Download or read book Mise en place de la v rification du nettoyage appliqu un pilote de d veloppement pharmaceutique written by Olivier Champion and published by . This book was released on 2007 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dans l’industrie pharmaceutique, le procédé de nettoyage doit être vérifié afin de prévenir les contaminations croisées ou le mix-up et afin d’avoir une trace écrite prouvant que le matériel est nettoyé et que ce nettoyage est efficace. Ce travail aborde dans une première partie, tirée d’une étude bibliographique, les étapes de la mise en place de la qualité dans les pratiques clinique et les pratiques de fabrication en Europe et aux Etats-Unis, et la nécessité de définir une norme internationale. Les pré-requis à la vérification du nettoyage seront ensuite abordés ainsi que la méthodologie de nettoyage ; avant de s’attacher à décrire les points indispensables à une démarche de vérification du nettoyage..La seconde partie présente la démarche mise en œuvre au sein d’un site de développement pharmaceutique dans le cas particulier d’un pilote 30/50kg destiné à recevoir des lots cliniques en parallèle de son activité actuelle avec des lots techniques. Pour répondre à ces contraintes, les différentes étapes de création de la documentation permettant la mise en place de la démarche de vérification du nettoyage appliquée au développement industriel sont expliquées.
Download or read book Modification d un processus de validation de nettoyage en industrie pharmaceutique suite l volution de la r glementation en vigueur written by Cécile Egea and published by . This book was released on 2017 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: La validation de nettoyage est une approche réglementée qui permet de s'assurer de l'efficacité des procédés de nettoyage mis en place pour un équipement et un produit donné. L'objectif final est la suppression des contaminations de tous types afin de favoriser la sécurité des patients et la qualité des produits. L'évolution des textes opposables confirme l'importance de ce sujet. En 2016, la mise à jour de l'annexe 15 des Bonnes Pratiques de Fabrication a mis en exergue des modifications importantes à mettre en place sur les sites de fabrication et de conditionnement de médicaments. La prise en compte des facteurs variables pouvant influencer la qualité du nettoyage et l'obtention du critère d'acceptation à partir d'une évaluation toxicologique sont deux points capitaux à prendre en compte dans l'adaptation de la validation de nettoyage à la nouvelle réglementation. Cette thèse d'exercice permet de mettre en avant la méthodologie à suivre afin de réaliser une validation de nettoyage conforme à la nouvelle réglementation en vigueur. L'application d'un cas pratique permet d'illustrer.
Download or read book Mise en place d un projet de validation du nettoyage des quipements dans l industrie pharmaceutique written by Céline Braxmaier 1981-..... and published by . This book was released on 2008 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Doing Business 2020 written by World Bank and published by World Bank Publications. This book was released on 2019-11-21 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seventeen in a series of annual reports comparing business regulation in 190 economies, Doing Business 2020 measures aspects of regulation affecting 10 areas of everyday business activity.
Download or read book Faecal Sludge Management written by Linda Strande and published by IWA Publishing. This book was released on 2014-08-15 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is estimated that literally billions of residents in urban and peri-urban areas of Africa, Asia, and Latin America are served by onsite sanitation systems (e.g. various types of latrines and septic tanks). Until recently, the management of faecal sludge from these onsite systems has been grossly neglected, partially as a result of them being considered temporary solutions until sewer-based systems could be implemented. However, the perception of onsite or decentralized sanitation technologies for urban areas is gradually changing, and is increasingly being considered as long-term, sustainable options in urban areas, especially in low- and middle-income countries that lack sewer infrastructures. This is the first book dedicated to faecal sludge management. It compiles the current state of knowledge of the rapidly evolving field of faecal sludge management, and presents an integrated approach that includes technology, management, and planning based on Sandecs 20 years of experience in the field. Faecal Sludge Management: Systems Approach for Implementation and Operation addresses the organization of the entire faecal sludge management service chain, from the collection and transport of sludge, and the current state of knowledge of treatment options, to the final end use or disposal of treated sludge. The book also presents important factors to consider when evaluating and upscaling new treatment technology options. The book is designed for undergraduate and graduate students, and engineers and practitioners in the field who have some basic knowledge of environmental and/or wastewater engineering.
Download or read book Global Burden of Disease and Risk Factors written by Alan D. Lopez and published by World Bank Publications. This book was released on 2006-04-02 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.
Download or read book Frontline and Factory written by Roy MacLeod and published by Springer Science & Business Media. This book was released on 2007-05-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a first considered attempt to study the factors that conditioned industrial chemistry for war in 1914-18. Taking a comparative perspective, it reflects on the experience of France, Germany, Austria, Russia, Britain, Italy and Russia, and points to significant similarities and differences. It looks at changing patterns in the organisation of industry, and at the emerging symbiosis between science, industry and the military.
