plant bioreactors and enzymatic processing, this reference will benefit students in the fields of biochemistry, genetics, molecular biology, and pharmaceutical sciences.

Download or read book Stochastic Global Optimization Methods and Applications to Chemical Biochemical Pharmaceutical and Environmental Processes written by Ch. Venkateswarlu and published by Elsevier. This book was released on 2019-11-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stochastic global optimization methods and applications to chemical, biochemical, pharmaceutical and environmental processes presents various algorithms that include the genetic algorithm, simulated annealing, differential evolution, ant colony optimization, tabu search, particle swarm optimization, artificial bee colony optimization, and cuckoo search algorithm. The design and analysis of these algorithms is studied by applying them to solve various base case and complex optimization problems concerning chemical, biochemical, pharmaceutical, and environmental engineering processes. Design and implementation of various classical and advanced optimization strategies to solve a wide variety of optimization problems makes this book beneficial to graduate students, researchers, and practicing engineers working in multiple domains. This book mainly focuses on stochastic, evolutionary, and artificial intelligence optimization algorithms with a special emphasis on their design, analysis, and implementation to solve complex optimization problems and includes a number of real applications concerning chemical, biochemical, pharmaceutical, and environmental engineering processes. - Presents various classical, stochastic, evolutionary, and artificial intelligence optimization algorithms for the benefit of the audience in different domains - Outlines design, analysis, and implementation of optimization strategies to solve complex optimization problems of different domains - Highlights numerous real applications concerning chemical, biochemical, pharmaceutical, and environmental engineering processes

Download or read book Process Synthesis for Fuel Ethanol Production written by C.A. Cardona and published by CRC Press. This book was released on 2009-12-03 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Process engineering can potentially provide the means to develop economically viable and environmentally friendly technologies for the production of fuel ethanol. Focusing on a key tool of process engineering, Process Synthesis for Fuel Ethanol Production is a comprehensive guide to the design and analysis of the most advanced technologies for fuel

Download or read book Fed Batch Cultures written by Henry C. Lim and published by Cambridge University Press. This book was released on 2013-04-22 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.

Download or read book Handbook of Research on Novel Soft Computing Intelligent Algorithms written by Pandian Vasant and published by IGI Global. This book was released on 2013-08-31 with total page 1173 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book explores emerging technologies and best practices designed to effectively address concerns inherent in properly optimizing advanced systems, demonstrating applications in areas such as bio-engineering, space exploration, industrial informatics, information security, and nuclear and renewable energies"--Provided by publisher.

Download or read book Biopharmaceutical Processing written by Gunter Jagschies and published by Elsevier. This book was released on 2018-01-18 with total page 1310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. - Offers a comprehensive, go-to reference for daily work decisions - Covers both upstream and downstream processes - Includes case studies that emphasize financial outcomes - Presents summaries, decision grids, graphs and overviews for quick reference

Download or read book Statistics for Biotechnology Process Development written by Todd Coffey and published by CRC Press. This book was released on 2018-05-16 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written specifically for biotechnology scientists, engineers, and quality professionals, this book describes and demonstrates the proper application of statistical methods throughout Chemistry, Manufacturing, and Controls (CMC). Filled with case studies, examples, and easy-to-follow explanations of how to perform statistics in modern software, it is the first book on CMC statistics written primarily for practitioners. While statisticians will also benefit from this book, it is written particularly for industry professionals who don’t have access to a CMC statistician or who want to be more independent in the design and analysis of their experiments. Provides an introduction to the statistical concepts important in the biotechnology industry Focuses on concepts with theoretical details kept to a minimum Includes lots of real examples and case studies to illustrate the methods Uses JMP software for implementation of the methods Offers a text suitable for scientists in the industry with some quantitative training Written and edited by seasoned veterans of the biotechnology industry, this book will prove useful to a wide variety of biotechnology professionals. The book brings together individual chapters that showcase the use of statistics in the most salient areas of CMC.