Download or read book Minimal Cells Design Construction Biotechnological Applications written by Alvaro R. Lara and published by Springer Nature. This book was released on 2019-12-04 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the design, generation and characterization of minimal cell systems. Written by leading experts, it presents an in-depth analysis of the current issues and challenges in the field, including recent advances in the generation and characterization of reduced-genome strains generated from model organisms with relevance in biotechnology, and basic research such as Escherichia coli, Corynebacterium glutamicum and yeast. It also discusses methodologies, such as bottom-up and top-down genome minimization strategies, as well as novel analytical and experimental approaches to characterize and generate minimal cells. Lastly, it presents the latest research related to minimal cells of serveral microorganisms, e.g. Bacillus subtilis. The design of biological systems for biotechnological purposes employs strategies aimed at optimizing specific tasks. This approach is based on enhancing certain biological functions while reducing other capacities that are not required or that could be detrimental to the desired objective. A highly optimized cell factory would be expected to have only the capacity for reproduction and for performing the expected task. Such a hypothetical organism would be considered a minimal cell. At present, numerous research groups in academia and industry are exploring the theoretical and practical implications of constructing and using minimal cells and are providing valuable fundamental insights into the characteristics of minimal genomes, leading to an understanding of the essential gene set. In addition, research in this field is providing valuable information on the physiology of minimal cells and their utilization as a biological chassis to which useful biotechnological functions can be added.
Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Download or read book Metabolic Engineering written by Sang Yup Lee and published by John Wiley & Sons. This book was released on 2021-06-02 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.
Download or read book The Minimal Cell written by Pier Luigi Luisi and published by Springer Science & Business Media. This book was released on 2010-11-01 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last ten years there has been a considerable increase of interest on the notion of the minimal cell. With this term we usually mean a cell-like structure containing the minimal and sufficient number of components to be defined as alive, or at least capable of displaying some of the fundamental functions of a living cell. In fact, when we look at extant living cells we realize that thousands of molecules are organized spatially and functionally in order to realize what we call cellular life. This fact elicits the question whether such huge complexity is a necessary condition for life, or a simpler molecular system can also be defined as alive. Obviously, the concept of minimal cell encompasses entire families of cells, from totally synthetic cells, to semi-synthetic ones, to primitive cell models, to simple biomimetic cellular systems. Typically, in the experimental approach to the construction of minimal the main ingredient is the compartment. Lipid vesicles (liposomes) are used to host simple and complex molecular transformations, from single or multiple enzymic reactions, to polymerase chain reactions, to gene expression. Today this research is seen as part of the broader scenario of synthetic biology but it is rooted in origins of life studies, because the construction of a minimal cell might provide biophysical insights into the origins of primitive cells, and the emergence of life on earth. The volume provides an overview of physical, biochemical and functional studies on minimal cells, with emphasis to experimental approaches. 15 International experts report on their innovative contributions to the construction of minimal cells.
Download or read book Issues in Bioengineering and Bioinformatics 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 2802 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Bioengineering and Bioinformatics: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bioengineering and Bioinformatics. The editors have built Issues in Bioengineering and Bioinformatics: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bioengineering and Bioinformatics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Bioengineering and Bioinformatics: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Proceedings of Fourth International Conference on Communication Computing and Electronics Systems written by V. Bindhu and published by Springer Nature. This book was released on 2023-03-14 with total page 1048 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes high-quality research papers presented at the Fourth International Conference on Communication, Computing and Electronics Systems (ICCCES 2022), held at the PPG Institute of Technology, Coimbatore, India, on September 15–16, 2022. The book focuses mainly on the research trends in cloud computing, mobile computing, artificial intelligence and advanced electronics systems. The topics covered are automation, VLSI, embedded systems, optical communication, RF communication, microwave engineering, artificial intelligence, deep learning, pattern recognition, communication networks, Internet of things, cyber-physical systems and healthcare informatics.
Download or read book Biodefense in the Age of Synthetic Biology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-05 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.
Download or read book Construction Biotechnology written by Volodymyr Ivanov and published by Springer. This book was released on 2016-10-20 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the first comprehensive text on construction biomaterials and bioprocesses. It details aspects of construction biotechnology, a new interdisciplinary area involving applications of environmental and industrial microbiology and biotechnology in geotechnical and civil engineering. It also critically reviews all existing and potential construction biotechnology processes. It discusses a number of topics including the biotechnological production of new construction materials such as self-healing concrete, construction biocomposites, construction bioplastics, and biotechnological admixtures to cement. It also addresses construction-related processes like biocementation, bioclogging, soil surface fixation and biosealing, microbial cements and grouts, the biocoating of construction material surfaces, the microbiology and biosafety of the construction environment, the prevention of biocorrosion as well as biodeterioration and biofouling in civil engineering. Biomediated precipitation of calcium, magnesium, and iron compounds as carbonates, phosphates, sulphides, and silicate minerals in soil for its clogging and strengthening are considered from geotechnical, chemical, and microbiological points of view. It offers an overview of the basic microbiology that will enable civil engineers to perform the construction biogeochemical processes. Design principles and considerations for different field implementations are discussed from a practical point of view. The book can be used as a textbook for graduate and senior undergraduate students in biotechnology, civil engineering and environmental engineering as well as a reference book for researchers and practitioners working in this new interdisciplinary area.