Download or read book How to Design Wastewater Systems for Local Conditions in Developing Countries written by David M. Robbins and published by IWA Publishing. This book was released on 2014-03-15 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a practical handbook providing a step-by-step approach to the techniques used for characterizing wastewater sources and investigating sites where collection, treatment and reuse/disposal technologies will be installed. It is intended to help enable local implementation of on-site and decentralized wastewater management system (DWMS)for wide scale use in development settings. How to Design Wastewater Systems for Local Conditions in Developing Countries helps local service providers and regulatory officials make informed decisions through the use of tools, checklists and case studies. It includes a link to a web based community of on-site and decentralized wastewater professionals, which contains related tools and case studies. This handbook serves as a reference for training classes, certification programs, and higher education programs in civil and sanitary engineering. There is an increasing interest on the part of local government officials and private sector service providers to implement wastewater treatment systems to solve sanitation problems. The model presented in this handbook promotes activities that first generate data related to source and site conditions that represent critical inputs, and then applies this information to the technology selection process. Matching the most appropriate technologies to the specific needs of the wastewater project is the key that leads to long term sustainability. How to Design Wastewater Systems for Local Conditions in Developing Countries is an invaluable resource for public sector decision makers and private sector service providers in developing countries. It is also a useful text for students at engineering colleges in developing countries interested in taking a class that teaches the methods of decentralized wastewater management system (DWMS) development.
Download or read book Comprehensive Cervical Cancer Control written by World Health Organization and published by World Health Organization. This book was released on 2006 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most women who die from cervical cancer, particularly in developing countries, are in the prime of their life. They may be raising children, caring for their family, and contributing to the social and economic life of their town or village. Their death is both a personal tragedy, and a sad and unnecessary loss to their family and their community. Unnecessary, because there is compelling evidence, as this Guide makes clear, that cervical cancer is one of the most preventable and treatable forms of cancer, as long as it is detected early and managed effectively. Unfortunately, the majority of women in developing countries still do not have access to cervical cancer prevention programmes. The consequence is that, often, cervical cancer is not detected until it is too late to be cured. An urgent effort is required if this situation is to be corrected. This Guide is intended to help those responsible for providing services aimed at reducing the burden posed by cervical cancer for women, communities and health systems. It focuses on the knowledge and skills needed by health care providers, at different levels of care.
Download or read book Oxford Textbook of Palliative Medicine written by Nathan I. Cherny and published by Oxford University Press, USA. This book was released on 2015 with total page 1281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasising the multi-disciplinary nature of palliative care the fourth edition of this text also looks at the individual professional roles that contribute to the best-quality palliative care.
Download or read book A Frequency Dictionary of French written by Deryle Lonsdale and published by Routledge. This book was released on 2009-03-25 with total page 974 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Frequency Dictionary of French is an invaluable tool for all learners of French, providing a list of the 5000 most frequently used words in the language. Based on a 23-million-word corpus of French which includes written and spoken material both from France and overseas, this dictionary provides the user with detailed information for each of the 5000 entries, including English equivalents, a sample sentence, its English translation, usage statistics, and an indication of register variation. Users can access the top 5000 words either through the main frequency listing or through an alphabetical index. Throughout the frequency listing there are thematically-organized lists of the top words from a variety of key topics such as sports, weather, clothing, and family terms. An engaging and highly useful resource, the Frequency Dictionary of French will enable students of all levels to get the most out of their study of French vocabulary. Former CD content is now available to access at www.routledge.com/9780415775311 as support material. Designed for use by corpus and computational linguists it provides the full text in a format that researchers can process and turn into suitable lists for their own research work. Deryle Lonsdale is Associate Professor in the Linguistics and English Language Department at Brigham Young University (Provo, Utah). Yvon Le Bras is Associate Professor of French and Department Chair of the French and Italian Department at Brigham Young University (Provo, Utah).
Download or read book Oxford Textbook of Palliative Care for Children written by Richard Hain and published by Oxford University Press. This book was released on 2021-03-24 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of palliative care for children facing life threatening illness and their families is now widely acknowledged as an essential part of care, which should be available to all children and families, throughout the child's illness and at the end of life. The new edition of the Oxford Textbook of Palliative Care for Children brings together the most up to date information, current knowledge, evidence, and developments of clinical practice in the field. The book is structured into four sections. 'Foundations of Care' describes core issues, the foundations on which paediatric palliative care is based. 'Child and Family Care' looks at different aspects of psychological, social, and cultural care for the sick child or young person, and their family. These chapters cover the time course of the illness, around the time of death and support for the bereaved family. 'Symptom Care' focuses on the uses of medication, specific symptoms, and their management. Finally, 'Delivery of Care' examines practical approaches to care in different environments and the needs of clinicians. Two new editors join the team from Canada and South Africa, reflecting our aims to contribute towards the development of care for children across the world, and to be a resource for both experienced clinicians and those new to the field. Comprehensive in scope, exhaustive in detail, and definitive in authority, this third edition has been thoroughly updated to cover new practices, current epidemiological data, and the evolving models that support the delivery of palliative medicine to children. This includes two new chapters, looking in detail at 'Decision Making' and 'Perinatal Care', and a new section highlighting the emerging importance of 'Palliative Care for Children in Humanitarian Crises'. This book is an essential resource for anyone who works with children worldwide.
