Download or read book Modeling Excitable Tissue written by Aslak Tveito and published by Springer Nature. This book was released on 2020-10-30 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access volume presents a novel computational framework for understanding how collections of excitable cells work. The key approach in the text is to model excitable tissue by representing the individual cells constituting the tissue. This is in stark contrast to the common approach where homogenization is used to develop models where the cells are not explicitly present. The approach allows for very detailed analysis of small collections of excitable cells, but computational challenges limit the applicability in the presence of large collections of cells.
Download or read book Modeling Excitable Tissue written by Aslak Tveito and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access volume presents a novel computational framework for understanding how collections of excitable cells work. The key approach in the text is to model excitable tissue by representing the individual cells constituting the tissue. This is in stark contrast to the common approach where homogenization is used to develop models where the cells are not explicitly present. The approach allows for very detailed analysis of small collections of excitable cells, but computational challenges limit the applicability in the presence of large collections of cells.
Download or read book Cellular Biophysics and Modeling written by Greg Conradi Smith and published by Cambridge University Press. This book was released on 2019-03-14 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: What every neuroscientist should know about the mathematical modeling of excitable cells, presented at an introductory level.
Download or read book Cellular Biophysics and Modeling written by Greg Conradi Smith and published by Cambridge University Press. This book was released on 2019-03-14 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.
Download or read book Modelling Organs Tissues Cells and Devices written by Socrates Dokos and published by Springer. This book was released on 2017-03-08 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a theoretical and practical overview of computational modeling in bioengineering, focusing on a range of applications including electrical stimulation of neural and cardiac tissue, implantable drug delivery, cancer therapy, biomechanics, cardiovascular dynamics, as well as fluid-structure interaction for modelling of organs, tissues, cells and devices. It covers the basic principles of modeling and simulation with ordinary and partial differential equations using MATLAB and COMSOL Multiphysics numerical software. The target audience primarily comprises postgraduate students and researchers, but the book may also be beneficial for practitioners in the medical device industry.
Download or read book The Physiology of Excitable Cells written by David J. Aidley and published by Cambridge University Press. This book was released on 1998-09-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of this highly successful text has been extensively revised and restructured to take account of the many recent advances in the subject and bring it right up to date. The classic observations of recent years can now be interpreted with the powerful new techniques of molecular biology. Consequently there is much new material throughout the book, including many new illustrations and extensive references to recent work. Its essential philosophy remains the same, though: fundamental concepts are clearly explained, and key experiments are examined in some detail. This textbook will be used by students of physiology, neuroscience, cell biology and biophysics. Specializing undergraduates and graduates as well as lecturers and researchers will find the text thorough and clearly written.
Download or read book Calcium Entry Channels in Non Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Download or read book Modeling Excitable Cells Using Hybrid Automata written by Pei Ye (Ph. D.) and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies written by Tetsuya Watanabe and published by Academic Press. This book was released on 2022-01-18 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies covers the neuronal cell communication system in excitable cells, recognizing the most relevant mechanisms of cell communication. Along with new findings in biotechnology, medicine and pathological cases for clinicians, the book highlights electrochemical potential in living nerve and muscle cells. Written for physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists, this book an essential read for a real understanding of the signals as we see them. Covers neuronal cell communication systems in excitable cells Presents new findings in biotechnology that are being applied in medicine and pathological cases Covers mathematical and physical bases for readers without background in these fields
Download or read book Ionic Channels of Excitable Membranes written by Bertil Hille and published by Sinauer Associates, Incorporated. This book was released on 1992 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.
Download or read book Modeling the Dynamics of Excitable Cells written by Asja Alić and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We consider an electrical parallel conductance membrane model which is an extension of the classical Hodgkin-Huxley neuronal model of excitability. This extended model describes the formation of the resting membrane potential and conductance, and the formation of action potentials in nodose A-type excitable cells. The model consists of a set of nonlinear ordinary differential equations which are numerically solved using the Python programming language. The results show that the model is capable of accurately describing experimental results including resting membrane potential and conductance, duration and form of action potentials, amplitude of the spike, oscillations, and activitydependent changes in [Ca2+] in the pericellular space and cytoplasm. This enables one to model the excitability of A-type nodose sensory neurons as well as to study the effects of ion channel modulators and their combinations under different environmental conditions such as variable extracellular Na+, K+, and Ca2+ concentrations and pericellular volume. The effects of tetrodotoxin which is found in pufferfish, 4-Aminopyridine chemical compound, and iberiotoxin which is found in the Indian Red Scorpion, were studied.