Download or read book Advances in Synthetic Biology written by Vijai Singh and published by Springer Nature. This book was released on 2020-04-13 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the design of emerging conceptual tools, technologies and systems including novel synthetic parts, devices, circuits, oscillators, biological gates, and small regulatory RNAs (riboregulators and riboswitches), which serve as versatile control elements for regulating gene expression. Synthetic biology, a rapidly growing field that involves the application of engineering principles in biology, is now being used to develop novel systems for a wide range of applications including diagnostics, cell reprogramming, therapeutics, enzymes, vaccines, biomaterials, biofuels, fine chemicals and many more. The book subsequently summarizes recent developments in technologies for assembling synthetic genomes, minimal genomes, synthetic biology toolboxes, CRISPR-Cas systems, cell-free protein synthesis systems and microfluidics. Accordingly, it offers a valuable resource not only for beginners in synthetic biology, but also for researchers, students, scientists, clinicians, stakeholders and policymakers interested in the potential held by synthetic biology.
Download or read book Cell Free Synthetic Biology written by Yuan Lu and published by Springer. This book was released on 2019-09-02 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes advanced studies in cell-free synthetic biology, an emerging biotechnology that focuses on cell-free protein synthesis and cell-free systems for fundamental and industrial research in areas such as genetic circuit design, small-molecule synthesis, complicated-macromolecule synthesis, unnatural-macromolecule synthesis, high-throughput screening, artificial cells, and biomaterials. Cell-free synthetic biology is now an integral part of developing fields like nanotechnology, materials science, and personalized medicine. The book discusses the main research directions in the development of cell-free systems, as well as a number of applications of cell-free synthetic biology, ranging from structural biology to the human health industry. It is intended for students and researchers in life sciences, synthetic biology, bioengineering, and chemical engineering.
Download or read book Cyanobacterial Biotechnology written by G. Subramanian and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprises select papers presented at a symposium held in September, 1996 in India. The contributors used the forum to disseminate their research findings.
Download or read book The Mechanisms of DNA Replication written by David Stuart and published by BoD – Books on Demand. This book was released on 2013-02-20 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.
Download or read book Systems Biology in Biotech Pharma written by Aleš Prokop and published by Springer Science & Business Media. This book was released on 2012-01-05 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.
Download or read book The Bioeconomy to 2030 Designing a Policy Agenda written by OECD and published by OECD Publishing. This book was released on 2009-04-15 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the current status of biotechnologies and, using quantitative analyses of data, it estimates biotechnological developments to 2015. Using other inputs, it creates scenarios to 2030.
Download or read book Chemical Synthetic Biology written by Pier Luigi Luisi and published by John Wiley & Sons. This book was released on 2011-02-10 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, Chemical Synthetic Biology shows how chemistry underpins synthetic biology. The book is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics, and bioinformatics.
Download or read book Current Developments in Biotechnology and Bioengineering written by Sudhir P. Singh and published by Elsevier. This book was released on 2018-11-20 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Developments in Biotechnology and Bioengineering: Synthetic Biology, Cell Engineering and Bioprocessing Technologies covers the current perspectives and outlook of synthetic biology in the agriculture, food and health sectors. This book begins with the basics about synthetic biology and cell engineering, and then explores this in more detail, focusing on topics like applications of synthetic biology, industrial bioprocesses, and future perspectives. Information on cell engineering is also presented, and manipulation in endogenous metabolic network is studied alongside advanced topics such as fine tuning of metabolic pathways, de novo biosynthetic pathway design, enzyme engineering targeted to improved kinetics and stability, and potential applications of the novel biological systems in bioprocess technology to achieve the production of value-added compounds with specific biological activities. - Assists in developing a conceptual understanding of synthetic biology and cellular and metabolic engineering. - Includes comprehensive information on new developments and advancements. - Lists applications of synthetic biology in agriculture, food, and health
Download or read book Design and Analysis of Biomolecular Circuits written by Heinz Koeppl and published by Springer Science & Business Media. This book was released on 2011-05-21 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with engineering aspects of the two emerging and intertwined fields of synthetic and systems biology. Both fields hold promise to revolutionize the way molecular biology research is done, the way today’s drug discovery works and the way bio-engineering is done. Both fields stress the importance of building and characterizing small bio-molecular networks in order to synthesize incrementally and understand large complex networks inside living cells. Reminiscent of computer-aided design (CAD) of electronic circuits, abstraction is believed to be the key concept to achieve this goal. It allows hiding the overwhelming complexity of cellular processes by encapsulating network parts into abstract modules. This book provides a unique perspective on how concepts and methods from CAD of electronic circuits can be leveraged to overcome complexity barrier perceived in synthetic and systems biology.