Download or read book The Disappearing Computer written by Norbert Streitz and published by Springer. This book was released on 2007-07-20 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines how the computer, as we currently know it, will be replaced by a new generation of technologies, moving computing off the desktop and ultimately integrating it with real world objects and everyday environments. It provides a unique combination of concepts, methods and prototypes of ubiquitous and pervasive computing reflecting the current interest in smart environments and ambient intelligence.
Download or read book William Trevor written by Suzanne Morrow Paulson and published by . This book was released on 1993 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Intensely poetic, understated, and ironic, William Trevor's fiction contains the very hallmarks of the modern short story, following a long tradition of Irish and British literature about the often painful and grueling route people travel in the simple effort to integrate themselves into society. In his many poignant stories - among them "Mulvihill's Memorial," "The Mark-2 Wife," "The Day We Got Drunk on Cake," "Lovers of Their Time," and "The Ballroom of Romance" - Trevor reveals his mastery of tragi-comedy, whereby human interaction at even the most parochial level lends to an understanding of the universal." "In this first book-length study of Trevor's stories, Suzanne Morrow Paulson provides a comprehensive overview of this Anglo-Irish writer's craft, examining his "masterpieces" of the form, his proficiency with the comic as well as the tragic. Trevor writes a personal sort of fiction, Paulson observes, rendering the grotesque aspects of human nature under stress, yet he transcends the personal because his art encourages sympathy for even the most ridiculous figures. Refuting critics who find his work dour and pessimistic, Paulson finds that most of Trevor's stories convey a genuine optimism and a love of people - a love based on a profound understanding of suffering, a sympathetic acceptance of human weakness, and shrewd insights into social hierarchies." "Paulson finds Trevor at his best in stories that express his sympathy for women, sensitive men, and adolescents who suffer from destructive stereotypes of feminine and masculine behavior. Paulson assigns the fiction discussed to four thematic groups: stories that explore the psychology of coping or failing to cope with trauma; stories about fathers and mothers who cannot understand themselves or their adolescent children; stories depicting the suffering of adolescent girls, spinsters, wives, and mothers as they conform to destructive stereotypes governing proper female behavior; and stories concerned with materialistic values promoted by advertising and the mass media." "In Parts 2 and 3 of this clear, concise introduction to the Trevor short-fiction canon Paulson has compiled, first, Trevor's comments on his art, his reader, and his community (including an original 1989 interview with the author), and, second, a survey of responses to Trevor's work and a brief gathering of articles and reviews published in Ireland, England, France, Canada, and America."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Download or read book Triglycidyl Isocyanurate written by D. Willcocks and published by . This book was released on 1998 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise assessment of the risks to human health and the environment posed by exposure to triglycidyl isocyanurate, a synthetic white powder or granule used mainly as a three-dimensional cross-linking or curing agent in polyester powder coatings and paints. The chemical is also used in solder mask inks in the printed circuit board industry.
Download or read book Social Learning Towards a Sustainable World written by Arjen E. J. Wals and published by Wageningen Academic Pub. This book was released on 2007 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents and discusses key principles, perspectives and practices of social learning in the context of sustainability. Social learning is explored from a range of fields challenged by sustainability. This book brings together a range of ideas, stories and discussions about purposeful learning in communities aimed at creating better prospects.
Download or read book World Health Organization Guidelines on the Pharmacological Treatment of Persisting Pain in Children with Medical Illnesses written by World Health Organization and published by . This book was released on 2012 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: These guidelines have been developed to support countries to relieve pain in their paediatric populations. These guidelines address persisting pain in children caused by conditions such as cancer, HIV/AIDS, sickle-cell disease, burns, trauma, and phantom limb pain. Recommendations -- developed following a careful and transparent appraisal of available evidence -- are presented for the pharmacological treatment of mild, moderate and severe pain. The guidelines include chapters on the various systems used to classify pain and on the evaluation of pain, which reviews the available tools for routine pain measurement in children. Provision of sustainable pain relief within health care systems is covered in a separate chapter. Since morphine and other opioid analgesics -- required for the relief of moderate-to-severe pain in children -- are listed under the 1961 UN Single Convention on Narcotic Drugs, the new guidelines include an annex explaining the Convention's requirements for the handling and procurement of opioid analgesics for the relief of pain.
