Download or read book Some Antiviral and Antineoplastic Drugs and Other Pharmaceutical Agents written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2000 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study but not in another involving treatment at a lower dose. Despite observation of toxic effects in some studies of humans human carcinogenicity data were judged to provide inadequate evidence of carcinogenicity in humans. Zidovudine was classified as possibly carcinogenic to humans. Similar weaknesses in human carcinogenicity data for zalcitabine which consistently induces thymic lymphomas in mice resulted in its classification as possibly carcinogenic to humans. The second monograph evaluates four DNA topoisomerase II inhibitors: etoposide teniposide mitoxantrone and amsacrine. Of these etoposide - one of the most widely used and effective cytotoxic drugs in combination therapy - was classified as probably carcinogenic to humans and etoposide in combination with cisplatin and bleomycin was judged to be carcinogenic to humans. Teniposide was classified as probably carcinogenic to humans and mitoxantrone and amsacrine were classified as possibly carcinogenic to humans. Of the three pharmaceutical agents evaluated in the final monograph hydroxyurea which is widely used in cancer treatment and increasingly in combination with didanosine in HIV infection could not be classified. Phenolphthalein a widely used laxative now being withdrawn from the market in many countries because of toxicological concerns was classified as possibly carcinogenic. Vitamin K substances could not be classified on the basis of available evidence.

Download or read book Per and polyfluorinated substances in the Nordic Countries written by Stefan Posner and published by Nordic Council of Ministers. This book was released on 2013-06-19 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Tema Nord report presents a study based on open information and custom market research to review the most common perfluorinated substances (PFC) with less focus on PFOS and PFOA. The study includes three major parts:1) Identification of relevant per-and polyfluorinated substances and their use in various industrial sectors in the Nordic market by interviews with major players and database information; 2) Emissions to and occurence in the Nordic environment of the substances described in 1); 3) A summary of knowledge of the toxic effects on humans and the environment of substances prioritized in 2); There is a lack of physical chemical data, analystical reference substances, human and environmental occurrence and toxicology data, as well as market information regarding PFCs other than PFOA and PFOS and the current legislation cannot enforce disclosure of specific PFC substance information.

Download or read book Unidentified written by Robert Salas and published by Career Press. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1969 the U.S. Air Force issued a statement that read' "No UFO reported, investigated and evaluated by the Air Force was ever an indication of threat to our national security." This statement is patently false. It has been proven untrue by the testimony of many military officers and airmen and documentation of incidents involving UFOs and nuclear weapons, testimonies of which the U.S. Air Force was fully aware. Unidentified details many of these testimonies, some for the first time. As partial justification for its position, the Air Force cites a University of Colorado study that was contracted and paid for by federal funds. Unidentified reveals how this study was actually just another part of the plan to cover up the reality of the UFO phenomenon. For the first time, Unidentified publishes evidence that the investigators for the Colorado study knew about the UFO-related missile shutdown incidents but did not investigate them or include them in their final report.

Download or read book Lost Secrets of the Sacred Ark written by Laurence Gardner and published by HarperCollins UK. This book was released on 2004 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ark of the Covenant is the source of one of the deepest mysteries of the Western world. Laurence Gardner has accessed Rosicrucian archives to reveal where the Ark is, what it is and how this lost secret of the distant past has led to the phenomenal new science of space-time manipulation.

Download or read book UFOs are Real written by Clifford E. Stone and published by S.P.I. Books. This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Encounter with Tiber written by Buzz Aldrin and published by Open Road Media. This book was released on 2013-05-28 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Apollo 11 astronaut and the Nebula Award–nominated author of Directive 51 present a novel that “conveys the wonder and promise of space” (Publishers Weekly). Born the year of the Moon landing, Chris Terence spends his life fighting to return humanity to that pinnacle. An engineering student with dreams of spaceflight, he finds upon graduation that the United States no longer has need for astronauts. Years of bureaucratic meddling have reduced the space program to a shell of itself, and it will take the greatest scientific find in history to send humanity skyward once more. After years battling budget hawks, Chris finally gets his chance to walk on the Moon. While there, he finds evidence of an ancient alien civilization, the Tiberians, who visited Earth’s satellite eight thousand years before. Understanding what happened to those long-forgotten travelers will define the lives of Chris and his son, as they fight against all odds to unlock the secrets of the universe. “The collaboration of the first man to pilot a moon lander (Aldrin) with a major voice in contemporary science fiction (Barnes) has produced a fascinating chronicle of man’s first encounter with alien intelligence” (Booklist).