Download or read book Electrostimulation written by J. Patrick Reilly and published by Artech House. This book was released on 2011 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrostimulation is defined as the action of electrical energy on nerve and muscle OCo the two classes of excitable tissue. This cutting-edge resource offers you broad coverage of the subject, expanding the scope of electrostimulation discussions to include accidental, aversive, and possibly harmful biological effects of electrical energy. The book enables you to develop standards for human exposure to electric currents having various waveforms, determine classes of nerve fibers brought to excitation within specified regions of the body due to certain types of exposure, and quantify how harmonic distortions influence the excitability of sinusoidal extrostimulation. This practical reference also offers guidance in using the SENN (Spatially Extended Nonlinear Node) computer model that simulates the interaction of applied electric energy with myelinated neurons.Moreover, you learn how to compare efficacy and hazard potential of various stun weapons, assess unintended nerve stimulation from MRI exposure of patients with metallic implants, and compare the safety margins between electrostimulation thresholds of sensory and motor neurons relative to unintended cardiac excitation or painful sensory responses."
Download or read book Cellular Automaton Modeling of Biological Pattern Formation written by Andreas Deutsch and published by Birkhäuser. This book was released on 2018-03-09 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text explores the use of cellular automata in modeling pattern formation in biological systems. It describes several mathematical modeling approaches utilizing cellular automata that can be used to study the dynamics of interacting cell systems both in simulation and in practice. New in this edition are chapters covering cell migration, tissue development, and cancer dynamics, as well as updated references and new research topic suggestions that reflect the rapid development of the field. The book begins with an introduction to pattern-forming principles in biology and the various mathematical modeling techniques that can be used to analyze them. Cellular automaton models are then discussed in detail for different types of cellular processes and interactions, including random movement, cell migration, adhesive cell interaction, alignment and cellular swarming, growth processes, pigment cell pattern formation, tissue development, tumor growth and invasion, and Turing-type patterns and excitable media. In the final chapter, the authors critically discuss possibilities and limitations of the cellular automaton approach in modeling various biological applications, along with future research directions. Suggestions for research projects are provided throughout the book to encourage additional engagement with the material, and an accompanying simulator is available for readers to perform their own simulations on several of the models covered in the text. QR codes are included within the text for easy access to the simulator. With its accessible presentation and interdisciplinary approach, Cellular Automaton Modeling of Biological Pattern Formation is suitable for graduate and advanced undergraduate students in mathematical biology, biological modeling, and biological computing. It will also be a valuable resource for researchers and practitioners in applied mathematics, mathematical biology, computational physics, bioengineering, and computer science. PRAISE FOR THE FIRST EDITION “An ideal guide for someone with a mathematical or physical background to start exploring biological modelling. Importantly, it will also serve as an excellent guide for experienced modellers to innovate and improve their methodologies for analysing simulation results.” —Mathematical Reviews
Download or read book Computational Physiology written by Kimberly J. McCabe and published by Springer Nature. This book was released on 2022-06-09 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access volume compiles student reports from the 2021 Simula Summer School in Computational Physiology. Interested readers will find herein a number of modern approaches to modeling excitable tissue. This should provide a framework for tools available to model subcellular and tissue-level physiology across scales and scientific questions. In June through August of 2021, Simula held the seventh annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). The course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. The majority of the school consists of group research projects conducted by Masters and PhD students from around the world, and advised by scientists at Simula, UiO and UCSD. Each group then produced a report that addreses a specific problem of importance in physiology and presents a succinct summary of the findings. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier computational studies or experimental findings. Reports from eight of the summer projects are included as separate chapters. The fields represented include cardiac geometry definition (Chapter 1), electrophysiology and pharmacology (Chapters 2–5), fluid mechanics in blood vessels (Chapter 6), cardiac calcium handling and mechanics (Chapter 7), and machine learning in cardiac electrophysiology (Chapter 8).
Download or read book Patterns in Excitable Media written by Sitabhra Sinha and published by CRC Press. This book was released on 2014-12-13 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excitable media comprise a class of models for a wide range of physical, chemical, and biological systems that exhibit spontaneous formation of spatial patterns. Patterns in Excitable Media: Genesis, Dynamics, and Control explores several aspects of the dynamics of such patterns-in particular their evolution upon interaction with structural and fun
Download or read book The Cellular Response of Excitable Tissue Models to Extracellular Stimulation written by Lianne A. Cartee and published by . This book was released on 1991 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Models of Calcium Signalling written by Geneviève Dupont and published by Springer. This book was released on 2016-06-07 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism. Geneviève Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Université Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbrück Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.
